| P50 | author | Irina Kowalska | Q57320527 |
| P2093 | author name string | Marek Straczkowski | |
| P2860 | cites work | Sphingomyelinase and ceramide suppress insulin-induced tyrosine phosphorylation of the insulin receptor substrate-1 | Q71070355 |
| | Rapid impairment of skeletal muscle glucose transport/phosphorylation by free fatty acids in humans | Q77765976 |
| | Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade | Q77795070 |
| | Muscle-specific overexpression of FAT/CD36 enhances fatty acid oxidation by contracting muscle, reduces plasma triglycerides and fatty acids, and increases plasma glucose and insulin | Q78239684 |
| | Stearoyl CoA desaturase 1 is elevated in obesity but protects against fatty acid-induced skeletal muscle insulin resistance in vitro | Q79222798 |
| | Chronic treatment with pioglitazone does not protect obese patients with diabetes mellitus type II from free fatty acid-induced insulin resistance | Q79297651 |
| | Short-term manipulation of plasma free fatty acids does not change skeletal muscle concentrations of ceramide and glucosylceramide in lean and overweight subjects | Q79691407 |
| | Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance | Q79930051 |
| | Tissue-specific effects of rosiglitazone and exercise in the treatment of lipid-induced insulin resistance | Q80171915 |
| | Inhibiting glycosphingolipid synthesis improves glycemic control and insulin sensitivity in animal models of type 2 diabetes | Q80241892 |
| | Leptin, skeletal muscle lipids, and lipid-induced insulin resistance | Q80301958 |
| | Prominent increase in plasma ganglioside GM3 is associated with clinical manifestations of type I Gaucher disease | Q80421291 |
| | Increased skeletal muscle ceramide level in men at risk of developing type 2 diabetes | Q80854696 |
| | Mechanism of free fatty acid-induced insulin resistance in humans | Q24562106 |
| | Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance | Q24629603 |
| | Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle | Q24685655 |
| | The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus | Q28190307 |
| | Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome | Q28205305 |
| | The multigenic sphingomyelin synthase family | Q28257423 |
| | Ceramide- and oxidant-induced insulin resistance involve loss of insulin-dependent Rac-activation and actin remodeling in muscle cells | Q28285526 |
| | Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity | Q28287290 |
| | Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance | Q28291556 |
| | Protein kinase C and lipid signaling for sustained cellular responses | Q28300819 |
| | Metformin and exercise reduce muscle FAT/CD36 and lipid accumulation and blunt the progression of high-fat diet-induced hyperglycemia | Q28581219 |
| | Cloning and characterization of the full-length cDNA and genomic sequences encoding murine acid ceramidase | Q28585526 |
| | Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle | Q28586493 |
| | Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes | Q29614548 |
| | Cellular mechanisms of insulin resistance | Q29619549 |
| | Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity | Q33834971 |
| | Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions | Q33863886 |
| | Fuel selection in human skeletal muscle in insulin resistance: a reexamination | Q33975119 |
| | De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway | Q34128457 |
| | Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism | Q34202240 |
| | Regulation of de novo sphingolipid biosynthesis and the toxic consequences of its disruption | Q34439648 |
| | Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus | Q34669998 |
| | The sphingomyelin-signaling pathway in skeletal muscles and its role in regulation of glucose uptake. | Q34702064 |
| | The therapeutic potential of modulating the ceramide/sphingomyelin pathway | Q34717833 |
| | Triglyceride accumulation protects against fatty acid-induced lipotoxicity | Q34866329 |
| | Enhanced insulin sensitivity in mice lacking ganglioside GM3. | Q34870497 |
| | Insulin resistance and chronic cardiovascular inflammatory syndrome | Q35146311 |
| | Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance. | Q35785726 |
| | Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid-induced insulin resistance | Q35785732 |
| | Muscle adaptation to short-term fasting in healthy lean humans | Q46656854 |
| | Effect of gender on lipid-induced insulin resistance in obese subjects | Q46827224 |
| | Ciliary neurotrophic factor prevents acute lipid-induced insulin resistance by attenuating ceramide accumulation and phosphorylation of c-Jun N-terminal kinase in peripheral tissues | Q46882472 |
| | Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content | Q46933158 |
| | Effects of pioglitazone and high-fat diet on ceramide metabolism in rat skeletal muscles. | Q50708121 |
| | Fatty acid-induced defects in insulin signalling, in myotubes derived from children, are related to ceramide production from palmitate rather than the accumulation of intramyocellular lipid. | Q50708945 |
| | Gender-related differences in the metabolic response to fasting. | Q51469590 |
| | A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism. | Q51562671 |
| | Skeletal muscle triglyceride levels are inversely related to insulin action. | Q51575343 |
| | Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects. | Q54095921 |
| | Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: problems and prospects. | Q54126871 |
| | Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents. | Q55033199 |
| | Conjugated linoleic acid increases skeletal muscle ceramide content and decreases insulin sensitivity in overweight, non-diabetic humans | Q63805162 |
