Targeted Agents for HER2-Positive Breast Cancer: Optimal Use in Older Patients

scientific article published on 08 December 2015

Targeted Agents for HER2-Positive Breast Cancer: Optimal Use in Older Patients is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S40266-015-0326-1
P932PMC publication ID4991772
P698PubMed publication ID26645293

P50authorStuart M LichtmanQ56984320
P2093author name stringJasmeet Chadha Singh
P2860cites workHigh risk of recurrence for patients with breast cancer who have human epidermal growth factor receptor 2-positive, node-negative tumors 1 cm or smallerQ24641848
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.Q27824766
Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study groupQ27824835
Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancerQ27824847
Lapatinib plus capecitabine for HER2-positive advanced breast cancerQ27851403
Trastuzumab emtansine for HER2-positive advanced breast cancerQ27851917
Trastuzumab emtansine versus treatment of physician's choice for pretreated HER2-positive advanced breast cancer (TH3RESA): a randomised, open-label, phase 3 trialQ27853001
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogeneQ27860693
Cardiac dysfunction in the trastuzumab clinical trials experienceQ28204298
The effect of dexrazoxane on myocardial injury in doxorubicin-treated children with acute lymphoblastic leukemiaQ28271441
Pertuzumab plus trastuzumab in combination with standard neoadjuvant anthracycline-containing and anthracycline-free chemotherapy regimens in patients with HER2-positive early breast cancer: a randomized phase II cardiac safety study (TRYPHAENA)Q28291395
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancerQ29547699
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancerQ29616112
Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancerQ29617440
US incidence of breast cancer subtypes defined by joint hormone receptor and HER2 statusQ30665329
Overview of breast cancer collaborative stage data items--their definitions, quality, usage, and clinical implications: a review of SEER data for 2004-2010.Q30870747
Adjuvant trastuzumab in the treatment of her-2-positive early breast cancer: a meta-analysis of published randomized trialsQ33293618
Pooled analysis of cardiac safety in patients with cancer treated with pertuzumabQ33930241
Rationale for trastuzumab (Herceptin) in adjuvant breast cancer trialsQ34218132
Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complexQ34314489
Age-specific changes in intrinsic breast cancer subtypes: a focus on older womenQ34359310
Trastuzumab plus adjuvant chemotherapy for human epidermal growth factor receptor 2-positive breast cancer: planned joint analysis of overall survival from NSABP B-31 and NCCTG N9831.Q34484185
Adjuvant paclitaxel and trastuzumab for node-negative, HER2-positive breast cancerQ35038093
Phase I/II study of trastuzumab in combination with everolimus (RAD001) in patients with HER2-overexpressing metastatic breast cancer who progressed on trastuzumab-based therapy.Q35170258
The cardiotoxicity of chemotherapeutic drugsQ35426013
Trastuzumab and cardiac dysfunction: update on preclinical studiesQ35581800
Adjuvant trastuzumab in HER2-positive breast cancerQ35710898
Continuous Trastuzumab Therapy in Breast Cancer Patients With Asymptomatic Left Ventricular DysfunctionQ36116313
ErbB2 overexpression upregulates antioxidant enzymes, reduces basal levels of reactive oxygen species, and protects against doxorubicin cardiotoxicity.Q36339400
Seven-year follow-up assessment of cardiac function in NSABP B-31, a randomized trial comparing doxorubicin and cyclophosphamide followed by paclitaxel (ACP) with ACP plus trastuzumab as adjuvant therapy for patients with node-positive, human epiderQ36339698
Cardiac toxicity of trastuzumab-related regimens in HER2-overexpressing breast cancerQ36860669
Trastuzumab-related cardiotoxicity in early breast cancer: a cohort studyQ37038459
Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapyQ37163797
Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeuticsQ37203741
Cardiac toxicity of ErbB2-targeted therapies: what do we know?Q37263119
Trastuzumab-related cardiotoxicity among older patients with breast cancerQ37289617
