| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1007/S00210-008-0263-1 |
| P698 | PubMed publication ID | 18278482 |
| P2093 | author name string | Raymond B Penn | |
| P2860 | cites work | Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP | Q22008544 |
| Functional Selectivity and Classical Concepts of Quantitative Pharmacology | Q22242288 | ||
| PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts | Q22254160 | ||
| AKAP proteins anchor cAMP-dependent protein kinase to KvLQT1/IsK channel complex | Q24291117 | ||
| mAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope | Q24291765 | ||
| Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel | Q24292184 | ||
| Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin | Q24296241 | ||
| Ezrin is a cyclic AMP-dependent protein kinase anchoring protein | Q24532065 | ||
| Voltage-dependent potentiation of L-type Ca2+ channels in skeletal muscle cells requires anchored cAMP-dependent protein kinase | Q24561617 | ||
| Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice | Q24650383 | ||
| Signaling and regulation of G protein-coupled receptors in airway smooth muscle | Q24806613 | ||
| RNA editing of the human serotonin 5-hydroxytryptamine 2C receptor silences constitutive activity | Q28139671 | ||
| Aspirin-sensitive asthma | Q28174122 | ||
| Membrane-bound protein kinase A inhibits smooth muscle cell proliferation in vitro and in vivo by amplifying cAMP-protein kinase A signals | Q28200099 | ||
| Caveolae and sorting in the trans-Golgi network of epithelial cells | Q40872630 | ||
| Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors | Q40889383 | ||
| The endothelin subtype A receptor undergoes agonist- and antagonist-mediated internalization in the absence of signaling | Q41030112 | ||
| beta2-adrenergic receptor desensitization, internalization, and phosphorylation in response to full and partial agonists | Q41091060 | ||
| Two isoforms of prostaglandin EP3 receptor exhibiting constitutive activity and agonist-dependent activity in Rho-mediated stress fiber formation | Q41109106 | ||
| Molecular mechanisms of beta-adrenergic relaxation of airway smooth muscle | Q41117644 | ||
| Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein | Q41216893 | ||
| VIP inhibits basal and histamine-stimulated proliferation of human airway smooth muscle cells | Q41342500 | ||
| Salmeterol stimulation dissociates beta2-adrenergic receptor phosphorylation and internalization | Q41852598 | ||
| Changes in beta 2-adrenoceptor and other signaling proteins produced by chronic administration of 'beta-blockers' in a murine asthma model | Q41928013 | ||
| Antagonists of bradykinin that stabilize a G-protein-uncoupled state of the B2 receptor act as inverse agonists in rat myometrial cells. | Q42491981 | ||
| Agonist-independent effects of muscarinic antagonists on Ca2+ and K+ currents in frog and rat cardiac cells | Q42506461 | ||
| Changes in the carboxyl-terminal domain of metabotropic glutamate receptor 1 by alternative splicing generate receptors with differing agonist-independent activity. | Q42518192 | ||
| The myocardium-protective Gly-49 variant of the beta 1-adrenergic receptor exhibits constitutive activity and increased desensitization and down-regulation | Q42521824 | ||
| RNA editing of the human serotonin 5-HT2C receptor alters receptor-mediated activation of G13 protein | Q42825199 | ||
| Inhibition of allergen-induced airway remodelling by tiotropium and budesonide: a comparison | Q80405294 | ||
| A-kinase anchoring proteins interact with phosphodiesterases in T lymphocyte cell lines | Q80833019 | ||
| Localization and upregulation of cysteinyl leukotriene-1 receptor in asthmatic bronchial mucosa | Q81118596 | ||
| Mitogenic effects of cytokines on smooth muscle are critically dependent on protein kinase A and are unmasked by steroids and cyclooxygenase inhibitors | Q81577516 | ||
| Cooperative mitogenic signaling by G protein-coupled receptors and growth factors is dependent on G(q/11) | Q83839356 | ||
| CysLT1 receptor upregulation by TGF-β and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4 | Q28203816 | ||
| Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation | Q28205761 | ||
| Paradoxical trafficking and regulation of 5-HT(2A) receptors by agonists and antagonists | Q28212355 | ||
| Dynamic complexes of beta2-adrenergic receptors with protein kinases and phosphatases and the role of gravin | Q28293178 | ||
