Increased expression of fatty acid synthase and acetyl-CoA carboxylase in the prefrontal cortex and cerebellum in the valproic acid model of autism

scientific article published on 05 July 2016

Increased expression of fatty acid synthase and acetyl-CoA carboxylase in the prefrontal cortex and cerebellum in the valproic acid model of autism is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3892/ETM.2016.3508
P932PMC publication ID4998172
P698PubMed publication ID27602061

P2093author name stringYasong Du
Wei Wu
Min Zhao
Xiaohong Li
Shunying Yu
Jijun Li
Yingmei Fu
Donghong Cui
Jianling Chen
P2860cites workThe SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiativeQ24620663
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2Q28209958
Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorderQ30534798
Valproic acid in pregnancy: how much are we endangering the embryo and fetus?Q34984538
Breastfeeding, infant formula supplementation, and Autistic Disorder: the results of a parent surveyQ35052232
Autistic children exhibit decreased levels of essential Fatty acids in red blood cellsQ35723146
Critical phosphorylation sites for acetyl-CoA carboxylase activity.Q36722109
Developmental profiles of lipogenic enzymes and their regulators in the neonatal mouse brainQ37352030
Valproic acid is a novel activator of AMP-activated protein kinase and decreases liver mass, hepatic fat accumulation, and serum glucose in obese miceQ37405427
Mitochondrial dysfunction in autismQ37558748
Microscopic neuroanatomic abnormalities in autismQ37703177
Alterations of neocortical development and maturation in autism: insight from valproic acid exposure and animal models of autismQ38042500
Dysregulation of the IGF-I/PI3K/AKT/mTOR signaling pathway in autism spectrum disordersQ38198830
Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells.Q38949147
Lapatinib alters the malignant phenotype of osteosarcoma cells via downregulation of the activity of the HER2-PI3K/AKT-FASN axis in vitroQ39068761
The ketogenic diet modifies social and metabolic alterations identified in the prenatal valproic acid model of autism spectrum disorderQ39161646
Globular adiponectin regulates energy homeostasis through AMP-activated protein kinase-acetyl-CoA carboxylase (AMPK/ACC) pathway in the hypothalamusQ39681057
Interaction between fatty acid synthase- and ErbB-systems in ovarian cancer cellsQ39847467
Linking etiologies in humans and animal models: studies of autismQ41429994
Altered brain phospholipid and acylcarnitine profiles in propionic acid infused rodents: further development of a potential model of autism spectrum disordersQ43092496
Up-regulation of Ras/Raf/ERK1/2 signaling impairs cultured neuronal cell migration, neurogenesis, synapse formation, and dendritic spine developmentQ43538904
Gestational, pathologic and biochemical differences between very long-chain acyl-CoA dehydrogenase deficiency and long-chain acyl-CoA dehydrogenase deficiency in the mouseQ43758997
Up-regulation of Ras/Raf/ERK1/2 signaling in the spinal cord impairs neural cell migration, neurogenesis, synapse formation, and dendritic spine developmentQ44769281
Is autism a disorder of fatty acid metabolism? Possible dysfunction of mitochondrial beta-oxidation by long chain acyl-CoA dehydrogenaseQ44895596
Behavioral alterations in rats prenatally exposed to valproic acid: animal model of autismQ44967603
Ketogenic diet attenuates kainic acid-induced hippocampal cell death by decreasing AMPK/ACC pathway activity and HSP70.Q46018201
Role of polyunsaturated fatty acids in the management of Egyptian children with autismQ46517246
Study of the serum levels of polyunsaturated fatty acids and the expression of related liver metabolic enzymes in a rat valproate-induced autism modelQ47656666
The 16p11.2 deletion mouse model of autism exhibits altered cortical progenitor proliferation and brain cytoarchitecture linked to the ERK MAPK pathway.Q47675041
Brain acetyl-CoA carboxylase: isozymic identification and studies of its regulation during development and altered nutritionQ48301041
Class I histone deacetylase inhibition ameliorates social cognition and cell adhesion molecule plasticity deficits in a rodent model of autism spectrum disorderQ48478335
Long-chain acyl-CoA dehydrogenase is a key enzyme in the mitochondrial beta-oxidation of unsaturated fatty acidsQ73835660
P433issue3
P921main subjectautismQ38404
fatty acidQ61476
P304page(s)1293-1298
P577publication date2016-07-05
P1433published inExperimental and Therapeutic MedicineQ23979083
P1476titleIncreased expression of fatty acid synthase and acetyl-CoA carboxylase in the prefrontal cortex and cerebellum in the valproic acid model of autism
P478volume12

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cites work (P2860)
Q93038010Prenatal metformin exposure or organic cation transporter 3 knock-out curbs social interaction preference in male mice
Q90729288Sensitivity to gene dosage and gene expression affects genes with copy number variants observed among neuropsychiatric diseases

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