| P2093 | author name string | Giorgio Lenaz | |
| | Christian Bergamini | |
| | Romana Fato | |
| | Paola Strocchi | |
| | Serena Leoni | |
| P2860 | cites work | Titrating the effects of mitochondrial complex I impairment in the cell physiology | Q77808181 |
| | Inter-mitochondrial complementation of mtDNA mutations and nuclear context | Q77852283 |
| | The enigmatic relationship between mitochondrial dysfunction and Leber's hereditary optic neuropathy | Q78059462 |
| | Mitochondrial diseases | Q80391768 |
| | Heterologous mitochondrial DNA recombination in human cells | Q80889065 |
| | Free radicals-mediated damage in transmitochondrial cells harboring the T14487C mutation in the ND6 gene of mtDNA | Q81594219 |
| | Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis | Q22242250 |
| | Structures and Proton-Pumping Strategies of Mitochondrial Respiratory Enzymes | Q22255650 |
| | Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism | Q24309753 |
| | Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism | Q24321359 |
| | Hereditary early-onset Parkinson's disease caused by mutations in PINK1 | Q24337084 |
| | Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space | Q24532259 |
| | The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria | Q24546038 |
| | α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies | Q24653247 |
| | Leber hereditary optic neuropathy: identification of the same mitochondrial ND1 mutation in six pedigrees | Q24678456 |
| | Mutation in the alpha-synuclein gene identified in families with Parkinson's disease | Q27860459 |
| | α-Synuclein in Lewy bodies | Q27860680 |
| | Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase | Q28116926 |
| | Electron transfer properties of NADH:ubiquinone reductase in the ND1/3460 and the ND4/11778 mutations of the Leber hereditary optic neuroretinopathy (LHON) | Q28251741 |
| | Human Complex I deficiency: Clinical spectrum and involvement of oxygen free radicals in the pathogenicity of the defect | Q28271238 |
| | Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy | Q28292821 |
| | URF6, last unidentified reading frame of human mtDNA, codes for an NADH dehydrogenase subunit | Q28304374 |
| | Mitochondrial disease in superoxide dismutase 2 mutant mice | Q28513450 |
| | Control of oxygen free radical formation from mitochondrial complex I: roles for protein kinase A and pyruvate dehydrogenase kinase | Q28582573 |
| | Mitochondrial oxidative stress in mice lacking the glutathione peroxidase-1 gene | Q28593572 |
| | Mitochondrial ROS-induced ROS release: an update and review | Q36531183 |
| | Bioenergetics and the formation of mitochondrial reactive oxygen species. | Q36631070 |
| | Mutations in structural genes of complex I associated with neurological diseases | Q36726628 |
| | Respiratory complex I: mechanistic and structural insights provided by the crystal structure of the hydrophilic domain | Q36726662 |
| | Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain | Q36727241 |
| | Metals ions and neurodegeneration | Q36733713 |
| | Oxidative stress, mitochondrial DNA mutation, and apoptosis in aging. | Q36803297 |
| | Mitochondrial optic neuropathies: how two genomes may kill the same cell type? | Q36811238 |
| | The role of Coenzyme Q in mitochondrial electron transport | Q36813585 |
| | Nitration in neurodegeneration: deciphering the "Hows" "nYs". | Q36837083 |
| | Physiological and pathological properties of alpha-synuclein | Q36866952 |
| | A Generalised Increase in Protein Carbonyls in the Brain in Parkinson's but Not Incidental Lewy Body Disease | Q36880536 |
| | Alterations in the distribution of glutathione in the substantia nigra in Parkinson's disease | Q36895132 |
| | Conjugates of Catecholamines with Cysteine and GSH in Parkinson's Disease: Possible Mechanisms of Formation Involving Reactive Oxygen Species | Q36899240 |
| | Mitochondrial mutations: genotype to phenotype. | Q37030151 |
| | Genetics of Parkinson disease | Q37037053 |
| | Mitochondria in the aetiology and pathogenesis of Parkinson's disease | Q37037953 |
| | Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase | Q37357532 |
| | Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease | Q37671552 |