Treatment of older patients with HER2-positive metastatic breast cancer with pertuzumab, trastuzumab, and docetaxel: subgroup analyses from a randomized, double-blind, placebo-controlled phase III trial (CLEOPATRA).Q37301426
Population-based estimate of the prevalence of HER-2 positive breast cancer tumors for early stage patients in the USQ37390917
Lapatinib plus Capecitabine for HER2-Positive Advanced-Stage Breast Cancer in Elderly Women: Review of the Anatolian Society of Medical Oncology (ASMO) ExperienceQ37677684
CLEOPATRA: a phase III evaluation of pertuzumab and trastuzumab for HER2-positive metastatic breast cancerQ37819435
Adjuvant trastuzumab in elderly with HER-2 positive breast cancer: a systematic review of randomized controlled trials.Q38006133
Cardiotoxicity of novel HER2-targeted therapies.Q38108380
Early and delayed clinical cardiotoxicity of doxorubicinQ42225832
Reduced cardiotoxicity of doxorubicin delivered on a weekly schedule. Assessment by endomyocardial biopsyQ42254236
Trastuzumab-associated cardiac adverse effects in the herceptin adjuvant trial.Q42626922
Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): survival outcomes of a randomised, open-label, multicentre, phase 3 trial and their association with pathological complete responseQ42677733
Phase I Study of Everolimus Plus Weekly Paclitaxel and Trastuzumab in Patients With Metastatic Breast Cancer Pretreated With TrastuzumabQ42848146
The lack of target specificity of small molecule anticancer kinase inhibitors is correlated with their ability to damage myocytes in vitroQ42910592
Fluorouracil, epirubicin, and cyclophosphamide with either docetaxel or vinorelbine, with or without trastuzumab, as adjuvant treatments of breast cancer: final results of the FinHer TrialQ43250043
6 months versus 12 months of adjuvant trastuzumab for patients with HER2-positive early breast cancer (PHARE): a randomised phase 3 trial.Q43784378
Phase II study of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancerQ43937165
Trastuzumab and vinorelbine as first-line therapy for HER2-overexpressing metastatic breast cancer: multicenter phase II trial with clinical outcomes, analysis of serum tumor markers as predictive factors, and cardiac surveillance algorithmQ44529239
The risk of toxicities from trastuzumab, alone or in combination, in an elderly breast cancer populationQ46659743
2 years versus 1 year of adjuvant trastuzumab for HER2-positive breast cancer (HERA): an open-label, randomised controlled trialQ47973074
Treatment with trastuzumab for 1 year after adjuvant chemotherapy in patients with HER2-positive early breast cancer: a 4-year follow-up of a randomised controlled trial.Q53158182
Prognostic importance of c-erbB-2 expression in breast cancer. International (Ludwig) Breast Cancer Study Group.Q53394493
Trastuzumab-associated cardiac events at 8 years of median follow-up in the Herceptin Adjuvant trial (BIG 1-01).Q54346018
Safety and efficacy of everolimus with exemestane vs. exemestane alone in elderly patients with HER2-negative, hormone receptor-positive breast cancer in BOLERO-2.Q54394851
Phase I trial of oral mTOR inhibitor everolimus in combination with trastuzumab and vinorelbine in pre-treated patients with HER2-overexpressing metastatic breast cancerQ59567546
Assessment of Cardiac Dysfunction in a Randomized Trial Comparing Doxorubicin and Cyclophosphamide Followed by Paclitaxel, With or Without Trastuzumab As Adjuvant Therapy in Node-Positive, Human Epidermal Growth Factor Receptor 2–Overexpressing BreQ61624905
Cardiac side effects of trastuzumab: lessons learned from targeting cancer pathwaysQ79888325
Long-term cardiac tolerability of trastuzumab in metastatic breast cancer: the M.D. Anderson Cancer Center experienceQ80112164
Reversibility of trastuzumab-related cardiotoxicity: new insights based on clinical course and response to medical treatmentQ81419131
Everolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (BOLERO-3): a randomised, double-blind, placebo-controlled phase 3 trialQ87702640
P433issue12
P304page(s)975-982
P577publication date2015-12-08
P1433published inDrugs & AgingQ5308946
P1476titleTargeted Agents for HER2-Positive Breast Cancer: Optimal Use in Older Patients
P478volume32

Search more.