| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2009PNAS..106.4635L |
| P356 | DOI | 10.1073/PNAS.0806474106 |
| P932 | PMC publication ID | 2651203 |
| P698 | PubMed publication ID | 19261853 |
| P5875 | ResearchGate publication ID | 24177891 |
| P50 | author | Mark R Cookson | Q67168137 |
| P2093 | author name string | Peter T Lansbury | |
| Yichin Liu | |||
| Zhihua Liu | |||
| Robin K Meray | |||
| Tom N Grammatopoulos | |||
| Ross A Fredenburg | |||
| Todd Logan | |||
| P2860 | cites work | Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases | Q24320112 |
| Solution structure of microtubule-associated protein light chain 3 and identification of its functional subdomains | Q28247288 | ||
| Parkin is associated with cellular vesicles | Q28578692 | ||
| Role of ubiquitin carboxy terminal hydrolase-L1 in neural cell apoptosis induced by ischemic retinal injury in vivo | Q28585083 | ||
| Impairment of the ubiquitin-proteasome system by protein aggregation | Q29614556 | ||
| The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B | Q29618194 | ||
| Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice | Q30764264 | ||
| Proteome analysis of human substantia nigra in Parkinson's disease. | Q31125603 | ||
| Farnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivo | Q33235032 | ||
| Aberrantly regulated proteins in frontotemporal dementia | Q33252959 | ||
| Towards complete sets of farnesylated and geranylgeranylated proteins | Q33281289 | ||
| The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility | Q34157005 | ||
| Isolation of PGP 9.5, a new human neurone-specific protein detected by high-resolution two-dimensional electrophoresis | Q34256444 | ||
| Discovery of Inhibitors that Elucidate the Role of UCH-L1 Activity in the H1299 Lung Cancer Cell Line | Q34266771 | ||
| Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1 | Q34502063 | ||
| Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory | Q34559237 | ||
| The S18Y polymorphic variant of UCH-L1 confers an antioxidant function to neuronal cells | Q34769852 | ||
| Two closely related ubiquitin C-terminal hydrolase isozymes function as reciprocal modulators of germ cell apoptosis in cryptorchid testis | Q35103266 | ||
| Apoptotic detection methods--from morphology to gene | Q35131424 | ||
| RhoB prenylation is driven by the three carboxyl-terminal amino acids of the protein: evidenced in vivo by an anti-farnesyl cysteine antibody | Q35331913 | ||
| Localization of ubiquitin C-terminal hydrolase L1 in mouse ova and its function in the plasma membrane to block polyspermy | Q35607417 | ||
| Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy | Q35676668 | ||
| PGP9.5 as a candidate tumor marker for non-small-cell lung cancer | Q35787842 | ||
| Isoprenylated proteins | Q36353778 | ||
| Thematic review series: lipid posttranslational modifications. CAAX modification and membrane targeting of Ras. | Q36423684 | ||
| The functions of UCH-L1 and its relation to neurodegenerative diseases | Q36856806 | ||
| Origins and effects of extracellular alpha-synuclein: implications in Parkinson's disease | Q37044665 | ||
| The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease | Q37054679 | ||
| Tetrapeptide inhibitors of protein farnesyltransferase: amino-terminal substitution in phenylalanine-containing tetrapeptides restores farnesylation | Q37188659 | ||
| Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity. | Q37325929 | ||
| Parkin suppresses wild-type alpha-synuclein-induced toxicity in SHSY-5Y cells | Q40636500 | ||
| Induction of adenylate cyclase sensitive dopamine D2-receptors in retinoic acid induced differentiated human neuroblastoma SHSY-5Y cells | Q41052317 | ||
| Analysis of cell-cycle profiles in transfected cells using a membrane-targeted GFP. | Q41054062 | ||
| Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance | Q41116771 | ||
| Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes | Q41271748 | ||
| Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells | Q42423397 | ||
| Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion. | Q42823924 | ||
| Cytosolic O-glycosylation is abundant in nerve terminals | Q43820039 | ||
| Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms | Q43849066 | ||
| Mutation analysis and association studies of the ubiquitin carboxy-terminal hydrolase L1 gene in Huntington's disease. | Q44068407 | ||
| Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion | Q44155992 | ||
| Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons | Q44258606 | ||
| Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants | Q44410269 | ||
| Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases | Q44727052 | ||
| Use of a membrane-localized green fluorescent protein allows simultaneous identification of transfected cells and cell cycle analysis by flow cytometry | Q44808200 | ||
| Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease? | Q45300712 | ||
| UCHL1 is a Parkinson's disease susceptibility gene | Q47866612 | ||
| Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons. | Q48093908 | ||
| Isolation and characterization of cytosolic and membrane-bound deubiquitinylating enzymes from bovine brain | Q48123213 | ||
| Altered gene expression in cells from patients with lysosomal storage disorders suggests impairment of the ubiquitin pathway. | Q48454804 | ||
| Genetic association between Ubiquitin Carboxy-terminal Hydrolase-L1 gene S18Y polymorphism and sporadic Alzheimer's disease in a Chinese Han population. | Q48576454 | ||
| Reduced ubiquitin C-terminal hydrolase-1 expression levels in dementia with Lewy bodies. | Q53376402 | ||
| Overexpression of ubiquitin carboxyl-terminal hydrolase L1 arrests spermatogenesis in transgenic mice. | Q53656438 | ||
| Complex interactions in Parkinson's disease: a two-phased approach. | Q54769772 | ||
| S18Y polymorphism in the UCH-L1 gene and Parkinson's disease: Evidence for an age-dependent relationship | Q57605900 | ||
| Mutation analysis and association studies of the UCHL1 gene in German Parkinson's disease patients | Q64778242 | ||
| Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease | Q64821269 | ||
| Synthetic prenylated peptides: studying prenyl protein-specific endoprotease and other aspects of protein prenylation | Q71999607 | ||
| Identification of proteins differentially expressed in quiescent and proliferatively senescent fibroblast cultures | Q72035084 | ||
| PGP9.5 as a marker for invasive colorectal cancer | Q77522166 | ||
| PGP9.5 overexpression in esophageal squamous cell carcinoma | Q79192990 | ||
| Substrate recognition and catalysis by UCH-L1 | Q79403462 | ||
| Reversible monoubiquitination regulates the Parkinson disease-associated ubiquitin hydrolase UCH-L1 | Q79677642 | ||
| Characterization of multimetric variants of ubiquitin carboxyl-terminal hydrolase L1 in water by small-angle neutron scattering | Q81549922 | ||
| The region-specific functions of two ubiquitin C-terminal hydrolase isozymes along the epididymis | Q82688254 | ||
| P433 | issue | 12 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | Parkinson's disease | Q11085 |
| neurotoxicity | Q3338704 | ||
| toxic encephalopathy | Q7830379 | ||
| Synuclein | Q24767155 | ||
| P304 | page(s) | 4635-4640 | |
| P577 | publication date | 2009-03-04 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease | |
| P478 | volume | 106 |
| Q33760617 | A combination of metabolic labeling and 2D-DIGE analysis in response to a farnesyltransferase inhibitor facilitates the discovery of new prenylated proteins |
| Q91995058 | A cysteine near the C-terminus of UCH-L1 is dispensable for catalytic activity but is required to promote AKT phosphorylation, eIF4F assembly, and malignant B-cell survival |
| Q28485362 | A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease |
| Q34050129 | A soluble α-synuclein construct forms a dynamic tetramer |
| Q34063163 | An optimal ubiquitin-proteasome pathway in the nervous system: the role of deubiquitinating enzymes |
| Q35917235 | Analysis of a membrane-enriched proteome from postmortem human brain tissue in Alzheimer's disease. |
| Q35353963 | Balancing act: deubiquitinating enzymes in the nervous system |
| Q50045673 | C-Terminal Farnesylation of UCH-L1 Plays a Role in Transport of Epstein-Barr Virus Primary Oncoprotein LMP1 to Exosomes. |
| Q57246845 | Chaperone-Mediated Autophagy and Parkinson's Disease |
| Q58766259 | Deubiquitinating Enzymes Related to Autophagy: New Therapeutic Opportunities? |
| Q34238665 | Differential effects of UCHL1 modulation on alpha-synuclein in PD-like models of alpha-synucleinopathy |
| Q92767762 | Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics |
| Q39074628 | Evaluation of prenylated peptides for use in cellular imaging and biochemical analysis |
| Q28732131 | Excess α-synuclein worsens disease in mice lacking ubiquitin carboxy-terminal hydrolase L1 |
| Q42655014 | Expression analysis of the long non-coding RNA antisense to Uchl1 (AS Uchl1) during dopaminergic cells' differentiation in vitro and in neurochemical models of Parkinson's disease |
| Q22241423 | Gene therapy in Parkinson's disease: rationale and current status |
| Q34916184 | Genome-wide single-cell-level screen for protein abundance and localization changes in response to DNA damage in S. cerevisiae. |
| Q38430423 | Identification of key genes and pathways in Parkinson's disease through integrated analysis |
| Q38993636 | In Situ Peroxidase Labeling and Mass-Spectrometry Connects Alpha-Synuclein Directly to Endocytic Trafficking and mRNA Metabolism in Neurons |
