Antiphospholipid antibody-induced miR-146a-3p drives trophoblast interleukin-8 secretion through activation of Toll-like receptor 8.

scientific article published on 29 March 2016

Antiphospholipid antibody-induced miR-146a-3p drives trophoblast interleukin-8 secretion through activation of Toll-like receptor 8. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/MOLEHR/GAW027
P932PMC publication ID4941806
P698PubMed publication ID27029214

P50authorLawrence W. ChamleyQ39050378
Jan J. BrosensQ37618319
P2093author name stringVikki M Abrahams
Jane E Salmon
Marta Guerra
Melissa J Mulla
Stefan M Gysler
P2860cites workMaternal cigarette smoking during pregnancy is associated with downregulation of miR-16, miR-21, and miR-146a in the placentaQ24613616
MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cellsQ24645977
Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signalsQ24649064
Histopathology in the placentae of women with antiphospholipid antibodies: A systematic review of the literatureQ38332194
Identification of miRNAs as potential modulators of tissue factor expression in patients with systemic lupus erythematosus and antiphospholipid syndromeQ38333095
Distinct subsets of microRNAs are expressed differentially in the human placentas of patients with preeclampsia.Q38516599
MicroRNA-155 inhibits migration of trophoblast cells and contributes to the pathogenesis of severe preeclampsia by regulating endothelial nitric oxide synthaseQ38997409
Effect of hydroxychloroquine on antiphospholipid antibody-induced changes in first trimester trophoblast functionQ39044818
MicroRNA-155 inhibits proliferation and migration of human extravillous trophoblast derived HTR-8/SVneo cells via down-regulating cyclin D1.Q39303428
MicroRNA-155 is involved in the remodelling of human-trophoblast-derived HTR-8/SVneo cells induced by lipopolysaccharidesQ39553937
Interleukin-8 (CXCL8) stimulates trophoblast cell migration and invasion by increasing levels of matrix metalloproteinase (MMP)2 and MMP9 and integrins alpha5 and beta1.Q39743504
Anti-phospholipid antibodies increase non-apoptotic trophoblast shedding: a contribution to the pathogenesis of pre-eclampsia in affected women?Q39821048
Reduced circulating miR-196b levels is associated with preeclampsia.Q40806450
Housekeeping genes for studies of plasma microRNA: A need for more precise standardizationQ40816584
Synthesis of beta2 glycoprotein 1 by the human placentaQ41101472
Antiphospholipid antibodies internalised by human syncytiotrophoblast cause aberrant cell death and the release of necrotic trophoblast debris.Q41924274
Is interleukin-3 important in antiphospholipid antibody-mediated pregnancy failure?Q42511087
Establishment and Characterization of First Trimester Human Trophoblast Cells with Extended LifespanQ42804803
Histologic features of placentas and abortion specimens from women with antiphospholipid and antiphospholipid-like syndromesQ47354685
Effect of beta2-glycoprotein I null mutation on reproductive outcome and antiphospholipid antibody-mediated pregnancy pathology in miceQ47725162
Human antiphospholipid antibodies induce TNFalpha in monocytes via Toll-like receptor 8.Q47758501
microRNA-210 negatively regulates LPS-induced production of proinflammatory cytokines by targeting NF-κB1 in murine macrophagesQ47781337
miRNA in plasma exosome is stable under different storage conditions.Q50692718
Modulation of trophoblast angiogenic factor secretion by antiphospholipid antibodies is not reversed by heparin.Q53250090
MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2.Q54733079
Defective endovascular trophoblast invasion in primary antiphospholipid antibody syndrome-associated early pregnancy failureQ57523494
Antiphospholipid antibodies prevent extravillous trophoblast differentiationQ60273555
The expression of Argonaute2 and related microRNA biogenesis proteins in normal and hypoxic trophoblastsQ79842633
TNF-alpha is a critical effector and a target for therapy in antiphospholipid antibody-induced pregnancy lossQ81178348
Antiphospholipid antibodies limit trophoblast migration by reducing IL-6 production and STAT3 activityQ82782633
MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteinsQ83586463
Antiphospholipid antibodies induce translocation of TLR7 and TLR8 to the endosome in human monocytes and plasmacytoid dendritic cellsQ84513241
NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responsesQ24670080
