Neuroscience of alcoholism: molecular and cellular mechanisms

scientific article published on 10 September 2009

Neuroscience of alcoholism: molecular and cellular mechanisms is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1007/S00018-009-0135-Y
P932PMC publication ID3747955
P698PubMed publication ID19756388

P2093author name stringSubhash C Pandey
Bela G Starkman
Amul Sakharkar
Sachin Moonat
P2860cites workEthanol consumption and resistance are inversely related to neuropeptide Y levelsQ22008512
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian developmentQ22010765
Translating the Histone CodeQ22065840
Alcoholism: A Systems Approach From Molecular Physiology to Addictive BehaviorQ22241964
Neuropharmacology of alcohol addictionQ22251110
Calmodulin-kinases: modulators of neuronal development and plasticityQ24315924
Epigenetic mechanisms in drug addictionQ24645709
Posttranscriptional regulation of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcoholQ24646484
CREB regulation of BK channel gene expression underlies rapid drug toleranceQ24655512
GDNF is a fast-acting potent inhibitor of alcohol consumption and relapseQ24658003
Neurotrophin-regulated signalling pathwaysQ24678332
The language of covalent histone modificationsQ27860931
Chromatin modifications and their functionQ27861067
Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected]Q28216807
Phosphorylated CREB binds specifically to the nuclear protein CBPQ28265019
The NR2B subtype of NMDA receptor: a potential target for the treatment of alcohol dependenceQ28265181
The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and negative affective states of alcohol addictionQ28289205
Transcription factors in long-term memory and synaptic plasticityQ28305935
Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAPQ28565555
betagamma Dimers mediate synergy of dopamine D2 and adenosine A2 receptor-stimulated PKA signaling and regulate ethanol consumptionQ28570732
Sustained Arc/Arg3.1 synthesis controls long-term potentiation consolidation through regulation of local actin polymerization in the dentate gyrus in vivoQ28909843
Epigenetic regulation in psychiatric disordersQ29616296
The DNA methyltransferases of mammalsQ29617317
MAPK cascade signalling and synaptic plasticityQ29619955
CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signalsQ29620470
Molecular basis of long-term plasticity underlying addictionQ29620539
The many faces of CREBQ29622920
Molecular mechanisms of dendritic spine morphogenesisQ29903592
Histone structure and functionQ30447149
A CRF(2) agonist administered into the central nucleus of the amygdala decreases ethanol self-administration in ethanol-dependent ratsQ30486940
Ethanol-BDNF interactions: still more questions than answers.Q30490427
Deficits in amygdaloid cAMP-responsive element-binding protein signaling play a role in genetic predisposition to anxiety and alcoholismQ30499064
Effects of chronic ethanol intake and its withdrawal on the expression and phosphorylation of the creb gene transcription factor in rat cortex.Q31963033
Ethanol sensitivity: a central role for CREB transcription regulation in the cerebellumQ33265511
The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice.Q33788860
A role for corticotropin releasing factor and urocortin in behavioral responses to stressors.Q33804777
Corticotropin releasing factor receptors and their ligand familyQ33921695
Competing interactions between micro-RNAs determine neural progenitor survival and proliferation after ethanol exposure: evidence from an ex vivo model of the fetal cerebral cortical neuroepitheliumQ34043222
Voluntary alcohol consumption is controlled via the neuropeptide Y Y1 receptor.Q34112613
Neurotrophins as synaptic modulatorsQ34186265
Neuroreceptors and ion channels as targets of alcoholQ34272857
Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptorsQ34303326
BDNF in schizophrenia, depression and corresponding animal modelsQ34385320
Suppression of ethanol self-administration by the neuropeptide Y (NPY) Y2 receptor antagonist BIIE0246: evidence for sensitization in rats with a history of dependenceQ34388058
Regulation of olfactory neurogenesis by amidated neuropeptidesQ34400306
Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanismQ34467554
