The role of complement in ocular pathology

scientific article published on 26 February 2008

The role of complement in ocular pathology is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1007/S00281-008-0110-Y
P2888exact matchhttps://scigraph.springernature.com/pub.10.1007/s00281-008-0110-y
P932PMC publication ID2315691
P698PubMed publication ID18299835
P5875ResearchGate publication ID5552185

P2093author name stringNalini S Bora
Puran S Bora
Purushottam Jha
P2860cites workComplement factor H: spatial and temporal expression and localization in the eyeQ80175120
Drusen complement components C3a and C5a promote choroidal neovascularizationQ24303123
A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degenerationQ24523983
Isolation and characterization of a membrane-attack-complex-inhibiting protein present in human serum and other biological fluidsQ24528248
Complement factor H polymorphism in age-related macular degenerationQ24553334
Structural basis for complement factor H linked age-related macular degenerationQ24676448
Differential gene expression in anatomical compartments of the human eye.Q24814005
Complement factor H variant increases the risk of age-related macular degenerationQ28239239
Differential expression of the complement regulatory proteins in the human eyeQ28285403
Molecular organization and function of the complement systemQ28289114
Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene clusterQ28304963
CD59, a complement regulatory protein, controls choroidal neovascularization in a mouse model of wet-type age-related macular degenerationQ28512384
Role of complement and complement membrane attack complex in laser-induced choroidal neovascularizationQ28513118
Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cellsQ28565650
Alcohol linked to enhanced angiogenesis in rat model of choroidal neovascularizationQ28567980
Identification and functional characterization of a new gene encoding the mouse terminal complement inhibitor CD59Q28589130
Complement factor H polymorphism and age-related macular degenerationQ29614931
Inflammatory mediators in uveitis: differential induction of cytokines and chemokines in Th1- versus Th2-mediated ocular inflammationQ30817180
Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: role of factor B and factor H.Q30819789
Comparison of the N-linked glycans from soluble and GPI-anchored CD59 expressed in CHO cellsQ31065746
Molecular cloning of rat and mouse membrane cofactor protein (MCP, CD46): preferential expression in testis and close linkage between the mouse Mcp and Cr2 genes on distal chromosome 1.Q31983999
T cell traffic and the inflammatory response in experimental autoimmune uveoretinitis.Q32068656
Age-related macular degeneration (AMD): pathogenesis and therapyQ33250352
Pathogenesis of laser-induced choroidal subretinal neovascularizationQ33254687
Estimation of systemic complement C3 activity in age-related macular degenerationQ33281594
Expression of adiponectin in choroidal tissue and inhibition of laser induced choroidal neovascularization by adiponectinQ33283093
Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunctionQ33301870
The simple design of complement factor H: Looks can be deceivingQ33372312
Genetic susceptibility to age related macular degenerationQ33831396
Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit diseaseQ33899675
Structure-function relationships of complement receptor type 1.Q33952060
Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degenerationQ34066021
Biological effects of C1 inhibitorQ34363269
Control of the complement system.Q34400002
Complement activation and inflammatory processes in Drusen formation and age related macular degenerationQ34521109
Cigarette smoke can activate the alternative pathway of complement in vitro by modifying the third component of complementQ34537546
Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degenerationQ34561066
Complement C3 variant and the risk of age-related macular degenerationQ34651682
Mechanisms of age-related macular degeneration.Q34684544
Immune privilege in the anterior chamber of the eye.Q34788773
Membrane inhibitor of reactive lysisQ35344434
Decay accelerating factor (CD55).Q35344453
Membrane cofactor proteinQ35483434
Complement regulatory activity of normal human intraocular fluid is mediated by MCP, DAF, and CD59.Q35677703
Chronic low level complement activation within the eye is controlled by intraocular complement regulatory proteins.Q35750345
A review of treatments for macular degeneration: a synopsis of currently approved treatments and ongoing clinical trialsQ35760590
Functions of human complement inhibitor C4b-binding protein in relation to its structureQ35793072
The complement system plays a critical role in the development of experimental autoimmune anterior uveitisQ35989062
Mouse complement regulatory protein Crry/p65 uses the specific mechanisms of both human decay-accelerating factor and membrane cofactor proteinQ36364346
Decay-Accelerating Factor and Membrane Cofactor ProteinQ36556201
Subretinal neovascularization. Natural history of an experimental modelQ36590902
Age-Related Macular Degeneration and Blindness due to Neovascular MaculopathyQ36592901
Multiple isoforms of guinea pig decay-accelerating factor (DAF) generated by alternative splicingQ36679434
Intraocular diseases - anterior uveitisQ36722849
Proctor Lecture. Experimental autoimmune uveitis: mechanisms of disease and clinical therapeutic indicationsQ36814119
The role of complement in inflammation and phagocytosisQ36845189
Molecular cloning, chromosomal localization, expression, and functional characterization of the mouse analogue of human CD59.Q36846093
Y402H polymorphism of complement factor H affects binding affinity to C-reactive proteinQ36860930
The role of complement system in ocular diseases including uveitis and macular degenerationQ36927874
Effect of C3 depletion on experimental Pseudomonas aeruginosa ocular infection: histopathological analysisQ37096638
Activation and control of the complement systemQ39761363
Alternate Pathway Activation of Complement in a Proteus mirabilis Ulceration of the CorneaQ40930848
Extrahepatic complement biosynthesis: where, when and why?Q41331539
Characterization of DAF-2, a high molecular weight form of decay-accelerating factor (DAF; CD55), as a covalently cross-linked dimer of DAF-1.Q41494520
Identification of a potent new pathogenic site in human retinal S-antigen which induces experimental autoimmune uveoretinitis in LEW ratsQ41731846
A potential role for immune complex pathogenesis in drusen formationQ41743141
Generation of complement-derived anaphylatoxins in normal human donor corneas.Q43621679
The effect of systemic decomplementation with cobra venom factor on corneal complement levels in guinea pigsQ44015454
Role of complement in murine corneal infection caused by Pseudomonas aeruginosa.Q44442651
Generation of complement membrane attack complex in normal human corneas.Q45969274
Genetic deficiency of C3 as well as CNS-targeted expression of the complement inhibitor sCrry ameliorates experimental autoimmune uveoretinitisQ46688037
Complement deposits on ocular tissues adjacent to sites of inflammationQ46890475
Suppression of complement regulatory proteins (CRPs) exacerbates experimental autoimmune anterior uveitis (EAAU).Q47298991
Type I collagen is the autoantigen in experimental autoimmune anterior uveitisQ47578616
Separation of self from non-self in the complement systemQ47688509
Molecular cloning and chromosomal localization of the mouse decay-accelerating factor genes. Duplicated genes encode glycosylphosphatidylinositol-anchored and transmembrane forms.Q48070636
Characterization of endotoxin-induced C5-derived chemotactic activity in aqueous humor.Q50207373
Effect of chronic ethanol consumption on the expression of complement components and acute-phase proteins in liver.Q51902264
Complement and complement regulatory proteins in human tears.Q53977565
Hemolytic complement activity in normal human donor corneasQ67241367
Expression of two molecular forms of the complement decay-accelerating factor in the eye and lacrimal glandQ67661602
Anaphylatoxin levels in human aqueous humorQ68802064
[The dynamics of leucocytes and complements in endotoxin induced uveitis]Q69743891
Distribution of hemolytic complement in the normal corneaQ70165529
Activated complement in inflamed aqueous humorQ71010555
Alternate and classical pathway components of complement in the normal corneaQ71493079
Tissue distribution of complement regulatory membrane proteins in ratsQ71626863
Hemolytic complement activity in aqueous humorQ71678376
Localization of the complement membrane attack complex inhibitor (CD59) in human conjunctiva and lacrimal glandQ71688788
A new model of subretinal neovascularization in the rabbitQ72016863
Mouse Crry/p65. Characterization of monoclonal antibodies and the tissue distribution of a functional homologue of human MCP and DAFQ72098270
Complement inhibitor of rat cell membrane resembling mouse Crry/p65Q72332712
Human corneal extract enhances serum complement activityQ72754900
Release of complement regulatory proteins from ocular surface cells in infectionsQ73657409
Cell surface regulators of complement, 5I2 antigen, and CD59, in the rat eye and adnexal tissuesQ78019721
P433issue2
P921main subjectpathologyQ7208
blood proteinsQ425056
eye diseaseQ3041498
complement system proteinsQ67999591
P304page(s)85-95
P577publication date2008-02-26
2008-04-01
P1433published inSeminars in ImmunopathologyQ15724576
P1476titleThe role of complement in ocular pathology
P478volume30

