Association of the Kir6.2 E23K variant with reduced acute insulin response in African-Americans

scientific article published on 16 September 2008

Association of the Kir6.2 E23K variant with reduced acute insulin response in African-Americans is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1210/JC.2008-0543
P932PMC publication ID2626454
P698PubMed publication ID18796522
P5875ResearchGate publication ID23260918

P50authorJerome I RotterQ59813011
Nicholette D PalmerQ88464225
Kent D TaylorQ89467237
Donald W BowdenQ92206005
Carl D. LangefeldQ102208371
Michael Bryer-AshQ114385367
P2860cites workGenetic epidemiology of insulin resistance and visceral adiposity. The IRAS Family Study design and methodsQ44396015
Minimal model-based insulin sensitivity has greater heritability and a different genetic basis than homeostasis model assessment or fasting insulinQ44433950
Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene regionQ44865544
Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: patient characteristics and initial response to sulfonylurea therapyQ45077978
Candidate gene association analysis for a quantitative trait, using parent-offspring trios.Q45935639
Common variants in the ATP-sensitive K+ channel genes KCNJ11 (Kir6.2) and ABCC8 (SUR1) in relation to glucose intolerance: population-based studies and meta-analysesQ46447198
Kir6.2 mutations are a common cause of permanent neonatal diabetes in a large cohort of French patientsQ47306165
MINMOD: a computer program to calculate insulin sensitivity and pancreatic responsivity from the frequently sampled intravenous glucose tolerance test.Q54421540
Quantitative traits associated with the Type 2 diabetes susceptibility allele in Kir6.2Q57112357
Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptorQ24304448
Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetesQ24338339
PedCheck: a program for identification of genotype incompatibilities in linkage analysisQ24539016
Activating mutations in the ABCC8 gene in neonatal diabetes mellitusQ27863930
Molecular biology of adenosine triphosphate-sensitive potassium channelsQ28141603
Adenosine 5'-triphosphate-sensitive potassium channelsQ28307662
Multipoint quantitative-trait linkage analysis in general pedigreesQ29614967
Accurate assessment of beta-cell function: the hyperbolic correctionQ34508795
The evolution of beta-cell dysfunction and insulin resistance in type 2 diabetesQ34655580
Neonatal and very-early-onset diabetes mellitusQ35687894
Roles of KATP channels as metabolic sensors in acute metabolic changesQ36135755
Abnormalities of pancreatic islets by targeted expression of a dominant-negative KATP channelQ36632145
Assessment of insulin sensitivity in vivoQ39816379
Promiscuous coupling between the sulphonylurea receptor and inwardly rectifying potassium channelsQ41229259
Quantitative estimation of insulin sensitivityQ41600825
Amino acid polymorphisms in the ATP-regulatable inward rectifier Kir6.2 and their relationships to glucose- and tolbutamide-induced insulin secretion, the insulin sensitivity index, and NIDDM.Q42551184
Reduced sample number for calculation of insulin sensitivity and glucose effectiveness from the minimal model. Suitability for use in population studiesQ43632818
K(IR)6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic beta-cell ATP-sensitive K(+) channelsQ43901662
Variations in insulin secretion in carriers of the E23K variant in the KIR6.2 subunit of the ATP-sensitive K(+) channel in the beta-cellQ44155606
The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetesQ44286437
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectpreproinsulinQ7240673
P304page(s)4979-4983
P577publication date2008-09-16
P1433published inThe Journal of Clinical Endocrinology and MetabolismQ3186902
P1476titleAssociation of the Kir6.2 E23K variant with reduced acute insulin response in African-Americans
P478volume93

Reverse relations

cites work (P2860)
Q28649579Genetic variations in magnesium-related ion channels may affect diabetes risk among African American and Hispanic American women
Q37267062Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance
Q33604496TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action.
Q39783056The ATP-sensitive K(+) channel ABCC8 S1369A type 2 diabetes risk variant increases MgATPase activity
Q37942030The molecular genetics of sulfonylurea receptors in the pathogenesis and treatment of insulin secretory disorders and type 2 diabetes

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