| | NADH- and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NADH–ubiquinone reductase preparation | Q39273179 |
| | Molecular Democracy: Who Shares the Controls? | Q39827592 |
| | Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species | Q40046145 |
| | Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria | Q40082378 |
| | Obligatory role for complex I inhibition in the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). | Q40220627 |
| | Investigation of the mechanism of proton translocation by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria: does the enzyme operate by a Q-cycle mechanism? | Q40299871 |
| | Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system | Q40324674 |
| | Severe impairment of complex I-driven adenosine triphosphate synthesis in leber hereditary optic neuropathy cybrids | Q40424707 |
| | Differentiation-specific effects of LHON mutations introduced into neuronal NT2 cells | Q40749783 |
| | Altered mitochondrial function and overgeneration of reactive oxygen species precede the induction of apoptosis by 1-O-octadecyl-2-methyl-rac-glycero-3-phosphocholine in p53-defective hepatocytes | Q40789106 |
| | Very rare complementation between mitochondria carrying different mitochondrial DNA mutations points to intrinsic genetic autonomy of the organelles in cultured human cells. | Q40831709 |
| | Diphenyleneiodonium, an NAD(P)H oxidase inhibitor, also potently inhibits mitochondrial reactive oxygen species production | Q40983329 |
| | Neuropathology of Parkinson's disease | Q41095404 |
| | Catalytic activity of complex I in cell lines that possess replacement mutations in the ND genes in Leber's hereditary optic neuropathy | Q41189121 |
| | Evidence that the blockade of mitochondrial respiration by the neurotoxin 1-methyl-4-phenylpyridinium (MPP+) involves binding at the same site as the respiratory inhibitor, rotenone | Q41231883 |
| | The cellular production of hydrogen peroxide | Q41880555 |
| | Superoxide production by NADH:ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane | Q41971010 |
| | Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state. | Q42123867 |
| | The contribution of mitochondrial respiratory complexes to the production of reactive oxygen species. | Q42514984 |
| | Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol. | Q42528691 |
| | Characterisation of the last Fe-S cluster-binding subunit of Neurospora crassa complex I. | Q42599856 |
| | The 14484 ND6 mtDNA mutation in Leber hereditary optic neuropathy does not affect fibroblast complex I activity. | Q42950983 |
| | Is Bax a mitochondrial mediator in apoptotic death of dopaminergic neurons in Parkinson's disease? | Q43548211 |
| | A central functional role for the 49-kDa subunit within the catalytic core of mitochondrial complex I. | Q43600883 |
| | Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease | Q43624453 |
| | The site of production of superoxide radical in mitochondrial Complex I is not a bound ubisemiquinone but presumably iron-sulfur cluster N2. | Q43750483 |
| | Generation of reactive oxygen species by the mitochondrial electron transport chain | Q43955844 |
| | Glycerophosphate-dependent hydrogen peroxide production by brown adipose tissue mitochondria and its activation by ferricyanide | Q43998719 |
| | EPR characterization of ubisemiquinones and iron-sulfur cluster N2, central components of the energy coupling in the NADH-ubiquinone oxidoreductase (complex I) in situ | Q44096849 |
| | Regulation of hydrogen peroxide production by brain mitochondria by calcium and Bax. | Q44163178 |
| | Leber's hereditary optic neuropathy (LHON) pathogenic mutations induce mitochondrial-dependent apoptotic death in transmitochondrial cells incubated with galactose medium | Q44226125 |
| | Transmembrane topology of the NuoL, M and N subunits of NADH:quinone oxidoreductase and their homologues among membrane-bound hydrogenases and bona fide antiporters | Q44235462 |
| | Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production | Q44258988 |
| | Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation. | Q44264439 |
| | Analysis of the subunit composition of complex I from bovine heart mitochondria | Q44367201 |
