Mini-review: novel therapeutic strategies to blunt actions of pneumolysin in the lungs

scientific article published on 15 July 2013

Mini-review: novel therapeutic strategies to blunt actions of pneumolysin in the lungs is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.3390/TOXINS5071244
P932PMC publication ID3737495
P698PubMed publication ID23860351
P5875ResearchGate publication ID249966230

P50authorAndrew SchallyQ141147
Trinad ChakrabortyQ90390457
Norman L BlockQ102145476
Supriya SridharQ114901854
Helena PillichQ125320923
Aluya OseghaleQ125321116
Ferenc RickQ42849967
Rudolf LucasQ56636149
Istvan CzikoraQ58903713
P2093author name stringBoris Gorshkov
Evgeny Zemskov
Maritza Romero
Jonathan Lawson
Martin Leustik
Alexander Verin
Umapathy Siddaramappa
P2860cites workComparison of the effects of macrolides, amoxicillin, ceftriaxone, doxycycline, tobramycin and fluoroquinolones, on the production of pneumolysin by Streptococcus pneumoniae in vitroQ81234083
Receptor activator of nuclear factor (NF)-kappaB ligand (RANKL) increases vascular permeability: impaired permeability and angiogenesis in eNOS-deficient miceQ79233971
Differential roles of p55 and p75 tumor necrosis factor receptors on stretch-induced pulmonary edema in miceQ80160163
Antagonists of growth-hormone-releasing hormone: an emerging new therapy for cancerQ37033860
Inhibition of in vitro human lymphocyte response by the pneumococcal toxin pneumolysinQ37042245
NADPH oxidase-derived reactive oxygen species in the regulation of endothelial phenotypeQ37085294
Inhibition of human polymorphonuclear leukocyte respiratory burst, bactericidal activity, and migration by pneumolysinQ37105935
Regulation of endothelial junctional permeabilityQ37122803
Production and purification of Streptococcus pneumoniae hemolysin (pneumolysin)Q37135636
TNF: a moonlighting protein at the interface between cancer and infectionQ37175520
Claudin-4 augments alveolar epithelial barrier function and is induced in acute lung injuryQ37343892
Acute bacterial pneumonia in rats increases alveolar epithelial fluid clearance by a tumor necrosis factor-alpha-dependent mechanismQ37362616
The Dual Role of TNF in Pulmonary EdemaQ37824251
Emerging themes of cAMP regulation of the pulmonary endothelial barrierQ37845025
Mapping the lectin-like activity of tumor necrosis factorQ38311192
Dichotomal role of TNF in experimental pulmonary edema reabsorptionQ38321813
Characterization of pneumolysin from Streptococcus pneumoniae, interacting with carbohydrate moiety and cholesterol as a component of cell membraneQ39508458
Protein kinase A and mitogen-activated protein kinase pathways mediate cAMP induction of alpha-epithelial Na+ channels (alpha-ENaC).Q40062449
Production and characterization of neutralizing and nonneutralizing monoclonal antibodies against listeriolysin O.Q40156355
Pleural-pulmonary aspects of Listeria monocytogenes infectionQ40269926
Involvement of microtubules and Rho pathway in TGF-beta1-induced lung vascular barrier dysfunctionQ40435805
Growth hormone-releasing hormone: synthesis and signaling.Q40519101
Role of protein kinase C isoforms in rat epididymal microvascular endothelial barrier functionQ40653322
cAMP-induced changes of apical membrane potentials of confluent H441 monolayersQ40654038
Pneumococcal Hemolysin: The Preparation of Concentrates, and Their Action on Red Cells.Q40696871
Listeriolysin of Listeria monocytogenes forms Ca2+-permeable pores leading to intracellular Ca2+ oscillationsQ40711338
Mechanisms of TNF-alpha stimulation of amiloride-sensitive sodium transport across alveolar epitheliumQ40806572
Diabetes-induced coronary vascular dysfunction involves increased arginase activityQ41817278
PNEUMOCOCCUS HEMOTOXIN.Q41843485
STUDIES ON OXIDATION AND REDUCTION BY PNEUMOCOCCUS : IV. OXIDATION OF HEMOTOXIN IN STERILE EXTRACTS OF PNEUMOCOCCUS.Q42144000
Functional identification of the alveolar edema reabsorption activity of murine tumor necrosis factor-alphaQ42169101
Fluid transport across cultured rat alveolar epithelial cells: a novel in vitro systemQ42457845
Constitutive eNOS-derived nitric oxide is a determinant of endothelial junctional integrityQ42482474
Protein kinase C-alpha signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier functionQ43579834
Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndromeQ43616371
Role of platelet-activating factor in pneumolysin-induced acute lung injuryQ44400936
Downregulation of ENaC activity and expression by TNF-α in alveolar epithelial cellsQ44599680
Novel role of microtubules in thrombin-induced endothelial barrier dysfunctionQ45171532
The lectin-like domain of tumor necrosis factor-alpha improves alveolar fluid balance in injured isolated rabbit lungsQ46628233
Differential roles of PKCalpha and PKCepsilon in controlling the gene expression of Nox4 in human endothelial cellsQ46740822
Effects of macrolides on pneumolysin of macrolide-resistant Streptococcus pneumoniaeQ46925781
Presence of nonhemolytic pneumolysin in serotypes of Streptococcus pneumoniae associated with disease outbreaksQ48078155
Differential activations of PKC/PKA related to microvasculopathy in diabetic GK ratsQ48850018
Epidemiology and etiology of childhood pneumoniaQ22241278
