Protective role of p53 in skin cancer: Carcinogenesis studies in mice lacking epidermal p53.

scientific article published on 03 March 2016

Protective role of p53 in skin cancer: Carcinogenesis studies in mice lacking epidermal p53. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.7897
P932PMC publication ID4991500
P698PubMed publication ID26959115

P50authorM. Llanos CasanovaQ73004131
Angustias PageQ42353148
Jesus M. ParamioQ43100805
Angel RamirezQ43127788
Manuel NavarroQ47159759
P2093author name stringAna Bravo
Josefa P Alameda
Cristian Suarez-Cabrera
P2860cites workHallmarks of Cancer: The Next GenerationQ22252312
p19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathwaysQ24799059
Sequences 5' of the bovine keratin 5 gene direct tissue- and cell-type-specific expression of a lacZ gene in the adult and during developmentQ28287453
Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.Q52544495
Evidence for nonautonomous effect of p53 tumor suppressor in carcinogenesis.Q53360026
Tumor surveillance via the ARF-p53 pathway.Q53430438
Induction of squamous cell carcinoma in p53-deficient mice after ultraviolet irradiation.Q53438471
Paradoxical tumor inhibitory effect of p53 loss in transgenic mice expressing epidermal-targeted v-rasHa, v-fos, or human transforming growth factor alpha.Q53451031
p53 gene dosage modifies growth and malignant progression of keratinocytes expressing the v-rasHa oncogene.Q53469072
Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.Q53478233
Spontaneous Squamous Cell Carcinoma Induced by the Somatic Inactivation of Retinoblastoma and Trp53 Tumor SuppressorsQ63884137
Genetic background alters the spectrum of tumors that develop in p53-deficient miceQ72864214
Inactivation of p53 in Human Keratinocytes Leads to Squamous Differentiation and Shedding via Replication Stress and Mitotic SlippageQ86121762
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumoursQ29547697
GammaH2AX and cancerQ29614974
Cancer. p53, guardian of the genomeQ29615610
p53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state.Q34060903
Inappropriate p53 activation during development induces features of CHARGE syndromeQ34315506
p53 status in stromal fibroblasts modulates tumor growth in an SDF1-dependent manner.Q34393678
Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53Q34487653
Identifying the cellular origin of squamous skin tumorsQ34938312
Loss of epithelial p53 and αv integrin cooperate through Akt to induce squamous cell carcinoma yet prevent remodeling of the tumor microenvironmentQ35002203
TP53 mutations in human skin cancers.Q35078728
Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors.Q35081777
Dicer cooperates with p53 to suppress DNA damage and skin carcinogenesis in miceQ35198355
p53 and the pathogenesis of skin cancerQ36149069
Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- miceQ36455201
New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53-/- mice by delaying carcinogenesisQ36455205
Embryonic stem cells shed new light on the developmental roles of p53.Q37367149
When mutants gain new powers: news from the mutant p53 field.Q37582777
The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 proteinQ37732831
The mutant p53 mouse as a pre-clinical modelQ38074014
Mutant p53 in cancer: new functions and therapeutic opportunitiesQ38197826
Unravelling mechanisms of p53-mediated tumour suppressionQ38205099
Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinomaQ38985425
Role of stat3 in skin carcinogenesis: insights gained from relevant mouse modelsQ39658067
An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutationsQ40198133
Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellumQ40442891
The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis--thirty-third G. H. A. Clowes Memorial Award Lecture.Q40720266
Epidermal Snail expression drives skin cancer initiation and progression through enhanced cytoprotection, epidermal stem/progenitor cell expansion and enhanced metastatic potentialQ41870134
PTEN ablation in Ras(Ha)/Fos skin carcinogenesis invokes p53-dependent p21 to delay conversion while p53-independent p21 limits progression via cyclin D1/E2 inhibition.Q42444812
Deregulated activity of Akt in epithelial basal cells induces spontaneous tumors and heightened sensitivity to skin carcinogenesisQ42521538
Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescenceQ43120565
p53 regulates Stat3 phosphorylation and DNA binding activity in human prostate cancer cells expressing constitutively active Stat3.Q44040215
Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumorsQ44287540
Cell-type, dose, and mutation-type specificity dictate mutant p53 functions in vivoQ44356808
Spontaneous tumor formation in Trp53-deficient epidermis mediated by chromosomal instability and inflammationQ46208058
P433issue15
P407language of work or nameEnglishQ1860
P921main subjectskin cancerQ192102
carcinogenesisQ1637543
P304page(s)20902-20918
P577publication date2016-04-01
P1433published inOncotargetQ1573155
P1476titleProtective role of p53 in skin cancer: Carcinogenesis studies in mice lacking epidermal p53
P478volume7

Reverse relations

cites work (P2860)
Q55054189Cutaneous Papillomaviruses and Non-melanoma Skin Cancer: Causal Agents or Innocent Bystanders?
Q88111934Epidermal FABP Prevents Chemical-Induced Skin Tumorigenesis by Regulation of TPA-Induced IFN/p53/SOX2 Pathway in Keratinocytes
Q92406820IKKβ overexpression together with a lack of tumour suppressor genes causes ameloblastic odontomas in mice
Q47098228The interplay of UV and cutaneous papillomavirus infection in skin cancer development
Q58695408Time-Series Analysis of Tumorigenesis in a Murine Skin Carcinogenesis Model

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