The risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome.

scientific article published on July 2008

The risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome. is …
instance of (P31):
scholarly articleQ13442814
meta-analysisQ815382

External links are
P356DOI10.1002/IJC.23508
P932PMC publication ID2627772
P698PubMed publication ID18398828
P5875ResearchGate publication ID5453548

P50authorInge BernsteinQ67837730
Jukka-Pekka MecklinQ20252267
Hans VasenQ51123729
Lone SundeQ51628358
Juul T WijnenQ55486718
P2093author name stringHenry T Lynch
Heikki J Järvinen
Patrice Watson
Torben Myrhøj
Markku Aarnio
P2860cites workRisk of gastric cancer in hereditary nonpolyposis colorectal cancer in KoreaQ57216053
Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer) DiagnosticsQ57741862
Extracolonic cancer in hereditary nonpolyposis colorectal cancerQ70557907
The potential role of serum CA 125 in an ultrasound-based screening program for familial ovarian cancerQ72361866
Male breast cancer in the hereditary nonpolyposis colorectal cancer syndromeQ77333259
What's the trouble with cytology?Q79329925
Cancer risk in mutation carriers of DNA-mismatch-repair genesQ34502900
Is surveillance of the small bowel indicated for Lynch syndrome families?Q35954134
Recommendations for the care of individuals with an inherited predisposition to Lynch syndrome: a systematic reviewQ36604730
Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer).Q36746989
Hereditary non-polyposis colorectal cancer: current risks of colorectal cancer largely overestimated.Q42920853
Is breast cancer part of the tumor spectrum of hereditary nonpolyposis colorectal cancer?Q43006441
MSH2 mutation carriers are at higher risk of cancer than MLH1 mutation carriers: a study of hereditary nonpolyposis colorectal cancer families.Q43604312
The risk of brain tumours in hereditary non-polyposis colorectal cancer (HNPCC).Q49119128
Cancer risk in young women at risk of hereditary nonpolyposis colorectal cancer: implications for gynecologic surveillanceQ50672676
Genotype-phenotype comparison of German MLH1 and MSH2 mutation carriers clinically affected with Lynch syndrome: a report by the German HNPCC ConsortiumQ51935195
Germ line mutations of mismatch repair genes in hereditary nonpolyposis colorectal cancer patients with small bowel cancer: International Society for Gastrointestinal Hereditary Tumours Collaborative StudyQ53254701
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)444-449
P577publication date2008-07-01
P1433published inInternational Journal of CancerQ332492
P1476titleThe risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome
P478volume123

Reverse relations

cites work (P2860)
Q57802927A framework to build capacity for a reflex-testing program for Lynch syndrome
Q33683102A genetic model for gallbladder carcinogenesis and its dissemination
Q33648552A molecular inversion probe-based next-generation sequencing panel to detect germline mutations in Chinese early-onset colorectal cancer patients
Q37089839A novel deleterious c.2656G>T MSH2 germline mutation in a Pakistani family with a phenotypic overlap of hereditary breast and ovarian cancer and Lynch syndrome
Q45936434A patient with four metachronous cancers and multiple adenomatous colon polyps harboring the American Founder Lynch syndrome mutation: a case report.
Q51331719A proportion of hereditary upper urinary tract urothelial carcinomas are misclassified as sporadic according to a multi-institutional database analysis: proposal of patient-specific risk identification tool
Q58574407A retrospective study of extracolonic, non-endometrial cancer in Swedish Lynch syndrome families
Q37838462A systematic review of gynecological cancer surveillance in women belonging to hereditary nonpolyposis colorectal cancer (Lynch syndrome) families
Q36416282ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes
Q83172998Adrenocortical carcinoma, an unusual extracolonic tumor associated with Lynch II syndrome
Q30426125Advances in the genetics of glioblastoma: are we reaching critical mass?
Q51759825Alcohol consumption and early-onset risk of colorectal cancer in Japanese patients with Lynch syndrome: a cross-sectional study conducted by the Japanese Society for Cancer of the Colon and Rectum
Q48246873Anaplastic oligodendroglioma in an adolescent with Lynch syndrome.
