Downregulation of hypothalamic insulin receptor expression elicits depressive-like behaviors in rats

scientific article published on 31 March 2011

Downregulation of hypothalamic insulin receptor expression elicits depressive-like behaviors in rats is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.BBR.2011.03.052
P932PMC publication ID3774048
P698PubMed publication ID21458499
P5875ResearchGate publication ID50987515

P2093author name stringSteven P Wilson
Claudia A Grillo
Gerardo G Piroli
Lawrence P Reagan
Marlene A Wilson
Kris F Kaigler
P2860cites workDepression: a new animal model sensitive to antidepressant treatmentsQ28254150
Prevalence of overweight and obesity in the United States, 1999-2004Q28305811
Lentivirus-mediated downregulation of hypothalamic insulin receptor expressionQ28577111
Central nervous system control of food intakeQ29547439
A neurotrophic model for stress-related mood disordersQ29616291
Obesity/hyperleptinemic phenotype impairs structural and functional plasticity in the rat hippocampusQ30460422
Leptin: a potential novel antidepressantQ30476721
Obesity is associated with a decreased leptin transport across the blood-brain barrier in ratsQ30652081
Acute administration of leptin produces anxiolytic-like effects: a comparison with fluoxetineQ33756416
Murine models of depressionQ33791052
Anxiety and depression in association with morbid obesity: changes with improved physical health after duodenal switchQ33895258
Learned and cognitive controls of food intakeQ34079599
Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studiesQ34101548
Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressantsQ34211475
Effects of leptin on memory processingQ34468427
Antidepressant-like effect of leptin in streptozotocin-induced diabetic miceQ34606978
Leptin facilitates learning and memory performance and enhances hippocampal CA1 long-term potentiation and CaMK II phosphorylation in ratsQ48445758
Central and medial amygdaloid brain-derived neurotrophic factor signaling plays a critical role in alcohol-drinking and anxiety-like behaviors.Q48450802
Differential effects of diazepam on anxiety in streptozotocin induced diabetic and non-diabetic ratsQ48491663
Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression.Q48635095
Depression and obesity: a meta-analysis of community-based studies.Q51908565
Prospective association between obesity and depression: evidence from the Alameda County StudyQ73189725
Impaired transport of leptin across the blood-brain barrier in obesityQ73305016
Afferent-specific modulation of short-term synaptic plasticity by neurotrophins in dentate gyrusQ73537425
ObesityQ80836155
Synaptic plasticity and mood disordersQ34622373
Plasticity in the visual system: role of neurotrophins and electrical activity.Q34850405
Obesity/hyperleptinemic phenotype adversely affects hippocampal plasticity: effects of dietary restrictionQ34990300
BDNF regulates the intrinsic excitability of cortical neuronsQ35039394
Novel actions of leptin in the hippocampusQ35160996
Depression and obesityQ35189669
The many lives of leptinQ35769087
Are mood disorders and obesity related? A review for the mental health professional.Q35783981
The role of delta opioid receptors in the anxiolytic actions of benzodiazepinesQ35844244
Association between obesity and psychiatric disorders in the US adult populationQ35880425
Glucocorticoids, depression, and mood disorders: structural remodeling in the brainQ36118319
Psychosocial and behavioral aspects of bariatric surgeryQ36129515
Leptin: a potential cognitive enhancer?Q36295304
Leptin and its role in hippocampal synaptic plasticityQ36470247
Approaching the shared biology of obesity and depression: the stress axis as the locus of gene-environment interactionsQ36553056
Obesity and hypertriglyceridemia produce cognitive impairmentQ36578894
Chronic restraint stress up-regulates GLT-1 mRNA and protein expression in the rat hippocampus: reversal by tianeptineQ36605320
Leptin regulation of neuronal excitability and cognitive functionQ37007039
The leptin hypothesis of depression: a potential link between mood disorders and obesity?Q37010885
Lipids and cognitionQ37736197
Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity.Q38294210
Decreased 5-HT transporter mRNA in neurons of the dorsal raphe nucleus and behavioral depression in the obese leptin-deficient ob/ob mouse.Q38308141
Behavioural despair in rats: A new model sensitive to antidepressant treatmentsQ40134604
Leptin promotes rapid dynamic changes in hippocampal dendritic morphologyQ41352832
The role of amygdalar mu-opioid receptors in anxiety-related responses in two rat modelsQ42022457
Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodentsQ42524355
Neurobehavioral deficits in db/db diabetic miceQ42736763
Increased expression of β amyloid precursor gene in the hippocampus of streptozotocin-induced diabetic mice with memory deficit and anxiety inductionQ42822227
A high-fat diet impairs neurogenesis: Involvement of lipid peroxidation and brain-derived neurotrophic factorQ42952281
Body dissatisfaction, dietary restraint, depression, and weight status in adolescentsQ43749080
BDNF attenuates hippocampal LTD via activation of phospholipase C: implications for a vertical shift in the frequency-response curve of synaptic plasticityQ44086538
Effects of selective serotonin reuptake inhibitors on immobility time in the tail suspension test in streptozotocin-induced diabetic miceQ44520667
Is obesity associated with major depression? Results from the Third National Health and Nutrition Examination SurveyQ44677815
Triglycerides induce leptin resistance at the blood-brain barrierQ44865501
Effects of altered amygdalar neuropeptide Y expression on anxiety-related behaviorsQ46381654
Memory impairment in obese Zucker rats: an investigation of cognitive function in an animal model of insulin resistance and obesity.Q46814093
The lifestyle challenge program: a multidisciplinary approach to weight managementQ47361382
Tianeptine increases brain-derived neurotrophic factor expression in the rat amygdala.Q48236930
Decreased plasma BDNF level in depressive patientsQ48335963
Stressor-specific regulation of distinct brain-derived neurotrophic factor transcripts and cyclic AMP response element-binding protein expression in the postnatal and adult rat hippocampusQ48339735
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectpreproinsulinQ7240673
P304page(s)230-235
P577publication date2011-03-31
P1433published inBehavioural Brain ResearchQ3619047
P1476titleDownregulation of hypothalamic insulin receptor expression elicits depressive-like behaviors in rats
P478volume222