Isolation and sequencing of cDNAs for splice variants of growth hormone-releasing hormone receptors from human cancers.Q24652328
More than a pore: the cellular response to cholesterol-dependent cytolysinsQ27023593
Uromodulin (Tamm-Horsfall glycoprotein): a renal ligand for lymphokinesQ28299295
Growth-hormone-releasing hormoneQ30452244
Role of VASP in reestablishment of epithelial tight junction assembly after Ca2+ switchQ30706595
Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathwayQ33552508
Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4.Q33750041
Specificity of the autolysin of Streptococcus (Diplococcus) pneumoniaeQ33793950
The autolytic enzyme LytA of Streptococcus pneumoniae is not responsible for releasing pneumolysinQ33996189
Pneumococcal virulence factors: structure and functionQ34010335
Upper and lower respiratory tract infection by Streptococcus pneumoniae is affected by pneumolysin deficiency and differences in capsule type.Q34123722
Synthesis and biological evaluation of superactive agonists of growth hormone-releasing hormoneQ34270999
Pneumolysin-induced lung injury is independent of leukocyte trafficking into the alveolar spaceQ34331893
Cytoskeletal regulation of pulmonary vascular permeabilityQ34377340
Structural elements of the cholesterol-dependent cytolysins that are responsible for their cholesterol-sensitive membrane interactionsQ34724964
Protein kinase C modulates pulmonary endothelial permeability: a paradigm for acute lung injuryQ35062604
Contribution of autolysin to virulence of Streptococcus pneumoniaeQ35099865
Effect of Streptococcus pneumoniae on human respiratory epithelium in vitroQ35111190
Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniaeQ35111311
Interaction of pneumolysin-sufficient and -deficient isogenic variants of Streptococcus pneumoniae with human respiratory mucosa.Q35383517
Neutralizing monoclonal antibodies against listeriolysin: mapping of epitopes involved in pore formationQ35501235
Cholesterol-dependent actin remodeling via RhoA and Rac1 activation by the Streptococcus pneumoniae toxin pneumolysinQ35669797
Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edemaQ35751094
Regulators of endothelial and epithelial barrier integrity and function in acute lung injuryQ35760657
Regulatory effects of iNOS on acute lung inflammatory responses in miceQ35843243
Specific uptake of tumor necrosis factor-alpha is involved in growth control of Trypanosoma brucei.Q36274117
Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeabilityQ36369969
Direct transmembrane interaction between actin and the pore-competent, cholesterol-dependent cytolysin pneumolysinQ36860052
Phosphorylation of GTP dissociation inhibitor by PKA negatively regulates RhoAQ36977651
The lectin-like domain of tumor necrosis factor improves lung function after rat lung transplantation--potential role for a reduction in reactive oxygen species generationQ36995337
Cloning and expression in Escherichia coli of the Streptococcus pneumoniae gene encoding pneumolysinQ37011884
Molecular cloning, characterization, and complete nucleotide sequence of the gene for pneumolysin, the sulfhydryl-activated toxin of Streptococcus pneumoniaeQ37018660
Purification of growth hormone-releasing factor from beef hypothalamus.Q51233029
The effects of pneumolysin and hydrogen peroxide, alone and in combination, on human ciliated epithelium in vitro.Q51706202
Role of pneumolysin for the development of acute lung injury in pneumococcal pneumonia.Q51804034
Streptococcus pneumoniae stimulates a STING- and IFN regulatory factor 3-dependent type I IFN production in macrophages, which regulates RANTES production in macrophages, cocultured alveolar epithelial cells, and mouse lungs.Q52891231
Contribution of individual tryptophan residues to the structure and activity of theta-toxin (perfringolysin O), a cholesterol-binding cytolysin.Q54577935
Management of Community-acquired Pneumonia in AdultsQ57237808
The lectin-like domain of tumor necrosis factor-α increases membrane conductance in microvascular endothelial cells and peritoneal macrophagesQ58858838
Effect of insertional inactivation of the genes encoding pneumolysin and autolysin on the virulence of Streptococcus pneumoniae type 3Q67516541
Pneumolysin induces the salient histologic features of pneumococcal infection in the rat lung in vivoQ67903731
Expression of the pneumolysin gene in Escherichia coli: rapid purification and biological propertiesQ69481233
Searching for autolysin functions. Characterization of a pneumococcal mutant deleted in the lytA geneQ69568308
Inhibition of human monocyte respiratory burst, degranulation, phospholipid methylation and bactericidal activity by pneumolysinQ69723289
Distinct roles for pneumolysin's cytotoxic and complement activities in the pathogenesis of pneumococcal pneumoniaQ71046224
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectStreptococcus pneumoniaeQ221179
lungQ7886
pneumoniaQ12192
streptolysinsQ76388187
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)1244-1260
P577publication date2013-07-15
P1433published inToxinsQ15724569
P1476titleMini-review: novel therapeutic strategies to blunt actions of pneumolysin in the lungs
P478volume5

