Creatine target engagement with brain bioenergetics: a dose-ranging phosphorus-31 magnetic resonance spectroscopy study of adolescent females with SSRI-resistant depression

scientific article published on 23 February 2016

Creatine target engagement with brain bioenergetics: a dose-ranging phosphorus-31 magnetic resonance spectroscopy study of adolescent females with SSRI-resistant depression is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00726-016-2194-3
P932PMC publication ID4974294
P698PubMed publication ID26907087
P5875ResearchGate publication ID295849740

P50authorPerry F RenshawQ87441912
P2093author name stringDouglas G Kondo
Tracy L Hellem
Xianfeng Shi
Young-Hoon Sung
Rebekah S Huber
Lauren N Forrest
P2860cites workThe concentration of creatine in meat, offal and commercial dog food.Q55067027
Involvement of PKA, PKC, CAMK-II and MEK1/2 in the acute antidepressant-like effect of creatine in mice.Q55073616
A Heteroskedasticity-Consistent Covariance Matrix Estimator and a Direct Test for HeteroskedasticityQ55879648
Depression in young people: initial presentation and clinical courseQ72854491
Frontal lobe in vivo (31)P-MRS reveals gender differences in healthy controls, not in schizophrenicsQ73431741
Efficacy of antidepressants in juvenile depression: meta-analysisQ22255557
Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasisQ24527330
The creatine kinase system and pleiotropic effects of creatineQ24609852
Creatine metabolism and psychiatric disorders: Does creatine supplementation have therapeutic value?Q24631151
Pharmacological approaches to the challenge of treatment-resistant depressionQ26798241
The neural effects of psychotropic medications in children and adolescentsQ26850357
Systematic review of management for treatment-resistant depression in adolescentsQ26865021
Lifetime prevalence of mental disorders in U.S. adolescents: results from the National Comorbidity Survey Replication--Adolescent Supplement (NCS-A)Q28111792
Sex differences in mitochondrial (dys)function: Implications for neuroprotectionQ28386911
A New Depression Scale Designed to be Sensitive to ChangeQ29614720
Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): initial reliability and validity dataQ29616031
Chronic high-dose creatine has opposing effects on depression-related gene expression and behavior in intact and sex hormone-treated gonadectomized male and female rats.Q30389926
Multinuclear magnetic resonance spectroscopy of high-energy phosphate metabolites in human brain following oral supplementation of creatine-monohydrateQ30810394
31P-magnetic resonance spectroscopy and thyroid hormones in major depressive disorder: toward a bioenergetic mechanism in depression?Q30812485
Endogenous synthesis and transport of creatine in the rat brain: an in situ hybridization studyQ31878568
Advanced In Vivo Heteronuclear MRS Approaches for Studying Brain Bioenergetics Driven by MitochondriaQ33374303
Cross-national associations between gender and mental disorders in the World Health Organization World Mental Health SurveysQ33604829
Sex-specific antidepressant effects of dietary creatine with and without sub-acute fluoxetine in ratsQ33771249
Review: magnetic resonance spectroscopy studies of pediatric major depressive disorderQ33783427
Evidence for the management of adolescent depression.Q33819692
Gender differences in unipolar depression: an update of epidemiological findings and possible explanationsQ34218386
A randomized, double-blind placebo-controlled trial of oral creatine monohydrate augmentation for enhanced response to a selective serotonin reuptake inhibitor in women with major depressive disorderQ34292341
Fluoxetine, cognitive-behavioral therapy, and their combination for adolescents with depression: Treatment for Adolescents With Depression Study (TADS) randomized controlled trialQ34341755
Psychometric properties of the Children's Depression Rating Scale-Revised in adolescentsQ34413013
Major depression in the national comorbidity survey-adolescent supplement: prevalence, correlates, and treatmentQ34454744
Mitochondrial creatine kinase in human health and diseaseQ34461137
Brain bioenergetics and response to triiodothyronine augmentation in major depressive disorderQ34587328
