Effector Protein Cig2 Decreases Host Tolerance of Infection by Directing Constitutive Fusion of Autophagosomes with the Coxiella-Containing Vacuole.

scientific article published on 19 July 2016

Effector Protein Cig2 Decreases Host Tolerance of Infection by Directing Constitutive Fusion of Autophagosomes with the Coxiella-Containing Vacuole. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MBIO.01127-16
P932PMC publication ID4958265
P698PubMed publication ID27435465

P50authorHayley J. NewtonQ48232510
P2093author name stringCraig R Roy
Lara J Kohler
Shireen A Sarraf
David D Arteaga
Shawna C O Reed
P2860cites workFunctional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell deathQ24294349
LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formationQ24294635
Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectorsQ24645159
Formation process of autophagosome is traced with Apg8/Aut7p in yeastQ24670615
Structural and spectral response of green fluorescent protein variants to changes in pHQ27618049
Phagolysosomes of Coxiella burnetii-infected cell lines maintain an acidic pH during persistent infectionQ28206600
Identification of OmpA, a Coxiella burnetii protein involved in host cell invasion, by multi-phenotypic high-content screeningQ28541251
Autophagy: process and functionQ29547296
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell deathQ29547297
Regulation mechanisms and signaling pathways of autophagyQ29547416
Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosisQ29614481
The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteriaQ29615619
Autophagy defends cells against invading group A StreptococcusQ29615620
Termination of autophagy and reformation of lysosomes regulated by mTORQ29619817
Coxiella burnetii phase I and II variants replicate with similar kinetics in degradative phagolysosome-like compartments of human macrophagesQ30495882
The role of anorexia in resistance and tolerance to infections in DrosophilaQ33481623
Coxiella burnetii type IV secretion-dependent recruitment of macrophage autophagosomesQ33603009
The Burkholderia pseudomallei type III secretion system and BopA are required for evasion of LC3-associated phagocytosisQ33849013
The Coxiella burnetii Dot/Icm system delivers a unique repertoire of type IV effectors into host cells and is required for intracellular replicationQ33921269
Coxiella burnetii localizes in a Rab7-labeled compartment with autophagic characteristicsQ34132094
Large-scale identification and translocation of type IV secretion substrates by Coxiella burnetii.Q34411597
Listeria monocytogenes infection causes metabolic shifts in Drosophila melanogasterQ34524970
Effector protein translocation by the Coxiella burnetii Dot/Icm type IV secretion system requires endocytic maturation of the pathogen-occupied vacuoleQ34563316
Bacterial colonization of host cells in the absence of cholesterol.Q34566110
Coxiella burnetii effector proteins that localize to the parasitophorous vacuole membrane promote intracellular replicationQ34955427
Isolation from animal tissue and genetic transformation of Coxiella burnetii are facilitated by an improved axenic growth mediumQ35080771
Advances in genetic manipulation of obligate intracellular bacterial pathogensQ35155325
Dot/Icm type IVB secretion system requirements for Coxiella burnetii growth in human macrophagesQ35187016
A screen of Coxiella burnetii mutants reveals important roles for Dot/Icm effectors and host autophagy in vacuole biogenesisQ35216620
Biochemical stratagem for obligate parasitism of eukaryotic cells by Coxiella burnetiiQ35368442
Natural history and pathophysiology of Q feverQ36081084
Fate of phase I and phase II Coxiella burnetii in several macrophage-like tumor cell linesQ36424529
Q Fever: an old but still a poorly understood diseaseQ36424664
Host pathways important for Coxiella burnetii infection revealed by genome-wide RNA interference screeningQ36576675
Computational modeling and experimental validation of the Legionella and Coxiella virulence-related type-IVB secretion signalQ36637597
Identification of Coxiella burnetii type IV secretion substrates required for intracellular replication and Coxiella-containing vacuole formationQ37124987
Activation of antibacterial autophagy by NADPH oxidasesQ37147170
Coxiella burnetii effector CvpB modulates phosphoinositide metabolism for optimal vacuole developmentQ37183766
The Coxiella burnetii ankyrin repeat domain-containing protein family is heterogeneous, with C-terminal truncations that influence Dot/Icm-mediated secretionQ37232712
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagyQ37246125
Axenic growth of Coxiella burnetiiQ38019885
Autophagy in antimicrobial immunityQ38207186
Galleria mellonella as an alternative model of Coxiella burnetii infectionQ40212721
Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagyQ40250473
The autophagic pathway is actively modulated by phase II Coxiella burnetii to efficiently replicate in the host cell.Q40465371
Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of pro-inflammatory cytokines and resistance to infection.Q40504222
Autophagy induction favours the generation and maturation of the Coxiella-replicative vacuoles.Q40506373
A technique for ultracryotomy of cell suspensions and tissuesQ41169027
Legionella pneumophila pathogenesis in the Galleria mellonella infection modelQ41824980
The ubiquitin-binding adaptor proteins p62/SQSTM1 and NDP52 are recruited independently to bacteria-associated microdomains to target Salmonella to the autophagy pathway.Q42142128
Fusogenicity of the Coxiella burnetii parasitophorous vacuoleQ44513104
Autophagy controls Salmonella infection in response to damage to the Salmonella-containing vacuole.Q50083524
Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC.Q51066780
P4510describes a project that usesImageJQ1659584
ImageQuantQ112270642
P433issue4
P921main subjectvacuoleQ127702
autophagosomeQ14882441
P577publication date2016-07-19
P1433published inmBioQ15817061
P1476titleEffector Protein Cig2 Decreases Host Tolerance of Infection by Directing Constitutive Fusion of Autophagosomes with the Coxiella-Containing Vacuole
P478volume7