| | The structure of neuromelanin as studied by chemical degradative methods | Q44530312 |
| | Regulation of brain mitochondrial H2O2 production by membrane potential and NAD(P)H redox state. | Q44545123 |
| | Two aspartic acid residues in the PSST-homologous NUKM subunit of complex I from Yarrowia lipolytica are essential for catalytic activity | Q44557676 |
| | High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria | Q28610852 |
| | Superoxide production and electron transport in mitochondrial oxidation of dihydroorotic acid | Q28620607 |
| | The gross structure of the respiratory complex I: a Lego System | Q28646274 |
| | Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants | Q28771379 |
| | Mitochondrial formation of reactive oxygen species | Q29547906 |
| | Hydroperoxide metabolism in mammalian organs | Q29614205 |
| | Mitochondrial respiratory-chain diseases | Q29614474 |
| | Chronic systemic pesticide exposure reproduces features of Parkinson's disease | Q29614763 |
| | Epidemiology of Parkinson's disease | Q29614901 |
| | High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease | Q29619113 |
| | Topology of superoxide production from different sites in the mitochondrial electron transport chain | Q29619855 |
| | Biochemical analysis of cybrids expressing mitochondrial DNA from Contursi kindred Parkinson's subjects | Q30307412 |
| | Parkinson's disease transgenic mitochondrial cybrids generate Lewy inclusion bodies. | Q30312062 |
| | Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled. | Q30440422 |
| | Origin and functional consequences of the complex I defect in Parkinson's disease | Q30469425 |
| | Kinetic Stabilization of the α-Synuclein Protofibril by a Dopamine-α-Synuclein Adduct | Q31029246 |
| | Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia | Q33322579 |
| | Cytotoxic and genotoxic potential of dopamine | Q33603762 |
| | Mitochondria, oxygen free radicals, disease and ageing | Q33922972 |
| | Mechanism of toxicity in rotenone models of Parkinson's disease | Q33974271 |
| | Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial NADH:ubiquinone oxidoreductase (complex I). | Q33980059 |
| | Rotenone model of Parkinson disease: multiple brain mitochondria dysfunctions after short term systemic rotenone intoxication | Q33990927 |
| | Energy converting NADH:quinone oxidoreductase (complex I). | Q33996552 |
| | Mitochondrial Complex I: structural and functional aspects | Q33997495 |
| | Bovine complex I is a complex of 45 different subunits. | Q33999203 |
| | The respiratory complex I of bacteria, archaea and eukarya and its module common with membrane-bound multisubunit hydrogenases | Q34001536 |
| | Characterization of two novel redox groups in the respiratory NADH:ubiquinone oxidoreductase (complex I). | Q34044400 |
| | Uncoupling to survive? The role of mitochondrial inefficiency in ageing | Q34071511 |
| | The mitochondrial production of reactive oxygen species: mechanisms and implications in human pathology | Q34109999 |
| | The incidence of mitochondrial encephalomyopathies in childhood: clinical features and morphological, biochemical, and DNA abnormalities | Q34191284 |
| | Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins | Q34248828 |
| | Initiation of neuronal damage by complex I deficiency and oxidative stress in Parkinson's disease. | Q34308036 |
| | Bioenergetics of mitochondrial diseases associated with mtDNA mutations | Q34337000 |
| | Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants | Q34402690 |
| | Dependence of H2O2 formation by rat heart mitochondria on substrate availability and donor age. | Q34419427 |
| | Complex I: a chimaera of a redox and conformation-driven proton pump? | Q34429353 |
| | ??? | Q64767196 |
| | Exploring the catalytic core of complex I by Yarrowia lipolytica yeast genetics | Q34429365 |
| | The origin of cluster N2 of the energy-transducing NADH-quinone oxidoreductase: comparisons of phylogenetically related enzymes | Q34429381 |
| | Respiratory complex I: structure, redox components, and possible mechanisms of energy transduction | Q34458879 |
| | Procaryotic complex I (NDH-1), an overview | Q34468645 |
