Inactivation of the maternal fragile X gene results in sensitization of GABAB receptor function in the offspring

scientific article published on 23 September 2008

Inactivation of the maternal fragile X gene results in sensitization of GABAB receptor function in the offspring is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1124/JPET.108.143990
P8608Fatcat IDrelease_3ovrgedbrfc5hoepyuqcwlwzlu
P932PMC publication ID2666962
P698PubMed publication ID18812493
P5875ResearchGate publication ID23277525

P2093author name stringBojana Zupan
Miklos Toth
P2860cites workDopamine production in the caudate putamen restores feeding in dopamine-deficient miceQ28504725
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Wild-type male offspring of fmr-1+/- mothers exhibit characteristics of the fragile X phenotypeQ30480496
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The GABAA receptor: a novel target for treatment of fragile X?Q36859341
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Pharmacokinetics of a single oral dose of baclofen in pediatric patients with gastroesophageal reflux diseaseQ42693507
GABA(B) receptor modulators potentiate baclofen-induced depression of dopamine neuron activity in the rat ventral tegmental areaQ43261524
Fragile X mice develop sensory hyperreactivity to auditory stimuliQ43574481
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(Over)correction of FMR1 deficiency with YAC transgenics: behavioral and physical featuresQ45866804
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RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area.Q46927228
Opposite changes in the mesolimbic dopamine metabolism in the nerve terminal and cell body sites induced by locally infused baclofen in the rat.Q48175690
Suppression of ethanol-induced locomotor stimulation by GABA-like drugsQ48343565
Gamma-hydroxybutyrate is a GABAB receptor agonist that increases a potassium conductance in rat ventral tegmental dopamine neuronsQ48379449
Fmrp is required for the establishment of the startle response during the critical period of auditory development.Q48455738
Mildly impaired water maze performance in male Fmr1 knockout miceQ48818692
Parenting in mothers with and without attention-deficit/hyperactivity disorder.Q52025413
Presynaptic modulation by dopamine and GABA opens a potassium channel in rat cortical, striatal and hippocampal synaptosomes via eicosanoids.Q54023201
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Fmr1 knockout mice: a model to study fragile X mental retardation. The Dutch-Belgian Fragile X ConsortiumQ72065437
Asymmetric neural control systems in human self-regulationQ72603210
GABAB-receptor activation alters the firing pattern of dopamine neurons in the rat substantia nigraQ72700454
GABA(B) receptors: altered coupling to G-proteins in rats sensitized to amphetamineQ73163695
Case study: maternal residual attention deficit disorder associated with failure to thrive in a two-month-old infantQ93868741
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)820-826
P577publication date2008-09-23
P1433published inJournal of Pharmacology and Experimental TherapeuticsQ1500272
P1476titleInactivation of the maternal fragile X gene results in sensitization of GABAB receptor function in the offspring
P478volume327

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cites work (P2860)
Q42959792Chemistry and pharmacology of GABAB receptor ligands
Q41497643Dopamine Release and Uptake Impairments and Behavioral Alterations Observed in Mice that Model Fragile X Mental Retardation Syndrome
Q34198650Fragile X and autism: Intertwined at the molecular level leading to targeted treatments
Q28235219KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability
Q30475378Maternal genetic mutations as gestational and early life influences in producing psychiatric disease-like phenotypes in mice
Q35188148Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome
Q27023257Targeted pharmacological treatment of autism spectrum disorders: fragile X and Rett syndromes
Q34213731The psychiatric presentation of fragile x: evolution of the diagnosis and treatment of the psychiatric comorbidities of fragile X syndrome
Q38046662mGluR antagonists and GABA agonists as novel pharmacological agents for the treatment of autism spectrum disorders

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