Action potential broadening in a presynaptic channelopathy

scientific article published on 06 July 2016

Action potential broadening in a presynaptic channelopathy is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2016NatCo...712102B
P356DOI10.1038/NCOMMS12102
P2888exact matchhttps://scigraph.springernature.com/pub.10.1038/ncomms12102
P932PMC publication ID4935806
P698PubMed publication ID27381274

P50authorDimitri KullmannQ27087835
Kirill VolynskiQ37839409
P2093author name stringRahima Begum
Yamina Bakiri
P2860cites workEpisodic ataxia/myokymia syndrome is associated with point mutations in the human potassium channel gene, KCNA1Q24312199
Episodic ataxia results from voltage-dependent potassium channels with altered functionsQ24312207
Episodic ataxia type-1 mutations in the hKv1.1 cytoplasmic pore region alter the gating properties of the channelQ24533155
Clinical, genetic, and expression studies of mutations in the potassium channel gene KCNA1 reveal new phenotypic variabilityQ28140752
A novel mutation in the human voltage-gated potassium channel gene (Kv1.1) associates with episodic ataxia type 1 and sometimes with partial epilepsyQ28198095
Episodic ataxia type 1 mutations in the human Kv1.1 potassium channel alter hKvbeta 1-induced N-type inactivationQ28206111
A mouse model of episodic ataxia type-1Q28213245
Identification of two new KCNA1 mutations in episodic ataxia/myokymia familiesQ28272045
Variable K(+) channel subunit dysfunction in inherited mutations of KCNA1Q28344387
Heteromultimeric K+ channels in terminal and juxtaparanodal regions of neuronsQ28505460
Localization of Kv1.1 and Kv1.2, two K channel proteins, to synaptic terminals, somata, and dendrites in the mouse brainQ28513040
Presynaptic Ca2+-activated K+ channels in glutamatergic hippocampal terminals and their role in spike repolarization and regulation of transmitter releaseQ28573459
Clinical, genetic, and expression studies of mutations in the potassium channel gene KCNA1 reveal new phenotypic variabilityQ30048274
Subcellular localization of K+ channels in mammalian brain neurons: remarkable precision in the midst of extraordinary complexityQ30393321
K+ channels at the axon initial segment dampen near-threshold excitability of neocortical fast-spiking GABAergic interneuronsQ30438904
Modulation by K+ channels of action potential-evoked intracellular Ca2+ concentration rises in rat cerebellar basket cell axonsQ30789432
Distinct Kv channel subtypes contribute to differences in spike signaling properties in the axon initial segment and presynaptic boutons of cerebellar interneuronsQ33575207
Differential triggering of spontaneous glutamate release by P/Q-, N- and R-type Ca2+ channelsQ34251501
Dendrotoxins: structure-activity relationships and effects on potassium ion channelsQ34373382
Episodic ataxia type 1 mutations in the KCNA1 gene impair the fast inactivation properties of the human potassium channels Kv1.4-1.1/Kvbeta1.1 and Kv1.4-1.1/Kvbeta1.2.Q50641836
Axon initial segment Kv1 channels control axonal action potential waveform and synaptic efficacy.Q51625741
Electrophysiological characterization of voltage-gated K(+) currents in cerebellar basket and purkinje cells: Kv1 and Kv3 channel subfamilies are present in basket cell nerve terminalsQ73338090
Differential gating and recruitment of P/Q-, N-, and R-type Ca2+ channels in hippocampal mossy fiber boutonsQ80141606
Ultra-rapid axon-axon ephaptic inhibition of cerebellar Purkinje cells by the pinceauQ87077553
Independent regulation of basal neurotransmitter release efficacy by variable Ca²+ influx and bouton size at small central synapsesQ34437468
Patch-clamp recordings from cerebellar basket cell bodies and their presynaptic terminals reveal an asymmetric distribution of voltage-gated potassium channels.Q34453063
High-fidelity transmission of sensory information by single cerebellar mossy fibre boutonsQ34728425
Selective Loss of Presynaptic Potassium Channel Clusters at the Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals Their Role in Ephaptic Control of Purkinje Cell Firing.Q35941447
Episodic ataxia type 1: a neuronal potassium channelopathyQ36774725
Nanoscale-targeted patch-clamp recordings of functional presynaptic ion channelsQ37192968
Main determinants of presynaptic Ca2+ dynamics at individual mossy fiber-CA3 pyramidal cell synapsesQ37198501
Control of K(Ca) channels by calcium nano/microdomainsQ37279412
Ca2+ current versus Ca2+ channel cooperativity of exocytosis.Q37443920
Deprivation-induced strengthening of presynaptic and postsynaptic inhibitory transmission in layer 4 of visual cortex during the critical periodQ37578453
Too many cooks? Intrinsic and synaptic homeostatic mechanisms in cortical circuit refinementQ37857840
Voltage-gated potassium channels and the diversity of electrical signallingQ37995127
How the 'slow' Ca(2+) buffer parvalbumin affects transmitter release in nanodomain-coupling regimesQ39978108
Analog modulation of spike-evoked transmission in CA3 circuits is determined by axonal Kv1.1 channels in a time-dependent mannerQ40234683
The NEURON simulation environmentQ41554850
Tuning of fast-spiking interneuron properties by an activity-dependent transcriptional switchQ42016652
Sparse but highly efficient Kv3 outpace BKCa channels in action potential repolarization at hippocampal mossy fiber boutons.Q42489317
Timing and efficacy of Ca2+ channel activation in hippocampal mossy fiber boutons.Q42690905
Modulation of inhibitory post-synaptic currents (IPSCs) in mouse cerebellar Purkinje and basket cells by snake and scorpion toxin K+ channel blockersQ43187117
GABA(B) receptor activation mediates frequency-dependent plasticity of developing GABAergic synapses.Q46294257
Nanodomain coupling between Ca2+ channels and Ca2+ sensors promotes fast and efficient transmitter release at a cortical GABAergic synapseQ46730437
Development of "Pinceaux" formations and dendritic translocation of climbing fibers during the acquisition of the balance between glutamatergic and gamma-aminobutyric acidergic inputs in developing Purkinje cellsQ46893567
Enhancement of GABA release through endogenous activation of axonal GABA(A) receptors in juvenile cerebellum.Q46899836
Dendritic control of spontaneous bursting in cerebellar Purkinje cells.Q47798394
Control of inhibitory synaptic outputs by low excitability of axon terminals revealed by direct recording.Q48105084
Patch-clamp recording from mossy fiber terminals in hippocampal slices.Q48175426
Developmental changes in potassium currents at the rat calyx of Held presynaptic terminal.Q48256230
Potentiation of cortical inhibition by visual deprivation.Q48438986
Targeted axon-attached recording with fluorescent patch-clamp pipettes in brain slices.Q48486925
The Cav2.1/alpha1A (P/Q-type) voltage-dependent calcium channel mediates inhibitory neurotransmission onto mouse cerebellar Purkinje cells.Q48849805
Ultrastructural localization of Shaker-related potassium channel subunits and synapse-associated protein 90 to septate-like junctions in rat cerebellar Pinceaux.Q48880114
Novel effects of dendrotoxin homologues on subtypes of mammalian Kv1 potassium channels expressed in Xenopus oocytes.Q49016503
Distribution of high-conductance Ca(2+)-activated K+ channels in rat brain: targeting to axons and nerve terminals.Q49158543
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)12102
P577publication date2016-07-06
P1433published inNature CommunicationsQ573880
P1476titleAction potential broadening in a presynaptic channelopathy
P478volume7