Reverse relations

cites work (P2860)
Q58493539Acanthamoeba
Q35075338Activated complement classical pathway in a murine model of oxygen-induced retinopathy
Q59055823Age-Related Macular Degeneration: Pathogenesis, Genetic Background, and the Role of Nutritional Supplements
Q36064197Angiogenin ameliorates corneal opacity and neovascularization via regulating immune response in corneal fibroblasts
Q37714090Clusterin and complement activation in exfoliation glaucoma
Q35209209Comparison of genome-wide gene expression in suture- and alkali burn-induced murine corneal neovascularization.
Q35915651Complement System in the Pathogenesis of Benign Lymphoepithelial Lesions of the Lacrimal Gland
Q83228071Complement and CD4 T cells drive context-specific corneal sensory neuropathy
Q37553920Complement expression in the retina is not influenced by short-term pressure elevation
Q33984464Complement mediated apoptosis leads to the loss of retinal ganglion cells in animal model of glaucoma
Q34299745Complement regulatory protein CD46 protects against choroidal neovascularization in mice
Q35947745Copy number variations and gene polymorphisms of complement components in ocular Behcet's disease and Vogt-Koyanagi-Harada syndrome
Q45249469Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis
Q34624453Inhibition of complement alternative pathway suppresses experimental autoimmune anterior uveitis by modulating T cell responses
Q37678807Mediators of ocular angiogenesis
Q33683165Modified C-Reactive Protein Might be a Target Autoantigen of TINU Syndrome
Q37273740Molecular pathology of age-related macular degeneration
Q59137366New insight into the role of the complement in the most common types of retinopathy-current literature review
Q38038206Ocular actions of platelet-activating factor: clinical implications
Q88984389Plasma Exosomes Contribute to Microvascular Damage in Diabetic Retinopathy by Activating the Classical Complement Pathway
Q33880596Relationship between complement membrane attack complex, chemokine (C-C motif) ligand 2 (CCL2) and vascular endothelial growth factor in mouse model of laser-induced choroidal neovascularization
Q34126362Resolution, the grail for healthy ocular inflammation
Q37116913Risk factors of uveitis in ankylosing spondylitis: An observational study
Q33683222Role of Ocular Complement Factor H in a Murine Model of Choroidal Neovascularization
Q41436924Suppression of complement activation by recombinant Crry inhibits experimental autoimmune anterior uveitis (EAAU).
Q42044277The Complement Regulatory Protein CD46 Deficient Mouse Spontaneously Develops Dry-Type Age-Related Macular Degeneration-Like Phenotype

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