The pathogenesis of pterygium: current concepts and their therapeutic implications.

scientific article published on January 2008

The pathogenesis of pterygium: current concepts and their therapeutic implications. is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1016/S1542-0124(12)70103-9
P698PubMed publication ID18264653

P50authorJeanie ChuiQ43291533
P2093author name stringDenis Wakefield
Minas T Coroneo
Nick Di Girolamo
P2860cites workInterferon alpha 2b treatment for residual ocular surface squamous neoplasia unresponsive to excision, cryotherapy and mitomycin-CQ83959973
Heredity in one hundred patients admitted for excision of pterygiaQ93591240
Long-term results after bare sclera pterygium resection with excimer smoothing and local application of mitomycin CQ94500888
The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumorsQ22010018
Pterygium as an early indicator of ultraviolet insolation: a hypothesisQ24563206
Topical ciclosporin in the treatment of ocular surface disordersQ24670344
Pegaptanib and ranibizumab for neovascular age-related macular degeneration: a systematic reviewQ24674561
Epidermal growth factor receptor signaling is partially responsible for the increased matrix metalloproteinase-1 expression in ocular epithelial cells after UVB radiationQ24675409
The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2Q24684014
The role of ultraviolet irradiation and heparin-binding epidermal growth factor-like growth factor in the pathogenesis of pterygiumQ24684329
Ku, a DNA repair protein with multiple cellular functions?Q28137885
Evidence of oxidative stress in human corneal diseasesQ28201957
The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create itQ28254798
International Union of Pharmacology. LX. Retinoic acid receptorsQ28276127
Serious complications of topical mitomycin-C after pterygium surgeryQ28317596
Differential expression of vascular endothelial growth factor implies the limbal origin of pterygiaQ28575259
Angiogenesis: an organizing principle for drug discovery?Q29614538
TGF-beta and epithelial-to-mesenchymal transitionsQ29616456
Evidence that fibroblasts derive from epithelium during tissue fibrosisQ29616581
Novel opportunities in the treatment and prevention of scarringQ31140991
Decreased pigment epithelium-derived factor and increased vascular endothelial growth factor levels in pterygiaQ31147742
In vivo confocal imaging of corneal neovascularizationQ31973047
Scar management: prevention and treatment strategiesQ33218798
Term Amniotic membrane is a high throughput source for multipotent Mesenchymal Stem Cells with the ability to differentiate into endothelial cells in vitroQ33274890
Safety profile of bevacizumab on cultured human corneal cellsQ33295166
Calcitonin gene-related peptide stimulates proliferation of human endothelial cellsQ33554982
Winglets of the eye: dominant transmission of early adult pterygium of the conjunctivaQ33597854
Pterygium and ultraviolet radiation: a positive correlationQ33643262
Growth factors: importance in wound healing and maintenance of transparency of the corneaQ33805838
Rapamycin inhibits corneal allograft rejection and neovascularizationQ72856048
Inhibition of hepatic stellate cell proliferation and activation by the semisynthetic analogue of fumagillin TNP-470 in ratsQ73119481
Roles of PPARs in health and disease.Q33934899
Age-related maculopathy and the impact of blue light hazard.Q33993191
Stimulation of epithelial cell growth by the neuropeptide substance PQ34058565
Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P.Q34158412
Proliferative effects of heparin-binding epidermal growth factor-like growth factor on pterygium epithelial cells and fibroblastsQ34285726
mTOR inhibitors: an overviewQ34302240
Intrastromal invasion by limbal epithelial cells is mediated by epithelial-mesenchymal transition activated by air exposureQ34312592
The corneal wound healing response: cytokine-mediated interaction of the epithelium, stroma, and inflammatory cells.Q34317970
