scholarly article | Q13442814 |
P50 | author | Donald K. Ingram | Q107733297 |
Johan Sandin | Q50637797 | ||
P2093 | author name string | Nigel H Greig | |
Joseph A Araujo | |||
Christina de Rivera | |||
Norton W Milgram | |||
P2860 | cites work | The scopolamine-reversal paradigm in rats and monkeys: the importance of computer-assisted operant-conditioning memory tasks for screening drug candidates. | Q51973289 |
Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging. | Q51997691 | ||
Visuospatial impairments in aged canines (Canis familiaris): the role of cognitive-behavioral flexibility. | Q52012363 | ||
Cholinesterase inhibitors, beta-amyloid precursor protein and amyloid beta-peptides in Alzheimer's disease. | Q52020724 | ||
Phenserine, a novel acetylcholinesterase inhibitor, attenuates impaired learning of rats in a 14-unit T-maze induced by blockade of the N-methyl-D-aspartate receptor. | Q52039414 | ||
Enhanced performance of spatial and visual recognition memory tasks by the selective acetylcholinesterase inhibitor E2020 in rhesus monkeys. | Q52042629 | ||
Effects of anticholinesterase drugs tacrine and E2020, the 5-HT(3) antagonist ondansetron, and the H(3) antagonist thioperamide, in models of cognition and cholinergic function. | Q52045840 | ||
Maze learning in aged rats is enhanced by phenserine, a novel anticholinesterase. | Q52054155 | ||
The effects of novel cholinesterase inhibitors and selective muscarinic receptor agonists in tests of reference and working memory. | Q52060302 | ||
Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a two-year longitudinal study. | Q52064446 | ||
Correlation of the intrinsic clearance of donepezil (Aricept) between in vivo and in vitro studies in rat, dog and human. | Q52132865 | ||
Effects of the potassium channel blockers, apamin and 4-aminopyridine, on scopolamine-induced deficits in the delayed matching to position task in rats: a comparison with the cholinesterase inhibitor E2020. | Q52189958 | ||
An inverted U-shaped curve for heptylphysostigmine on radial maze performance in rats: comparison with other cholinesterase inhibitors. | Q52201942 | ||
Differential alteration of various cholinergic markers in cortical and subcortical regions of human brain in Alzheimer's disease. | Q53192718 | ||
Cognitive and behavioral sensitivity to scopolamine in Alzheimer patients and controls. | Q53195328 | ||
Pathological changes in the nucleus of Meynert in Alzheimer's and Parkinson's diseases. | Q53198385 | ||
Scopolamine model of dementia: electroencephalogram findings and cognitive performance. | Q53225073 | ||
Diffuse plaques contain C-terminal A beta 42 and not A beta 40: evidence from cats and dogs | Q71594507 | ||
Locomotor activity rhythms in dogs vary with age and cognitive status | Q73835824 | ||
The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches. | Q37354760 | ||
Estimation of working memory in macaques for studying drugs for the treatment of cognitive disorders | Q37354764 | ||
Phenserine Efficacy in Alzheimer's Disease | Q37510264 | ||
The canine as a model of human cognitive aging: recent developments | Q38441952 | ||
Anticholinergic sensitivity in patients with dementia of the Alzheimer type and age-matched controls. A dose-response study | Q38489258 | ||
Pharmacologic modelling of Alzheimer's disease | Q39753042 | ||
Cholinergic receptors in aging and Alzheimer's disease | Q39753054 | ||
Neurotransmitter enzyme abnormalities in senile dementia. Choline acetyltransferase and glutamic acid decarboxylase activities in necropsy brain tissue | Q39835119 | ||
Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging | Q39897525 | ||
The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice. | Q40227332 | ||
Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-beta peptide | Q40281052 | ||
Rodent models of memory dysfunction in Alzheimer's disease and normal aging: moving beyond the cholinergic hypothesis | Q40653119 | ||
Central Anticholinergic Hypersensitivity in Aging | Q41084079 | ||
Scopolamine challenges in Alzheimer's disease | Q41490389 | ||
Possible role of the cholinergic system and disease models. | Q41573860 | ||
Region-specific age at onset of beta-amyloid in dogs | Q41733900 | ||
Effects of amyloid-beta-(25-35) on passive avoidance, radial-arm maze learning and choline acetyltransferase activity in the rat. | Q42498874 | ||
Effect of phenserine treatment on brain functional activity and amyloid in Alzheimer's disease | Q42646408 | ||
Aged dogs demonstrate both increased sensitivity to scopolamine impairment and decreased muscarinic receptor density | Q42757338 | ||
Magnetic resonance imaging of anatomic and vascular characteristics in a canine model of human aging | Q43405668 | ||
Donepezil reverses a mnemonic deficit produced by scopolamine but not by perforant path lesion or transient cerebral ischaemia | Q44039758 | ||
Oxidative damage increases with age in a canine model of human brain aging | Q44068708 | ||
Dietary enrichment counteracts age-associated cognitive dysfunction in canines | Q44188916 | ||
Loss of muscarinic M4 receptors in hippocampus of Alzheimer patients | Q44265136 | ||
Decreased muscarinic receptor binding in cerebral cortex and hippocampus in Alzheimer's disease | Q44466201 | ||
Dose-specific effects of scopolamine on canine cognition: impairment of visuospatial memory, but not visuospatial discrimination | Q44804443 | ||
Donepezil-induced improvement in delayed matching accuracy by young and old rhesus monkeys | Q45020579 | ||
Nicotinic and muscarinic cholinergic receptors in Alzheimer's disease and related disorders | Q45030829 | ||
The cholinesterase inhibitor, phenserine, improves Morris water maze performance of scopolamine-treated rats | Q45202745 | ||
Beta-amyloid accumulation correlates with cognitive dysfunction in the aged canine | Q46089691 | ||
