Towards reconciling structure and function in the nuclear pore complex

scientific article published on 29 January 2008

Towards reconciling structure and function in the nuclear pore complex is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/S00418-007-0371-X
P932PMC publication ID2228380
P698PubMed publication ID18228033
P5875ResearchGate publication ID5623901

P50authorBirthe FahrenkrogQ41629404
Ueli AebiQ14594735
Roderick LimQ42598489
P2860cites workCryo-electron tomography provides novel insights into nuclear pore architecture: implications for nucleocytoplasmic transportQ41629388
Transport between the cell nucleus and the cytoplasmQ22065411
Nuclear envelope permeabilityQ22122423
Proteomic analysis of the mammalian nuclear pore complexQ24305242
GLFG and FxFG nucleoporins bind to overlapping sites on importin-betaQ24310348
The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complexQ24316128
Disorder in the nuclear pore complex: the FG repeat regions of nucleoporins are natively unfoldedQ24554044
Identification of different roles for RanGDP and RanGTP in nuclear protein importQ24561933
Gradient of increasing affinity of importin beta for nucleoporins along the pathway of nuclear importQ24652021
Signals and structural features involved in integral membrane protein targeting to the inner nuclear membraneQ24672562
Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complexQ24676068
The yeast nuclear pore complex: composition, architecture, and transport mechanismQ24680784
A large particle associated with the perimeter of the nuclear pore complexQ24681457
Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear traffickingQ27625995
Structure of the C-terminal FG-nucleoporin binding domain of Tap/NXF1Q27638140
Structural basis for the interaction between NTF2 and nucleoporin FxFG repeatsQ27639170
The three-dimensional structure of the autoproteolytic, nuclear pore-targeting domain of the human nucleoporin Nup98Q27639518
Structural basis for the interaction between the Tap/NXF1 UBA domain and FG nucleoporins at 1A resolutionQ27640483
Crystal structure of the N-terminal domain of the human protooncogene Nup214/CANQ27643706
Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular slidingQ27644208
Molecular characterization of the Ran-binding zinc finger domain of Nup153Q27644396
Minimal nuclear pore complexes define FG repeat domains essential for transportQ27931250
Nuclear mRNA export requires specific FG nucleoporins for translocation through the nuclear pore complexQ27931590
Molecular architecture of the yeast nuclear pore complex: localization of Nsp1p subcomplexesQ27933725
Binding dynamics of structural nucleoporins govern nuclear pore complex permeability and may mediate channel gatingQ27935153
Natively unfolded nucleoporins gate protein diffusion across the nuclear pore complex.Q27938407
Yeast nuclear pore complexes have a cytoplasmic ring and internal filaments.Q27939927
The N-terminal domain of Nup159 forms a beta-propeller that functions in mRNA export by tethering the helicase Dbp5 to the nuclear poreQ27939942
Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporinsQ28131733
Intrinsically disordered proteinQ28191444
Nup214-Nup88 nucleoporin subcomplex is required for CRM1-mediated 60 S preribosomal nuclear exportQ28238313
Isolation of a protein that is essential for the first step of nuclear protein importQ28243173
Entropic elasticity of lambda-phage DNAQ28247727
Polymer brushesQ28248200
G2 arrest and impaired nucleocytoplasmic transport in mouse embryos lacking the proto-oncogene CAN/Nup214Q28504583
The crystal structure of mouse Nup35 reveals atypical RNP motifs and novel homodimerization of the RRM domainQ28506997
Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporinsQ28573887
Peering through the pore: nuclear pore complex structure, assembly, and functionQ28609626
The Saccharomyces cerevisiae nucleoporin Nup2p is a natively unfolded proteinQ28909274
Intrinsically unstructured proteinsQ29614784
Transport into and out of the nucleusQ29615611
Three-dimensional architecture of the isolated yeast nuclear pore complex: functional and evolutionary implicationsQ29616786
