SPDEF functions as a colorectal tumor suppressor by inhibiting β-catenin activity.

scientific article published on February 2013

SPDEF functions as a colorectal tumor suppressor by inhibiting β-catenin activity. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1053/J.GASTRO.2013.01.043
P932PMC publication ID3738069
P698PubMed publication ID23376423
P5875ResearchGate publication ID235396682

P50authorNoah F. ShroyerQ41770096
Bruce J AronowQ87932047
P2093author name stringGang Chen
Eileen King
Allison Price
Yuan-Hung Lo
Taeko K Noah
Mary-Kay Washington
P2860cites workPDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expressionQ22011032
Atonal homolog 1 is a tumor suppressor geneQ28474993
Transcription factor achaete scute-like 2 controls intestinal stem cell fateQ28507783
Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiationQ28587525
Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysinQ28589898
The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epitheliumQ28591094
Paneth cells constitute the niche for Lgr5 stem cells in intestinal cryptsQ29616197
Global gene expression analysis identifies PDEF transcriptional networks regulating cell migration during cancer progressionQ30157655
Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cellsQ33296957
Prostate-derived Ets transcription factor as a favorable prognostic marker in ovarian cancer patientsQ33681985
Transcriptional regulation of p21/CIP1 cell cycle inhibitor by PDEF controls cell proliferation and mammary tumor progressionQ33799676
Cloning and expression of the mouse Pse gene encoding a novel Ets family memberQ33890058
NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter.Q34111030
Complex interplay between β-catenin signalling and Notch effectors in intestinal tumorigenesisQ34157489
Pdef expression in human breast cancer is correlated with invasive potential and altered gene expression.Q34220844
A role for Hath1, a bHLH transcription factor, in colon adenocarcinomaQ34480271
HATH1 expression in mucinous cancers of the colorectum and related lesionsQ34568757
Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer.Q34604859
Intestine-specific ablation of mouse atonal homolog 1 (Math1) reveals a role in cellular homeostasisQ34637765
Pathology of mouse models of intestinal cancer: consensus report and recommendationsQ35075841
Mechanisms and functional consequences of PDEF protein expression loss during prostate cancer progression.Q35082366
Atonal homolog 1 is required for growth and differentiation effects of notch/gamma-secretase inhibitors on normal and cancerous intestinal epithelial cellsQ35401731
PDEF is a negative regulator of colon cancer cell growth and migrationQ35948104
Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic diseaseQ36281413
Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancerQ36570605
Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancerQ37158989
Interaction of Muc2 and Apc on Wnt signaling and in intestinal tumorigenesis: potential role of chronic inflammationQ37232595
Loss of PDEF, a prostate-derived Ets factor is associated with aggressive phenotype of prostate cancer: regulation of MMP 9 by PDEF.Q39692770
SAM pointed domain ETS factor (SPDEF) regulates terminal differentiation and maturation of intestinal goblet cells.Q39794269
In situ hybridization to identify gut stem cellsQ43202412
Simultaneous determination of matrix metalloproteinase (MMP)-7, MMP-1, -3, and -13 gene expression by multiplex PCR in colorectal carcinomasQ44855281
Expression of MMP-7(PUMP-1) mRNA in human colorectal cancersQ70768830
Modulation of matrilysin levels in colon carcinoma cell lines affects tumorigenicity in vivoQ72132819
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectcolonic neoplasmQ3542029
P304page(s)1012-1023.e6
P577publication date2013-02-01
P1433published inGastroenterologyQ4039279
P1476titleSPDEF functions as a colorectal tumor suppressor by inhibiting β-catenin activity
P478volume144

Reverse relations

cites work (P2860)
Q41863094A tight junction between E-Cadherin and the prostate tumor suppressor SPDEF
Q58740515AR-PDEF pathway promotes tumour proliferation and upregulates MYC-mediated gene transcription by promoting MAD1 degradation in ER-negative breast cancer
Q37190790Analysis of different components in the peritumoral tissue microenvironment of colorectal cancer: A potential prospect in tumorigenesis
Q98386385Atonal bHLH transcription factor 1 is an important factor for maintaining the balance of cell proliferation and differentiation in tumorigenesis
Q58696663ELF3, ELF5, EHF and SPDEF Transcription Factors in Tissue Homeostasis and Cancer
Q42293061Gene signature driving invasive mucinous adenocarcinoma of the lung.
Q46643872Genome-wide association study for genetic variants related with maximal voluntary ventilation reveals two novel genomic signals associated with lung function
Q93049342Glutamate Ionotropic Receptor Kainate Type Subunit 3 (GRIK3) promotes epithelial-mesenchymal transition in breast cancer cells by regulating SPDEF/CDH1 signaling
Q33890004Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer
Q26765746Mutant p53 and ETS2, a Tale of Reciprocity
Q37610677Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation.
Q39455125Role of ADAM10 in intestinal crypt homeostasis and tumorigenesis
Q51066347SPDEF Induces Quiescence of Colorectal Cancer Cells by Changing the Transcriptional Targets of β-catenin.
Q34257025SPDEF inhibits prostate carcinogenesis by disrupting a positive feedback loop in regulation of the Foxm1 oncogene
Q37566504Spdef deletion rescues the crypt cell proliferation defect in conditional Gata6 null mouse small intestine
Q37594953Transcriptional Regulation by ATOH1 and its Target SPDEF in the Intestine.
Q39214992Wnt signaling in triple-negative breast cancer.

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