Q35469854Applying public health screening criteria: how does universal newborn screening compare to universal tumor screening for Lynch syndrome in adults with colorectal cancer?
Q39042915Approach to Lynch Syndrome for the Gastroenterologist.
Q84030213Atypical identification of Lynch syndrome by immunohistochemistry and microsatellite instability analysis on jejunal adenocarcinoma
Q37114675Biomarker in Colorectal Cancer.
Q34161642Breast cancer susceptibility: current knowledge and implications for genetic counselling
Q36245422Breast carcinoma and Lynch syndrome: molecular analysis of tumors arising in mutation carriers, non-carriers, and sporadic cases
Q34910918Cancer Genetics: Risks and Mechanisms of Cancer in Women with Inherited Susceptibility to Epithelial Ovarian Cancer
Q38100658Cancer risk in Lynch Syndrome
Q33582756Cancer risk in MLH1, MSH2 and MSH6 mutation carriers; different risk profiles may influence clinical management
Q50556962Cancer risks and immunohistochemical profiles linked to the Danish MLH1 Lynch syndrome founder mutation.
Q92134834Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database
Q39198359Cancer screening behaviors and risk perceptions among family members of colorectal cancer patients with unexplained mismatch repair deficiency
Q84347151Causes of death of mutation carriers in Finnish Lynch syndrome families
Q35019094Cervical neuroendocrine tumor in a young female with Lynch Syndrome
Q90410559Challenges in the identification of inherited risk of ovarian cancer: where should we go from here?
Q87092782Changes in Specialists’ Perspectives on Cancer Genetic Testing, Prophylactic Surgery and Insurance Discrimination: Then and Now
Q38929029Changing patterns of referrals and outcomes of genetic participation in gynaecological-oncology multidisciplinary care
Q62978086Characteristics of Lynch syndrome associated ovarian cancer
Q90729302Clinical Factors Associated with Urinary Tract Cancer in Individuals with Lynch Syndrome
Q26749157Clinical Genetic Testing in Gastroenterology
Q92403143Clinical characteristics of patients with colorectal cancer with double somatic mismatch repair mutations compared with Lynch syndrome
Q38100643Clinical importance of Familial Pancreatic Cancer Registry in Japan: a report from kick-off meeting at International Symposium on Pancreas Cancer 2012.
Q35954814Clinicopathological Features and Management of Cancers in Lynch Syndrome
Q34174654Clinicopathological and genetic features of Chinese hereditary nonpolyposis colorectal cancer (HNPCC).
Q55924124Colorectal cancer
Q35318672Combined colonoscopy and endometrial biopsy cancer screening results in women with Lynch syndrome
Q35474031Comparative effectiveness of screening strategies for Lynch syndrome.
Q30587310Comparing universal Lynch syndrome tumor-screening programs to evaluate associations between implementation strategies and patient follow-through
Q91895870Comparison of screening strategies for Lynch syndrome in patients with newly diagnosed endometrial cancer: a prospective cohort study in China
Q64238410Comprehensive Paired Tumor/Germline Testing for Lynch Syndrome: Bringing Resolution to the Diagnostic Process
Q35991337Creation of a network to promote universal screening for Lynch syndrome: the LynchSyndrome Screening Network
Q34639739Current advance in small bowel tumors
Q21328691Current hypotheses on how microsatellite instability leads to enhanced survival of Lynch Syndrome patients
Q35211661Decisions about prophylactic gynecologic surgery: a qualitative study of the experience of female Lynch syndrome mutation carriers
Q26796491Deficient mismatch repair: Read all about it (Review)
Q52673450Desmoplastic Tumor Microenvironment and Immunotherapy in Cholangiocarcinoma.
