CXCR4 chemokine receptor signaling induces apoptosis in acute myeloid leukemia cells via regulation of the Bcl-2 family members Bcl-XL, Noxa, and Bak

scientific article published on 24 June 2013

CXCR4 chemokine receptor signaling induces apoptosis in acute myeloid leukemia cells via regulation of the Bcl-2 family members Bcl-XL, Noxa, and Bak is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M113.449926
P932PMC publication ID3743469
P698PubMed publication ID23798675
P5875ResearchGate publication ID242018763

P2093author name stringHaiming Dai
Scott H Kaufmann
B Douglas Smith
X Wei Meng
Kevin L Peterson
Judith E Karp
Allan D Hess
Paula A Schneider
Karen E Hedin
Christie Rodriguez-Ramirez
Kimberly N Kremer
P2860cites workHIV-1 gp120- and gp160-induced apoptosis in cultured endothelial cells is mediated by caspasesQ24273423
Neutrophil apoptosis mediated by nicotinic acid receptors (GPR109A)Q24297428
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteinsQ24302494
The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensationQ24616946
Hypoxia-inducible factors and the response to hypoxic stressQ24629323
HIV and the chemokine system: 10 years laterQ27473020
Mitochondrial apoptosis induced by the HIV-1 envelopeQ28251618
Pertussis toxin, an inhibitor of G(αi) PCR, inhibits bile acid- and cytokine-induced apoptosis in primary rat hepatocytesQ28482165
Hypoxia-induced modulation of apoptosis and BCL-2 family proteins in different cancer cell typesQ28484877
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1Q29615241
CXCL12 chemokine expression and secretion regulates colorectal carcinoma cell anoikis through Bim-mediated intrinsic apoptosis.Q33705126
Induction of apoptosis by cancer chemotherapy.Q33876771
CXCL12 (SDF-1)/CXCR4 pathway in cancerQ34116260
BH3 mimetic obatoclax enhances TRAIL-mediated apoptosis in human pancreatic cancer cellsQ34168014
Binding of FADD and caspase-8 to molluscum contagiosum virus MC159 v-FLIP is not sufficient for its antiapoptotic functionQ34357751
High cell surface death receptor expression determines type I versus type II signalingQ35371553
Dual mTORC1/mTORC2 inhibition diminishes Akt activation and induces Puma-dependent apoptosis in lymphoid malignanciesQ35669226
Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginaseQ35677647
Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent processQ36057887
Drug therapy for acute myeloid leukemiaQ36115808
A death-promoting role for extracellular signal-regulated kinaseQ36519679
MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complexQ36706340
Apoptosis in the development of the immune systemQ36850158
Novel therapies targeting the apoptosis pathway for the treatment of acute myeloid leukemiaQ37001406
Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML.Q37234641
Context-dependent Bcl-2/Bak interactions regulate lymphoid cell apoptosis.Q37258521
Nuclear localization of CXCR4 determines prognosis for colorectal cancer patientsQ37456485
ERK and cell death: mechanisms of ERK-induced cell death--apoptosis, autophagy and senescenceQ37618297
Exploiting cellular pathways to develop new treatment strategies for AML.Q37670417
Update on clinical experience with AMD3100, an SDF-1/CXCL12-CXCR4 inhibitor, in mobilization of hematopoietic stem and progenitor cellsQ37753850
BH3-only proteins: Orchestrators of apoptosisQ37819153
Leukemia stem cells and microenvironment: biology and therapeutic targetingQ37827279
The vascular niche: home for normal and malignant hematopoietic stem cellsQ37925467
How to manage high-risk acute myeloid leukemiaQ37960820
CXCR7 impact on CXCL12 biology and disease.Q38059938
G alpha i2 and ZAP-70 mediate RasGRP1 membrane localization and activation of SDF-1-induced T cell functionsQ38361884
Phosphatidylserine exposure during apoptosis reflects bidirectional trafficking between plasma membrane and cytoplasm.Q39303314
Role of the CXCR4/CXCL12 axis in lymphangioleiomyomatosis and angiomyolipomaQ39687406
Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligandsQ39819165
Human immunodeficiency virus-induced apoptosis of human breast cancer cells via CXCR4 is mediated by the viral envelope protein but does not require CD4.Q40010695
Targeting of CD44 eradicates human acute myeloid leukemic stem cellsQ40228130
Antigen recognition induces phosphatidylserine exposure on the cell surface of human CD8+ T cellsQ40243201
MicroRNA-146a and AMD3100, two ways to control CXCR4 expression in acute myeloid leukemiasQ40298036
CXCR4 regulates migration and development of human acute myelogenous leukemia stem cells in transplanted NOD/SCID miceQ40566210
Leukocyte-endothelium interaction promotes SDF-1-dependent polarization of CXCR4.Q40645309
Development and functional characterization of human bone marrow mesenchymal cells immortalized by enforced expression of telomeraseQ40667068
ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53.Q40753388
Phorbol 12-myristate 13-acetate inhibits death receptor-mediated apoptosis in Jurkat cells by disrupting recruitment of Fas-associated polypeptide with death domainQ40765687
Stromal derived factor-1 alpha (SDF-1 alpha) induces CD4+ T cell apoptosis via the functional up-regulation of the Fas (CD95)/Fas ligand (CD95L) pathwayQ40818185
The chemokine receptor CXCR-4 is expressed on CD34+ hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1.Q41034523
Identification and characterization of the CXCR4 chemokine receptor in human T cell lines: ligand binding, biological activity, and HIV-1 infectivityQ41049440
Bak and Bax are non-redundant during infection- and DNA damage-induced apoptosisQ41914649
Stromal cell-derived factor-1 signaling via the CXCR4-TCR heterodimer requires phospholipase C-β3 and phospholipase C-γ1 for distinct cellular responsesQ41978128
Gα13 and Rho mediate endosomal trafficking of CXCR4 into Rab11+ vesicles upon stromal cell-derived factor-1 stimulationQ42687594
Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerizationQ42800693
Mobilization of PML/RARalpha negative peripheral blood stem cells with a combination of G-CSF and CXCR4 blockade in relapsed acute promyelocytic leukemia pre-treated with arsenic trioxideQ42938366
Effects of anti-CD44 monoclonal antibodies on differentiation and apoptosis of human myeloid leukemia cell linesQ43833436
Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemiaQ44536202
Engraftment of acute myeloid leukemia in NOD/SCID mice is independent of CXCR4 and predicts poor patient survivalQ48022888
CXCR7 mediated Giα independent activation of ERK and Akt promotes cell survival and chemotaxis in T cells.Q54551125
CXCR7: a new SDF-1-binding receptor in contrast to normal CD34(+) progenitors is functional and is expressed at higher level in human malignant hematopoietic cells.Q54646578
Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4.Q55067967
Phosphatidylserine exposure in B lymphocytes: a role for lipid packingQ57374987
Binding of the glucocorticoid receptor to the rat liver nuclear matrix. The role of disulfide bond formationQ58290684
The Role of CXCR4 in the Prediction of Bone Metastases from Breast Cancer: A Pilot StudyQ59674884
Single-step separation of red blood cells. Granulocytes and mononuclear leukocytes on discontinuous density gradients of Ficoll-HypaqueQ68821605
CXCR4 physically associates with the T cell receptor to signal in T cellsQ80139488
High expression of CXCR4 and CXCR7 predicts poor survival in gallbladder cancerQ85070128
P433issue32
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
apoptotic processQ14599311
acute myeloid leukemiaQ264118
P304page(s)22899-22914
P577publication date2013-06-24
P1433published inJournal of Biological ChemistryQ867727
P1476titleCXCR4 chemokine receptor signaling induces apoptosis in acute myeloid leukemia cells via regulation of the Bcl-2 family members Bcl-XL, Noxa, and Bak
P478volume288