Solar UV irradiation and dermal photoagingQ34421848
Acute response of human skin to solar radiation: regulation and function of the p53 proteinQ34421866
Vascular endothelial growth factor (VEGF) as a target of bevacizumab in cancer: from the biology to the clinicQ34569109
MMPs in the eye: emerging roles for matrix metalloproteinases in ocular physiology.Q34572802
Calcineurin inhibitors and rapamycin: cancer protection or promotion?Q34578721
Type I interferon receptors: biochemistry and biological functions.Q34628239
Current concepts and techniques in pterygium treatmentQ34637375
Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrestQ34687606
PPAR-gamma activation inhibits angiogenesis by blocking ELR+CXC chemokine production in non-small cell lung cancerQ34768343
Nuclear effects: unexpected intracellular actions of insulin-like growth factor binding protein-3.Q34962746
Ultraviolet-B irradiation and matrix metalloproteinases: from induction via signaling to initial eventsQ35027219
The treatment of pterygiumQ35103620
Corneal nerves: structure, contents and functionQ35107870
Microsatellite instability and loss of heterozygosity in human pterygia.Q35300524
Capillaries in the epithelium of pterygiumQ35302160
Evaluation of loss of heterozygosity and microsatellite instability in human pterygium: clinical correlations.Q35302853
Apoptosis and apoptosis related gene expression in normal conjunctiva and pterygiumQ35313406
The fate of limbal epithelial progenitor cells during explant culture on intact amniotic membraneQ35391431
Interferons: mechanisms of action and clinical applicationsQ35587300
No association of p53 codon 72 and p21 codon 31 polymorphisms in Taiwan Chinese patients with pterygiumQ35592238
Characterisation of myofibroblasts in fibrovascular tissues of primary and recurrent pterygiaQ35592993
Molecular mechanisms of neuroprotective action of immunosuppressants--facts and hypotheses.Q35748218
Pathogenesis of pterygia: role of cytokines, growth factors, and matrix metalloproteinasesQ35749761
Corneal epithelial stem cells at the limbus: looking at some old problems from a new angleQ35755158
Expression of insulin-like growth factor binding protein-3 in pterygium tissueQ35769363
Fibroblasts isolated from human pterygia exhibit transformed cell characteristicsQ41478615
P53 expression in altered limbal basal cells of pingueculae, pterygia, and limbal tumorsQ41679881
Interactions of the skin and nervous systemQ41714577
Progenitor cells in healing after pterygium excisionQ42135449
Expression of p27(KIP1) and cyclin D1, and cell proliferation in human pterygiumQ42288910
Ocular surface toxicity associated with topical interferon alpha-2bQ42410166
Interferon alpha eye drops: treatment of atypical lymphoid hyperplasia with secondary alopeciaQ42410168
Expression of vimentin by rabbit corneal epithelial cells during wound repairQ42454452
Involvement of bone marrow-derived stem and progenitor cells in the pathogenesis of pterygiumQ42458079
Differential effects of epidermal growth factor and interleukin 6 on corneal epithelial cells and vascular endothelial cellsQ42475425
In vivo corneal confocal microscopic findings of palisades of Vogt and its underlying limbal stromaQ42476910
The involvement of adult stem cells originated from bone marrow in the pathogenesis of pterygiaQ42485962
Immunohistochemical evidence that human pterygia originate from an invasion of vimentin-expressing altered limbal epithelial basal cellsQ42491756
Expression of p63 and p16 in primary and recurrent pterygiaQ42491771
Pterygia pathogenesis: corneal invasion by matrix metalloproteinase expressing altered limbal epithelial basal cellsQ42504127
Beta-catenin activation and epithelial-mesenchymal transition in the pathogenesis of pterygiumQ42510196
MLH1 and MSH2 expression in pterygiaQ42511682
Migration of 3T3 and lung fibroblasts in response to calcitonin gene-related peptide and bombesinQ42815062