Q37797761Diagnosing Hereditary Colorectal Cancer
Q34610509Diagnosis and management of hereditary colorectal cancer syndromes: Lynch syndrome as a model
Q46585107Dietary patterns and colorectal adenomas in Lynch syndrome: the GEOLynch cohort study
Q47756509Discordant Mismatch Repair Protein Immunoreactivity in Lynch Syndrome-Associated Neoplasms:  A Recommendation for Screening Synchronous/Metachronous Neoplasms
Q34507528Distinct gene expression profiles in ovarian cancer linked to Lynch syndrome
Q50742113Distinct molecular profiles in Lynch syndrome-associated and sporadic ovarian carcinomas
Q104739130Double somatic mismatch repair gene pathogenic variants as common as Lynch syndrome among endometrial cancer patients
Q24655053EGAPP supplementary evidence review: DNA testing strategies aimed at reducing morbidity and mortality from Lynch syndrome
Q26865704Early detection and prevention of pancreatic cancer: is it really possible today?
Q60302084Endometrial Carcinoma, Grossing and Processing Issues: Recommendations of the International Society of Gynecologic Pathologists
Q36178261Endometrial and Ovarian Cancer in Lynch Syndrome
Q37288004Endometrial and ovarian cancer in women with Lynch syndrome: update in screening and prevention
Q28303873Endometrial cancer and Lynch syndrome: clinical and pathologic considerations
Q83133097Endometrial cancers and predisposition
Q40804249Equivalent Helicobacter pylori infection rates in Lynch syndrome mutation carriers with and without a first-degree relative with gastric cancer
Q34514962Estimating penetrance from multiple case families with predisposing mutations: extension of the 'genotype-restricted likelihood' (GRL) method
Q44719816Excess of extracolonic non-endometrial multiple primary cancers in MSH2 germline mutation carriers over MLH1.
Q30453984Extracolonic Manifestations of Lynch Syndrome
Q38467435Familial colorectal cancer
Q34265940Features of ovarian cancer in Lynch syndrome (Review).
Q44117163First degree relatives and familial aggregation of gastric cancer: who to choose for control in case-control studies?
Q35038381First reported case of a squamous cell carcinoma arising in the duodenum in a patient with Lynch syndrome
Q38062023Follow-up recommendations and risk-reduction initiatives for Lynch syndrome
Q38934067Gastric carcinoma in canines and humans, a review.
Q37921953Gastric tumours in hereditary cancer syndromes: clinical features, molecular biology and strategies for prevention
Q35885813Gender-Specific Aspects of Lynch Syndrome and Familial Adenomatous Polyposis
Q90321477Genetic Counseling and Surveillance Focused on Lynch Syndrome
Q37798758Genetic counseling considerations in the evaluation of families for Lynch syndrome--a review
Q37468316Genetic risk and gynecologic cancers.
Q53137270Genetic testing for Lynch syndrome in the province of Ontario.
Q51219045Genetics of gastric cancer.
Q38211737Genetics, biomarkers, hereditary cancer syndrome diagnosis, heterogeneity and treatment: a review
Q28394400Germline rearrangements in families with strong family history of glioma and malignant melanoma, colon, and breast cancer
Q34481263Germline truncating-mutations in BRCA1 and MSH6 in a patient with early onset endometrial cancer
Q27691826Glioblastoma genetics: in rapid flux
Q39558666Glioblastoma multiforme as initial internal malignancy in Muir-Torre syndrome (MTS).
Q48345663Glioblastomas, astrocytomas and oligodendrogliomas linked to Lynch syndrome
Q51063696Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-society Task Force on colorectal cancer
Q83769643HNPCC (hereditary non-polyposis colorectal cancer) or Lynch syndrome: a syndrome related to a failure of DNA repair system
Q37221783Health benefits and cost-effectiveness of primary genetic screening for Lynch syndrome in the general population.
Q37910384Hereditary Colon Cancer Syndromes
Q38061384Hereditary Renal Tumor Syndromes: Imaging Findings and Management Strategies
Q36990149Hereditary cancer registries improve the care of patients with a genetic predisposition to cancer: contributions from the Dutch Lynch syndrome registry
Q38241489Hereditary cancer syndromes with high risk of endometrial and ovarian cancer: surgical options for personalized care
Q33918280Hereditary colon cancer: lynch syndrome
Q34648373Hereditary nonpolyposis colorectal cancer (HNPCC)/Lynch syndrome
Q34480707Hereditary ovarian cancer: not only BRCA 1 and 2 genes.