Molecular mechanism of the nuclear protein import cycleQ29617058
Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycleQ29619289
The GTP-binding protein Ran/TC4 is required for protein import into the nucleusQ29620192
Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factorQ29620193
Architecture and design of the nuclear pore complexQ29622853
Nuclear transport of single molecules: dwell times at the nuclear pore complex.Q41873308
Significant proportions of nuclear transport proteins with reduced intracellular mobilities resolved by fluorescence correlation spectroscopyQ41958794
Evidence for Ca2+- and ATP-sensitive peripheral channels in nuclear pore complexesQ43726397
Passive transport of macromolecules through Xenopus laevis nuclear envelopeQ44729129
Rapid evolution exposes the boundaries of domain structure and function in natively unfolded FG nucleoporinsQ46062002
AFM and SFG studies of pHEMA-based hydrogel contact lens surfaces in saline solution: adhesion, friction, and the presence of non-crosslinked polymer chains at the surfaceQ46073323
Friction studies of hydrogel contact lenses using AFM: non-crosslinked polymers of low friction at the surfaceQ46462321
Structural basis for the high-affinity binding of nucleoporin Nup1p to the Saccharomyces cerevisiae importin-beta homologue, Kap95pQ46476120
Nucleoporin domain topology is linked to the transport status of the nuclear pore complexQ46620275
Multiple conformations in the ligand-binding site of the yeast nuclear pore-targeting domain of Nup116pQ46654951
Nuclear side conformational changes in the nuclear pore complex following calcium release from the nuclear membraneQ46735884
Binding dynamics of isolated nucleoporin repeat regions to importin-betaQ46843299
Nanomechanical basis of selective gating by the nuclear pore complexQ46966189
Karyopherins and kissing cousinsQ47721363
AFM force measurements on microtubule-associated proteins: the projection domain exerts a long-range repulsive forceQ48773095
Domain topology of the p62 complex within the 3-D architecture of the nuclear pore complex.Q48791551
Domain-specific antibodies reveal multiple-site topology of Nup153 within the nuclear pore complexQ48841715
Calcium-mediated structural changes of native nuclear pore complexes monitored by time-lapse atomic force microscopyQ48921292
The location of the transport gate in the nuclear pore complex.Q48945948
Nanomechanical interactions of phenylalanine-glycine nucleoporins studied by single molecule force-volume spectroscopyQ50165583
Changes in nucleoporin domain topology in response to chemical effectors.Q50645127
Passive and facilitated transport in nuclear pore complexes is largely uncoupled.Q50705004
Fine structure of the pore-annulus complex in the nuclear envelope and annulate lamellae of germ cellsQ52507011
Cell-cycle-dependent dynamics of nuclear pores: pore-free islands and lamins.Q53590705
Nuclear Pore Complex Structure and Dynamics Revealed by Cryoelectron TomographyQ57793026
A Saturated FG-Repeat Hydrogel Can Reproduce the Permeability Properties of Nuclear Pore ComplexesQ58076940
FG-Rich Repeats of Nuclear Pore Proteins Form a Three-Dimensional Meshwork with Hydrogel-Like PropertiesQ58076963
The ultrastructure of the nuclear envelope of amphibian oocytes: a reinvestigation. II. The immature oocyte and dynamic aspectsQ71429872
Entropic exclusion by neurofilament sidearms: a mechanism for maintaining interfilament spacingQ74020158
Association of nuclear pore FG-repeat domains to NTF2 import and export complexesQ79425999
Cse1p-binding dynamics reveal a binding pattern for FG-repeat nucleoporins on transport receptorsQ80794608
The nuclear pore complex up closeQ36456427
Dynamic nuclear pore complexes: life on the edge.Q36508009
The nuclear pore complex: oily spaghetti or gummy bear?Q36908126
Nuclear pore complex number and distribution throughout the Saccharomyces cerevisiae cell cycle by three-dimensional reconstruction from electron micrographs of nuclear envelopesQ36941909
Distinct functional domains within nucleoporins Nup153 and Nup98 mediate transcription-dependent mobility.Q37221202
Adsorbed gels versus brushes: viscoelastic differencesQ37636096