A phase I, pharmacokinetic, dosage escalation study of creatine monohydrate in subjects with amyotrophic lateral sclerosisQ34610044
Practice parameter for the assessment and treatment of children and adolescents with depressive disordersQ34720078
Stress, sensitive periods and maturational events in adolescent depressionQ34760313
Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010.Q35040553
The increasing burden of depressionQ35090232
Measurement of creatine kinase reaction rate in human brain using magnetization transfer image-selected in vivo spectroscopy (MT-ISIS) and a volume ³¹P/¹H radiofrequency coil in a clinical 3-T MRI systemQ35126978
Creatine, similarly to ketamine, affords antidepressant-like effects in the tail suspension test via adenosine A₁ and A2A receptor activationQ35587857
The NIMH experimental medicine initiativeQ35754731
Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: a 31-phosphorus magnetic resonance spectroscopy studyQ36271087
Optimizing early Go/No Go decisions in CNS drug developmentQ36288836
Creatine as a Novel Treatment for Depression in Females Using Methamphetamine: A Pilot StudyQ36387048
Switching to another SSRI or to venlafaxine with or without cognitive behavioral therapy for adolescents with SSRI-resistant depression: the TORDIA randomized controlled trialQ36514240
Cerebral energetic effects of creatine supplementation in humansQ36603260
Correlation, regression, and repeated dataQ36749064
Creatine: endogenous metabolite, dietary, and therapeutic supplementQ36789361
Using the general linear mixed model to analyse unbalanced repeated measures and longitudinal dataQ36888585
The ABCs of depression: integrating affective, biological, and cognitive models to explain the emergence of the gender difference in depressionQ37143464
Functions and effects of creatine in the central nervous system.Q37172733
Expression and function of AGAT, GAMT and CT1 in the mammalian brainQ37225751
Chronic creatine supplementation alters depression-like behavior in rodents in a sex-dependent manner.Q37480270
Sex, trauma, stress hormones and depressionQ37601945
Sex differences in the pharmacokinetics and pharmacodynamics of antidepressants: an updated reviewQ37683984
Update on the use of MR for assessment and diagnosis of psychiatric diseasesQ37716336
Beyond the serotonin hypothesis: Mitochondria, inflammation and neurodegeneration in major depression and affective spectrum disordersQ37778476
Impaired mitochondrial function in psychiatric disordersQ38003304
A review of the clinical, economic, and societal burden of treatment-resistant depression: 1996-2013.Q38208786
A mitochondrial bioenergetic basis of depressionQ38254909
Creatine as a booster for human brain function. How might it work?Q38571612
Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adultsQ40283412
Comparative quantification of dietary supplemented neural creatine concentrations with (1)H-MRS peak fitting and basis spectrum methods.Q40790278
Presentation and course of major depressive disorder during childhood and later years of the life spanQ41017525
Comparing age at onset of major depression and other psychiatric disorders by birth cohorts in five US community populationsQ41168227
The modulation of NMDA receptors and L-arginine/nitric oxide pathway is implicated in the anti-immobility effect of creatine in the tail suspension test.Q41630586
Treatment monitoring of brain creatine deficiency syndromes: a 1H- and 31P-MR spectroscopy studyQ42165444
Brain phosphorous metabolism in depressive disorders detected by phosphorus-31 magnetic resonance spectroscopyQ43737909
Multinuclear magnetic resonance spectroscopy studies of brain purines in major depressionQ43812681
Puberty and depression: the roles of age, pubertal status and pubertal timingQ44075236
Sexual dimorphism in rat cerebrum and cerebellum: different patterns of catalytically active creatine kinase isoenzymes during postnatal development and agingQ44277445
Analog classroom assessment of Adderall in children with ADHD.Q44382273
Kinetics of creatine in blood and brain after intraperitoneal injection in the rat.Q44438162
