Pertuzumab for the treatment of patients with previously untreated HER2-positive metastatic breast cancer

scientific article

Pertuzumab for the treatment of patients with previously untreated HER2-positive metastatic breast cancer is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1358/DOT.2012.48.11.1885879
P932PMC publication ID3786342
P698PubMed publication ID23170307

P2093author name stringM B Smith
J Reardon
E M Olson
P2860cites workPhase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapyQ37163797
Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor modelsQ39771295
Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer.Q40001571
The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells.Q40571024
Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growthQ44120544
Rationale for fixed dosing of pertuzumab in cancer patients based on population pharmacokinetic analysisQ46242920
A phase I study of the safety and pharmacokinetics of the combination of pertuzumab (rhuMab 2C4) and capecitabine in patients with advanced solid tumorsQ46616115
Drug interaction potential of trastuzumab emtansine (T-DM1) combined with pertuzumab in patients with HER2-positive metastatic breast cancerQ47943905
Maximizing human epidermal growth factor receptor 2 inhibition: a new oncologic paradigm in the era of targeted therapy.Q54525291
Pertuzumab monotherapy after trastuzumab-based treatment and subsequent reintroduction of trastuzumab: activity and tolerability in patients with advanced human epidermal growth factor receptor 2-positive breast cancer.Q54525297
Identification of the sites of IgG catabolism in the ratQ70391543
Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumabQ81190157
Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancerQ81378656
Trastuzumab beyond progression in human epidermal growth factor receptor 2-positive advanced breast cancer: a german breast group 26/breast international group 03-05 study.Q27851468
Randomized study of Lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancerQ27851549
Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancerQ27851691
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogeneQ27860693
Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trialQ28254919
Open-label, phase II, multicenter, randomized study of the efficacy and safety of two dose levels of Pertuzumab, a human epidermal growth factor receptor 2 dimerization inhibitor, in patients with human epidermal growth factor receptor 2-negative meQ30376023
Prognosis of women with metastatic breast cancer by HER2 status and trastuzumab treatment: an institutional-based reviewQ33561966
The EGF receptor family as targets for cancer therapyQ34293543
Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complexQ34314489
The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunitiesQ34399306
Dose scheduling--HerceptinQ34428758
Cardiac toxicity and efficacy of trastuzumab combined with pertuzumab in patients with [corrected] human epidermal growth factor receptor 2-positive metastatic breast cancerQ34775370
Inhibition of vascular endothelial growth factor in the treatment of colorectal cancerQ35152539
Lapatinib plus capecitabine in women with HER-2-positive advanced breast cancer: final survival analysis of a phase III randomized trialQ35584284
Growth factors and cancerQ36441643
A phase Ib study of pertuzumab, a recombinant humanised antibody to HER2, and docetaxel in patients with advanced solid tumoursQ36610615
Phase I and pharmacokinetic study of HER2-targeted rhuMAb 2C4 (Pertuzumab, RO4368451) in Japanese patients with solid tumorsQ37140621
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectmetastatic breast cancerQ12859063
pertuzumabQ1998021
P1104number of pages10
P304page(s)713-722
P577publication date2012-11-01
P1433published inDrugs of TodayQ15751956
P1476titlePertuzumab for the treatment of patients with previously untreated HER2-positive metastatic breast cancer
P478volume48

Reverse relations

Q52578959Current Therapies for Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer Patients.cites workP2860

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