Functional organization of the nuclear envelopeQ38195057
Nup214 is required for CRM1-dependent nuclear protein export in vivoQ38411212
The permeability barrier of nuclear pore complexes appears to operate via hydrophobic exclusionQ39647313
Distinct functions of the Drosophila Nup153 and Nup214 FG domains in nuclear protein transportQ39744547
Structure, biochemistry, and functions of the nuclear envelope.Q39952726
Modulation of nuclear pore topology by transport modifiersQ40227899
Quantitative topographical analysis of nuclear pore complex function using scanning force microscopyQ40264816
Macromolecular crowding: biochemical, biophysical, and physiological consequencesQ40488946
Toward a molecular understanding of the structure and function of the nuclear pore complex.Q40943127
Molecular dissection of the nuclear pore complexQ41063786
Snapshots of nuclear pore complexes in action captured by cryo-electron tomographyQ41624126
Nup98 is a mobile nucleoporin with transcription-dependent dynamicsQ30475776
Reversibility in nucleocytoplasmic transportQ30479838
Nuclear import time and transport efficiency depend on importin beta concentration.Q30480491
Nuclear hourglass technique: an approach that detects electrically open nuclear pores in Xenopus laevis oocyteQ30482126
Imaging of single-molecule translocation through nuclear pore complexesQ30832298
Experimental studies on amphibian oocyte nuclei. I. Investigation of the structure of the nuclear membrane by means of the electron microscopeQ33197613
Flexible phenylalanine-glycine nucleoporins as entropic barriers to nucleocytoplasmic transportQ33246576
Efficiency, selectivity, and robustness of nucleocytoplasmic transportQ33290827
The maximal size of protein to diffuse through the nuclear pore is larger than 60kDaQ33781297
Nuclear pore complex is able to transport macromolecules with diameters of about 39 nmQ33953659
Visualization of transport-related configurations of the nuclear pore transporterQ34126294
Electrical dimension of the nuclear envelope.Q34127742
Conformational changes of the in situ nuclear pore complexQ34170828
The nuclear pore complex as a transport machine.Q34205241
Simple fold composition and modular architecture of the nuclear pore complexQ34478878
A general amphipathic alpha-helical motif for sensing membrane curvature.Q34601480
The nuclear pore complex: nucleocytoplasmic transport and beyondQ35564601
Virtual gating and nuclear transport: the hole pictureQ35587487
Translocation through the nuclear pore complex: selectivity and speed by reduction-of-dimensionalityQ36090722
Modularity within the architecture of the nuclear pore complex.Q36101124
Simple kinetic relationships and nonspecific competition govern nuclear import rates in vivo.Q36119204
Octagonal nuclear poresQ36189025
On the octagonality of the nuclear pore complexQ36192246
On the attachment of the nuclear pore complexQ36196142
Protein import through the nuclear pore complex is a multistep processQ36221436
Interactions and structure of the nuclear pore complex revealed by cryo-electron microscopyQ36221543
Architecture of the Xenopus nuclear pore complex revealed by three-dimensional cryo-electron microscopy.Q36232581
Versatility at the nuclear pore complex: lessons learned from the nucleoporin Nup153.Q36245336
The FG-repeat asymmetry of the nuclear pore complex is dispensable for bulk nucleocytoplasmic transport in vivoQ36322759
Importin beta contains a COOH-terminal nucleoporin binding region important for nuclear transportQ36322989
The cytoplasmic filaments of the nuclear pore complex are dispensable for selective nuclear protein importQ36323649
From the trap to the basket: getting to the bottom of the nuclear pore complexQ36364506
The direction of transport through the nuclear pore can be invertedQ36428044
P433issue2
P921main subjectcellQ7868
biomedical investigative techniqueQ66648976
P304page(s)105-116
P577publication date2008-01-29
2008-02-01
P1433published inHistochemistry and Cell BiologyQ1524012
P1476titleTowards reconciling structure and function in the nuclear pore complex
P478volume129

Reverse relations

cites work (P2860)
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