HHLA2, a member of the B7 family, is expressed in human osteosarcoma and is associated with metastases and worse survival

scientific article published on 17 August 2016

HHLA2, a member of the B7 family, is expressed in human osteosarcoma and is associated with metastases and worse survival is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/SREP31154
P932PMC publication ID4987662
P698PubMed publication ID27531281

P50authorRichard G GorlickQ56427012
P2093author name stringBang H Hoang
David S Geller
Xingxing Zang
Jonathan Gill
Sajida Piperdi
Pratistha Koirala
Michael E Roth
Jordan M Chinai
Maya Ghorpade
Michelle R Ewart
Yekaterina V Fatakhova
P2860cites workSecond and subsequent recurrences of osteosarcoma: presentation, treatment, and outcomes of 249 consecutive cooperative osteosarcoma study group patientsQ82929476
Platelet-derived growth factor receptor as a prognostic marker and a therapeutic target for imatinib mesylate therapy in osteosarcomaQ37109503
Immune infiltration and PD-L1 expression in the tumor microenvironment are prognostic in osteosarcomaQ37125088
Chromothripsis: chromosomes in crisisQ38059925
Translational biology of osteosarcomaQ38260633
Enhanced T-cell immunity to osteosarcoma through antibody blockade of PD-1/PD-L1 interactions.Q38902256
Correlation between clinical outcome and growth factor pathway expression in osteogenic sarcomaQ39956327
Endogenous retroviruses provide the primary polyadenylation signal for two new human genes (HHLA2 and HHLA3).Q40936070
Exomics and immunogenics: Bridging mutational load and immune checkpoints efficacyQ41983246
Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanomaQ42874163
HHLA2 and TMIGD2: new immunotherapeutic targets of the B7 and CD28 familiesQ43245544
Pattern of disease recurrence and prognostic factors in patients with osteosarcoma treated with contemporary chemotherapyQ44667120
B7-H5 costimulates human T cells via CD28HQ24295841
Identification of IGPR-1 as a novel adhesion molecule involved in angiogenesisQ24307624
Massive genomic rearrangement acquired in a single catastrophic event during cancer developmentQ24631164
Evaluation of eIF4E expression in an osteosarcoma-specific tissue microarrayQ24635844
PD-1 and its ligands in tolerance and immunityQ28131650
Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systemsQ28294477
Dissemination and growth of cancer cells in metastatic sitesQ29555846
Osteosarcoma incidence and survival rates from 1973 to 2004: data from the Surveillance, Epidemiology, and End Results ProgramQ33406382
Programmed cell death ligand 1 expression in osteosarcomaQ33848154
Neoantigens in cancer immunotherapy.Q34470074
Osteosarcoma: a review of diagnosis, management, and treatment strategiesQ34626942
The molecular pathogenesis of osteosarcoma: a reviewQ34629074
Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcomaQ34793401
Human cancer immunotherapy with antibodies to the PD-1 and PD-L1 pathway.Q34809019
A New B7:CD28 Family Checkpoint Target for Cancer Immunotherapy: HHLA2.Q35612992
Expression, Clinical Significance, and Receptor Identification of the Newest B7 Family Member HHLA2 ProteinQ35613102
Objective measurement and clinical significance of TILs in non-small cell lung cancerQ36047422
HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell functionQ36932447
The B7 family and cancer therapy: costimulation and coinhibitionQ36944386
Evolution of the B7 family: co-evolution of B7H6 and NKp30, identification of a new B7 family member, B7H7, and of B7's historical relationship with the MHC.Q37007501
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)31154
P577publication date2016-08-17
P1433published inScientific ReportsQ2261792
P1476titleHHLA2, a member of the B7 family, is expressed in human osteosarcoma and is associated with metastases and worse survival
P478volume6

Reverse relations

cites work (P2860)
Q91738964Association of high PDPN expression with pulmonary metastasis of osteosarcoma and patient prognosis
Q61814936B7-H5/CD28H is a co-stimulatory pathway and correlates with improved prognosis in pancreatic ductal adenocarcinoma
Q89475415B7-H7 (HHLA2) inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling
Q90281737CD28 Homolog Is a Strong Activator of Natural Killer Cells for Lysis of B7H7+ Tumor Cells
Q90207349CD28 family of receptors inter-connect in the regulation of T-cells
Q89589912Comprehensive molecular profiling of the B7 family in gastrointestinal cancer
Q92782141HHLA2 and PD-L1 co-expression predicts poor prognosis in patients with clear cell renal cell carcinoma
Q64080810HHLA2 in intrahepatic cholangiocarcinoma: an immune checkpoint with prognostic significance and wider expression compared with PD-L1
Q93187257HHLA2 is a novel immune checkpoint protein in pancreatic ductal adenocarcinoma and predicts post-surgical survival
Q90442569HHLA2 is a novel prognostic predictor and potential therapeutic target in malignant glioma
Q90269754HHLA2 overexpression is a novel biomarker of malignant status and poor prognosis in gastric cancer
Q64250330Macrophages from Susceptible and Resistant Chicken Lines have Different Transcriptomes following Marek's Disease Virus Infection
Q39416195New B7 Family Checkpoints in Human Cancers
Q92344203New Insights about the Wnt/β-Catenin Signaling Pathway in Primary Bone Tumors and Their Microenvironment: A Promising Target to Develop Therapeutic Strategies?
Q92292617Overexpression of B7H5/CD28H is associated with worse survival in human gastric cancer
Q64107489Overexpression of HHLA2 in human clear cell renal cell carcinoma is significantly associated with poor survival of the patients
Q53834241Overexpression of HHLA2, a member of the B7 family, is associated with worse survival in human colorectal carcinoma
Q55240839The association of human endogenous retrovirus-H long terminal repeat-associating protein 2 (HHLA2) expression with gastric cancer prognosis.
Q38684886The expanding repertoire of targets for immune checkpoint inhibition in bladder cancer: What lies beneath the tip of the iceberg, PD-L1.
Q39160982The third group of the B7-CD28 immune checkpoint family: HHLA2, TMIGD2, B7x, and B7-H3.
Q48158394Wide expression and significance of alternative immune checkpoint molecules, B7x and HHLA2, in PD-L1 negative human lung cancers.

Search more.