| A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty | Q28298512 | ||
| A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia | Q28299144 | ||
| Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein | Q28301562 | ||
| Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors | Q28378928 | ||
| Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor | Q28504814 | ||
| beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking | Q28507206 | ||
| Cloning and characterization of AKAP 95, a nuclear protein that associates with the regulatory subunit of type II cAMP-dependent protein kinase | Q28565409 | ||
| The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling | Q28571079 | ||
| AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum | Q28571497 | ||
| Novel brain-specific 5-HT4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain | Q28574308 | ||
| Targeting of Protein Kinase A by Muscle A Kinase-anchoring Protein (mAKAP) Regulates Phosphorylation and Function of the Skeletal Muscle Ryanodine Receptor | Q28578195 | ||
| PDE4D plays a critical role in the control of airway smooth muscle contraction | Q28587530 | ||
| Differential activation of Gq/11 and Gi(3) proteins at 5-hydroxytryptamine(2C) receptors revealed by antibody capture assays: influence of receptor reserve and relationship to agonist-directed trafficking | Q28609340 | ||
| Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2 | Q28611497 | ||
| Regulation of G protein-coupled receptor-adenylyl cyclase responsiveness in human airway smooth muscle by exogenous and autocrine adenosine | Q31834448 | ||
| Antigen-specific CD4+ T cells drive airway smooth muscle remodeling in experimental asthma | Q33771393 | ||
| Characterization of RANTES- and aminooxypentane-RANTES-triggered desensitization signals reveals differences in recruitment of the G protein-coupled receptor complex. | Q33873311 | ||
| Human eosinophil major basic protein is an endogenous allosteric antagonist at the inhibitory muscarinic M2 receptor | Q33894905 | ||
| Constitutive activity of G protein coupled receptors and drug action | Q33919901 | ||
| Beta-adrenergic agonists regulate KCa channels in airway smooth muscle by cAMP-dependent and -independent mechanisms | Q34121141 | ||
| Regulation of G protein-coupled receptor kinases | Q34126348 | ||
| Neural regulation of airway smooth muscle tone | Q34175736 | ||
| Ryanodine receptors/calcium release channels in heart failure and sudden cardiac death | Q34198372 | ||
| Constitutively active mutants of rhodopsin | Q34244263 | ||
| Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins | Q34306079 | ||
| Constitutive activity of the serotonin2C receptor inhibits in vivo dopamine release in the rat striatum and nucleus accumbens. | Q34310093 | ||
| Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists | Q34429705 | ||
| Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2. | Q34536660 | ||
| Inverse agonism or neutral antagonism at G-protein coupled receptors: a medicinal chemistry challenge worth pursuing? | Q34578757 | ||
| Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus | Q34584278 | ||
| Phosphodiesterases regulate airway smooth muscle function in health and disease | Q36820316 | ||
| Modulating G-protein-coupled receptors: from traditional pharmacology to allosterics | Q36888345 | ||
| The evasive nature of drug efficacy: implications for drug discovery | Q36894549 | ||
| A-kinase anchoring proteins: trafficking in G-protein-coupled receptors and the proteins that regulate receptor biology. | Q36929783 | ||
| Reversal of allergen-induced airway remodeling by CysLT1 receptor blockade | Q37144437 | ||
| Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice | Q37369510 | ||
| The small heat shock-related protein, HSP20, is a cAMP-dependent protein kinase substrate that is involved in airway smooth muscle relaxation. | Q37377529 | ||
| Effects of acute and chronic administration of beta-adrenoceptor ligands on airway function in a murine model of asthma | Q37415568 | ||
| High-affinity binding of the regulatory subunit (RII) of cAMP-dependent protein kinase to microtubule-associated and other cellular proteins | Q37575501 | ||
| Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas | Q38315242 | ||
| Salmeterol-induced desensitization, internalization and phosphorylation of the human beta2-adrenoceptor | Q39449855 | ||