Cutoff in potency implicates alcohol inhibition of N-methyl-D-aspartate receptors in alcohol intoxicationQ34506594
Increase in expression of alpha1 and alpha2/delta1 subunits of L-type high voltage-gated calcium channels after sustained ethanol exposure in cerebral cortical neuronsQ34572792
NMDA receptor subunits: function and pharmacology.Q34579640
Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders.Q34587312
Protein kinases and addiction.Q34630295
The role of protein kinase A in acute ethanol-induced neurobehavioral actions in rats.Q34639302
Viral vector-induced amygdala NPY overexpression reverses increased alcohol intake caused by repeated deprivations in Wistar rats.Q37359251
Central neuropeptide Y in anxiety- and stress-related behavior and in ethanol intakeQ37361345
Activity-dependent dendritic release of BDNF and biological consequences.Q37373464
Role of protein kinase C epsilon (PKCvarepsilon) in the reduction of ethanol reinforcement due to mGluR5 antagonism in the nucleus accumbens shell.Q37398846
Gi is involved in ethanol inhibition of L-type calcium channels in undifferentiated but not differentiated PC-12 cells.Q38295858
Antagonism of NPY-induced feeding by pretreatment with cyclic AMP response element binding protein antisense oligonucleotideQ38307803
Life without neuropeptide Y.Q38332512
Ethanol inhibition of recombinant NMDA receptors is not altered by coexpression of CaMKII-alpha or CaMKII-betaQ39971284
Attenuation of brain derived neurotrophic factor (BDNF) by ethanol and cytoprotective effect of exogenous BDNF against ethanol damage in neuronal cellsQ40483688
Alcohol dependence and anxiety disorders: what is the relationship?Q40641947
Selective breeding for alcohol preference and associated responsesQ40710552
Ethanol inhibition of N-methyl-D-aspartate receptors is reduced by site-directed mutagenesis of a transmembrane domain phenylalanine residueQ40778511
Amygdaloid CRF pathways. Role in autonomic, neuroendocrine, and behavioral responses to stressQ40788434
Ethanol sensitivity of recombinant human N-methyl-D-aspartate receptorsQ40834702
NPY upregulates genes containing cyclic AMP response element in human neuroblastoma cell lines bearing Y1 and Y2 receptors: involvement of CREB.Q40997193
Selective effects of ethanol on the generation of cAMP by particular members of the adenylyl cyclase familyQ41262256
Centrally administered neuropeptide Y (NPY) produces anxiolytic-like effects in animal anxiety modelsQ41277218
PKA isoforms, neural pathways, and behaviour: making the connectionQ41541408
Increased expression of protein kinase A inhibitor alpha (PKI-alpha) and decreased PKA-regulated genes in chronic intermittent alcohol exposureQ41588279
Increase of extracellular corticotropin-releasing factor-like immunoreactivity levels in the amygdala of awake rats during restraint stress and ethanol withdrawal as measured by microdialysisQ41680193
Ethanol-induced translocation of cAMP-dependent protein kinase to the nucleus. Mechanism and functional consequencesQ41689646
Critical dependence of cAMP response element-binding protein phosphorylation on L-type calcium channels supports a selective response to EPSPs in preference to action potentials.Q41713158
Ethanol regulates calcium channel subunits by protein kinase C delta -dependent and -independent mechanisms.Q41738910
Regulation of ERK phosphorylation by ethanol in fetal cortical neuronsQ42440353
Chronic ethanol administration decreases phosphorylation of cyclic AMP response element-binding protein in granule cells of rat cerebellumQ42449089
Differences in basal levels of CREB and NPY in nucleus accumbens regions between C57BL/6 and DBA/2 mice differing in inborn alcohol drinking behaviorQ42453594
Rat neuropeptide Y precursor gene expression. mRNA structure, tissue distribution, and regulation by glucocorticoids, cyclic AMP, and phorbol esterQ42501657
Homeostatic plasticity during alcohol exposure promotes enlargement of dendritic spinesQ42506908
Effect of neuropeptide Y (NPY) on oral ethanol intake in Wistar, alcohol-preferring (P), and -nonpreferring (NP) ratsQ43567210
Effect of prenatal and postnatal ethanol exposure on Ca2+ /calmodulin-dependent protein kinase II in rat cerebral cortexQ43660182
