Randomised controlled trial testing the effect of cotrimoxazole prophylaxis on morbidity and mortality outcomes in breastfed HIV-exposed uninfected infants: study protocol

scientific article published on 12 July 2016

Randomised controlled trial testing the effect of cotrimoxazole prophylaxis on morbidity and mortality outcomes in breastfed HIV-exposed uninfected infants: study protocol is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1136/BMJOPEN-2015-010656
P932PMC publication ID4947798
P698PubMed publication ID27406638

P50authorLouise KuhnQ61451544
Photini KiepielaQ77767253
Anna CoutsoudisQ42177417
Gita RamjeeQ42571276
P2093author name stringBrodie Daniels
Shabashini Reddy
Elizabeth Spooner
Eshia Moodley-Govender
Linda Zako
Noluthando Ngomane
P2860cites workCo-operation of TLR4 and raft proteins in LPS-induced pro-inflammatory signalingQ26866939
Breast milk and gut microbiota in African mothers and infants from an area of high HIV prevalenceQ28535435
The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencingQ29615054
High incidence of antimicrobial resistant organisms including extended spectrum beta-lactamase producing Enterobacteriaceae and methicillin-resistant Staphylococcus aureus in nasopharyngeal and blood isolates of HIV-infected children from Cape Town,Q33326481
Role of postnatal acquisition of the intestinal microbiome in the early development of immune function.Q33635276
Endotoxin binding and elimination by monocytes: secretion of soluble CD14 represents an inducible mechanism counteracting reduced expression of membrane CD14 in patients with sepsis and in a patient with paroxysmal nocturnal hemoglobinuria.Q33751658
Early weaning of HIV-exposed uninfected infants and risk of serious gastroenteritis: Findings from two perinatal HIV prevention trials in Kampala, UgandaQ33926411
Mortality of infected and uninfected infants born to HIV-infected mothers in Africa: a pooled analysisQ34355499
Time for new recommendations on cotrimoxazole prophylaxis for HIV-exposed infants in developing countries?Q34368707
Morbidity among human immunodeficiency virus-exposed but uninfected, human immunodeficiency virus-infected, and human immunodeficiency virus-unexposed infants in Zimbabwe before availability of highly active antiretroviral therapyQ43542964
Adverse reactions to trimethoprim-sulfamethoxazole among children with human immunodeficiency virus infectionQ43597700
Impact of cotrimoxazole prophylaxis on the health of breast-fed, HIV-exposed, HIV-negative infants in a resource-limited settingQ43621620
Routinely available cotrimoxazole prophylaxis and occurrence of respiratory and diarrhoeal morbidity in infants born to HIV-infected mothers in South Africa.Q43739856
Reduced thymic size but no evidence of impaired thymic function in uninfected children born to human immunodeficiency virus-infected mothersQ45371185
Aiming at a moving target: research ethics in the context of evolving standards of care and preventionQ45712244
Maternal HIV infection and antibody responses against vaccine-preventable diseases in uninfected infantsQ46328518
Child mortality according to maternal and infant HIV status in ZimbabweQ46339318
Growth Faltering in Rural Gambian Infants Is Associated with Impaired Small Intestinal Barrier Function, Leading to Endotoxemia and Systemic InflammationQ47933958
Evidence of impact of maternal HIV infection on immunoglobulin levels in HIV-exposed uninfected children.Q53305666
Influence of early gut microbiota on the maturation of childhood mucosal and systemic immune responsesQ58590807
[Complementary feeding]Q79368157
Effect of formula composition on the development of infant gut microbiotaQ84143418
Severe infections in HIV-exposed uninfected infants: clinical evidence of immunodeficiencyQ84229726
High Incidence of Invasive Group B Streptococcal Infections in HIV-Exposed Uninfected InfantsQ84791566
Co-trimoxazole as prophylaxis against opportunistic infections in HIV-infected Zambian children (CHAP): a double-blind randomised placebo-controlled trialQ34369756
Human milk: a source of more life than we imagineQ34524241
Efficacy and safety of an extended nevirapine regimen in infant children of breastfeeding mothers with HIV-1 infection for prevention of postnatal HIV-1 transmission (HPTN 046): a randomised, double-blind, placebo-controlled trialQ34634644
Protective efficacy of co-trimoxazole prophylaxis against malaria in HIV exposed children in rural Uganda: a randomised clinical trialQ34748630
Mucosal immunity: integration between mother and the breast-fed infantQ35172894
Effects of cessation of breastfeeding in HIV-1-exposed, uninfected children in MalawiQ35452458
Health outcomes of HIV-exposed uninfected African infantsQ35825690
Reconsidering empirical cotrimoxazole prophylaxis for infants exposed to HIV infectionQ35839094
Microbial translocation in the pathogenesis of HIV infection and AIDS.Q36558287
Protection of the neonate by the innate immune system of developing gut and of human milkQ36702572
Role of intestinal mucosal integrity in HIV transmission to infants through breast-feeding: the BAN studyQ37037065
Gut microbial colonisation in premature neonates predicts neonatal sepsisQ37047543
Impact of trimethoprim-sulfamethoxazole prophylaxis on falciparum malaria infection and diseaseQ37339874
Effects of cotrimoxazole prophylactic treatment on adverse health outcomes among HIV-exposed, uninfected infantsQ37555921
The importance of the development of the intestinal microbiota in infancyQ37601278
Breast milk as the gold standard for protective nutrientsQ37682382
Microbiota-stimulated immune mechanisms to maintain gut homeostasisQ37775371
Infant morbidity, mortality, and breast milk immunologic profiles among breast-feeding HIV-infected and HIV-uninfected women in BotswanaQ38396143
Optimal breastfeeding practices and infant and child mortality: a systematic review and meta-analysisQ38562007
Effect of exclusive breastfeeding and complementary feeding on infant growth and morbidity.Q39732369
Human monocyte CD14 is upregulated by lipopolysaccharide.Q39824929
Detection of low-concentration host mRNA transcripts in Malawian children at risk for environmental enteropathyQ40051745
Containing antimicrobial resistance: a renewed effortQ42338259
P433issue7
P921main subjectchild mortalityQ61559
breastfeedingQ174876
maternal healthQ6786626
study protocolQ111908491
P304page(s)e010656
P577publication date2016-07-12
P1433published inBMJ OpenQ17003470
P1476titleRandomised controlled trial testing the effect of cotrimoxazole prophylaxis on morbidity and mortality outcomes in breastfed HIV-exposed uninfected infants: study protocol
P478volume6

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cites work (P2860)
Q53733974Co-trimoxazole for HIV-exposed uninfected infants.
Q38819314Co-trimoxazole prophylaxis, asymptomatic malaria parasitemia, and infectious morbidity in HIV-exposed uninfected infants in Malawi: The BAN study
Q91214793Effect of co-trimoxazole prophylaxis on morbidity and mortality of HIV-exposed, HIV-uninfected infants in South Africa: a randomised controlled, non-inferiority trial
Q33867971Growth pattern in Ethiopian infants - the impact of exposure to maternal HIV infection in relation to socio-economic factors