Distinct cellular expressions of creatine synthetic enzyme GAMT and creatine kinases uCK-Mi and CK-B suggest a novel neuron-glial relationship for brain energy homeostasisQ44971585
Brain region- and sex-specific modulation of mitochondrial glucocorticoid receptor phosphorylation in fluoxetine treated stressed rats: effects on energy metabolismQ45297040
A pilot dose-finding clinical trial of creatine monohydrate augmentation to SSRIs/SNRIs/NASA antidepressant treatment in major depressionQ45331177
STAR*D: revising conventional wisdom.Q45931500
Antidepressant effect detected on proton magnetic resonance spectroscopy in drug-naïve female patients with first-episode major depression.Q45946184
Creatine monohydrate in resistant depression: a preliminary studyQ46910762
Suicidality in pediatric patients treated with antidepressant drugsQ46977975
The influence of age and sex on the prevalence of depressive conditions: report from the National Survey of Psychiatric MorbidityQ47915818
Involvement of PI3K/Akt Signaling Pathway and Its Downstream Intracellular Targets in the Antidepressant-Like Effect of Creatine.Q48083788
Increase of total creatine in human brain after oral supplementation of creatine-monohydrateQ48114355
31P magnetic resonance spectroscopy in the frontal lobe of major depressed patientsQ48293704
Distribution of the creatine transporter throughout the human brain reveals a spectrum of creatine transporter immunoreactivity.Q48583660
Lower levels of nucleoside triphosphate in the basal ganglia of depressed subjects: a phosphorous-31 magnetic resonance spectroscopy studyQ48823084
Brain creatine depletion in vegetarians? A cross-sectional ¹H-magnetic resonance spectroscopy (¹H-MRS) studyQ48832841
Gender differences in 12-week antidepressant treatment outcomes for a naturalistic secondary care cohort: the CRESCEND studyQ48932584
National Institute of Mental Health clinical trials: new opportunities, new expectations.Q50644922
Emergence of gender differences in depression during adolescence: national panel results from three countries.Q50691155
Major depressive disorder in older adolescents: prevalence, risk factors, and clinical implications.Q50856088
Development of depression from preadolescence to young adulthood: emerging gender differences in a 10-year longitudinal studyQ50902337
Estimating correlation coefficient between two variables with repeated observations using mixed effects model.Q51941505
Effect of phosphomonoesters, phosphodiesters, and phosphocreatine on glutamate uptake by synaptic vesicles.Q52191375
Randomized, controlled trial of amitriptyline versus placebo for adolescents with "treatment-resistant" major depression.Q54138607
P433issue8
P921main subjectteenagerQ1492760
P304page(s)1941-1954
P577publication date2016-02-23
P1433published inAmino AcidsQ15757015
P1476titleCreatine target engagement with brain bioenergetics: a dose-ranging phosphorus-31 magnetic resonance spectroscopy study of adolescent females with SSRI-resistant depression
P478volume48

Reverse relations

cites work (P2860)
Q47695444A randomized, double-blind, placebo-controlled, proof-of-concept trial of creatine monohydrate as adjunctive treatment for bipolar depression
Q38645491An Open-Label Pilot Study of Combined Augmentation With Creatine Monohydrate and 5-Hydroxytryptophan for Selective Serotonin Reuptake Inhibitor- or Serotonin-Norepinephrine Reuptake Inhibitor-Resistant Depression in Adult Women
Q92876206Creatine for the Treatment of Depression
Q55020079Creatine: a miserable life without it.
Q89747533Dietary creatine intake and depression risk among U.S. adults
Q104795025Differential and spatial expression meta-analysis of genes identified in genome-wide association studies of depression
Q47872069Differential neurometabolite alterations in brains of medication-free individuals with bipolar disorder and those with unipolar depression: a two-dimensional proton magnetic resonance spectroscopy study
Q95643364Novel Targets for Fast Antidepressant Responses: Possible Role of Endogenous Neuromodulators
Q91893883The Assertive Brain: Anterior Cingulate Phosphocreatine plus Creatine Levels Correlate With Self-Directedness in Healthy Adolescents

Search more.