In vitro antiangiogenic activity in ex vivo expanded human limbocorneal epithelial cells cultivated on human amniotic membrane.Q42826911
Postoperative subconjunctival 5-fluorouracil in the management of recurring pterygiumQ42840582
Interferon treatment of childhood conjunctival lymphomaQ43008360
The NK1 receptor and its participation in the synergistic enhancement of corneal epithelial migration by substance P and insulin-like growth factor-1.Q43167668
Halting pterygium recurrence by postoperative 5-fluorouracilQ43542516
Expression of vascular endothelial growth factor and inducible nitric oxide synthase in pterygiaQ43757699
Effects of cyclosporin A on human conjunctival fibroblastsQ43762272
Photoreactivation of ultraviolet radiation-induced basic fibroblast growth factor (bFGF) and the role of bFGF in corneal lesion formation in Monodelphis domesticaQ43825662
Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-alphaalpha and -alphabeta receptorsQ44175822
5-Fluorouracil as chemoadjuvant for primary pterygium surgery: preliminary reportQ44527446
Genetic polymorphism of hOGG1 and risk of pterygium in ChineseQ44723563
Everolimus and mycophenolate mofetil are potent inhibitors of fibroblast proliferation after lung transplantation.Q44741825
Antiinflammatory therapy for dry eye.Q44763839
TNP-470, an angiogenesis inhibitor, suppresses the progression of peritoneal fibrosis in mouse experimental modelQ45085906
Age-related changes in superoxide dismutase, glutathione peroxidase, catalase and xanthine oxidoreductase/xanthine oxidase activities in the rabbit corneaQ45121201
Hyperexpression of low-density lipoprotein receptors and hydroxy-methylglutaryl-coenzyme A-reductase in human pinguecula and primary pterygium.Q45124543
Topical cyclosporine inhibits conjunctival epithelial apoptosis in experimental murine keratoconjunctivitis siccaQ45190856
Inhibitory effect of rapamycin on corneal neovascularization in vitro and in vivoQ45238764
Enhanced inhibition of hepatitis B virus production by asialoglycoprotein receptor-directed interferonQ45749666
Blockade of TGF-beta by in vivo gene transfer of a soluble TGF-beta type II receptor in the muscle inhibits corneal opacification, edema and angiogenesisQ45873481
CGRP increases the rate of corneal re-epithelialization in an in vitro whole mount preparationQ46545329
Adjuvant topical interferon-alpha-2b treatment in epithelial tumors of the ocular surfaceQ46621269
Increased oxidative DNA damage, 8-hydroxydeoxy- guanosine, in human pterygium.Q46661621
Calcineurin inhibitors decrease DNA repair and apoptosis in human keratinocytes following ultraviolet B irradiationQ46811087
Detection of point mutations at codon 12 of KI-ras in ophthalmic pterygia.Q47251754
Evaluation of TNF-alpha and IL-1beta polymorphisms in Taiwan Chinese patients with pterygiumQ47375806
UVB-Elicited Induction of MMP-1 Expression in Human Ocular Surface Epithelial Cells Is Mediated through the ERK1/2 MAPK-Dependent PathwayQ47423766
Skin damage and mitochondrial dysfunction after acute ultraviolet B irradiation: relationship with nitric oxide production.Q47683385
Loss of heterozygosity and p53 expression in PterygiumQ47956883
H2O2 is an important mediator of UVB-induced EGF-receptor phosphorylation in cultured keratinocytesQ47993793
Expression of nuclear retinoic acid receptor and retinoid X receptor mRNA in the cornea and conjunctivaQ48002577
Cell cycle inhibition by the anti-angiogenic agent TNP-470 is mediated by p53 and p21WAF1/CIP1Q35774769
Immunolocalisation of E-cadherin and beta-catenin in human pterygiumQ35953948
Inhibition of experimental corneal neovascularisation by bevacizumab (Avastin)Q35956190
Polymorphic variation in hOGG1 and risk of cancer: a review of the functional and epidemiologic literatureQ35975818
5-fluorouracil vs. beta-irradiation in the prevention of pterygium recurrenceQ35978239
Age-related nuclear cataract-oxidation is the key.Q36111043
Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapyQ36165553
The role of oxidative stress in glaucomaQ36368431
Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A: roles of the nuclear factor of activated T cells and cyclooxygenase 2Q36369190
Cellular aspects of photocarcinogenesisQ36390333
Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesisQ36569348
Regression of Experimental Iris Neovascularization with Systemic Alpha-interferonQ36695100
Nitric oxide in blood. The nitrosative-oxidative disequilibrium hypothesis on the pathogenesis of cardiovascular diseaseQ36715892
The clinical applications of fluorouracil in ophthalmic practiceQ36729597
Diverse actions of retinoid receptors in cancer prevention and treatment.Q36883185
Role of mTOR in solid tumor systems: a therapeutical target against primary tumor growth, metastases, and angiogenesisQ36916764
A methionine aminopeptidase-2 inhibitor, PPI-2458, for the treatment of rheumatoid arthritisQ36987028
A role for NF-kappaB-dependent gene transactivation in sunburn.Q37202396
Pterygium excision with conjunctival autografting: an effective and safe techniqueQ37303859
Oculocutaneous manifestations in xeroderma pigmentosaQ37305867
Cell cycle kinetics in pterygium at three latitudesQ37311320
Neovascularization and mast cells with tryptase activity increase simultaneously in human pterygiumQ37580210
Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformationQ38289991
The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosomeQ38305593
Pterygial derived fibroblasts express functionally active histamine and epidermal growth factor receptorsQ39205948
THE OCULAR EFFECTS OF VITAMIN A DEFICIENCY IN MAN IN THE TROPICS.Q39403680
Immunohistochemical study of p53, p21 and PCNA in pterygiumQ39540607
Inhibition of corneal neovascularization by a peroxisome proliferator-activated receptor-gamma ligandQ39708256
Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivoQ39801075
Collagenase and other proteinases in the cornea of the retinol-deficient ratQ39950956
The role of substance P in the pathogenesis of pterygia.Q40075689
Peroxisome proliferator-activated receptor-gamma antagonists exhibit potent antiproliferative effects versus many hematopoietic and epithelial cancer cell linesQ40148519
All-trans retinoic acid antagonizes UV-induced VEGF production and angiogenesis via the inhibition of ERK activation in human skin keratinocytesQ40261067
Anti-proliferative effect of peroxisome proliferator-activated receptor gamma agonists on human malignant melanoma cells in vitroQ40308015
Interferon alpha 2a down-regulates VEGF expression through PI3 kinase and MAP kinase signaling pathways.Q40468150
Treatment of photodamage with topical tretinoin: an overviewQ41416427
Abnormal expression of the p53 tumor suppressor gene in the conjunctiva of patients with pterygiumQ73138208
H2O2 is required for UVB-induced EGF receptor and downstream signaling pathway activationQ73370504
Local chemotherapy with interferon-alpha for conjunctival mucosa-associated lymphoid tissue lymphoma: a preliminary reportQ73585661
Calcitonin gene-related peptide induces IL-8 synthesis in human corneal epithelial cellsQ73644537
Presence and possible significance of immunohistochemically demonstrable metallothionein expression in pterygium versus pinguecula and normal conjunctivaQ73797082
Peroxisome proliferator-activated receptor-gamma agonists increase vascular endothelial growth factor expression in human vascular smooth muscle cellsQ73800249
Proliferative activity and p53 expression in primary and recurrent pterygiaQ73800672
UVB-induced cyclobutane pyrimidine dimer frequency correlates with skin cancer mutational hotspots in p53Q73910280
Treatment of conjunctival and corneal intraepithelial neoplasia with topical interferon alpha-2bQ73947296
Expression of stem cell factor in pterygiumQ74062940
Cyclosporine reduces left ventricular mass with chronic aortic banding in mice, which could be due to apoptosis and fibrosisQ74183611