Q34977063Hereditary ovarian carcinoma: heterogeneity, molecular genetics, pathology, and management
Q30249161High risk factors of pancreatic carcinoma.
Q37968220Identification of Individuals at Risk for Lynch Syndrome Using Targeted Evaluations and Genetic Testing: National Society of Genetic Counselors and the Collaborative Group of the Americas on Inherited Colorectal Cancer Joint Practice Guideline
Q55058657Identification of a novel MSH6 germline variant in a family with multiple gastro-intestinal malignancies by next generation sequencing.
Q35179173Immunohistochemical analysis of mismatch repair proteins in Iranian colorectal cancer patients at risk for lynch syndrome
Q92461421Immunotherapy in colorectal cancer: rationale, challenges and potential
Q37146388Implementing screening for Lynch syndrome among patients with newly diagnosed colorectal cancer: summary of a public health/clinical collaborative meeting
Q26772272Implications of mismatch repair-deficient status on management of early stage colorectal cancer
Q90529965Importance of gastric cancer for the diagnosis and surveillance of Japanese Lynch syndrome patients
Q48249964Increasing awareness and knowledge of lifestyle recommendations for cancer prevention in Lynch syndrome carriers: Randomized controlled trial.
Q38006385Inherited Risk of Ovarian Cancer and the Implications for Screening
Q35000971Integrated analysis of mismatch repair system in malignant astrocytomas.
Q37073180Intraductal papillary mucinous neoplasm of the pancreas with loss of mismatch repair in a patient with Lynch syndrome
Q91879304Investigating the Link between Lynch Syndrome and Breast Cancer
Q37073606Is it all Lynch syndrome?: An assessment of family history in individuals with mismatch repair-deficient tumors
Q91852820Lynch Syndrome in Urologic Malignancies - What Does the Urologist Need to Know?
Q35821477Lynch Syndrome in patients with clear cell and endometrioid cancers of the ovary
Q37994931Lynch or Not Lynch? Is that Always a Question?
Q26797255Lynch syndrome and Lynch syndrome mimics: The growing complex landscape of hereditary colon cancer
Q28067471Lynch syndrome and exposure to aristolochic acid in upper-tract urothelial carcinoma: its clinical impact?
Q47630690Lynch syndrome and sextuple primary malignancies.
Q36758454Lynch syndrome related endometrial cancer: clinical significance beyond the endometrium
Q37987828Lynch syndrome: clinical, pathological, and genetic insights
Q37430836Management of extracolonic tumours in patients with Lynch syndrome
Q34988799Management of ovarian and endometrial cancers in women belonging to HNPCC carrier families: review of the literature and results of cancer risk assessment in Polish HNPCC families
Q30426539Management of precancerous conditions and lesions in the stomach (MAPS): guideline from the European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter Study Group (EHSG), European Society of Pathology (ESP), and the Sociedade Portu
Q57698678Management of precancerous conditions and lesions in the stomach (MAPS): guideline from the European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter Study Group (EHSG), European Society of Pathology (ESP), and the Sociedade Portug
Q36958508Metastatic colorectal carcinoma mimicking primary ovarian carcinoma presenting as ‘giant’ ovarian tumors in an individual with probable Lynch syndrome: a case report
Q45152203Microsatellite Instability andTARBP2Mutation Study in Upper Urinary Tract Urothelial Carcinoma
Q90284677Microsatellite Instability in Endometrial Carcinoma by Immunohistochemistry, Association with Clinical and Histopathologic Parameters
Q24627393Microsatellite instability in colorectal cancer
Q83835402Microsatellite instability in colorectal cancer: from molecular oncogenic mechanisms to clinical implications
Q36124008Microsatellite instability testing and its role in the management of colorectal cancer.
Q43864989Milestones of Lynch syndrome: 1895-2015.