| | Key role for ceramides in mediating insulin resistance in human muscle cells | Q64377214 |
| | Ceramidase activity in porcine epidermis | Q68883188 |
| | A role for sphingolipids in producing the common features of type 2 diabetes, metabolic syndrome X, and Cushing's syndrome | Q36056351 |
| | Ceramide-1-phosphate: the "missing" link in eicosanoid biosynthesis and inflammation | Q36361048 |
| | Ceramides in insulin resistance and lipotoxicity | Q36381594 |
| | Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A. | Q36461897 |
| | Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism | Q36861002 |
| | Ceramide: a contributor to insulin resistance or an innocent bystander? | Q37155568 |
| | Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisited | Q37246314 |
| | Ganglioside GM3 participates in the pathological conditions of insulin resistance | Q38294772 |
| | Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle | Q38333897 |
| | Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide. | Q39575996 |
| | Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism. | Q39940319 |
| | CPT I overexpression protects L6E9 muscle cells from fatty acid-induced insulin resistance | Q40216131 |
| | Increased Akt protein expression is associated with decreased ceramide content in skeletal muscle of troglitazone-treated mice | Q40442066 |
| | Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling | Q40445604 |
| | TNFalpha-induced insulin resistance in adipocytes as a membrane microdomain disorder: involvement of ganglioside GM3. | Q40526304 |
| | Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B. | Q40541165 |
| | Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells | Q40546613 |
| | Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus | Q41019246 |
| | Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase | Q41197168 |
| | Dexamethasone Effect on the Phospholipid Content of Isolated Fat Cell Ghosts from Adrenalectomized Rats | Q41733159 |
| | Effects of cell-permeable ceramides and tumor necrosis factor-alpha on insulin signaling and glucose uptake in 3T3-L1 adipocytes | Q42449038 |
| | Ceramide content is increased in skeletal muscle from obese insulin-resistant humans | Q42454790 |
| | Effect of sphingoid bases on basal and insulin-stimulated 2-deoxyglucose transport in skeletal muscle | Q42456100 |
| | Reduced lipid oxidation in skeletal muscle from type 2 diabetic subjects may be of genetic origin: evidence from cultured myotubes | Q42457784 |
| | Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate | Q42476162 |
| | 1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo. | Q42481698 |
| | Type I Gaucher disease, a glycosphingolipid storage disorder, is associated with insulin resistance | Q42522752 |
| | 13C/31P NMR studies on the mechanism of insulin resistance in obesity | Q42544164 |
| | Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate | Q42556020 |
| | Inhibition of ceramide production reverses TNF-induced insulin resistance | Q42824895 |
| | Dexamethasone increases neutral sphingomyelinase activity and sphingosine levels in 3T3-L1 fibroblasts | Q42832975 |
| | Plasma free Fatty Acid uptake and oxidation are already diminished in subjects at high risk for developing type 2 diabetes | Q43778791 |
| | Unsaturated fatty acid-mediated decreases in sterol regulatory element-mediated gene transcription are linked to cellular sphingolipid metabolism | Q43798531 |
| | Ceramides and sphingomyelins in skeletal muscles of the rat: content and composition. Effect of prolonged exercise. | Q43852581 |
| | Fatty acid-induced insulin resistance: decreased muscle PI3K activation but unchanged Akt phosphorylation | Q43852976 |
| | Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle | Q43990155 |
| | Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha | Q44043178 |
| | Effect of acute exercise on the content of free sphinganine and sphingosine in different skeletal muscle types of the rat. | Q44183246 |
| | Involvement of sphingosine in dexamethasone-induced thymocyte apoptosis | Q44251664 |
| | A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids | Q44276635 |
| | 1,2-Diacylglycerols but not phorbol esters stimulate sphingomyelin hydrolysis in GH3 pituitary cells | Q44693718 |
| | Effect of streptozotocin-diabetes on the functioning of the sphingomyelin-signalling pathway in skeletal muscles of the rat. | Q44776221 |
| | Exercise and training effects on ceramide metabolism in human skeletal muscle. | Q44861257 |
| | Relationship between insulin sensitivity and sphingomyelin signaling pathway in human skeletal muscle | Q44865479 |
| | Rosiglitazone enhances glucose tolerance by mechanisms other than reduction of fatty acid accumulation within skeletal muscle | Q45064070 |
| | Concentrations of sphingosine and sphinganine in plasma of patients with type 2 diabetes. | Q45197957 |
| | Thiazolidinediones enhance skeletal muscle triacylglycerol synthesis while protecting against fatty acid-induced inflammation and insulin resistance | Q46265499 |
| | Dose-response effect of elevated plasma free fatty acid on insulin signaling | Q46513253 |
| | Human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity. | Q46610480 |
| P433 | issue | 1 | |
| P921 | main subject | sphingolipids | Q410395 |
| | insulin resistance | Q1053470 |
| | preproinsulin | Q7240673 |
| P304 | page(s) | 13-24 | |
| P577 | publication date | 2008-05-10 | |
| P1433 | published in | The review of diabetic studies : RDS | Q26853988 |
| P1476 | title | The role of skeletal muscle sphingolipids in the development of insulin resistance | |
| P478 | volume | 5 | |