Common folate gene variant, MTHFR C677T, is associated with brain structure in two independent cohorts of people with mild cognitive impairment

scientific article published on 04 October 2012

Common folate gene variant, MTHFR C677T, is associated with brain structure in two independent cohorts of people with mild cognitive impairment is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.NICL.2012.09.012
P8608Fatcat IDrelease_6spez4lwkfcgjdciyc6clwstcy
P932PMC publication ID3757723
P698PubMed publication ID24179750
P5875ResearchGate publication ID232063740

P50authorRobert C. GreenQ7342606
Alzheimer's Disease Neuroimaging InitiativeQ4738819
Paul M. ThompsonQ18387155
Neda JahanshadQ28516595
Arthur W. TogaQ28516610
Clifford JackQ30505709
Andrew J. SaykinQ30514182
Michael W. WeinerQ56850515
Mario RiverolQ57062450
Xue HuaQ66730604
Joshua C BisQ79326643
Lewis KullerQ88077314
Oscar L LopezQ90469677
Derrek P HibarQ114261136
Omid KohannimQ114261150
Priya RajagopalanQ114270401
Sarah K. MadsenQ114270445
Cardiovascular Health Study (CHS)Q114270470
Jason L. SteinQ47502517
James T BeckerQ48199149
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A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductaseQ24324172
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrationsQ24644637
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The heritability of plasma homocysteine, and the influence of genetic variation in the homocysteine methylation pathway.Q51467429
The C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene and vascular dementia.Q53235784
Recruitment of adults 65 years and older as participants in the cardiovascular health studyQ57392546
MTHFR (677 and 1298) and IL-6-174 G/C genes in pathogenesis of Alzheimer's and vascular dementia and their epistatic interactionQ82122205
The Alzheimer's disease neuroimaging initiativeQ31030939
Silent brain infarcts: a systematic reviewQ31116425
Influence of the MTHFR C677T polymorphism on magnetic resonance imaging hyperintensity volume and cognition in geriatric depressionQ33585775
Genome-wide association study of homocysteine levels in Filipinos provides evidence for CPS1 in women and a stronger MTHFR effect in young adultsQ33815554
Volume of white matter hyperintensities in healthy adults: contribution of age, vascular risk factors, and inflammation-related genetic variantsQ34213287
Modification of brain aging and neurodegenerative disorders by genes, diet, and behaviorQ34711201
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathwayQ35002165
Homocysteine effects on brain volumes mapped in 732 elderly individualsQ35340452
Obesity is linked with lower brain volume in 700 AD and MCI patientsQ35401263
Tensor-based morphometry as a neuroimaging biomarker for Alzheimer's disease: an MRI study of 676 AD, MCI, and normal subjectsQ35401597
Gestational vitamin B deficiency leads to homocysteine-associated brain apoptosis and alters neurobehavioral development in ratsQ35750107
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MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkersQ37158181
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Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association studyQ37306645
Inverse consistent mapping in 3D deformable image registration: its construction and statistical propertiesQ38398565
Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trialQ38487526
Association study of gene polymorphisms involved in vascular alterations in elderly hypertensives with subjective memory complaintsQ42791922
Improvement of cognitive functions after cobalamin/folate supplementation in elderly patients with dementia and elevated plasma homocysteineQ43652333
Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's diseaseQ43661047
The C677T methylenetetrahydrofolate reductase mutation is not associated with Alzheimer's disease.Q43801062
The effect of increased concentrations of homocysteine on the concentration of (E)-4-hydroxy-2-nonenal in the plasma and cerebrospinal fluid of patients with Alzheimer's disease.Q43963242
MTHFR Gene Polymorphism as a Risk Factor for Silent Brain Infarcts and White Matter Lesions in the Japanese General PopulationQ44400113
Plasma total homocysteine levels and cranial magnetic resonance imaging findings in elderly persons: the Cardiovascular Health StudyQ44734507
Homocysteine and methylenetetrahydrofolate reductase polymorphism in Alzheimer's disease.Q44836998
Genetic variation in homocysteine metabolism, cognition, and white matter lesionsQ46238036
Association of MTHFR gene polymorphism C677T with susceptibility to late-onset Alzheimer's diseaseQ46628259
ACE, MTHFR, factor V Leiden, and APOE polymorphisms in patients with vascular and Alzheimer's dementiaQ47860994
Lesion probability maps of white matter hyperintensities in elderly individuals: results of the Austrian stroke prevention studyQ48587526
P433issue1
P921main subjectfolic acidQ127060
mild cognitive impairmentQ1472703
P304page(s)179-187
P577publication date2012-10-04
P1433published inNeuroImage: ClinicalQ22907265
P1476titleCommon folate gene variant, MTHFR C677T, is associated with brain structure in two independent cohorts of people with mild cognitive impairment
P478volume1

Reverse relations

cites work (P2860)
Q57029710Early Manifestations of Brain Aging in Mice Due to Low Dietary Folate and Mild MTHFR Deficiency
Q30762566Functional brain connectivity using fMRI in aging and Alzheimer's disease
Q28542010Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers
Q47934665Genetic effect of MTHFR C677T polymorphism on the structural covariance network and white-matter integrity in Alzheimer's disease.
Q24289409Genetics of the connectome
Q30981669Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2
Q43001820Methylenetetrahydrofolate reductase C677T variant in Indian children with craniosynostosis: Its role in the pathogenesis, risk of craniosynostosis
Q30680866Neuroimaging and genetic risk for Alzheimer's disease and addiction-related degenerative brain disorders
Q38118617Neuroimaging, nutrition, and iron-related genes
Q35032519Regional brain shrinkage over two years: individual differences and effects of pro-inflammatory genetic polymorphisms.
Q38802908Shared Genetic Risk Factors for Late-Life Depression and Alzheimer's Disease
Q37077593The C677T variant in MTHFR modulates associations between blood-based and cerebrospinal fluid biomarkers of neurodegeneration
Q87898390The C677T variant in MTHFR modulates associations between brain integrity, mood, and cognitive functioning in old age
Q38955440The Methylenetetrahydrofolate Reductase C677T Polymorphism and Risk for Late-Onset Alzheimer's disease: Further Evidence in an Italian Multicenter Study

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