Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients

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Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1186/CC7130
P932PMC publication ID2646310
P698PubMed publication ID19025590
P5875ResearchGate publication ID23489553

P50authorHermann HallerQ56955546
P2093author name stringJan T Kielstein
Danilo Fliser
Robert Faulhaber-Walter
Philipp Kümpers
Sascha David
Carsten Hafer
Alexander Lukasz
Rüdiger Horn
P2860cites workAngiopoietin-2 is increased in severe sepsis: correlation with inflammatory mediatorsQ42504250
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The Tie-2 ligand angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanismQ45248496
Angiopoietin-2, marker and mediator of endothelial activation with prognostic significance early after trauma?Q45979392
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Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammationQ46931416
VEGF/VPF overexpression in skin of transgenic mice induces angiogenesis, vascular hyperpermeability and accelerated tumor developmentQ47741437
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Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3'-Kinase/Akt signal transduction pathwayQ73333644
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Angiopoietin-2, permeability oedema, occurrence and severity of ALI/ARDS in septic and non-septic critically ill patientsQ81468897
Vascular endothelial growth factor is increased during the first 48 hours of human septic shock and correlates with vascular permeabilityQ81551352
Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activationQ22004269
Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloningQ24310148
Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortalityQ24676668
Bench-to-bedside review: sepsis is a disease of the microcirculationQ24800640
Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humansQ25255098
Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome NetworkQ27861021
Thrombin induces increased expression and secretion of angiopoietin-2 from human umbilical vein endothelial cellsQ28203283
Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeatsQ28214611
Hypoxia-inducible angiopoietin-2 expression is mimicked by iodonium compounds and occurs in the rat brain and skin in response to systemic hypoxia and tissue ischemiaQ28344343
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The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care MedicineQ29618869
Circulating angiopoietin 2 correlates with mortality in a surgical population with acute lung injury/adult respiratory distress syndromeQ33682542
Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivoQ34037478
Mechanisms of sepsis-induced organ dysfunctionQ34703764
The role of the endothelium in severe sepsis and multiple organ dysfunction syndromeQ35051545
Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cellsQ35070344
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference.Q35094247
Pulmonary artery catheter versus pulse contour analysis: a prospective epidemiological studyQ35629946
Endothelium as an organ systemQ35760637
Pulmonary endothelium in acute lung injury: from basic science to the critically ill.Q35838918
Lipopolysaccharide Induces Disseminated Endothelial Apoptosis Requiring Ceramide GenerationQ36380942
Angiopoietins: a link between angiogenesis and inflammation.Q36625591
Circulating angiopoietin-1 and angiopoietin-2 in critically ill patients: development and clinical application of two new immunoassaysQ36955225
Admission angiopoietin levels in children with septic shock.Q37367802
A prospective, observational study of soluble FLT-1 and vascular endothelial growth factor in sepsisQ37735839
Hypoxic regulation of angiopoietin-2 expression in endothelial cells.Q38346353
Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathwayQ38525872
Assessment of cardiac preload and extravascular lung water by single transpulmonary thermodilutionQ40767929
Angiopoietin-1 protects the adult vasculature against plasma leakage.Q40890338
P433issue6
P921main subjectpatientQ181600
P304page(s)R147
P577publication date2008-11-21
P1433published inCritical CareQ5186602
P1476titleExcess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients
P478volume12

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cites work (P2860)
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