| Q36954995 | Increased generation of cyclopentenone prostaglandins after brain ischemia and their role in aggregation of ubiquitinated proteins in neurons |
| Q92343428 | Inhibition of UCH-L1 Deubiquitinating Activity with Two Forms of LDN-57444 Has Anti-Invasive Effects in Metastatic Carcinoma Cells |
| Q38872092 | Inhibition of UCH-L1 in oligodendroglial cells results in microtubule stabilization and prevents α-synuclein aggregate formation by activating the autophagic pathway: implications for multiple system atrophy |
| Q36939128 | Is the amyloid hypothesis of Alzheimer's disease therapeutically relevant? |
| Q54223105 | Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer's disease. |
| Q35634151 | Isoprenoids and related pharmacological interventions: potential application in Alzheimer's disease |
| Q38972179 | Life and death in the trash heap: The ubiquitin proteasome pathway and UCHL1 in brain aging, neurodegenerative disease and cerebral Ischemia |
| Q28118642 | Loss of β-glucocerebrosidase activity does not affect alpha-synuclein levels or lysosomal function in neuronal cells |
| Q33580301 | Mass spectrometry assessment of ubiquitin carboxyl-terminal hydrolase L1 partitioning between soluble and particulate brain homogenate fractions |
| Q38687124 | Mechanisms of regulation and diversification of deubiquitylating enzyme function. |
| Q41535966 | Metabolic Labeling with an Alkyne-modified Isoprenoid Analog Facilitates Imaging and Quantification of the Prenylome in Cells |
| Q41598067 | Modification of ubiquitin-C-terminal hydrolase-L1 by cyclopentenone prostaglandins exacerbates hypoxic injury. |
| Q37853789 | Molecular chaperones and associated cellular clearance mechanisms against toxic protein conformers in Parkinson's disease |
| Q39489133 | N-terminal deletion does not affect α-synuclein membrane binding, self-association and toxicity in human neuroblastoma cells, unlike yeast |
| Q41427586 | NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease |
| Q38544296 | Nanoscale Assemblies of Small Molecules Control the Fate of Cells |
| Q92453381 | Optimization of Metabolic Labeling with Alkyne-Containing Isoprenoid Probes |
| Q34992469 | Protein prenylation: enzymes, therapeutics, and biotechnology applications |
| Q89355462 | Proteomic Analysis of Hippocampus in a Mouse Model of Depression Reveals Neuroprotective Function of Ubiquitin C-terminal Hydrolase L1 (UCH-L1) via Stress-induced Cysteine Oxidative Modifications |
| Q34183008 | Proteomic profiling of the epileptic dentate gyrus |
| Q35241298 | Proteomics in neurodegenerative diseases: Methods for obtaining a closer look at the neuronal proteome |
| Q38058956 | Recent advances in protein prenyltransferases: substrate identification, regulation, and disease interventions |
| Q38120938 | Regulation of proteolysis by human deubiquitinating enzymes |
| Q37704633 | S-nitrosylation of UCHL1 induces its structural instability and promotes α-synuclein aggregation. |
| Q44360675 | Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system. |
| Q35224118 | Serum levels of neuron-specific ubiquitin carboxyl-terminal esterase-L1 predict brain injury in a canine model of hypothermic circulatory arrest |
| Q36555388 | Single-residue posttranslational modification sites at the N-terminus, C-terminus or in-between: To be or not to be exposed for enzyme access |
| Q35064948 | Synaptic therapy in Alzheimer's disease: a CREB-centric approach |
| Q26767879 | The Ubiquitin-Proteasome System: Potential Therapeutic Targets for Alzheimer's Disease and Spinal Cord Injury |
| Q26766125 | The business of deubiquitination - location, location, location |
| Q26828378 | The role of deubiquitinating enzymes in synaptic function and nervous system diseases |
| Q34774553 | The ubiquitin C-terminal hydrolase L1 (UCH-L1) C terminus plays a key role in protein stability, but its farnesylation is not required for membrane association in primary neurons |
| Q34411338 | Therapeutic approaches to preventing cell death in Huntington disease |
| Q59133543 | Ubiquitin C-terminal Hydrolase L1 Regulates Lipid Raft-dependent Endocytosis |
| Q26741828 | Ubiquitin C-terminal hydrolase L1 (UCH-L1): structure, distribution and roles in brain function and dysfunction |
| Q33799710 | Ubiquitin C-terminal hydrolase-L1 protects cystic fibrosis transmembrane conductance regulator from early stages of proteasomal degradation |
| Q27661287 | Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation |
| Q34012297 | Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implications |
| Q47348414 | a-Factor Analogues Containing Alkyne- and Azide-Functionalized Isoprenoids Are Efficiently Enzymatically Processed and Retain Wild-Type Bioactivity. |
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