Preclinical evidence of multiple mechanisms underlying trastuzumab resistance in gastric cancer.

scientific article published on 22 February 2016

Preclinical evidence of multiple mechanisms underlying trastuzumab resistance in gastric cancer. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.7575
P932PMC publication ID4951299
P698PubMed publication ID26919099

P50authorAnna TeseiQ38641349
Chiara ArientiQ57079239
Sara PignattaQ57231219
Michele ZanoniQ57231223
Michela TebaldiQ57231224
Gianluca TedaldiQ87377375
P2093author name stringAlberto Del Rio
Silvia Carloni
P2860cites workIQGAP1 and IQGAP2 are reciprocally altered in hepatocellular carcinomaQ21261901
IQGAP1 protein binds human epidermal growth factor receptor 2 (HER2) and modulates trastuzumab resistanceQ24309891
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Lapatinib plus paclitaxel versus paclitaxel alone in the second-line treatment of HER2-amplified advanced gastric cancer in Asian populations: TyTAN--a randomized, phase III studyQ27853010
Nuclear HER4 mediates acquired resistance to trastuzumab and is associated with poor outcome in HER2 positive breast cancerQ27853060
Receptor tyrosine kinase ERBB4 mediates acquired resistance to ERBB2 inhibitors in breast cancer cells.Q27853122
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Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancerQ29619394
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ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: receptor overexpression does not determine growth dependencyQ33963261
HER2 as a Prognostic Marker in Gastric Cancer - A Systematic Analysis of Data from the LiteratureQ34223664
Sensitive detection of somatic point mutations in impure and heterogeneous cancer samplesQ34327021
Mechanism of action of trastuzumab and scientific updateQ34437163
Transcriptional and posttranslational up-regulation of HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinaseQ34720797
Activation loop phosphorylation and catalysis in protein kinases: is there functional evidence for the autoinhibitor model?Q35047964
MAP kinases and CDKs: kinetic basis for catalytic activationQ35054246
Heterogeneous amplification of ERBB2 in primary lesions is responsible for the discordant ERBB2 status of primary and metastatic lesions in gastric carcinomaQ35700713
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Increased signalling of EGFR and IGF1R, and deregulation of PTEN/PI3K/Akt pathway are related with trastuzumab resistance in HER2 breast carcinomas.Q35889941
The ErbB receptors and their ligands in cancer: an overview.Q36108987
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A helix scaffold for the assembly of active protein kinasesQ36871421
Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapiesQ37143534
Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathwaysQ37425090
Unraveling trastuzumab and lapatinib inefficiency in gastric cancer: Future steps (Review).Q37567784
Mechanisms of resistance to HER family targeting antibodiesQ37671920
An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer modelsQ37690880
Evaluation of the association of PIK3CA mutations and PTEN loss with efficacy of trastuzumab therapy in metastatic breast cancer.Q37877173
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Different genome organization in two new cell lines established from human gastric carcinoma.Q38502122
Development of trastuzumab-resistant human gastric carcinoma cell lines and mechanisms of drug resistanceQ38860383
Anti-HER3 Monoclonal Antibody Inhibits Acquired Trastuzumab-Resistant Gynecologic CancersQ38867798
Prolonged exposure to (R)-bicalutamide generates a LNCaP subclone with alteration of mitochondrial genomeQ39036776
The HER2-miR125a5p/miR125b loop in gastric and esophageal carcinogenesisQ39160504
Effects of anti-VEGF on pharmacokinetics, biodistribution, and tumor penetration of trastuzumab in a preclinical breast cancer model.Q39416858
Resistance to EGFR-targeted therapy: a family affairQ39589553
Randomized phase III trial of fluorouracil alone versus fluorouracil plus cisplatin versus uracil and tegafur plus mitomycin in patients with unresectable, advanced gastric cancer: The Japan Clinical Oncology Group Study (JCOG9205).Q40613157
Identification of cadherin-11 down-regulation as a common response of astrocytoma cells to transforming growth factor-alphaQ40818375
Effects of oncogenic ErbB2 on G1 cell cycle regulators in breast tumour cellsQ40887267
Molecular genetics and in vitro sensitivity of a new human cell line, KKP, from a gastric adenocarcinoma.Q41019667
Prognostic significance of c-erbB2 overexpression in patients with metastatic gastric cancerQ44978934
HER-2 amplification is highly homogenous in gastric cancer.Q51779078
SLUG silencing increases radiosensitivity of melanoma cells in vitro.Q53128776
Protein expression of HER2, 3, 4 in gastric cancer: correlation with clinical features and survival.Q53598605
Comparison of HER2 gene amplification assessed by fluorescence in situ hybridization and HER2 protein expression assessed by immunohistochemistry in gastric cancer.Q53645618
Early HER2 dysregulation in gastric and oesophageal carcinogenesisQ58003579
Combined analysis of Rac1, IQGAP1, Tiam1 and E-cadherin expression in gastric cancerQ60056795
Paclitaxel enhances in vitro radiosensitivity of squamous carcinoma cell lines of the head and neckQ71767596
The prognostic significance of HER2 positivity for advanced gastric cancer patients undergoing first-line modified FOLFOX-6 regimenQ83858971
P433issue14
P407language of work or nameEnglishQ1860
P921main subjecttrastuzumabQ412616
P304page(s)18424-18439
P577publication date2016-04-01
P1433published inOncotargetQ1573155
P1476titlePreclinical evidence of multiple mechanisms underlying trastuzumab resistance in gastric cancer
P478volume7

Reverse relations

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Q93441396CAEP
Q94340154KKP
Q94340160KKP HR
Q54908217NCI-N87
Q95993868NCI-N87 HR
Q98128798RAL

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Q92073891Epidermal Growth Factor Receptor Family and its Role in Gastric Cancer
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Q38703402Quantitative proteomics profiling reveals activation of mTOR pathway in trastuzumab resistance
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Q48549971miR-200c inhibits TGF-β-induced-EMT to restore trastuzumab sensitivity by targeting ZEB1 and ZEB2 in gastric cancer

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