Chemotaxis of human keratocytes is increased by platelet-derived growth factor-BB, epidermal growth factor, transforming growth factor-alpha, acidic fibroblast growth factor, insulin-like growth factor-I, and transforming growth factor-betaQ74210957
Neurotrophic influences on corneal epithelial cellsQ74282200
Intercellular communication between vascular smooth muscle and endothelial cells mediated by heparin-binding epidermal growth factor-like growth factor and vascular endothelial growth factorQ74489334
Repeated subinflammatory ultraviolet B irradiation increases substance P and calcitonin gene-related peptide content and augments mustard oil-induced neurogenic inflammation in the skin of ratsQ74619742
Overexpression of p53 tumor suppressor gene in pterygiaQ74651920
Distribution of extracellular matrix proteins in pterygia: an immunohistochemical studyQ75356792
Distribution of cyclosporin A in ocular tissues after topical administration to albino rabbits and beagle dogsQ77387249
Expression of p53 protein in pterygiumQ77481771
Molecular regulation of UVB-induced cutaneous angiogenesisQ77519518
Regression of presumed primary conjunctival and corneal intraepithelial neoplasia with topical interferon alpha-2bQ77532280
The effect of cyclosporin A on cultured rabbit subconjunctival fibroblast proliferationQ77785093
Surgically induced necrotizing scleritis after pterygium excision and conjunctival autograftQ77829811
Interaction of zinc and vitamin A on the ocular surfaceQ78665720
Angiogenesis in pterygium: morphometric and immunohistochemical studyQ78763445
Nitric oxide synthase inhibition by N(G)-nitro-L-arginine methyl ester retards vascular sprouting in angiogenesisQ78818668
Induction of matrix metalloproteinase-9 secretion from human keratinocytes in culture by ultraviolet B irradiationQ79213663
Ultraviolet fluorescence photography: patterns in established pterygiaQ79373861
Pioglitazone increases the numbers and improves the functional capacity of endothelial progenitor cells in patients with diabetes mellitusQ79424828
[Exposure of Tenon's capsule fibroblasts of pterygium to cyclosporin 0.05%]Q79712516
Suppression of inflammation and structural damage in experimental arthritis through molecular targeted therapy with PPI-2458Q79844524
Angiogenesis in pterygium: study of microvessel density, vascular endothelial growth factor, and thrombospondin-1Q79845968
Sustained intraocular rapamycin delivery effectively prevents high-risk corneal allograft rejection and neovascularization in rabbitsQ80024594
Tumor-volume increase at beginning of primary treatment with topical interferon alpha 2-beta in a case of conjunctiva-cornea intraepithelial neoplasiaQ80183172
Subconjunctival bevacizumab for corneal neovascularizationQ80215584
Bevacizumab as a potent inhibitor of inflammatory corneal angiogenesis and lymphangiogenesisQ80381830
Comparison of limbal-conjunctival autograft and intraoperative 0.02% mitomycin-C for treatment of primary pterygiumQ80762414
Systemic remission of non-Hodgkin's lymphoma after intralesional interferon alpha-2b to bilateral conjunctival lymphomasQ80871624
Treatment of early pterygium recurrence with topical administration of interferon alpha-2bQ80948315
Temporary amniotic membrane patch for the treatment of primary pterygium: mechanisms of reducing the recurrence rateQ81232447
Bevacizumab inhibits corneal neovascularization in an alkali burn induced model of corneal angiogenesisQ81588770
UVB irradiation increases the release of SCF from human epidermal cellsQ81688983
Biological activity of bevacizumab, a humanized anti-VEGF antibody in vitroQ81735598
Raman scattering properties of human pterygium tissueQ81774514
Investigation of nitric oxide in pterygiumQ82164007
Inhibition of corneal neovascularization by rapamycinQ83283294
Endothelial progenitor cells in pterygium pathogenesisQ83864171
Modulation of cholesterol homeostasis by antiproliferative drugs in human pterygium fibroblasts.Q50466826
