Lopinavir/ritonavir in the treatment of HIV-1 infection: a review.

scientific article published on October 2008

Lopinavir/ritonavir in the treatment of HIV-1 infection: a review. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.2147/TCRM.S3285
P932PMC publication ID2621403
P698PubMed publication ID19209283

P2093author name stringJonathan Shuter
Ashish Chandwani
P2860cites workThe KLEAN study of fosamprenavir-ritonavir versus lopinavir-ritonavir, each in combination with abacavir-lamivudine, for initial treatment of HIV infection over 48 weeks: a randomised non-inferiority trialQ28256092
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Efficacy and safety of darunavir-ritonavir at week 48 in treatment-experienced patients with HIV-1 infection in POWER 1 and 2: a pooled subgroup analysis of data from two randomised trialsQ31108441
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Lopinavir/ritonavir: a review of its use in the management of HIV infectionQ34652472
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The tablet formulation of lopinavir/ritonavir provides similar bioavailability to the soft-gelatin capsule formulation with less pharmacokinetic variability and diminished food effect.Q53580804
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Ritonavir-Boosted Tipranavir Demonstrates Superior Efficacy to Ritonavir-Boosted Protease Inhibitors in Treatment-Experienced HIV-Infected Patients: 24-Week Results of the RESIST-2 TrialQ58291350
Potent inhibition of the cytochrome P-450 3A-mediated human liver microsomal metabolism of a novel HIV protease inhibitor by ritonavir: A positive drug-drug interactionQ78045189
Efficacy of the protease inhibitors tipranavir plus ritonavir in treatment-experienced patients: 24-week analysis from the RESIST-1 trialQ79273817
Low incidence of severe liver events in HIV patients with and without hepatitis C or B coinfection receiving lopinavir/ritonavirQ79466019
A once-daily lopinavir/ritonavir-based regimen provides noninferior antiviral activity compared with a twice-daily regimenQ80210009
Effects of lopinavir-ritonavir combined therapy during the rat pregnancy. Morphological and biochemical aspectsQ80310912
Lopinavir/ritonavir monotherapy as a simplification strategy in routine clinical practiceQ80446898
Virological success of lopinavir/ritonavir salvage regimen is affected by an increasing number of lopinavir/ritonavir-related mutations.Q38914190
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Genotypic and phenotypic cross-resistance patterns to lopinavir and amprenavir in protease inhibitor-experienced patients with HIV viremiaQ44191601
Analysis of the virological response with respect to baseline viral phenotype and genotype in protease inhibitor-experienced HIV-1-infected patients receiving lopinavir/ritonavir therapy.Q44252661
Forty-eight-week evaluation of lopinavir/ritonavir, a new protease inhibitor, in human immunodeficiency virus-infected childrenQ44360402
Improving lopinavir genotype algorithm through phenotype correlations: novel mutation patterns and amprenavir cross-resistanceQ44361062
The plasma and intracellular steady-state pharmacokinetics of lopinavir/ritonavir in HIV-1-infected patientsQ44479509
The protease inhibitor lopinavir-ritonavir may produce opiate withdrawal in methadone-maintained patientsQ44540993
Atazanavir plus ritonavir or saquinavir, and lopinavir/ritonavir in patients experiencing multiple virological failuresQ44561806
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Interactions between amprenavir and the lopinavir-ritonavir combination in heavily pretreated patients infected with human immunodeficiency virusQ44827288
Baseline HIV-1 RNA level and CD4 cell count predict time to loss of virologic response to nelfinavir, but not lopinavir/ritonavir, in antiretroviral therapy-naive patientsQ44951046
Coadministration of lopinavir/ritonavir and phenytoin results in two-way drug interaction through cytochrome P-450 inductionQ44973440
Short communication: liver toxicity of lopinavir-containing regimens in HIV-infected patients with or without hepatitis C coinfectionQ45016085
Metabolism and disposition of the HIV-1 protease inhibitor lopinavir (ABT-378) given in combination with ritonavir in rats, dogs, and humansQ45117927
HIV-infected patients receiving lopinavir/ritonavir-based antiretroviral therapy achieve high rates of virologic suppression despite adherence rates less than 95%.Q45187803
Metabolic evaluation of HIV-infected patients receiving a regimen containing lopinavir/ritonavir (Kaletra).Q45245267
Top stories of 2004. Back to the future: lopinavir/ritonavir as "monotherapy".Q45270739
Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: a phase II randomised controlled trialQ45405108
Randomized study of saquinavir with ritonavir or nelfinavir together with delavirdine, adefovir, or both in human immunodeficiency virus-infected adults with virologic failure on indinavir: AIDS Clinical Trials Group Study 359.Q45740263
Human immunodeficiency virus protease inhibitorsQ45751680
Cerebrospinal fluid and plasma HIV-1 RNA levels and lopinavir concentrations following lopinavir/ritonavir regimenQ46374842
Efficacy and safety of once-daily darunavir/ritonavir versus lopinavir/ritonavir in treatment-naive HIV-1-infected patients at week 48.Q46492574
A randomized trial to evaluate lopinavir/ritonavir versus saquinavir/ritonavir in HIV-1-infected patients: the MaxCmin2 trial.Q46746589
Comparison of atazanavir with lopinavir/ritonavir in patients with prior protease inhibitor failure: a randomized multinational trialQ46765423
Seven-year efficacy of a lopinavir/ritonavir-based regimen in antiretroviral-naïve HIV-1-infected patientsQ46794117
Lopinavir/ritonavir monotherapy or plus zidovudine and lamivudine in antiretroviral-naive HIV-infected patientsQ46807881
Treatment response to ritonavir-boosted tipranavir versus ritonavir-boosted lopinavir in HIV-1 patients with higher lopinavir mutation scoresQ46843318
Treatment for adult HIV infection: 2006 recommendations of the International AIDS Society-USA panelQ50105738
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P433issue5
P921main subjectHIVQ15787
lopinavirQ422585
ritonavirQ422618
lopinavir/ritonavirQ3836750
P304page(s)1023-1033
P577publication date2008-10-01
P1433published inTherapeutics and Clinical Risk ManagementQ15766913
P1476titleLopinavir/ritonavir in the treatment of HIV-1 infection: a review
P478volume4