O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence

scientific article published on 23 May 2016

O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1073/PNAS.1600509113
P932PMC publication ID4988580
P698PubMed publication ID27217568

P2093author name stringZhiguo Zhang
Jong-Sun Lee
P2860cites workCrystal structure of the nucleosome core particle at 2.8 A resolutionQ22122355
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TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASSQ24312040
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Crosstalk between O-GlcNAcylation and proteolytic cleavage regulates the host cell factor-1 maturation pathwayQ24338891
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Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cellsQ27934187
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A Cul4 E3 ubiquitin ligase regulates histone hand-off during nucleosome assembly.Q27936513
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Drosophila Yemanuclein and HIRA cooperate for de novo assembly of H3.3-containing nucleosomes in the male pronucleusQ28486084
Aging leads to increased levels of protein O-linked N-acetylglucosamine in heart, aorta, brain and skeletal muscle in Brown-Norway ratsQ28568308
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Telomeres shorten during ageing of human fibroblastsQ29547357
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Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescenceQ29620428
Hir proteins are required for position-dependent gene silencing in Saccharomyces cerevisiae in the absence of chromatin assembly factor IQ33775938
New functions for an old variant: no substitute for histone H3.3.Q33812007
The essence of senescenceQ34288983
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Histone H3.3 and its proteolytically processed form drive a cellular senescence programmeQ34533167
Asf1/HIRA facilitate global histone deacetylation and associate with HP1 to promote nucleosome occupancy at heterochromatic lociQ34562251
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Chromatin remodelling beyond transcription: the INO80 and SWR1 complexes.Q34607379
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HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasiaQ34697738
Conservation of deposition-related acetylation sites in newly synthesized histones H3 and H4.Q34709355
Phosphorylation of H4 Ser 47 promotes HIRA-mediated nucleosome assembly.Q35098573
Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex.Q35273985
Diverse factors are involved in maintaining X chromosome inactivationQ35289356
O-GlcNAc a sensor of cellular state: the role of nucleocytoplasmic glycosylation in modulating cellular function in response to nutrition and stressQ35828212
Human histone acetyltransferase 1 protein preferentially acetylates H4 histone molecules in H3.1-H4 over H3.3-H4.Q35838917
Nucleosome stability mediated by histone variants H3.3 and H2A.Z.Q35840889
Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viabilityQ36233025
Dynamic nucleosomesQ36408578
Cell signaling, the essential role of O-GlcNAc!Q36510087
Chromatin challenges during DNA replication and repairQ36744476
The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expressionQ36850449
Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc).Q37303993
Hira-dependent histone H3.3 deposition facilitates PRC2 recruitment at developmental loci in ES cellsQ37337181
Dynamics of histone H3.3 deposition in proliferating and senescent cells reveals a DAXX-dependent targeting to PML-NBs important for pericentromeric heterochromatin organizationQ37529988
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Transcriptional regulation of cellular senescenceQ37850681
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PP1α, PP1β and Wip-1 regulate H4S47 phosphorylation and deposition of histone H3 variant H3.3.Q39130206
Chromatin assembly factor-1, a marker of clinical value to distinguish quiescent from proliferating cellsQ40571002
Identification of an ubinuclein 1 region required for stability and function of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complexQ42555165
Isolation and characterization of a new gene encoding a member of the HIRA family of proteins from Drosophila melanogasterQ42678537
Essential role of the glycosyltransferase sxc/Ogt in polycomb repression.Q45991772
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in miceQ47315084
Hayflick, his limit, and cellular ageingQ48774640
Dynamics of histone H3 deposition in vivo reveal a nucleosome gap-filling mechanism for H3.3 to maintain chromatin integrity.Q51543312
The power and the promise of oncogene-induced senescence markers.Q53345760
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Methods for studying pro- and antiapoptotic genes in nonimmortal cellsQ73983320
P4510describes a project that usesImageJQ1659584
P433issue23
P407language of work or nameEnglishQ1860
P921main subjectmolecular chaperonesQ422496
P304page(s)E3213-20
P577publication date2016-05-23
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleO-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence
P478volume113

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cites work (P2860)
Q58692776'-GlcNAc Code' Mediated Biological Functions of Downstream Proteins
Q42364240Aging, Metabolism, and Cancer Development: from Peto's Paradox to the Warburg Effect
Q57125790Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit
Q39241437O-GlcNAcylation and chromatin remodeling in mammals: an up-to-date overview.
Q92824117Pak2 kinase promotes cellular senescence and organismal aging
Q38794897Potential coordination role between O-GlcNAcylation and epigenetics
Q54943102Single Nucleotide Polymorphisms in the HIRA Gene Affect Litter Size in Small Tail Han Sheep.
Q55154360The Art of War: harnessing the epigenome against cancer.
Q39241431The sweet side of the cell cycle

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