Mast cells in pterygium: number and phenotype.Q50518695
TNP-470 (a fungus-derived inhibitor of angiogenesis) reduces proliferation of cultured fibroblasts isolated from primary pterygia: a possible drug therapy for pterygia.Q50522116
Topical interferon alpha 2 beta therapy in the management of conjunctival papilloma.Q50700331
Fibroblasts isolated from human pterygia exhibit altered lipid metabolism characteristics.Q50734739
In vivo characterization of bone marrow-derived fibroblasts recruited into fibrotic lesions.Q50770519
Characterization and distribution of bone marrow-derived cells in mouse cornea.Q50779656
Deficiency of glutathione S-transferases T1 and M1 as heritable factors of increased cutaneous UV sensitivity.Q50978155
Calcineurin inhibitors reduce nuclear localization of transcription factor NFAT in UV-irradiated keratinocytes and reduce DNA repair.Q51141964
Outcomes of autoconjunctival grafting for primary pterygia when performed by consultant compared with trainee ophthalmologists.Q51998801
Vascular endothelial growth factor causally contributes to the angiogenic response upon ultraviolet B irradiation in vivo.Q52767251
Effects of interferon alpha on vascular endothelial growth factor gene transcription and tumor angiogenesis.Q52952533
Topical interferon alfa-2b for the treatment of recalcitrant ocular surface squamous neoplasia.Q53518458
Enzyme-independent nitric oxide formation during UVA challenge of human skin: characterization, molecular sources, and mechanisms.Q53596160
UVB-mediated induction of cytokines and growth factors in pterygium epithelial cells involves cell surface receptors and intracellular signaling.Q54600008
Bone marrow-derived cells in normal human corneal stroma.Q54623495
Effect of p53 codon 72 polymorphism on p53 protein expression in pterygium.Q54683733
Topical alpha-interferon in recurrent conjunctival papilloma.Q54773100
Connective tissue growth factor in pterygium: simultaneous presence with vascular endothelial growth factor - possible contributing factor to conjunctival scarring.Q54787565
Overexpression of Insulin-like growth factor-binding protein-2 in pterygium body fibroblasts.Q54792716
Neurotrophic and anhidrotic keratopathy treated with substance P and insulinlike growth factor 1.Q55067125
Effects of rIFN Alpha, Beta, and Gamma on the Morphology, Proliferation, and Cell Surface Antigen Expression of Human Dermal Microvascular Endothelial Cells In VitroQ56657417
Corneal Changes Associated With Chronic UV IrradiationQ57245145
Growth factors in cultured pterygium fibroblasts: immunohistochemical and ELISA analysisQ57669695
Ultraviolet radiation stimulates expression of Snail family transcription factors in keratinocytesQ58394174
Intraoperative and post operative treatment with 5-fluorouracil and mitomycin-c: long term effects in vivo on subconjunctival and scleral fibroblastsQ67577740
Potent anti-angiogenic action of AGM-1470: comparison to the fumagillin parentQ67682540
Cultivation of human dermal microvascular endothelial cells in vitro: Immunocytochemical and ultrastructural characterization and effect of treatment with three synthetic retinoidsQ67901674
Interleukin 6 facilitates corneal epithelial wound closure in vivoQ68038290
Interleukin 6 promotes epithelial migration by a fibronectin-dependent mechanismQ68040795
Modulation of rabbit keratocyte production of collagen, sulfated glycosaminoglycans and fibronectin by retinol and retinoic acidQ68978097
Topical retinoic acid in dysplastic and metaplastic keratinization of corneoconjunctival epitheliumQ69018424
An investigation of aetiology and heredity of pterygium. Report of 11 cases in a familyQ69413338
Topical retinoid treatment for various dry-eye disordersQ69880484
Topical retinoid therapy for squamous metaplasia of various ocular surface disorders. A multicenter, placebo-controlled double-masked studyQ70248173
Immunologic basis for the pathogenesis of pterygiumQ70379137