| Functional selectivity of D2 receptor ligands in a Chinese hamster ovary hD2L cell line: evidence for induction of ligand-specific receptor states | Q39688191 | ||
| The natural inverse agonist agouti-related protein induces arrestin-mediated endocytosis of melanocortin-3 and -4 receptors | Q40220162 | ||
| Delineation of type I protein kinase A-selective signaling events using an RI anchoring disruptor | Q40275163 | ||
| AKAP-Lbc nucleates a protein kinase D activation scaffold | Q40512904 | ||
| Arrestin specificity for G protein-coupled receptors in human airway smooth muscle | Q40797346 | ||
| Versatility of GPCR recognition by drugs: from biological implications to therapeutic relevance | Q34650437 | ||
| Beta-arrestin-biased ligands at seven-transmembrane receptors | Q34654662 | ||
| Airway smooth muscle | Q34662827 | ||
| Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the beta 2-adrenoceptor | Q34723904 | ||
| Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors | Q34968199 | ||
| Constitutive activity of human prostaglandin E receptor EP3 isoforms | Q35026091 | ||
| Involvement of cysteinyl leukotrienes in airway smooth muscle cell DNA synthesis after repeated allergen exposure in sensitized Brown Norway rats | Q35029119 | ||
| The β-adrenergic receptor kinase in heart failure | Q35547403 | ||
| Localized effects of cAMP mediated by distinct routes of protein kinase A. | Q35625604 | ||
| Theophylline: mechanism of action and use in asthma and chronic obstructive pulmonary disease | Q35677605 | ||
| Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D | Q35801500 | ||
| Proliferative aspects of airway smooth muscle. | Q35862082 | ||
| Endothelin-1-induced potentiation of human airway smooth muscle proliferation: an ETA receptor-mediated phenomenon | Q35873519 | ||
| Airway smooth muscle: immunomodulatory cells? | Q36040284 | ||
| Building better mouse models of asthma | Q36062587 | ||
| A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling | Q36082162 | ||
| Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors | Q36160942 | ||
| A protein kinase bound to the projection portion of MAP 2 (microtubule-associated protein 2) | Q36205280 | ||
| Airway remodeling contributes to the progressive loss of lung function in asthma: an overview | Q36256195 | ||
| Airway smooth muscle: a modulator of airway remodeling in asthma | Q36256199 | ||
| Historical review: Negative efficacy and the constitutive activity of G-protein-coupled receptors. | Q36301820 | ||
| Seven-transmembrane receptor signaling through beta-arrestin | Q36305171 | ||
| Recent developments in constitutive receptor activity and inverse agonism, and their potential for GPCR drug discovery | Q36365614 | ||
| G-Protein-coupled receptor-associated A-kinase anchoring proteins: AKAP79 and AKAP250 (gravin). | Q36380034 | ||
| Phosphodiesterase inhibitors in airways disease | Q36386790 | ||
| Novel concepts of neuropeptide-based drug therapy: vasoactive intestinal polypeptide and its receptors | Q36394458 | ||
| Airway remodeling from bench to bedside: current perspectives | Q36423453 | ||
| GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling | Q36440674 | ||
| A-kinase anchoring proteins take shape | Q36463252 | ||
| The where's and when's of kinase anchoring | Q36475672 | ||
| Remodeling in asthma and chronic obstructive pulmonary disease | Q36518612 | ||
| Targeting G protein-coupled receptor signaling in asthma | Q36530502 | ||
| Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma | Q36807115 | ||
| Fluticasone inhibits but does not reverse allergen-induced structural airway changes | Q43545267 | ||
| Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma | Q43601724 | ||
| Effects of non-bronchoconstrictive doses of inhaled propranolol on airway responsiveness to methacholine | Q43647210 | ||
| IL-13 and IL-4 up-regulate cysteinyl leukotriene 1 receptor expression in human monocytes and macrophages | Q43710176 | ||
| Interferon-gamma modulates cysteinyl leukotriene receptor-1 expression and function in human airway myocytes | Q43819603 | ||
| A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model | Q43846995 | ||
| Fluticasone inhibits the progression of allergen-induced structural airway changes | Q44016402 | ||
| Rapid desensitization of the serotonin(2C) receptor system: effector pathway and agonist dependence | Q44106343 | ||