Reverse relations

cites work (P2860)
Q39877099A combination of an anti-SLAMF6 antibody and ibrutinib efficiently abrogates expansion of chronic lymphocytic leukemia cells
Q64950548Advances in Tumor-Stroma Interactions: Emerging Role of Cytokine Network in Colorectal and Pancreatic Cancer.
Q54228829CXCR4 as a novel predictive biomarker for metastasis and poor prognosis in colorectal cancer.
Q92589961Chemokines in COPD: From Implication to Therapeutic Use
Q30378038Diagnostic Flow Cytometry and the AIDS Pandemic.
Q38401664Emerging therapeutic targets for the treatment of human acute myeloid leukemia (part 1) - gene transcription, cell cycle regulation, metabolism and intercellular communication
Q36444091Histone Deacetylase Inhibitors Target the Leukemic Microenvironment by Enhancing a Nherf1-Protein Phosphatase 1α-TAZ Signaling Pathway in Osteoblasts
Q49167307Histone deacetylase inhibitors reduce differentiating osteoblast-mediated protection of acute myeloid leukemia cells from cytarabine.
Q36504317Imiquimod-induced apoptosis of melanoma cells is mediated by ER stress-dependent Noxa induction and enhanced by NF-κB inhibition.
Q52646257Intracranial injection of recombinant stromal-derived factor-1 alpha (SDF-1α) attenuates traumatic brain injury in rats.
Q33925386Mcl-1 dependence predicts response to vorinostat and gemtuzumab ozogamicin in acute myeloid leukemia.
Q46121766MiR-98 is involved in rat embryo implantation by targeting Bcl-xl
Q37082659Molecular dissection of valproic acid effects in acute myeloid leukemia identifies predictive networks
Q34164077Osteoblasts protect AML cells from SDF-1-induced apoptosis.
Q58596666Osteogenic niche in the regulation of normal hematopoiesis and leukemogenesis
Q36243756Phase I study of the safety and pharmacokinetics of plerixafor in children undergoing a second allogeneic hematopoietic stem cell transplantation for relapsed or refractory leukemia.
Q58796650Potential use of compounds from sea cucumbers as MDM2 and CXCR4 inhibitors to control cancer cell growth
Q38706127Reciprocal Interactions of Leukemic Cells with Bone Marrow Stromal Cells Promote Enrichment of Leukemic Stem Cell Compartments in Response to Curcumin and Daunorubicin
Q93056683T140 Inhibits Apoptosis and Promotes Proliferation and Matrix Formation Through the SDF-1/CXC Receptor-4 Signaling Pathway in Endplate Chondrocytes of the Rat Intervertebral Discs
Q37140477Targeted positron emission tomography imaging of CXCR4 expression in patients with acute myeloid leukemia
Q93108227Targeting Leukemia Stem Cell-Niche Dynamics: A New Challenge in AML Treatment
Q26770388Targeting the leukemia-stroma interaction in acute myeloid leukemia: rationale and latest evidence
Q38447268Targeting the microenvironment in acute myeloid leukemia
Q89142853Tissue-Nonspecific Alkaline Phosphatase Is Required for MC3T3 Osteoblast-Mediated Protection of Acute Myeloid Leukemia Cells from Apoptosis
Q38871451lncRNA co-expression network model for the prognostic analysis of acute myeloid leukemia
Q34219369β-Arrestin1 and distinct CXCR4 structures are required for stromal derived factor-1 to downregulate CXCR4 cell-surface levels in neuroblastoma

Search more.