Q29248750Mismatch Repair Polymorphisms as Markers of Breast Cancer Prevalence in the Breast Cancer Family Registry
Q38741029Mismatch repair deficiency testing in clinical practice
Q26747329Molecular Subtypes and Personalized Therapy in Metastatic Colorectal Cancer
Q37710556Molecular Testing for Gastrointestinal Cancer.
Q26764919Molecular alterations in gastric cancer with special reference to the early-onset subtype
Q41343102Molecular analysis of Iranian colorectal cancer patients at risk for Lynch syndrome: a new molecular, clinicopathological feature
Q50055151Molecular classification and precision therapy of cancer: immune checkpoint inhibitors
Q88783378Molecular subtype classification of urothelial carcinoma in Lynch syndrome
Q38732720Müllerian intra-abdominal carcinomatosis in hereditary breast ovarian cancer syndrome: implications for risk-reducing surgery
Q37830205Newer developments in the therapeutics of the transitional cell carcinoma of renal pelvis
Q35744898Novel germline MSH2 mutation in lynch syndrome patient surviving multiple cancers
Q27315851Observational Study: Familial Relevance and Oncological Significance of Revised Bethesda Guidelines in Colorectal Patients That Have Undergone Curative Resection
Q37390074Occult transitional cell carcinoma and Lynch syndrome incidentally revealed after laparoscopic hysterectomy and cystoscopy during staging for endometrial cancer
Q45068704Ovarian Cancer Prevention in High-risk Women
Q83572257Ovarian cancer linked to Lynch syndrome typically presents as early-onset, non-serous epithelial tumors
Q38143316Ovarian cancer: risk factors, treatment and management
Q27024662PMS2 monoallelic mutation carriers: the known unknown
Q47153954Pancreatic Cancer in Lynch Syndrome Patients
Q36182997Pancreatic cancer and a novel MSH2 germline alteration
Q90565268Pathologic findings and clinical outcomes in women undergoing risk-reducing surgery to prevent ovarian and fallopian tube carcinoma: A large prospective single institution experience
Q37693658Pathological features and clinical behavior of Lynch syndrome-associated ovarian cancer.
Q62002182Pathophysiology of Hereditary Diffuse Gastric Cancer
Q49551587Patient communication of cancer genetic test results in a diverse population
Q46324177Phenotypic and genotypic heterogeneity of Lynch syndrome: a complex diagnostic challenge
Q43625600Phenotypic heterogeneity of hereditary gynecologic cancers: a report from the Creighton hereditary cancer registry
Q47745633Prevalence and prognostic role of mismatch repair gene defect in endometrial cancer patients
Q34600647Primary peritoneal cancer after bilateral salpingo-oophorectomy in two patients with Lynch syndrome
Q42378389Profiling cancer-associated genetic alterations and molecular classification of cancer in Korean gastric cancer patients.
Q37834463Prophylactic surgery in Lynch syndrome
Q34459728Prospective study of combined colon and endometrial cancer screening in women with lynch syndrome: a patient-centered approach
Q36219067Pseudomyxoma peritonei of a mature ovarian teratoma caused by mismatch repair deficiency in a patient with Lynch syndrome: a case report
Q51743129Recognizing Gynecological Cancer in Primary Care: Risk Factors, Red Flags, and Referrals.
Q44080353Recurrence and variability of germline EPCAM deletions in Lynch syndrome.
Q40516598Reproductive Decision-Making in MMR Mutation Carriers After Results Disclosure: Impact of Psychological Status in Childbearing Options.
Q90210420Resolving gastric cancer aetiology: an update in genetic predisposition
Q24610838Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications
Q36824964Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts
Q36758605Risk assessment, genetic testing, and management of Lynch syndrome
Q36903207Risk of breast cancer in Lynch syndrome: a systematic review.
Q36897112Risk of colorectal and endometrial cancers in EPCAM deletion-positive Lynch syndrome: a cohort study
Q34163849Risk of endometrial cancer for women diagnosed with HNPCC-related colorectal carcinoma
Q33880380Risk of pancreatic cancer in families with Lynch syndrome
Q34346668Risk of urothelial bladder cancer in Lynch syndrome is increased, in particular among MSH2 mutation carriers
Q37996440Role of common genetic variants in ovarian cancer susceptibility and outcome: progress to date from the Ovarian Cancer Association Consortium (OCAC).