Reverse relations

cites work (P2860)
Q93087864A Kinetic Map of the Homomeric Voltage-Gated Potassium Channel (Kv) Family
Q33870521A channelopathy mutation in the voltage-sensor discloses contributions of a conserved phenylalanine to gating properties of Kv1.1 channels and ataxia
Q42291619Alteration of Neuronal Excitability and Short-Term Synaptic Plasticity in the Prefrontal Cortex of a Mouse Model of Mental Illness
Q91646184Discovery of a small molecule modulator of the Kv1.1/Kvβ1 channel complex that reduces neuronal excitability and in vitro epileptiform activity
Q28075997Dynamic Control of Neurotransmitter Release by Presynaptic Potential
Q90289757Excitability Tuning of Axons by Afterdepolarization
Q50963364Genetic perturbations suggest a role of the resting potential in regulating the expression of the ion channels of the KCNA and HCN families in octopus cells of the ventral cochlear nucleus.
Q40443495Kv1.1 channelopathy abolishes presynaptic spike width modulation by subthreshold somatic depolarization
Q47232708Loss of Cntnap2 Causes Axonal Excitability Deficits, Developmental Delay in Cortical Myelination, and Abnormal Stereotyped Motor Behavior.
Q64269448Modeling Analysis of Axonal After Potential at Hippocampal Mossy Fibers
Q30839225Mutations underlying Episodic Ataxia type-1 antagonize Kv1.1 RNA editing
Q64092805Past and Future of Analog-Digital Modulation of Synaptic Transmission
Q55097137Purkinje Cell Signaling Deficits in Animal Models of Ataxia.
Q42290716Resistance to action potential depression of a rat axon terminal in vivo
Q58710987Sodium Channel-Dependent and -Independent Mechanisms Underlying Axonal Afterdepolarization at Mouse Hippocampal Mossy Fibers
Q91740733Subcellular control of membrane excitability in the axon
Q64084428The subthreshold-active K7 current regulates neurotransmission by limiting spike-induced Ca influx in hippocampal mossy fiber synaptic terminals
Q64106970Therapy of episodic ataxias: case report and review of the literature

Search more.