Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers

scientific article published on 31 December 2008

Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1051762171
P356DOI10.1186/1476-4598-7-94
P932PMC publication ID2639620
P698PubMed publication ID19117505
P5875ResearchGate publication ID23714707

P50authorRagnhild A. LotheQ11996941
Rolf Inge SkotheimQ76361066
Geir HoffQ114094518
Morten H. VatnQ76356809
P2093author name stringGuro E Lind
Vera L Costa
Gunn I Meling
Torleiv O Rognum
Espen Thiis-Evensen
Terje Ahlquist
P2860cites workHIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cellsQ24291505
cDNA cloning and sequence of MAL, a hydrophobic protein associated with human T-cell differentiationQ24299157
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Methylation-specific PCR: a novel PCR assay for methylation status of CpG islandsQ24631957
CpG island methylator phenotype in colorectal cancerQ24672170
A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell linesQ24792846
Methylation changes in faecal DNA: a marker for colorectal cancer screening?Q28257322
Detection of aberrant methylation in fecal DNA as a molecular screening tool for colorectal cancer and precancerous lesionsQ28292507
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancerQ29614277
The epigenetic progenitor origin of human cancerQ29617486
Comparing the DNA hypermethylome with gene mutations in human colorectal cancerQ33300134
Expression of the hMLH1 gene is a possible predictor for the clinical response to 5-fluorouracil after a surgical resection in colorectal cancerQ33337155
Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis.Q33775531
Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.Q33888431
Pathology of colorectal cancerQ34296722
Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers.Q34318634
Expression of MAL and MAL2, two elements of the protein machinery for raft-mediated transport, in normal and neoplastic human tissueQ34323521
Multiplexed profiling of candidate genes for CpG island methylation status using a flexible PCR/LDR/Universal Array assayQ34338885
MGMT promoter methylation and field defect in sporadic colorectal cancer.Q34452509
Epigenetic inactivation of the HOXA gene cluster in breast cancerQ34580018
Genetic and epigenetic alterations in colon cancerQ34762615
Hypermethylation of the TPEF/HPP1 gene in primary and metastatic colorectal cancersQ34769653
CpG island methylation in aberrant crypt foci of the colorectumQ35748049
Aging and DNA methylation in colorectal mucosa and cancerQ77670111
Population-based surveillance by colonoscopy: effect on the incidence of colorectal cancer. Telemark Polyp Study IQ77872399
DNA hypermethylation of MAL: a promising diagnostic biomarker for colorectal tumorsQ80098072
O6-methylguanine-DNA methyltransferase promoter hypermethylation in colorectal carcinogenesisQ80286842
Promoter methylation of the PTEN gene is a common molecular change in breast cancerQ80403566
Screening for genomic fragments that are methylated specifically in colorectal carcinoma with a methylated MLH1 promoterQ80404744
PTEN promoter is methylated in a proportion of invasive breast cancersQ80594418
Hypermethylation of the MLH1 promoter with concomitant absence of transcript and protein occurs in small patches of crypt cells in unaffected mucosa from sporadic colorectal carcinomaQ82797873
Extensive DNA methylation in normal colorectal mucosa in hyperplastic polyposis.Q35760876
Considerations when analyzing the methylation status of PTEN tumor suppressor geneQ35788734
Frequent CpG island methylation in serrated adenomas of the colorectumQ35791305
Genetic alterations within the retinoblastoma locus in colorectal carcinomas. Relation to DNA ploidy pattern studied by flow cytometric analysisQ35993699
Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer.Q36276940
Hypermethylated MAL gene - a silent marker of early colon tumorigenesisQ36539162
DNA hypermethylation in the normal colonic mucosa of patients with colorectal cancerQ36613849
RAS signaling in colorectal carcinomas through alteration of RAS, RAF, NF1, and/or RASSF1AQ36730389
Profiling CpG island field methylation in both morphologically normal and neoplastic human colonic mucosaQ36755132
Colorectal cancer: a multipathway diseaseQ36787380
CpG island methylation in familial colorectal cancer patients not fulfilling the Amsterdam criteriaQ36854134
Molecular heterogeneity of colorectal cancer: Implications for cancer controlQ37006555
High-resolution mapping of DNA methylation in human genome using oligonucleotide tiling arrayQ38308810
Epigenetic inactivation of a cluster of genes flanking MLH1 in microsatellite-unstable colorectal cancerQ40073646
Inactivation of HOXA genes by hypermethylation in myeloid and lymphoid malignancy is frequent and associated with poor prognosis.Q40085449
Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps.Q40458838
Clustering of gene hypermethylation associated with clinical risk groups in neuroblastomaQ40524531
Promoter methylation and silencing of PTEN in gastric carcinomaQ43918868
Genetic tumor markers with prognostic impact in Dukes' stages B and C colorectal cancer patientsQ44678560
Epigenetic inactivation of RUNX3 in microsatellite unstable sporadic colon cancersQ45073501
Proximal and distal colorectal cancers show distinct gene-specific methylation profiles and clinical and molecular characteristics.Q46018478
Mismatch repair deficiency and CpG island hypermethylation in sporadic colon adenocarcinomas.Q46022384
Epigenetic patterns in the progression of esophageal adenocarcinomaQ46291635
Quantitative detection of promoter hypermethylation in multiple genes in the serum of patients with colorectal cancer.Q46718275
The carboxyl-terminal half region of ADAMTS-1 suppresses both tumorigenicity and experimental tumor metastatic potentialQ47351603
PTEN methylation and expression in glioblastomasQ48232099
Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band.Q53346861
Promoter hypermethylation of tumor-related genes in the progression of colorectal neoplasia.Q53364696
Prognostic value of p16INK4a and p14ARF gene hypermethylation in human colon cancer.Q53624460
The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer.Q54572656
Influence of methylated p15 and p16 genes on clinicopathological features in colorectal cancer.Q54590260
Aberrant promoter methylation of multiple genes during multistep pathogenesis of colorectal cancers.Q54648210
Detection in fecal DNA of colon cancer-specific methylation of the nonexpressed vimentin gene.Q54650748
Aberrant CpG island hypermethylation of multiple genes in colorectal neoplasia.Q54719199
Promoter methylation precedes chromosomal alterations in colorectal cancer development.Q54878251
ADAMTS1, CRABP1, and NR3C1 identified as epigenetically deregulated genes in colorectal tumorigenesis.Q55025133
DNA methylation, field effects, and colorectal cancer.Q55041248
AngiogenesisQ56689455
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasiaQ57240085
Promoter methylation status of the MGMT, hMLH1, and CDKN2A/p16 genes in non-neoplastic mucosa of patients with and without colorectal adenomasQ59549786
P304page(s)94
P577publication date2008-12-31
P1433published inMolecular CancerQ15724585
P1476titleGene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers
P478volume7

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