Prolonged localized tissue effects from 5-minute exposures to fluorouracil and mitomycin CQ70556350
Subconjunctival fibrosis after conjunctival autograftQ70733281
Substance P and nitric oxide mediate would healing of ultraviolet photodamaged rat skin: evidence for an effect of nitric oxide on keratinocyte proliferationQ70958189
Immunohistochemical localization of basic fibroblast growth factor, platelet derived growth factor, transforming growth factor-beta and tumor necrosis factor-alpha in the pterygiumQ71343752
The tachykinin NK1 receptor mediates the migration-promoting effect of substance P on human skin fibroblasts in cultureQ71345757
Stimulation of the chemotactic migration of human fibroblasts by substance PQ71606688
Synergistic effects of substance P with insulin-like growth factor-1 on epithelial migration of the corneaQ71615024
Cyclosporin A is a substance P (tachykinin NK1) receptor antagonistQ71735660
Antiproliferative and synergistic effect of interferon alpha-2a, retinoids and their association in established human cancer cell linesQ72105995
Increased interleukin-1 activity in the injured vitamin A-deficient corneaQ72360627
Increased numbers of mast cells in pterygiaQ72437566
Epithelial wound healing in the denervated corneaQ72460884
P433issue1
P921main subjectpathogenesisQ372016
pterygiumQ1862972
P304page(s)24-43
P577publication date2008-01-01
P1433published inThe Ocular SurfaceQ15764153
P1476titleThe pathogenesis of pterygium: current concepts and their therapeutic implications
P478volume6

Reverse relations

cites work (P2860)
Q53516902A comparative study of different concentrations of topical bevacizumab on the recurrence rate of excised primary pterygium: a short-term follow-up study.
Q50581470A novel graft option after pterygium excision: platelet-rich fibrin for conjunctivoplasty.
Q33832040Aberrant DNA methylation of matrix remodeling and cell adhesion related genes in pterygium
Q33914637Aberrant expression of genes and proteins in pterygium and their implications in the pathogenesis
Q35195192An update on the surgical management of pterygium and the role of loteprednol etabonate ointment
Q37097531Calcium-binding S100 protein expression in pterygium
Q37548603Chondrocyte-derived extracellular matrix suppresses pathogenesis of human pterygium epithelial cells by blocking the NF-κB signaling pathways
Q64986317Circular RNAs: Novel Promising Biomarkers in Ocular Diseases.
Q50580294Comparison of autologous fibrin glue versus nylon sutures for securing conjunctival autografting in pterygium surgery.
Q39098931Comparison of gene expression profiles in primary and immortalized human pterygium fibroblast cells
Q90150922Corneal Reinnervation and Sensitivity Recovery after Pterygium Excision
Q37051043Correlations Between Histopathologic Changes and Clinical Features in Pterygia
Q35645052Cyclooxygenase-2-expressing macrophages in human pterygium co-express vascular endothelial growth factor
Q90115068DNA methyltransferase inhibitor suppresses fibrogenetic changes in human conjunctival fibroblasts
Q53614805Effect of porcine chondrocyte-derived extracellular matrix on the pterygium in mouse model.
Q58762689Efficacy and Safety of Bevacizumab in the Treatment of Pterygium: An Updated Meta-Analysis of Randomized Controlled Trials
Q33598302Efficacy of curcumin in inducing apoptosis and inhibiting the expression of VEGF in human pterygium fibroblasts
Q30940749Expression analysis of human pterygium shows a predominance of conjunctival and limbal markers and genes associated with cell migration.
Q35820399Fixation and its role in the causation, laterality and location of pterygium: a study in amblyopes and non-amblyopes
Q92158443Identification and Interaction Analysis of Significant Genes and MicroRNAs in Pterygium
Q64102934Identification of pathogenic genes of pterygium based on the Gene Expression Omnibus database
Q50552869Identification of pterygium-related mRNA expression profiling by microarray analysis.