MicroRNAs and their isomiRs function cooperatively to target common biological pathwaysQ27499590
The widespread regulation of microRNA biogenesis, function and decayQ28131796
Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohortQ28741729
MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory responseQ29615493
miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blastsQ30496174
Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndromeQ33630007
Identification of MyD88 as a novel target of miR-155, involved in negative regulation of Helicobacter pylori-induced inflammationQ34103235
MicroRNA-155 contributes to preeclampsia by down-regulating CYR61.Q34114198
miR-155 and its star-form partner miR-155* cooperatively regulate type I interferon production by human plasmacytoid dendritic cellsQ34138772
Serum and urinary cell-free MiR-146a and MiR-155 in patients with systemic lupus erythematosusQ34144124
A role for uric acid and the Nalp3 inflammasome in antiphospholipid antibody-induced IL-1β production by human first trimester trophoblast.Q34769721
Identification of microRNAs that regulate TLR2-mediated trophoblast apoptosis and inhibition of IL-6 mRNA.Q35021710
Interferon-α and angiogenic dysregulation in pregnant lupus patients who develop preeclampsiaQ35236547
Viral single stranded RNA induces a trophoblast pro-inflammatory and antiviral response in a TLR8-dependent and -independent mannerQ35617081
Expression Profile of MicroRNAs and mRNAs in Human Placentas From Pregnancies Complicated by Preeclampsia and Preterm LaborQ35930887
Prediction of adverse pregnancy outcome by the presence of lupus anticoagulant, but not anticardiolipin antibody, in patients with antiphospholipid antibodiesQ35977256
New facet of antiphospholipid antibodiesQ36242855
Immunomodulatory molecules are released from the first trimester and term placenta via exosomesQ36501381
ApoE Receptor 2 Mediation of Trophoblast Dysfunction and Pregnancy Complications Induced by Antiphospholipid Antibodies in MiceQ36619367
The c-Myc-regulated microRNA-17~92 (miR-17~92) and miR-106a~363 clusters target hCYP19A1 and hGCM1 to inhibit human trophoblast differentiation.Q36759672
TLR3-induced placental miR-210 down-regulates the STAT6/interleukin-4 pathwayQ36976363
Human placental trophoblasts confer viral resistance to recipient cellsQ37031670
Polymorphic mature microRNAs from passenger strand of pre-miR-146a contribute to thyroid cancerQ37083534
miR-210 inhibits trophoblast invasion and is a serum biomarker for preeclampsia.Q37271482
Elevated levels of hypoxia-inducible microRNA-210 in pre-eclampsia: new insights into molecular mechanisms for the diseaseQ37295740
Antiphospholipid antibodies induce a pro-inflammatory response in first trimester trophoblast via the TLR4/MyD88 pathwayQ37409260
Predictors of Pregnancy Outcomes in Patients With Lupus: A Cohort StudyQ37420173
The role of placental exosomes in reproductionQ37717747
MicroRNAs: the fine-tuners of Toll-like receptor signallingQ37844405
Obstetric and vascular APS: same autoantibodies but different diseases?Q38013583
Pregnancy morbidity in antiphospholipid syndrome: what is the impact of treatment?Q38175887
P433issue7
P921main subjectinterleukinsQ194908
toll-like receptorQ408004
P304page(s)465-474
P577publication date2016-03-29
P1433published inMolecular Human ReproductionQ15761794
P1476titleAntiphospholipid antibody-induced miR-146a-3p drives trophoblast interleukin-8 secretion through activation of Toll-like receptor 8.
P478volume22

Reverse relations

cites work (P2860)
Q49998565Antiphospholipid Antibodies Inhibit Trophoblast Toll-like Receptor and Inflammasome Negative Regulators.
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Q39264755Emerging Treatment Models in Rheumatology: Antiphospholipid Syndrome and Pregnancy: Pathogenesis to Translation
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Q49456387Janus-Faced Myeloid-Derived Suppressor Cell Exosomes for the Good and the Bad in Cancer and Autoimmune Disease
Q64108214New Biomarkers for Atherothrombosis in Antiphospholipid Syndrome: Genomics and Epigenetics Approaches
Q90432999Role of microRNAs in the Development of Cardiovascular Disease in Systemic Autoimmune Disorders
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Q52323268Toll-like receptors in lupus nephritis.
Q38731888miR-146a-5p mediates epithelial-mesenchymal transition of oesophageal squamous cell carcinoma via targeting Notch2.

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