Berberine reverses free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKbeta

scientific article published on February 2008

Berberine reverses free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKbeta is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3748/WJG.14.876
P932PMC publication ID2687054
P698PubMed publication ID18240344

P2093author name stringHui Dong
Guang Chen
Li-Jun Xu
Ping Yi
Fu-Er Lu
Kai-Fu Wang
P2860cites workIKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB ActivationQ24321727
Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylationQ28140878
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of IkkbetaQ28188643
Protective effects of Huanglian Jiedu decoction on vascular endothelial function in type 2 diabetic ratsQ28194954
Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinasesQ28195772
Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin actionQ28199220
Prevention of fat-induced insulin resistance by salicylateQ28345600
Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretionQ28578447
Heterozygosity with respect to Zfp148 causes complete loss of fetal germ cells during mouse embryogenesisQ28585214
NF-kappaB: a key role in inflammatory diseasesQ29617726
A central role for JNK in obesity and insulin resistanceQ29619778
The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosisQ36368249
The importance of free fatty acids in the development of Type 2 diabetes.Q36921672
Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1Q39677505
Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant statesQ40250572
Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytesQ40555990
c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascadeQ40692121
Effects of berberine on glucose metabolism in vitroQ40693802
Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.Q40701074
Cross-talk mechanisms in the development of insulin resistance of skeletal muscle cells palmitate rather than tumour necrosis factor inhibits insulin-dependent protein kinase B (PKB)/Akt stimulation and glucose uptakeQ42479373
High glucose and glucosamine induce insulin resistance via different mechanisms in 3T3-L1 adipocytesQ42489573
Stimulation of glucose transport by thyroid hormone in 3T3-L1 adipocytes: increased abundance of GLUT1 and GLUT4 glucose transporter proteinsQ42805864
Insulin sensitizing and insulinotropic action of berberine from Cortidis rhizomaQ42811484
Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2.Q42825786
Fatty acid-induced insulin resistance in adipocytesQ42835299
Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylationQ44268162
Salicylate prevents hepatic insulin resistance caused by short-term elevation of free fatty acids in vivoQ46939071
Effects of huanglian jiedu decoction on signal transduction of insulin receptor and insulin receptor substrate in adipose tissue of insulin resistant ratsQ51485006
Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathwayQ52828725
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectpreproinsulinQ7240673
adipocyteQ357519
insulin resistanceQ1053470
fatty acidQ61476
P304page(s)876-883
P577publication date2008-02-01
P1433published inWorld Journal of GastroenterologyQ15708885
P1476titleBerberine reverses free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKbeta
P478volume14

Reverse relations

cites work (P2860)
Q362083944-Hydroxyisoleucine ameliorates an insulin resistant-like state in 3T3-L1 adipocytes by regulating TACE/TIMP3 expression
Q28282643Advance of studies on anti-atherosclerosis mechanism of berberine
Q38012073Antidiabetic Properties of Berberine: From Cellular Pharmacology to Clinical Effects
Q35145862Antioxidant and anti-inflammatory activities of berberine in the treatment of diabetes mellitus
Q59796170Barberry in the treatment of obesity and metabolic syndrome: possible mechanisms of action
Q58587589Berberine Attenuated Proliferation, Invasion and Migration by Targeting the AMPK/HNF4α/WNT5A Pathway in Gastric Carcinoma
Q39547455Berberine acutely activates the glucose transport activity of GLUT1
Q38965186Berberine and Its Role in Chronic Disease
Q98281109Berberine improves intralipid-induced insulin resistance in murine
Q36405309Berberine in Combination with Insulin Has Additive Effects on Titanium Implants Osseointegration in Diabetes Mellitus Rats
Q38025153Berberine on metabolic and cardiovascular risk factors: an analysis from preclinical evidences to clinical trials
Q37728794Berberine reduces endoplasmic reticulum stress and improves insulin signal transduction in Hep G2 cells
Q51537680Berberine relieves insulin resistance via the cholinergic anti-inflammatory pathway in HepG2 cells
Q38335523Berberine-Improved Visceral White Adipose Tissue Insulin Resistance Associated with Altered Sterol Regulatory Element-Binding Proteins, Liver X Receptors, and Peroxisome Proliferator-Activated Receptors Transcriptional Programs in Diabetic Hamsters
Q58755932Effects of Vaspin on Insulin Resistance in Rats and Underlying Mechanisms
Q34368848Effects of berberine and red yeast on proinflammatory cytokines IL-6 and TNF-α in peripheral blood mononuclear cells (PBMCs) of human subjects
Q41841136Effects of berberine on amelioration of hyperglycemia and oxidative stress in high glucose and high fat diet-induced diabetic hamsters in vivo
Q38901054Effects of er-miao-san extracts on TNF-alpha-induced MMP-1 expression in human dermal fibroblasts
Q59337043Fibroblast growth factor-1 as a mediator of paracrine effects of canine adipose tissue-derived mesenchymal stem cells on in vitro-induced insulin resistance models
Q85015724Metformin regulates hepatic lipid metabolism through activating AMP-activated protein kinase and inducing ATGL in laying hens
Q37151820Oxidized LDL impair adipocyte response to insulin by activating serine/threonine kinases.
Q64354593The Pathogenesis of Diabetes Mellitus by Oxidative Stress and Inflammation: Its Inhibition by Berberine
Q26851917The antihyperglycemic effects of Rhizoma Coptidis and mechanism of actions: a review of systematic reviews and pharmacological research
Q37036239The characterization of high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model
Q34671018Yi-Qi-Zeng-Min-Tang, a Chinese medicine, ameliorates insulin resistance in type 2 diabetic rats
Q37369567α-Linolenic acid suppresses cholesterol and triacylglycerol biosynthesis pathway by suppressing SREBP-2, SREBP-1a and -1c expression

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