| Muscarinic M3-receptors mediate cholinergic synergism of mitogenesis in airway smooth muscle | Q44286303 | ||
| Receptors and pathways mediating the effects of prostaglandin E2 on airway tone | Q44346690 | ||
| Mechanism of beta-adrenergic receptor desensitization in cardiac hypertrophy is increased beta-adrenergic receptor kinase | Q44771333 | ||
| Ligand-directed functional heterogeneity of histamine H1 receptors: novel dual-function ligands selectively activate and block H1-mediated phospholipase C and adenylyl cyclase signaling | Q44915339 | ||
| Protective effects of tiotropium bromide in the progression of airway smooth muscle remodeling | Q45253834 | ||
| The mammalian beta 2-adrenergic receptor: reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system | Q46158674 | ||
| Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists | Q46427567 | ||
| Effects of ciclesonide and fluticasone propionate on allergen-induced airway inflammation and remodeling features. | Q46469358 | ||
| Corticosteroids prevent myofibroblast accumulation and airway remodeling in mice | Q46572428 | ||
| Prostaglandin E2 protects lower airways against bronchoconstriction | Q46661216 | ||
| Cooperative regulation of p70S6 kinase by receptor tyrosine kinases and G protein-coupled receptors augments airway smooth muscle growth | Q46785132 | ||
| Allosteric site in M2 acetylcholine receptors: evidence for a major conformational change upon binding of an orthosteric agonist instead of an antagonist | Q46857215 | ||
| Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice | Q47859877 | ||
| The A-kinase anchor protein MAP2B and cAMP-dependent protein kinase are associated with class C L-type calcium channels in neurons | Q48095798 | ||
| Critical role of cAMP-dependent protein kinase anchoring to the L-type calcium channel Cav1.2 via A-kinase anchor protein 150 in neurons | Q48284563 | ||
| Molecular characterization of the cAMP-dependent protein kinase bound to microtubule-associated protein 2 | Q48965057 | ||
| Cytokines regulate beta-2-adrenergic receptor responsiveness in airway smooth muscle via multiple PKA- and EP2 receptor-dependent mechanisms. | Q50750497 | ||
| Type 2 cytokines in the pathogenesis of sustained airway dysfunction and airway remodeling in mice. | Q51636510 | ||
| Single amino acids determine specificity of binding of protein kinase A regulatory subunits by protein kinase A anchoring proteins. | Q52174193 | ||
| EP(2) receptor mediates bronchodilation by PGE(2) in mice. | Q52539531 | ||
| Mechanisms of proliferation synergy by receptor tyrosine kinase and G protein-coupled receptor activation in human airway smooth muscle. | Q52541175 | ||
| Cutting edge: A-kinase anchor proteins are involved in maintaining resting T cells in an inactive state. | Q52546138 | ||
| The use of stimulus-biased assay systems to detect agonist-specific receptor active states: implications for the trafficking of receptor stimulus by agonists. | Q52926779 | ||
| A major functional role for phosphodiesterase 4D5 in human airway smooth muscle cells. | Q53536541 | ||
| beta-adrenoceptor mediated responses in rat pulmonary artery: putative role of TASK-1 related K channels. | Q53620423 | ||
| alpha-Thrombin increases cytosolic calcium and induces human airway smooth muscle cell proliferation. | Q54166692 | ||
| DNA antisense therapy for asthma in an animal model | Q59060753 | ||
| Beta-adrenoceptor blockade with propranolol and bronchial responsiveness to a number of bronchial provocation tests in non-asthmatic subjects | Q69866493 | ||
| Sustained activation of a G protein-coupled receptor via "anchored" agonist binding. Molecular localization of the salmeterol exosite within the 2-adrenergic receptor | Q71514922 | ||
| Adenosine-induced bronchoconstriction and contraction of airway smooth muscle from allergic rabbits with late-phase airway obstruction: evidence for an inducible adenosine A1 receptor | Q72317964 | ||
| A beta-adrenergic receptor kinase dominant negative mutant attenuates desensitization of the beta 2-adrenergic receptor | Q72403577 | ||
| Activation of calcium currents in cardiac myocytes by empty beta-adrenoceptors | Q72636897 | ||
| Unoccupied beta-adrenoceptor-induced adenylyl cyclase stimulation in turkey erythrocyte membranes | Q72798062 | ||
| Antagonist-stimulated internalization of the G protein-coupled cholecystokinin receptor | Q73128169 | ||
| Human calcitonin receptors exhibit agonist-independent (constitutive) signaling activity | Q73167117 | ||