| | The NADH:ubiquinone oxidoreductase (complex I) from Escherichia coli | Q34468649 |
| | Reactive oxygen species and signal transduction | Q34497624 |
| | Respiratory chain supercomplexes | Q34499026 |
| | Mitochondrial ROS metabolism: modulation by uncoupling proteins. | Q34499078 |
| | Proton pumping by NADH:ubiquinone oxidoreductase. A redox driven conformational change mechanism? | Q34534253 |
| | Optic nerve degeneration and mitochondrial dysfunction: genetic and acquired optic neuropathies | Q34535175 |
| | Organization of iron-sulfur clusters in respiratory complex I. | Q34559653 |
| | Oxidatively modified proteins in aging and disease | Q34615830 |
| | Neuropathology of mitochondrial diseases | Q34633350 |
| | The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer's and Parkinson's diseases | Q34679230 |
| | The mitochondrial electron transfer chain | Q34697908 |
| | Iron–sulfur clusters/semiquinones in Complex I | Q34747335 |
| | From NADH to ubiquinone in Neurospora mitochondria | Q34807417 |
| | Glutathione, iron and Parkinson's disease | Q34816461 |
| | Mitochondrial threshold effects. | Q35017647 |
| | LHON and other optic nerve atrophies: the mitochondrial connection | Q35183311 |
| | Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies | Q35764504 |
| | Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons | Q35786982 |
| | Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies | Q35829548 |
| | Bioenergetics shapes cellular death pathways in Leber's hereditary optic neuropathy: a model of mitochondrial neurodegeneration | Q35849790 |
| | Synucleins and their relationship to Parkinson's disease. | Q35926973 |
| | Intracellular generation of reactive oxygen species by mitochondria | Q36041440 |
| | Mitochondrial encephalomyopathies: an update | Q36081150 |
| | Mitochondrial metabolism of reactive oxygen species. | Q36088215 |
| | Environmental toxins and alpha-synuclein in Parkinson's disease | Q36161877 |
| | Mitochondria take center stage in aging and neurodegeneration | Q36264218 |
| | Expanding insights of mitochondrial dysfunction in Parkinson's disease. | Q36404133 |
| | Genetic findings in Parkinson's disease and translation into treatment: a leading role for mitochondria? | Q36499640 |
| | Leber's hereditary optic neuropathy: a multifactorial disease. | Q36531117 |
| | Functional significance of conserved histidines and arginines in the 49-kDa subunit of mitochondrial complex I. | Q44788626 |
| | Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease | Q44808814 |
| | Regulation of NADH/CoQ oxidoreductase: do phosphorylation events affect activity? | Q44871296 |
| | The mitochondrial respiratory chain is partially organized in a supercomplex assembly: kinetic evidence using flux control analysis | Q44942853 |
| | Dopamine-derived dopaminochrome promotes H(2)O(2) release at mitochondrial complex I: stimulation by rotenone, control by Ca(2+), and relevance to Parkinson disease | Q45264842 |
| | Expression and characterization of the 66-kilodalton (NQO3) iron-sulfur subunit of the proton-translocating NADH-quinone oxidoreductase of Paracoccus denitrificans. | Q45947496 |
| | Generation of superoxide-radical by the NADH:ubiquinone oxidoreductase of heart mitochondria | Q46419471 |
| | A possible site of superoxide generation in the complex I segment of rat heart mitochondria | Q46500408 |
| | Conformation-driven and semiquinone-gated proton-pump mechanism in the NADH-ubiquinone oxidoreductase (complex I). | Q46648740 |
| | Localization of the site of oxygen radical generation inside the complex I of heart and nonsynaptic brain mammalian mitochondria. | Q46785663 |
| | Redox cycling of adrenaline and adrenochrome catalysed by mitochondrial Complex I. | Q46951804 |
| | Structure-function studies of iron-sulfur clusters and semiquinones in the NADH-Q oxidoreductase segment of the respiratory chain | Q47729468 |
| | Minimum birth prevalence of mitochondrial respiratory chain disorders in children | Q47835071 |
| | Increased nigral iron content in postmortem parkinsonian brain | Q48182830 |
| | Accumulation of alpha-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy | Q48342277 |
| | Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: a LAMMA study | Q48419227 |
| | Relationship among alpha-synuclein accumulation, dopamine synthesis, and neurodegeneration in Parkinson disease substantia nigra | Q48452025 |
| | Protein Nitration in Parkinsonʼs Disease | Q48463667 |
| | Nigral and Cortical Lewy Bodies and Dystrophic Nigral Neurites in Parkinsonʼs Disease and Cortical Lewy Body Disease Contain α-synuclein Immunoreactivity | Q48463677 |
| | Substrate and Site Specificity of Hydrogen Peroxide Generation in Mouse Mitochondria | Q48533485 |
| | Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons | Q48588748 |
| | Glycoxidation and oxidative stress in Parkinson disease and diffuse Lewy body disease | Q48888308 |
| | Crosslinking of alpha-synuclein by advanced glycation endproducts--an early pathophysiological step in Lewy body formation? | Q49019886 |
| | The kinetics of the redox reactions of ubiquinone related to the electron-transport activity in the respiratory chain | Q52473651 |
| | Functional alterations of the mitochondrially encoded ND4 subunit associated with Leber's hereditary optic neuropathy. | Q52541439 |
| | Leber's hereditary optic neuropathy: biochemical effect of 11778/ND4 and 3460/ND1 mutations and correlation with the mitochondrial genotype | Q52553363 |
| | Three classes of inhibitors share a common binding domain in mitochondrial complex I (NADH:ubiquinone oxidoreductase). | Q52567911 |
| | Disruption of the gene encoding the NADH-binding subunit of NADH: ubiquinone oxidoreductase in Neurospora crassa. Formation of a partially assembled enzyme without FMN and the iron-sulphur cluster N-3. | Q54638678 |
| | Parkinson's disease | Q56877819 |
| | Biochemical features of mtDNA 14484 (ND6/M64V) point mutation associated with Leber's hereditary optic neuropathy | Q57012820 |
| | Role of mitochondria in oxidative stress and ageing | Q57014212 |
| | Chapter 4 Leber's Hereditary Optic Neuropathy | Q57721287 |
| | Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis | Q58454329 |
| | Superoxide Radical Formation by Pure Complex I (NADH:Ubiquinone Oxidoreductase) from Yarrowia lipolytica | Q58782439 |
| | Proton-translocation by membrane-bound NADH:ubiquinone-oxidoreductase (complex I) through redox-gated ligand conduction | Q58782802 |
| | MITOCHONDRIAL FUNCTION IN PARKINSON'S DISEASE | Q59697249 |
| | Direct and respiratory chain-mediated redox cycling of adrenochrome | Q68457352 |
| | Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease | Q69356679 |
| | Abnormalities of the electron transport chain in idiopathic Parkinson's disease | Q69361952 |
| | Mitochondrial complex I deficiency in Parkinson's disease | Q69370277 |
| | Coupling of dopamine oxidation (monoamine oxidase activity) to glutathione oxidation via the generation of hydrogen peroxide in rat brain homogenates | Q71482505 |
| | The role of transition metals in the pathogenesis of Parkinson's disease | Q71629174 |
| | Diphenyleneiodonium inhibits reduction of iron-sulfur clusters in the mitochondrial NADH-ubiquinone oxidoreductase (Complex I) | Q72135899 |
| | Are mitochondria a permanent source of reactive oxygen species? | Q73270584 |
| | Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria | Q74115847 |
| | Catalytic properties of the mitochondrial NADH–ubiquinone oxidoreductase (Complex I) and the pseudo-reversible active/inactive enzyme transition | Q74567714 |
| | Inhibitors of NADH–ubiquinone reductase: an overview | Q74567735 |
| | A reductant-induced oxidation mechanism for Complex I | Q74567756 |
| | Generation of superoxide anion by succinate-cytochrome c reductase from bovine heart mitochondria | Q77677718 |
| P433 | issue | 12 | |
| P921 | main subject | reactive oxygen species | Q424361 |
| | neurodegeneration | Q1755122 |
| | mitochondrion | Q39572 |
| P304 | page(s) | 2487-2501 | |
| P577 | publication date | 2008-06-06 | |
| P13046 | publication type of scholarly work | review article | Q7318358 |
| P1433 | published in | Neurochemical Research | Q15716728 |
| P1476 | title | Generation of reactive oxygen species by mitochondrial complex I: implications in neurodegeneration | |
| P478 | volume | 33 | |