Q83159492Sarcomas associated with hereditary nonpolyposis colorectal cancer: broad anatomical and morphological spectrum
Q37071737Screening adherence and cancer risk perceptions in colorectal cancer survivors with Lynch-like syndrome.
Q48107196Screening for Lynch syndrome using risk assessment criteria in patients with ovarian cancer.
Q33715019Screening of the DNA mismatch repair genes MLH1, MSH2 and MSH6 in a Greek cohort of Lynch syndrome suspected families
Q53251543Strategies for screening for pancreatic adenocarcinoma in high-risk patients: the place of endoscopic ultrasound
Q48219440Suggestion of added value by bevacizumab to chemotherapy in patients with unresectable or recurrent small bowel cancer.
Q38108741Surveillance for urinary tract cancer in Lynch syndrome.
Q36205603Synchronous and metachronous malignancy in endometrial cancer patients treated in a tertiary care center of Thailand
Q58568666Synchronous endometrial and ovarian cancer in Lynch syndrome with a germline mutation: A case report
Q34121605Synchronous gastric and sebaceous cancers, a rare manifestation of MLH1-related Muir-Torre syndrome
Q64934285Systematic Review: An Update on the Spectrum of Urological Malignancies in Lynch Syndrome.
Q36210453TP53 Polymorphisms and Colorectal Cancer Risk in Patients with Lynch Syndrome in Taiwan: A Retrospective Cohort Study
Q36245933Targeted DNA Sequencing Detects Mutations Related to Susceptibility among Familial Non-medullary Thyroid Cancer
Q48483117Teenage colorectal polyposis and cancer may be caused by constitutional mismatch repair deficiency (CMMRD).
Q37058193The double-edged sword of ovarian cancer information for women at increased risk who have previously taken part in screening
Q34081267The genetic basis of Lynch syndrome and its implications for clinical practice and risk management
Q38789406The genetic prediction of risk for gynecologic cancers.
Q34775177The inherited genetics of ovarian and endometrial cancer
Q59548976The results of gynecologic surveillance in families with hereditary nonpolyposis colorectal cancer
Q37524923The risk of colorectal cancer is not increased after a diagnosis of urothelial cancer: a population-based study
Q43970731The spectrum of urological malignancy in Lynch syndrome
Q83830781Thirty-Nine-Year-Old With Familial Colon Cancer, and Variant of Undetermined Significance in MSH6
Q38979257Time to incorporate germline multigene panel testing into breast and ovarian cancer patient care
Q47729288Towards gene- and gender-based risk estimates in Lynch syndrome; age-specific incidences for 13 extra-colorectal cancer types
Q52577954Tumor development in Japanese patients with Lynch syndrome
Q37731657Two cases of successful pregnancies after hysteroscopic removal of endometrioid adenocarcinoma grade I, stage IA, in young women with Lynch syndrome
Q38737901Understanding the Pathogenicity of Noncoding Mismatch Repair Gene Promoter Variants in Lynch Syndrome
Q93345706Universal tumor screening for Lynch syndrome: perspectives of Canadian pathologists and genetic counselors
Q36990046Update on Lynch syndrome genomics
Q43662370Upper Urinary Tract Carcinoma in Lynch Syndrome Cases
Q51421660Upper tract urothelial carcinomas: frequency of association with mismatch repair protein loss and lynch syndrome
Q34604182Ureteroscopic management of upper tract urothelial carcinoma (UTUC) in patients with Lynch Syndrome (hereditary nonpolyposis colorectal cancer syndrome)
Q41345672Urinary Tract Cancer in Lynch Syndrome; Increased Risk in Carriers of MSH2 Mutations.
Q51020589Urinary tract cancer in patients with hereditary non-polyposis colorectal cancer
Q59272977Uroepithelial and kidney carcinoma in Lynch syndrome

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