| Lysophosphatidic acid and EGF stimulate mitogenesis in human airway smooth muscle cells | Q73575759 | ||
| Mouse model of airway remodeling: strain differences | Q73663337 | ||
| Repeated allergen inhalations induce DNA synthesis in airway smooth muscle and epithelial cells in vivo | Q74408626 | ||
| beta -Arrestins regulate protease-activated receptor-1 desensitization but not internalization or Down-regulation | Q77123098 | ||
| Effects of LTD4 on human airway smooth muscle cell proliferation, matrix expression, and contraction In vitro: differential sensitivity to cysteinyl leukotriene receptor antagonists | Q77217279 | ||
| Cellular and molecular mechanisms regulating airway smooth muscle proliferation and cell adhesion molecule expression | Q77563925 | ||
| MAPK superfamily activation in human airway smooth muscle: mitogenesis requires prolonged p42/p44 activation | Q78252875 | ||
| Components of airway hyperresponsiveness and their associations with inflammation and remodeling in mice | Q79828951 | ||
| P433 | issue | 2 | |
| P921 | main subject | asthma | Q35869 |
| G protein-coupled receptor | Q38173 | ||
| P1104 | number of pages | 21 | |
| P304 | page(s) | 149-169 | |
| P577 | publication date | 2008-02-16 | |
| P1433 | published in | Naunyn-Schmiedeberg's Archives of Pharmacology | Q1468251 |
| P1476 | title | Embracing emerging paradigms of G protein-coupled receptor agonism and signaling to address airway smooth muscle pathobiology in asthma | |
| P478 | volume | 378 |
| Q37114730 | Agonizing over agonism: should asthmatics turn their beta-receptors on or off? |
| Q37440525 | Airway smooth muscle in airway reactivity and remodeling: what have we learned? |
| Q34421820 | Anti-mitogenic effects of β-agonists and PGE2 on airway smooth muscle are PKA dependent. |
| Q24646260 | Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine model |
| Q38817408 | Bronchoprotection and bronchorelaxation in asthma: New targets, and new ways to target the old ones |
| Q45912105 | Do β-adrenoceptor agonists induce homologous or heterologous desensitization in rat urinary bladder? |
| Q39315980 | Endogenous Gs-coupled receptors in smooth muscle exhibit differential susceptibility to GRK2/3-mediated desensitization |
| Q37503670 | Exploiting functional domains of GRK2/3 to alter the competitive balance of pro- and anticontractile signaling in airway smooth muscle |
| Q42368298 | Heat Shock-Related Protein 20 Peptide Decreases Human Airway Constriction Downstream of β2-Adrenergic Receptor |
| Q45352520 | How reliable are G-protein-coupled receptor antibodies? |
| Q34226789 | Inverse agonism and its therapeutic significance |
| Q37629298 | KCNQ (Kv7) potassium channel activators as bronchodilators: combination with a β2-adrenergic agonist enhances relaxation of rat airways |
| Q35950205 | Kv7 potassium channels in airway smooth muscle cells: signal transduction intermediates and pharmacological targets for bronchodilator therapy. |
| Q33993700 | Loss of regulator of G protein signaling 5 promotes airway hyperresponsiveness in the absence of allergic inflammation. |
| Q38166604 | Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung |
| Q37822833 | New perspectives regarding β(2) -adrenoceptor ligands in the treatment of asthma |
| Q88577168 | Pepducins as a potential treatment strategy for asthma and COPD |
| Q26778685 | Pharmacologic rationale underlying the therapeutic effects of tiotropium/olodaterol in COPD |
| Q38362661 | Pharmacologic rationale, efficacy and safety of the fixed-dose co-formulation of indacaterol and glycopyrronium |
| Q28476500 | Receptor-mediated enhancement of beta adrenergic drug activity by ascorbate in vitro and in vivo |
| Q37762035 | Regulation of T cells in airway disease by beta-agonist |
| Q37366450 | Role of Abl in airway hyperresponsiveness and airway remodeling |
| Q36051502 | Specificity of arrestin subtypes in regulating airway smooth muscle G protein-coupled receptor signaling and function |
| Q37357146 | The dopamine D1 receptor is expressed and facilitates relaxation in airway smooth muscle |
| Q38152743 | β-Adrenoceptor modulation in chronic obstructive pulmonary disease: present and future perspectives. |
| Q34044729 | β-Agonist-mediated relaxation of airway smooth muscle is protein kinase A-dependent. |
| Q38791742 | β2 Agonists |
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