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cites work (P2860)
Q91770164CAL02, a novel antitoxin liposomal agent, in severe pneumococcal pneumonia: a first-in-human, double-blind, placebo-controlled, randomised trial
Q27684952Conformational Analysis of the Streptococcus pneumoniae Hyaluronate Lyase and Characterization of Its Hyaluronan-specific Carbohydrate-binding Module
Q47651769Cytokine-Ion Channel Interactions in Pulmonary Inflammation
Q35953618Deletion analysis of Streptococcus pneumoniae late competence genes distinguishes virulence determinants that are dependent or independent of competence induction
Q55287568Hsp70 Suppresses Mitochondrial Reactive Oxygen Species and Preserves Pulmonary Microvascular Barrier Integrity Following Exposure to Bacterial Toxins.
Q35603391Inhalation therapy with the synthetic TIP-like peptide AP318 attenuates pulmonary inflammation in a porcine sepsis model
Q53269550Liposomes as novel anti-infectives targeting bacterial virulence factors?
Q53693867Multifaceted Role of Pneumolysin in the Pathogenesis of Myocardial Injury in Community-Acquired Pneumonia.
Q35833122New therapeutic approach to heart failure due to myocardial infarction based on targeting growth hormone-releasing hormone receptor
Q36189529Novel GHRH antagonists suppress the growth of human malignant melanoma by restoring nuclear p27 function.
Q60952635Pharmacological Targeting of Pore-Forming Toxins as Adjunctive Therapy for Invasive Bacterial Infection
Q36741309Pneumococcal Pneumolysin Induces DNA Damage and Cell Cycle Arrest
Q33601853Randomized controlled study of the safety and immunogenicity of pneumococcal vaccine formulations containing PhtD and detoxified pneumolysin with alum or adjuvant system AS02V in elderly adults
Q38598360Streptococcal toxins: role in pathogenesis and disease
Q42214099TBX21 participates in innate immune response by regulating Toll-like receptor 2 expression in Streptococcus pneumoniae infections

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