Acute myeloid leukemia with complex karyotypes and abnormal chromosome 21: Amplification discloses overexpression of APP, ETS2, and ERG genes

scholarly article

Acute myeloid leukemia with complex karyotypes and abnormal chromosome 21: Amplification discloses overexpression of APP, ETS2, and ERG genes is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2004PNAS..101.3915B
P356DOI10.1073/PNAS.0400272101
P932PMC publication ID374344
P698PubMed publication ID15007164
P5875ResearchGate publication ID7887706

P50authorClara D. BloomfieldQ4793409
Albert de la ChapelleQ5618748
Sandya LiyanarachchiQ43376214
Krzysztof MrózekQ66385542
Ramana V DavuluriQ89014659
Herbert AuerQ91733852
Michael A CaligiuriQ97333782
Amy S RuppertQ114341048
Claudia D BaldusQ114529739
Stephan M. TannerQ114529751
Martin GuimondQ125296596
P2093author name stringNehad Mohamed
P2860cites workModel-based analysis of oligonucleotide arrays: expression index computation and outlier detectionQ27860727
The DNA sequence of human chromosome 21Q28145358
Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461)Q28209814
An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocationQ28253702
Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemiaQ33330210
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The biological role of the Alzheimer amyloid precursor protein in epithelial cellsQ34589247
New mechanisms of AML1 gene alteration in hematological malignanciesQ35046095
Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosisQ36400886
MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemiaQ38294261
Loss of genetic material is more common than gain in acute myeloid leukemia with complex aberrant karyotype: a detailed analysis of 125 cases using conventional chromosome analysis and fluorescence in situ hybridization including 24-color FISH.Q38487721
Spectral karyotyping in patients with acute myeloid leukemia and a complex karyotype shows hidden aberrations, including recurrent overrepresentation of 21q, 11q, and 22q.Q38489443
Increased expression and processing of the Alzheimer amyloid precursor protein in pancreatic cancer may influence cellular proliferationQ40617477
Comparison of gene expression profiles of lymphoma cell lines from transformed follicular lymphoma, Burkitt's lymphoma and de novo diffuse large B-cell lymphomaQ40635674
ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathwayQ40674424
Amyloid beta protein precursor is involved in the growth of human colon carcinoma cell in vitro and in vivoQ40815925
High-throughput analysis of subtelomeric chromosome rearrangements by use of array-based comparative genomic hybridizationQ41048598
Oncogenic transcription factors in the human acute leukemiasQ41628889
The chromosome 21 transcription factor ETS2 transactivates the beta-APP promoter: implications for Down syndromeQ42798732
CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML).Q44068434
Comparative analysis of MLL partial tandem duplication and FLT3 internal tandem duplication mutations in 956 adult patients with acute myeloid leukemiaQ44449269
Amplification of ETS2 oncogene in acute nonlymphoblastic leukemia with t(6;21;18)Q45100648
Gene expression profiling identifies significant differences between the molecular phenotypes of bone marrow-derived and circulating human CD34+ hematopoietic stem cellsQ47571879
Presence of soluble amyloid beta-peptide precedes amyloid plaque formation in Down's syndromeQ70908071
Spectral karyotyping and fluorescence in situ hybridization detect novel chromosomal aberrations, a recurring involvement of chromosome 21 and amplification of the MYC oncogene in acute myeloid leukaemia M2Q73942158
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectkaryotypeQ189967
leukemiaQ29496
acute myeloid leukemiaQ264118
overexpressionQ61643320
P304page(s)3915-3920
P577publication date2004-03-08
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleAcute myeloid leukemia with complex karyotypes and abnormal chromosome 21: Amplification discloses overexpression of APP, ETS2, and ERG genes
P478volume101