Effects of voluntary ethanol intake on the expression of Ca(2+) /calmodulin-dependent protein kinase IV and on CREB expression and phosphorylation in the rat nucleus accumbensQ43821961
Actin polymerization and ERK phosphorylation are required for Arc/Arg3.1 mRNA targeting to activated synaptic sites on dendritesQ43922419
The decreased cellular expression of neuropeptide Y protein in rat brain structures during ethanol withdrawal after chronic ethanol exposureQ44030567
Brain-derived neurotrophic factor triggers transcription-dependent, late phase long-term potentiation in vivo.Q44115028
Neuropeptide Y administration into the amygdala does not affect ethanol consumptionQ44177750
ERK regulation in chronic ethanol exposure and withdrawalQ44182606
The decreased phosphorylation of cyclic adenosine monophosphate (cAMP) response element binding (CREB) protein in the central amygdala acts as a molecular substrate for anxiety related to ethanol withdrawal in ratsQ44377045
The transient depression of hippocampal CA1 LTP induced by chronic intermittent ethanol exposure is associated with an inhibition of the MAP kinase pathwayQ44444440
Ethanol consumption and serotonin-1A (5-HT1A) receptor function in heterozygous BDNF (+/-) miceQ44444835
Changes of phosphorylation of cAMP response element binding protein in rat nucleus accumbens after chronic ethanol intake: naloxone reversalQ44574276
The cyclic AMP/protein kinase A signal transduction pathway modulates tolerance to sedative and hypothermic effects of ethanolQ44579515
RACK1 and brain-derived neurotrophic factor: a homeostatic pathway that regulates alcohol addiction.Q44695622
Neuropeptide-Y Y5 receptors modulate the onset and maintenance of operant ethanol self-administrationQ44703424
Effects of PKA modulation on the expression of neuropeptide Y in rat amygdaloid structures during ethanol withdrawalQ44714467
Ethanol effects on cell signaling mechanismsQ44867630
Neuroscience of addictionQ44880443
Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice.Q44908892
Partial deletion of the cAMP response element-binding protein gene promotes alcohol-drinking behaviors.Q44911155
Assessment of ethanol consumption and water drinking by NPY Y(2) receptor knockout miceQ44941276
Expression of the neurotrophin receptor trkB is regulated by the cAMP/CREB pathway in neurons.Q44963988
Corticotropin-releasing factor gene expression is down-regulated in the central nucleus of the amygdala of alcohol-preferring rats which exhibit high anxiety: a comparison between rat lines selectively bred for high and low alcohol preferenceQ45100564
DNA hypermethylation of the alpha synuclein promoter in patients with alcoholismQ45239060
Role of CpG islands in the up-regulation of NMDA receptor NR2B gene expression following chronic ethanol treatment of cultured cortical neurons of miceQ45262444
The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats.Q45270557
Different expression of brain-derived neurotrophic factor in the nucleus accumbens of alcohol-preferring (P) and -nonpreferring (NP) ratsQ45275384
The dopamine D3 receptor is part of a homeostatic pathway regulating ethanol consumption.Q46156049
Epigenetic regulation in alcohol-related brain damageQ46206968
Ethanol attenuates the HFS-induced, ERK-mediated LTP in a dose-dependent manner in rat striatumQ46302677
Chronic ethanol causes heterologous desensitization of receptors by reducing alpha s messenger RNA.Q46303647
Potential role of cAMP response element-binding protein in ethanol-induced N-methyl-D-aspartate receptor 2B subunit gene transcription in fetal mouse cortical cellsQ46387499
Acute ethanol inhibits extracellular signal-regulated kinase, protein kinase B, and adenosine 3':5'-cyclic monophosphate response element binding protein activity in an age- and brain region-specific mannerQ46440626
Repeated alcohol administration during adolescence causes changes in the mesolimbic dopaminergic and glutamatergic systems and promotes alcohol intake in the adult rat.Q34902591
Alcoholism: allostasis and beyondQ35073089
Ethanol and brain plasticity: receptors and molecular networks of the postsynaptic density as targets of ethanolQ35209844
The pharmacology of human appetite expression.Q35731315
Chronic alcohol drinking alters neuronal dendritic spines in the brain reward center nucleus accumbensQ35762266
Local effects of BDNF on dendritic growthQ35808549
CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2Q35848528
Distribution of NPY receptors in the hypothalamusQ35874614
Interactions between NPY and CRF in the amygdala to regulate emotionalityQ35874620
The role of mesolimbic dopamine in the development and maintenance of ethanol reinforcement.Q35888462
Allostasis and dysregulation of corticotropin-releasing factor and neuropeptide Y systems: implications for the development of alcoholismQ35975282
Epigenetic regulation by histone methylation and histone variantsQ36022792
Mutations at F637 in the NMDA receptor NR2A subunit M3 domain influence agonist potency, ion channel gating and alcohol actionQ36053122
The key to development: interpreting the histone code?Q36083253
Prospects: histone deacetylase inhibitorsQ36223192
Histone arginine methylation and its dynamic regulationQ36250971
The "ups and downs" of signaling cascades in addictionQ36309741
Brain-derived neurotrophic factor and control of synaptic consolidation in the adult brain.Q36542068
The alcohol-preferring P rat and animal models of excessive alcohol drinkingQ36589453
Regulation of mitogen-activated protein kinases by glutamate receptorsQ36612272
Protein kinase C epsilon mediation of CRF- and ethanol-induced GABA release in central amygdalaQ36751542
Neuropeptide Y administration into the amygdala suppresses ethanol drinking in alcohol-preferring (P) rats following multiple deprivations.Q36776154
Epigenetics and microRNAsQ36783160
Neuropeptide Y in the central nucleus of the amygdala suppresses dependence-induced increases in alcohol drinkingQ36784753
A key role for corticotropin-releasing factor in alcohol dependenceQ36880698
Histone deacetylase inhibitors: molecular mechanisms of actionQ36908440
CaM kinase II phosphorylation of slo Thr107 regulates activity and ethanol responses of BK channelsQ36951665
The immediate early gene arc/arg3.1: regulation, mechanisms, and function.Q37041486
The emerging functions of histone demethylasesQ37087004
Ethanol's molecular targetsQ37165668
Emerging role of epigenetics in the actions of alcoholQ37212299
Unraveling the molecular mechanisms of alcohol dependenceQ37326030
Ethanol causes translocation of cAMP-dependent protein kinase catalytic subunit to the nucleusQ37332039
Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats.Q46529874
The forced swimming-induced behavioural immobility response involves histone H3 phospho-acetylation and c-Fos induction in dentate gyrus granule neurons via activation of the N-methyl-D-aspartate/extracellular signal-regulated kinase/mitogen- and stQ46567043
Chronic ethanol intake-induced changes in open-field behavior and calcium/calmodulin-dependent protein kinase IV expression in nucleus accumbens of rats: naloxone reversalQ46577551
Innate differences in the expression of brain-derived neurotrophic factor in the regions within the extended amygdala between alcohol preferring and nonpreferring ratsQ46620449
Brain chromatin remodeling: a novel mechanism of alcoholism.Q46667140
Effector immediate-early gene arc in the amygdala plays a critical role in alcoholismQ46717130
Effects of a metabotropic, mglu5, glutamate receptor antagonist on ethanol consumption by genetic drinking ratsQ46722222
The decreased cyclic-AMP dependent-protein kinase A function in the nucleus accumbens: a role in alcohol drinking but not in anxiety-like behaviors in ratsQ46727182
The slowpoke gene is necessary for rapid ethanol tolerance in DrosophilaQ46790621
Acute in vivo effect of ethanol (binge drinking) on histone H3 modifications in rat tissuesQ46825072
Up-regulation of NMDA receptor subunits in rat brain following chronic ethanol treatmentQ47759859
Involvement of the cyclic AMP-responsive element binding protein gene transcription factor in genetic preference for alcohol drinking behaviorQ48097308
Morphological Alterations in Hippocampus After Long-Term Alcohol Consumption in MiceQ48167329
Innate differences of neuropeptide Y (NPY) in hypothalamic nuclei and central nucleus of the amygdala between selectively bred rats with high and low alcohol preferenceQ48169561
Effects of ethanol on the function of G proteins in rat cerebral cortex membranes.Q48193605
Increased drinking during withdrawal from intermittent ethanol exposure is blocked by the CRF receptor antagonist D-Phe-CRF(12-41).Q48220534