Reverse relations

cites work (P2860)
Q36339790A neuronal MCT2 knockdown in the rat somatosensory cortex reduces both the NMR lactate signal and the BOLD response during whisker stimulation
Q38364557Anti-diabetic and neuroprotective effects of pancreatic islet transplantation into the central nervous system
Q98945320Beneficial Effect of Genistein on Diabetes-Induced Brain Damage in the ob/ob Mouse Model
Q26739671Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans
Q48498076Changes in Brain 14-3-3 Proteins in Response to Insulin Resistance Induced by a High Palatable Diet
Q37919080Chronic stress, metabolism, and metabolic syndrome
Q99709166Clinical Evidence of Antidepressant Effects of Insulin and Anti-Hyperglycemic Agents and Implications for the Pathophysiology of Depression-A Literature Review
Q56337964Cross-species evidence from human and rat brain transcriptome for growth factor signaling pathway dysregulation in major depression
Q48069313Depression mediates impaired glucose tolerance and cognitive dysfunction: A neuromodulatory role of rosiglitazone.
Q26864574Diabetes-associated depression: the serotonergic system as a novel multifunctional target
Q37719351Dietary restriction reverses obesity-induced anhedonia
Q47585512Diets rich in saturated fat and fructose induce anxiety and depression-like behaviours in the rat: is there a role for lipid peroxidation?
Q47562648Differential effects of chronic stress in young-adult and old female mice: cognitive-behavioral manifestations and neurobiological correlates.
Q47812135Effect of streptozotocin-induced diabetes on performance on a progressive ratio schedule
Q64911679Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism.
Q48223579Hippocampal GSK3β as a Molecular Link Between Obesity and Depression.
Q36186276Hippocampal Insulin Resistance Impairs Spatial Learning and Synaptic Plasticity
Q38606226Hippocampal insulin resistance and cognitive dysfunction
Q33628048Insulin Resistance as a Link between Amyloid-Beta and Tau Pathologies in Alzheimer's Disease
Q64262753Insulin Resistance as a Shared Pathogenic Mechanism Between Depression and Type 2 Diabetes
Q26825385Insulin in the brain: there and back again
Q28079442Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood
Q96343906Insulin receptor substrate in brain-enriched exosomes in subjects with major depression: on the path of creation of biosignatures of central insulin resistance
Q61037242Insulin resistance is associated with depression risk in polycystic ovary syndrome
Q53767591Insulin resistance-a missing link no more.
Q37924942Intranasal administration of insulin to the brain impacts cognitive function and peripheral metabolism
Q37217434Metabolic disturbances connecting obesity and depression.
Q36220289Models and mechanisms for hippocampal dysfunction in obesity and diabetes
Q34113945Mood, food, and obesity
Q88881379Neurobiological and Systemic Effects of Chronic Stress
Q38189558Neuroendocrine link between stress, depression and diabetes
Q37715594Preserved energy balance in mice lacking FoxO1 in neurons of Nkx2.1 lineage reveals functional heterogeneity of FoxO1 signaling within the hypothalamus
Q36651084Stop signs in hippocampal insulin signaling: the role of insulin resistance in structural, functional and behavioral deficits
Q34445871Therapeutic effect of vagus nerve stimulation on depressive-like behavior, hyperglycemia and insulin receptor expression in Zucker fatty rats

Search more.