Q36690857Immunohistochemical detection of Hsp90 and Ki-67 in pterygium
Q90076641Impact of pterygium on the ocular surface and meibomian glands
Q36102681Influence of Light Emitting Diode-Derived Blue Light Overexposure on Mouse Ocular Surface
Q28469505Inhibition of Pterygium Fibroblast Migration and Outgrowth by Bevacizumab and Cyclosporine A Involves Down-Regulation of Matrix Metalloproteinases-3 and -13
Q91833192Interferon Alpha-2b Eye Drops Prevent Recurrence of Pterygium After the Bare Sclera Technique: A Single-Center, Sequential, and Controlled Study
Q46343413Local pro-inflammatory cytokine and nitric oxide responses are elevated in patients with pterygium
Q28308320Localization of the low-affinity nerve growth factor receptor p75 in human limbal epithelial cells
Q42374084Low recurrence rate of anchored conjunctival rotation flap technique in pterygium surgery.
Q36574123Lymphatic microvessel density as a predictive marker for the recurrence time of pterygium: a three-year follow-up study.
Q92987907MiR-21 promotes pterygium cell proliferation through the PTEN/AKT pathway
Q34314409Molecular effects of doxycycline treatment on pterygium as revealed by massive transcriptome sequencing.
Q47954026Myofibroblast transdifferentiation: The dark force in ocular wound healing and fibrosis.
Q48348460Occupational Exposure to Solar Radiation at Different Latitudes and Pterygium: A Systematic Review of the Last 10 Years of Scientific Literature
Q58764503Ologen Implantation versus Conjunctival Autograft Transplantation for Treatment of Pterygium
Q34756125Ophthalmic pterygium: a stem cell disorder with premalignant features
Q42624145Ophthalmology in Persian medicine
Q89919437Optical Analysis and Reappraisal of the Peripheral Light Focusing Theory of Nasal Pterygia Formation
Q93013171Optical coherence tomography angiography for marginal corneal vascular remodelling after pterygium surgery with limbal-conjunctival autograft
Q34534444Oral doxycycline reduces pterygium lesions; results from a double blind, randomized, placebo controlled clinical trial
Q37482419Outdoor Air Pollution and Pterygium in Korea.
Q34475106Overexpression of urokinase-type plasminogen activator in pterygia and pterygium fibroblasts.
Q36048439Positive Association between Blood 25-Hydroxyvitamin D Levels and Pterygium after Control for Sunlight Exposure
Q36263397Prolidase Enzyme Activity in Conjunctiva and Pterygium Tissues.
Q34127741Proteomic analysis in pterygium; upregulated protein expression of ALDH3A1, PDIA3, and PRDX2.
Q47657903Pterygium: descriptive nomenclature of the past
Q47653081Pterygium: evolution of medical and surgical treatments.
Q53827430Pyroptosis in pterygium pathogenesis.
Q47111851Relationship between expression of cyclooxygenase 2 and neovascularization in human pterygia
Q37110100Relationship between the expression of cyclooxygenase-2 and survivin in primary pterygium.
Q58708834Solar Radiation Exposure and Outdoor Work: An Underestimated Occupational Risk
Q33760855Structure and biological roles of mucin-type O-glycans at the ocular surface
Q35924313Survivin and p53 expression in primary and recurrent pterygium in Chinese patients
Q55177567The Role of Limbal Epithelial Stem Cells in Regulating Corneal (Lymph)angiogenic Privilege and the Micromilieu of the Limbal Niche following UV Exposure.
Q90697233The in vitro anti-fibrotic effect of Pirfenidone on human pterygium fibroblasts is associated with down-regulation of autocrine TGF-β and MMP-1
Q26753002The use of dry amniotic membrane in pterygium surgery
Q34347718Ultraviolet light and ocular diseases.
Q47094974Vitamin D and vitamin D receptor in patients with ophthalmic pterygium
Q84462988[Pterygium surgery. Complication following adjuvant radiotherapy]
Q84067006[Pterygium. Etiology, clinical aspects and novel adjuvant therapies]
Q34781453miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium
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