α4-Integrin Antibody Treatment Blocks Monocyte/Macrophage Traffic to, Vascular Cell Adhesion Molecule-1 Expression in, and Pathology of the Dorsal Root Ganglia in an SIV Macaque Model of HIV-Peripheral Neuropathy

scientific article published on 05 May 2016

α4-Integrin Antibody Treatment Blocks Monocyte/Macrophage Traffic to, Vascular Cell Adhesion Molecule-1 Expression in, and Pathology of the Dorsal Root Ganglia in an SIV Macaque Model of HIV-Peripheral Neuropathy is …
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scholarly articleQ13442814

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P356DOI10.1016/J.AJPATH.2016.03.007
P932PMC publication ID4929389
P698PubMed publication ID27157989

P50authorJessica R LakritzQ32168945
Tricia H BurdoQ103027533
P2093author name stringKenneth C Williams
Andrew D Miller
Derek M Thibault
Jake A Robinson
Jennifer H Campbell
P2860cites workTwo calcium-binding proteins in infiltrate macrophages of rheumatoid arthritisQ24297982
Leukocyte integrins: role in leukocyte recruitment and as therapeutic targets in inflammatory diseaseQ26822941
CCR5 antagonism in HIV infection: current concepts and future opportunitiesQ26865457
Anti-α4 antibody treatment blocks virus traffic to the brain and gut early, and stabilizes CNS injury late in infectionQ27322602
A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosisQ29616119
Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytesQ29616210
The heterodimeric complex of MRP-8 (S100A8) and MRP-14 (S100A9). Antibody recognition, epitope definition and the implications for structureQ30978929
Increased monocyte turnover from bone marrow correlates with severity of SIV encephalitis and CD163 levels in plasmaQ33792327
Magnetic resonance spectroscopy reveals that activated monocytes contribute to neuronal injury in SIV neuroAIDS.Q33919945
Central nervous system damage, monocytes and macrophages, and neurological disorders in AIDS.Q34132328
Recently infiltrating MAC387(+) monocytes/macrophages a third macrophage population involved in SIV and HIV encephalitic lesion formationQ34839993
Novel approaches to treating inflammatory bowel disease: targeting alpha-4 integrinQ35593026
Monocyte Traffic, Dorsal Root Ganglion Histopathology, and Loss of Intraepidermal Nerve Fiber Density in SIV Peripheral NeuropathyQ35792802
Dorsal root ganglia damage in SIV-infected rhesus macaques: an animal model of HIV-induced sensory neuropathyQ35952086
Anti-α4 Integrin Antibody Blocks Monocyte/Macrophage Traffic to the Heart and Decreases Cardiac Pathology in a SIV Infection Model of AIDS.Q36168754
Loss of intraepidermal nerve fiber density during SIV peripheral neuropathy is mediated by monocyte activation and elevated monocyte chemotactic proteinsQ36383524
Rosuvastatin treatment reduces markers of monocyte activation in HIV-infected subjects on antiretroviral therapyQ37528422
Mechanisms of distal axonal degeneration in peripheral neuropathies.Q38330759
Immune Suppression by Myeloid Cells in HIV Infection: New Targets for ImmunotherapyQ39048479
Simian immunodeficiency virus encephalitis in rhesus macaques is associated with rapid disease progression.Q39588377
Pathology of simian immunodeficiency virus induced disease.Q40631660
Reduced intraepidermal nerve fiber density in HIV-associated sensory neuropathyQ40667434
Neuropathogenesis of simian immunodeficiency virus infection in macaque monkeys.Q41468236
The monoclonal antibody MAC387 detects an epitope on the calcium-binding protein MRP14.Q41492947
A benefit-risk analysis of natalizumab in the treatment of patients with multiple sclerosis when considering the risk of progressive multifocal leukoencephalopathyQ42252182
The importance of monocytes and macrophages in HIV pathogenesis, treatment, and cure.Q43505499
Tumor necrosis factor-α-dependent infiltration of macrophages into the dorsal root ganglion in a rat disc herniation modelQ44697260
Pathogenesis of simian immunodeficiency virus-induced alterations in macaque trigeminal gangliaQ45408576
Immunotoxicity profile of natalizumab.Q45979796
Natalizumab treatment reduces endothelial activity in MS patientsQ59273802
Experimental arthritis causes tumor necrosis factor-α-dependent infiltration of macrophages into rat dorsal root ganglia which correlates with pain-related behaviorQ60680206
Expression and complex formation of S100-like proteins MRP8 and MRP14 by macrophages during renal allograft rejectionQ71639283
P4510describes a project that usesImageJQ1659584
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectMacacaQ177601
pathologyQ7208
antibodyQ79460
macrophageQ184204
cell adhesionQ187640
P304page(s)1754-1761
P577publication date2016-05-05
P1433published inThe American Journal of PathologyQ4744259
P1476titleα4-Integrin Antibody Treatment Blocks Monocyte/Macrophage Traffic to, Vascular Cell Adhesion Molecule-1 Expression in, and Pathology of the Dorsal Root Ganglia in an SIV Macaque Model of HIV-Peripheral Neuropathy
P478volume186

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Q38809806An oral form of methylglyoxal-bis-guanylhydrazone reduces monocyte activation and traffic to the dorsal root ganglia in a primate model of HIV-peripheral neuropathy
Q64077411Antineuroinflammatory drugs in HIV-associated neurocognitive disorders as potential therapy
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Q38598335Update of HIV-Associated Sensory Neuropathies