Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy

scientific article published on 08 August 2016

Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2016NatCo...712335S
P6179Dimensions Publication ID1043247439
P356DOI10.1038/NCOMMS12335
P932PMC publication ID4979067
P698PubMed publication ID27498556

P50authorJames P. AllisonQ6140731
P2093author name stringPadmanee Sharma
Sumit K Subudhi
Baoxiang Guan
Lewis Zhichang Shi
Jianjun Gao
Tihui Fu
Jianfeng Chen
Jorge M Blando
Liangwen Xiong
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PD-1 blockade induces responses by inhibiting adaptive immune resistanceQ29620856
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Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells.Q35126816
Combination therapy with anti-CTLA-4 and anti-PD-1 leads to distinct immunologic changes in vivoQ35235365
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PD-1 blockade enhances T-cell migration to tumors by elevating IFN-γ inducible chemokinesQ36334073
Interleukin 7 regulates the survival and generation of memory CD4 cellsQ36371578
Differential tumor surveillance by natural killer (NK) and NKT cells.Q36375962
Effector CD8+ T-cell Engraftment and Antitumor Immunity in Lymphodepleted Hosts Is IL7Rα DependentQ36616920
Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsetsQ36742299
Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors.Q36941194
Inhibitory role of the transcription repressor Gfi1 in the generation of thymus-derived regulatory T cells.Q37117826
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IL-7 receptor expression provides the potential for long-term survival of both CD62Lhigh central memory T cells and Th1 effector cells during Leishmania major infectionQ37367860
Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS).Q37684283
Interleukin-7 mediates selective expansion of tumor-redirected cytotoxic T lymphocytes (CTLs) without enhancement of regulatory T-cell inhibitionQ39085608
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)12335
P577publication date2016-08-08
P1433published inNature CommunicationsQ573880
P1476titleInterdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy
P478volume7

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