Visual-discrimination learning ability and beta-amyloid accumulation in the dog. | Q46235992 | ||
Application of an automated voxel-based morphometry technique to assess regional gray and white matter brain atrophy in a canine model of aging | Q46245858 | ||
Muscarinic and nicotinic receptors synergistically modulate working memory and attention in humans | Q46475895 | ||
Anticholinesterase and pharmacokinetic profile of phenserine in healthy elderly human subjects | Q46774121 | ||
A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: effects on cognitive function and brain Abeta. | Q46813624 | ||
Changes in brain cholinesterases in senile dementia of Alzheimer type | Q48176243 | ||
Cognitive functions and aging in the dog: acquisition of nonspatial visual tasks | Q48179028 | ||
Soluble beta-amyloid[25-35] reversibly impairs hippocampal synaptic plasticity and spatial learning | Q48262827 | ||
Necropsy evidence of central cholinergic deficits in senile dementia | Q48319379 | ||
Selective loss of central cholinergic neurons in Alzheimer's disease | Q48342983 | ||
Brain muscarinic receptors in senile dementia | Q48479457 | ||
Diffuse beta-amyloid plaques and hyperphosphorylated tau are unrelated processes in aged dogs with behavioral deficits | Q48496234 | ||
Visuospatial function in the beagle dog: an early marker of cognitive decline in a model of human aging and dementia | Q48583221 | ||
Human memory and the cholinergic system. A relationship to aging? | Q48584703 | ||
Autoradiographic distribution of M1, M2, M3, and M4 muscarinic receptor subtypes in Alzheimer's disease | Q48654715 | ||
Pharmacological modulation of Alzheimer's beta-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions | Q48696243 | ||
Phenserine: a physostigmine derivative that is a long-acting inhibitor of cholinesterase and demonstrates a wide dose range for attenuating a scopolamine-induced learning impairment of rats in a 14-unit T-maze | Q48824371 | ||
The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics | Q48944505 | ||
Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. | Q50869517 | ||
Role of acetylcholinesterase inhibitors in the metabolism of amyloid precursor protein | Q24302890 | ||
Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction | Q28111935 | ||
The cholinergic hypothesis of geriatric memory dysfunction | Q28277644 | ||
Cholinergic treatments with emphasis on m1 muscarinic agonists as potential disease-modifying agents for Alzheimer's disease | Q28287090 | ||
A specific amyloid-beta protein assembly in the brain impairs memory | Q28854597 | ||
The integrated role of desferrioxamine and phenserine targeted to an iron-responsive element in the APP-mRNA 5'-untranslated region | Q30776788 | ||
Donepezil. Pharmacoeconomic implications of therapy | Q33761849 | ||
The beta-amyloid precursor protein and its derivatives: from biology to learning and memory processes | Q33863439 | ||
Neuroprotective effects of cognitive enrichment | Q33999196 | ||
Spatial learning and memory as a function of age in the dog. | Q34370735 | ||
Why so few drugs for Alzheimer's disease? Are methods failing drugs? | Q34440659 | ||
Landmark discrimination learning in the dog. | Q35039179 | ||
Effect of age and level of cognitive function on spontaneous and exploratory behaviors in the beagle dog | Q35042013 | ||
Current treatments for Alzheimer's disease: cholinesterase inhibitors. | Q35205238 | ||
Effects of age on measures of complex working memory span in the beagle dog (Canis familiaris) using two versions of a spatial list learning paradigm | Q35974291 | ||
Further evidence for the cholinergic hypothesis of aging and dementia from the canine model of aging | Q36082211 | ||
The canine model of human cognitive aging and dementia: pharmacological validity of the model for assessment of human cognitive-enhancing drugs | Q36082227 | ||
Behavior problems in geriatric pets. | Q36099805 | ||
An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease | Q36172619 | ||
Assessment of nutritional interventions for modification of age-associated cognitive decline using a canine model of human aging | Q36272892 | ||
Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development | Q36318080 | ||
Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function | Q36325260 | ||
Region specific neuron loss in the aged canine hippocampus is reduced by enrichment | Q36380222 | ||
Therapeutic options for cognitive decline in senior pets | Q36646583 | ||
Phenserine | Q36861622 | ||
Anti-dementia drugs and hippocampal-dependent memory in rodents | Q36925129 | ||
Interactions between the amyloid and cholinergic mechanisms in Alzheimer's disease | Q37207763 | ||
Animal models of Alzheimer's disease: therapeutic implications. | Q37354734 | ||
P433 | issue | 1 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 143-155 | |
P577 | publication date | 2011-01-01 | |
P1433 | published in | Journal of Alzheimer's Disease | Q6294755 |
P1476 | title | Cholinesterase inhibitors improve both memory and complex learning in aged beagle dogs | |
P478 | volume | 26 |
Q36126681 | Antioxidants in Down syndrome |
Q64963501 | Canine Cognitive Dysfunction and Alzheimer’s Disease – Two Facets of the Same Disease? |
Q28552599 | Cognitive Impairments Induced by Concussive Mild Traumatic Brain Injury in Mouse Are Ameliorated by Treatment with Phenserine via Multiple Non-Cholinergic and Cholinergic Mechanisms |
Q46540446 | Neurobehavioral deficits and brain oxidative stress induced by chronic low dose exposure of persistent organic pollutants mixture in adult female rat. |
Q38099889 | New pharmacological approaches to the cholinergic system: an overview on muscarinic receptor ligands and cholinesterase inhibitors |
Q60530192 | Response to stimulus relations by a dog (Canis lupus familiaris) |