The MAPK cascade is required for mammalian associative learningQ48240059
Structural and functional conservation of vertebrate corticotropin-releasing factor genes: evidence for a critical role for a conserved cyclic AMP response elementQ48278494
Potential role of the gene transcription factor cyclic AMP-responsive element binding protein in ethanol withdrawal-related anxiety.Q48299733
Microinjection of a corticotropin-releasing factor antagonist into the central nucleus of the amygdala reverses anxiogenic-like effects of ethanol withdrawalQ48320890
Central and medial amygdaloid brain-derived neurotrophic factor signaling plays a critical role in alcohol-drinking and anxiety-like behaviors.Q48450802
Chronic ethanol exposure impairs phosphorylation of CREB and CRE-binding activity in rat striatumQ48472883
Neurone specific regulation of dendritic spines in vivo by post synaptic density 95 protein (PSD-95).Q48553849
Corticotropin releasing factor (CRF): studies in alcohol preferring and non-preferring ratsQ48565681
Overexpression of neuropeptide Y in the central nucleus of the amygdala decreases ethanol self-administration in "anxious" ratsQ48570305
CREB and NF-kappaB transcription factors regulate sensitivity to excitotoxic and oxidative stress induced neuronal cell deathQ48570984
Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis.Q48668820
High ethanol consumption and low sensitivity to ethanol-induced sedation in protein kinase A-mutant mice.Q48723131
NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expressionQ48894918
Effects of ethanol and anesthetics on type 1 and 5 metabotropic glutamate receptors expressed in Xenopus laevis oocytesQ48947223
Brain-derived neurotrophic factor causes cAMP response element-binding protein phosphorylation in absence of calcium increases in slices and cultured neurons from rat visual cortex.Q49084663
Altered amygdalar CRF release and increased anxiety-like behavior in Sardinian alcohol-preferring rats: a microdialysis and behavioral studyQ49113872
Epigenetic mechanisms in psychiatry.Q51873225
Lifetime comorbidity of DSM-IV mood and anxiety disorders and specific drug use disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions.Q51919869
Decreased alcohol consumption by verapamil in alcohol preferring rats.Q52060600
Antisense inhibition of neuropeptide Y (NPY)-Y1 receptor expression blocks the anxiolytic-like action of NPY in amygdala and paradoxically increases feeding.Q52205337
Ethanol inhibits NMDA-activated ion current in hippocampal neuronsQ56226684
Modifications in number and morphology of dendritic spines resulting from chronic ethanol consumption and withdrawal: a Golgi study in the mouse anterior and posterior hippocampusQ69108879
Modulatory effects of acute ethanol on metabotropic glutamate responses in cultured Purkinje neuronsQ70839400
Chronic ethanol administration decreases brain-derived neurotrophic factor gene expression in the rat hippocampusQ70875626
Ethanol specifically potentiates GABA-mediated neurotransmission in feline cerebral cortexQ71251678
Effects of nimodipine and other calcium channel antagonists in alcohol-preferring AA ratsQ71334148
Ethanol exposure alters the phosphorylation of cyclic AMP responsive element binding protein and cyclic AMP responsive element binding activity in rat cerebellumQ71418814
Chronic ethanol consumption and hippocampal neuron dendritic spines: a morphometric and physiological analysisQ71474968
Quantitative changes in G proteins do not mediate ethanol-induced downregulation of adenylyl cyclase in mouse cerebral cortexQ72289548
Voluntary consumption of ethanol in 15 inbred mouse strainsQ72579770
Isradipine and naltrexone in combination with isradipine interact with a period of abstinence to reduce rats' intakes of an alcoholic beverageQ74075419
Positive and negative regulatory mechanisms that mediate long-term memory storageQ74747032
Identification of ethanol responsive domains of adenylyl cyclaseQ79305157
P433issue1
P921main subjectalcoholismQ15326
P304page(s)73-88
P577publication date2009-09-10
P1433published inCellular and Molecular Life SciencesQ5058352
P1476titleNeuroscience of alcoholism: molecular and cellular mechanisms
P478volume67

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