Reverse relations

cites work (P2860)
Q38714587A Farnesylated Coxiella burnetii Effector Forms a Multimeric Complex at the Mitochondrial Outer Membrane during Infection
Q52317660Actin polymerization in the endosomal pathway, but not on the Coxiella-containing vacuole, is essential for pathogen growth.
Q30846778Alterations of the Coxiella burnetii Replicative Vacuole Membrane Integrity and Interplay with the Autophagy Pathway
Q92072320Bacterial Manipulation of Autophagic Responses in Infection and Inflammation
Q92205736Coxiella burnetii Type 4B Secretion System-dependent manipulation of endolysosomal maturation is required for bacterial growth
Q90131507Coxiella burnetii utilizes both glutamate and glucose during infection with glucose uptake mediated by multiple transporters
Q92187377Defying Death - How Coxiella burnetii Copes with Intentional Host Cell Suicide
Q90001376Dependency of Coxiella burnetii Type 4B Secretion on the Chaperone IcmS
Q48232386Dot/Icm-translocated proteins important for biogenesis of the Coxiella burnetii-containing vacuole identified by screening of an effector mutant sub-library
Q90604239EirA is a novel protein essential for intracellular replication of Coxiella burnetii
Q37670759High-Content Imaging Reveals Expansion of the Endosomal Compartment during Coxiella burnetii Parasitophorous Vacuole Maturation
Q92956896Host cell depletion of tryptophan by IFNγ-induced Indoleamine 2,3-dioxygenase 1 (IDO1) inhibits lysosomal replication of Coxiella burnetii
Q89420806Interaction between autophagic vesicles and the Coxiella-containing vacuole requires CLTC (clathrin heavy chain)
Q39437877Legionella and Coxiella effectors: strength in diversity and activity
Q44288392Macrophage Autophagy and Bacterial Infections
Q47138796Mechanisms of action of Coxiella burnetii effectors inferred from host-pathogen protein interactions
Q64274708Noncanonical Inhibition of mTORC1 by Coxiella burnetii Promotes Replication within a Phagolysosome-Like Vacuole
Q91983210Taming the Triskelion: Bacterial Manipulation of Clathrin
Q36230455The Effector Cig57 Hijacks FCHO-Mediated Vesicular Trafficking to Facilitate Intracellular Replication of Coxiella burnetii
Q64243788The cAMP effectors, Rap2b and EPAC, are involved in the regulation of the development of the Coxiella burnetii containing vacuole by altering the fusogenic capacity of the vacuole
Q47299307Type IV secretion in Gram-negative and Gram-positive bacteria

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