Chronic lymphocytic leukemia therapy: new targeted therapies on the way

scientific article published on 17 March 2016

Chronic lymphocytic leukemia therapy: new targeted therapies on the way is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1517/14656566.2016.1168401
P932PMC publication ID4955400
P698PubMed publication ID26988407

P50authorCandida VitaleQ61134902
P2093author name stringJan A Burger
P2860cites workmiR-15 and miR-16 induce apoptosis by targeting BCL2Q24536069
Involvement of the bcl-2 gene in human follicular lymphomaQ69870224
Minimal residual disease quantification is an independent predictor of progression-free and overall survival in chronic lymphocytic leukemia: a multivariate analysis from the randomized GCLLSG CLL8 trialQ83441006
Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelinesQ24616084
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing plateletsQ27683708
Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinibQ27853011
PI3K in lymphocyte development, differentiation and activationQ28187880
A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activationQ28202234
Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signallingQ28272891
Idelalisib and rituximab in relapsed chronic lymphocytic leukemiaQ28306347
The Bcl2 family: regulators of the cellular life-or-death switchQ29614982
Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemiaQ29620690
Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignanciesQ30500362
Obinutuzumab (GA101) in relapsed/refractory chronic lymphocytic leukemia: final data from the phase 1/2 GAUGUIN studyQ30843979
Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory diseaseQ33398808
Ibrutinib as initial therapy for elderly patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma: an open-label, multicentre, phase 1b/2 trialQ33412064
Ibrutinib for previously untreated and relapsed or refractory chronic lymphocytic leukaemia with TP53 aberrations: a phase 2, single-arm trialQ33419580
Ibrutinib combined with bendamustine and rituximab compared with placebo, bendamustine, and rituximab for previously treated chronic lymphocytic leukaemia or small lymphocytic lymphoma (HELIOS): a randomised, double-blind, phase 3 studyQ33428297
Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignanciesQ33893704
Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicityQ33896738
Outcomes of first-line treatment for chronic lymphocytic leukemia with 17p deletionQ33978930
Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110δ, for relapsed/refractory chronic lymphocytic leukemiaQ34009003
Modeling tumor-host interactions of chronic lymphocytic leukemia in xenografted mice to study tumor biology and evaluate targeted therapyQ34020276
Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765.Q34026194
The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivoQ34029869
Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemiaQ34052075
Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trialQ34141305
Safety and activity of ibrutinib plus rituximab for patients with high-risk chronic lymphocytic leukaemia: a single-arm, phase 2 studyQ34240404
Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemiaQ34402999
Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex.Q34443608
Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic LeukemiaQ34504188
The lymph node microenvironment promotes B-cell receptor signaling, NF-κB activation, and tumor proliferation in chronic lymphocytic leukemiaQ34542102
Ofatumumab as single-agent CD20 immunotherapy in fludarabine-refractory chronic lymphocytic leukemiaQ34617307
Tyrosine kinases and their substrates in B lymphocytesQ34658255
The Bcl-2-regulated apoptotic pathwayQ35218049
Three-year follow-up of treatment-naïve and previously treated patients with CLL and SLL receiving single-agent ibrutinibQ35450520
Obinutuzumab plus fludarabine/cyclophosphamide or bendamustine in the initial therapy of CLL patients: the phase 1b GALTON trialQ35560022
The Bruton tyrosine kinase inhibitor ibrutinib with chemoimmunotherapy in patients with chronic lymphocytic leukemia.Q35583403
Basal B-cell receptor signaling in B lymphocytes: mechanisms of regulation and role in positive selection, differentiation, and peripheral survivalQ35666655
Bruton tyrosine kinase is essential for botrocetin/VWF-induced signaling and GPIb-dependent thrombus formation in vivoQ35849237
Etiology of Ibrutinib Therapy Discontinuation and Outcomes in Patients With Chronic Lymphocytic LeukemiaQ35903984
Pharmacological and Protein Profiling Suggests Venetoclax (ABT-199) as Optimal Partner with Ibrutinib in Chronic Lymphocytic LeukemiaQ35958056
The phosphoinositide-3-kinase (PI3K)-delta and gamma inhibitor, IPI-145 (Duvelisib), overcomes signals from the PI3K/AKT/S6 pathway and promotes apoptosis in CLL.Q36021849
Novel targeted agents and the need to refine clinical end points in chronic lymphocytic leukemiaQ36135185
Incidence and risk factors of bleeding-related adverse events in patients with chronic lymphocytic leukemia treated with ibrutinibQ36337598
Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic LeukemiaQ36490049
A phase 2 study of idelalisib plus rituximab in treatment-naïve older patients with chronic lymphocytic leukemiaQ36519986
Fludarabine, cyclophosphamide, and rituximab treatment achieves long-term disease-free survival in IGHV-mutated chronic lymphocytic leukemiaQ36597026
Bruton's tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL).Q37596620
Long-term results of the fludarabine, cyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemiaQ37634897
Prolonged lymphocytosis during ibrutinib therapy is associated with distinct molecular characteristics and does not indicate a suboptimal response to therapyQ37655012
CD20 as a target for therapeutic type I and II monoclonal antibodies.Q37720878
Anti-CD20 antibody therapy for B-cell lymphomasQ38012522
B cell receptor signaling in chronic lymphocytic leukemiaQ38127513
B-cell receptor signaling in lymphoid malignancies and autoimmunityQ38212804
Targeting BCL2 for the treatment of lymphoid malignanciesQ38232485
Management of adverse events associated with idelalisib treatment: expert panel opinionQ38366294
A phase 1 study of obinutuzumab induction followed by 2 years of maintenance in patients with relapsed CD20-positive B-cell malignanciesQ38474278
BTK inhibition targets in vivo CLL proliferation through its effects on B-cell receptor signaling activityQ39056302
CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viabilityQ39642145
The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemiaQ39722770
Bruton's tyrosine kinase: from X-linked agammaglobulinemia toward targeted therapy for B-cell malignanciesQ41524241
Outcomes of patients with chronic lymphocytic leukemia after discontinuing ibrutinibQ41601558
A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2.Q41855372
Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells.Q42519684
PI3K-δ and PI3K-γ inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease modelsQ42708522
Phase 1 study results of the type II glycoengineered humanized anti-CD20 monoclonal antibody obinutuzumab (GA101) in B-cell lymphoma patients.Q43757205
Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cdelta.Q44189712
B-cell receptor signaling in chronic lymphocytic leukemia.Q50674847
Chronic lymphocytic leukaemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.Q52836247
Ibrutinib treatment affects collagen and von Willebrand factor-dependent platelet functions.Q54316160
Ibrutinib inhibits collagen-mediated but not ADP-mediated platelet aggregation.Q54328623
Obinutuzumab plus Chlorambucil in Patients with CLL and Coexisting ConditionsQ56657194
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
lymphocyteQ715347
chronic lymphocytic leukemiaQ1088156
P304page(s)1077-1089
P577publication date2016-03-17
P1433published inExpert Opinion on PharmacotherapyQ5421212
P1476titleChronic lymphocytic leukemia therapy: new targeted therapies on the way
P478volume17

Reverse relations

cites work (P2860)
Q93023511An in vitro assay for biomarker discovery and dose prediction applied to ibrutinib plus venetoclax treatment of CLL
Q37696319Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9
Q61795626Hepatocyte Growth Factor: A Microenvironmental Resource for Leukemic Cell Growth
Q49912101Microenvironment-induced CD44v6 promotes early disease progression in chronic lymphocytic leukemia

Search more.