Molecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies.

scientific article published on 04 July 2008

Molecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/S00535-008-2180-Y
P698PubMed publication ID18600385
P5875ResearchGate publication ID5251704

P50authorJingting LiQ56754375
P2093author name stringHui Wang
Dan Xu
Jie Ping
Zhang-Xiu Liao
P2860cites workDiscoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagenQ28205871
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The bone marrow functionally contributes to liver fibrosis.Q51805517
A Germline DNA Polymorphism Enhances Alternative Splicing of theKLF6Tumor Suppressor Gene and Is Associated with Increased Prostate Cancer RiskQ57540252
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Fibrotic disease and the T(H)1/T(H)2 paradigmQ35852270
Immunomodulation of activated hepatic stellate cells by mesenchymal stem cellsQ36174278
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Leptin in the field of hepatic fibrosis: a pivotal or an incidental player?Q36587716
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Expression of Smads during in vitro transdifferentiation of hepatic stellate cells to myofibroblastsQ38301076
Regulation of alpha1(I) collagen messenger RNA decay by interactions with alphaCP at the 3'-untranslated regionQ38344613
Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitorsQ39807542
Posttranscriptional regulation of collagen alpha1(I) mRNA in hepatic stellate cellsQ40023264
Pentoxifylline downregulates alpha (I) collagen expression by the inhibition of Ikappabalpha degradation in liver stellate cellsQ40064031
Leptin stimulates alpha1(I) collagen expression in human hepatic stellate cells via the phosphatidylinositol 3-kinase/Akt signalling pathwayQ40071517
Proteasome inhibition induces hepatic stellate cell apoptosisQ40324324
Effect of IL-4 and IL-13 on collagen production in cultured LI90 human hepatic stellate cellsQ40444779
Cytokines and cellular crosstalk involved in the activation of fat-storing cellsQ40477129
Collagenases and liver fibrosisQ40477146
How can transforming growth factor beta be targeted usefully to combat liver fibrosis?Q40518301
The future of GI and liver research: editorial perspectives. III. JNK/AP-1 regulation of hepatocyte deathQ40589728
Apoptotic body engulfment by a human stellate cell line is profibrogenic.Q40647924
Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P450 2E1-derived reactive oxygen speciesQ40757681
Upstream tissue inhibitor of metalloproteinases-1 (TIMP-1) element-1, a novel and essential regulatory DNA motif in the human TIMP-1 gene promoter, directly interacts with a 30-kDa nuclear protein.Q40897756
Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.Q40902696
Stimulation of hepatic lipocyte collagen production by Kupffer cell-derived transforming growth factor beta: implication for a pathogenetic role in alcoholic liver fibrogenesisQ41228197
Peroxisome proliferator-activated receptors and hepatic stellate cell activationQ41758990
Transforming growth factors (TGF alpha and TGF beta 1) stimulate chondroitin sulfate and hyaluronate synthesis in cultured rat liver fat storing cellsQ42005914
Attenuated liver fibrosis in the absence of B cellsQ42018300
Selective targeting of pentoxifylline to hepatic stellate cells using a novel platinum-based linker technology.Q42805358
NF-kappaB inhibits expression of the alpha1(I) collagen gene.Q42809416
JunD regulates transcription of the tissue inhibitor of metalloproteinases-1 and interleukin-6 genes in activated hepatic stellate cellsQ43597895
Prevention of rat hepatic fibrosis by the protease inhibitor, camostat mesilate, via reduced generation of active TGF-betaQ43619440
Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in ratsQ43720079
TAK1/JNK and p38 have opposite effects on rat hepatic stellate cellsQ43779218
Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition: implications for reversibility of liver fibrosisQ43858122
Activation of peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growthQ44378715
Protective effect of IGF-1 on experimental liver cirrhosis-induced common bile duct ligation.Q44706857
Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cellsQ44710999
Systemic infusion of FLK1(+) mesenchymal stem cells ameliorate carbon tetrachloride-induced liver fibrosis in miceQ44981280
Therapeutic efficacy of an angiotensin II receptor antagonist in patients with nonalcoholic steatohepatitisQ45070082
Cirrhotic rat livers with extensive fibrosis can be safely transduced with clinical-grade adenoviral vectors. Evidence of cirrhosis reversionQ45158832
Imatinib mesylate (STI-571) attenuates liver fibrosis development in rats.Q45200719
Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis.Q45212249
In pursuit of the "Holy Grail"--stem cells, hepatic injury, fibrogenesis and repairQ45250495
Urokinase-type plasminogen activator gene therapy in liver cirrhosis is mediated by collagens gene expression down-regulation and up-regulation of MMPs, HGF and VEGF.Q45862339
Rat hepatic stellate cells produce cytokine-induced neutrophil chemoattractant in culture and in vivoQ46195186
Targeted inhibition of the KLF6 splice variant, KLF6 SV1, suppresses prostate cancer cell growth and spread.Q46581129
Rat hepatic stellate cells become retinoid unresponsive during activationQ46777616
SMAD and p38 MAPK signaling pathways independently regulate alpha1(I) collagen gene expression in unstimulated and transforming growth factor-beta-stimulated hepatic stellate cells.Q50781080
P433issue6
P304page(s)419-428
P577publication date2008-07-04
P1433published inJournal of GastroenterologyQ15764399
P1476titleMolecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies
P478volume43

Reverse relations

cites work (P2860)
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