Identification of direct tyrosine kinase substrates based on protein kinase assay-linked phosphoproteomics

scientific article published on 22 June 2013

Identification of direct tyrosine kinase substrates based on protein kinase assay-linked phosphoproteomics is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/MCP.O113.027722
P932PMC publication ID3790304
P698PubMed publication ID23793017

P50authorRobert L. GeahlenQ42692859
Liang XueQ60178829
P2093author name stringW Andy Tao
P2860cites workImmunoaffinity profiling of tyrosine phosphorylation in cancer cellsQ21735929
Structural basis for the recognition of c-Src by its inactivator CskQ24311447
LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activationQ24315021
The protein-tyrosine kinase Syk interacts with TRAF-interacting protein TRIP in breast epithelial cellsQ24317705
BLNK: a central linker protein in B cell activationQ24322718
MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substratesQ24322852
A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38deltaQ24535672
B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1Q24675505
Global, in vivo, and site-specific phosphorylation dynamics in signaling networksQ27864128
Syk-dependent phosphorylation of microtubules in activated B-lymphocytesQ28138928
Oncogenic kinase signallingQ28189493
Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosineQ28626542
Protein kinases--the major drug targets of the twenty-first century?Q29615339
A tissue-specific atlas of mouse protein phosphorylation and expressionQ29616549
Signaling--2000 and beyondQ29617413
Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiaeQ29618445
Activation of the Src-family tyrosine kinase Hck by SH3 domain displacementQ30014848
A motif-based profile scanning approach for genome-wide prediction of signaling pathwaysQ30168316
Catalytic specificity of phosphotyrosine kinases Blk, Lyn, c-Src and Syk as assessed by phage displayQ30176866
Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cellsQ30441486
Hitting the target: emerging technologies in the search for kinase substratesQ30719336
An iterative statistical approach to the identification of protein phosphorylation motifs from large-scale data setsQ31016283
Applications of one-bead one-compound combinatorial libraries and chemical microarrays in signal transduction researchQ31146586
Rapid ubiquitination of Syk following GPVI activation in plateletsQ33211646
Thrombin-induced tyrosine phosphorylation of HS1 in human platelets is sequentially catalyzed by Syk and Lyn tyrosine kinases and associated with the cellular migration of the proteinQ33292118
In-depth analyses of kinase-dependent tyrosine phosphoproteomes based on metal ion-functionalized soluble nanopolymersQ33609440
BLNK: connecting Syk and Btk to calcium signalsQ33830846
A semisynthetic epitope for kinase substrates.Q34100971
Early events in B cell activationQ34101385
Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeastQ34156122
Nuclear translocation of the Hsp70/Hsp90 organizing protein mSTI1 is regulated by cell cycle kinases.Q34293945
BLNK mediates Syk-dependent Btk activationQ34476463
Quantitative analysis of ERK2 interactions with substrate proteins: roles for kinase docking domains and activity in determining binding affinityQ34509259
Identification of c-Src tyrosine kinase substrates using mass spectrometry and peptide microarrays.Q34807910
Global proteomic assessment of the classical protein-tyrosine phosphatome and "Redoxome"Q35222996
Sensitive kinase assay linked with phosphoproteomics for identifying direct kinase substrates.Q35889476
Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substratesQ36102107
KESTREL: a powerful method for identifying the physiological substrates of protein kinasesQ36334959
Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates.Q36446309
The SYK tyrosine kinase: a crucial player in diverse biological functionsQ36662082
Absolute quantification of protein and post-translational modification abundance with stable isotope-labeled synthetic peptidesQ37078446
Syk and pTyr'd: Signaling through the B cell antigen receptorQ37237143
Quantitative phosphoproteomics identifies substrates and functional modules of Aurora and Polo-like kinase activities in mitotic cellsQ37254703
Identification of CDK2 substrates in human cell lysatesQ37384948
Mass spectrometry-based proteomics and network biologyQ37996108
Studies of a germinal centre B-cell expressed gene, GCET2, suggest its role as a membrane associated adapter protein.Q38619809
Quantitative phospho-proteomics to investigate the polo-like kinase 1-dependent phospho-proteomeQ39451744
QIKS--Quantitative identification of kinase substratesQ39729724
C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1.Q40285081
Selective ion tracing and MSn analysis of peptide digests from FSBA-treated kinases for the analysis of protein ATP-binding sites.Q40300733
Anti-sulfonylbenzoate antibodies as a tool for the detection of nucleotide-binding proteins for functional proteomics.Q40481414
Phosphorylation- and activation-independent association of the tyrosine kinase Syk and the tyrosine kinase substrates Cbl and Vav with tubulin in B-cellsQ40982657
Neurotransmitters drive combinatorial multistate postsynaptic density networks.Q41184685
A novel whole-cell lysate kinase assay identifies substrates of the p38 MAPK in differentiating myoblasts.Q42158457
Global identification of protein kinase substrates by protein microarray analysisQ42212790
Universal and confident phosphorylation site localization using phosphoRS.Q45927182
Searching for biomarkers of Aurora-A kinase activity: identification of in vitro substrates through a modified KESTREL approachQ46637118
A liquid chromatography/mass spectrometry-based method for the selection of ATP competitive kinase inhibitorsQ46644558
Identification of the catalytic subunit of an oligomeric casein kinase (G type). Affinity labeling of the nucleotide site using 5'-[p-(fluorosulfonyl)benzoyl]adenosineQ70900718
Quantitative proteomic analysis of chromatin-associated factorsQ73599437
A systematic MS-based approach for identifying in vitro substrates of PKA and PKG in rat uteriQ80468487
Quantitative analysis of protein phosphorylation on a system-wide scale by mass spectrometry-based proteomicsQ85195020
P433issue10
P304page(s)2969-2980
P577publication date2013-06-22
P1433published inMolecular & Cellular ProteomicsQ6895932
P1476titleIdentification of direct tyrosine kinase substrates based on protein kinase assay-linked phosphoproteomics
P478volume12

Reverse relations

cites work (P2860)
Q34604043Analytical challenges translating mass spectrometry-based phosphoproteomics from discovery to clinical applications
Q31117395Determinants of Macromolecular Specificity from Proteomics-Derived Peptide Substrate Data.
Q33993750Getting Syk: spleen tyrosine kinase as a therapeutic target.
Q48715855Identification of Plant Kinase Substrates Based on Kinase Assay-Linked Phosphoproteomics
Q34468439Identification of extracellular signal-regulated kinase 1 (ERK1) direct substrates using stable isotope labeled kinase assay-linked phosphoproteomics
Q27853177Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules.
Q51118716Phosphoproteomics analysis identifies novel candidate substrates of the non-receptor tyrosine kinase, SRMS
Q35417864Protein networks and activation of lymphocytes
Q38199160Proteomic analysis of phosphorylation in cancer
Q90589318Quantitative phosphoproteomic analysis identifies the potential therapeutic target EphA2 for overcoming sorafenib resistance in hepatocellular carcinoma cells
Q47672478Recent advances in phosphoproteomics and application to neurological diseases
Q26781752Recent findings and technological advances in phosphoproteomics for cells and tissues
Q92784359Reconstructing kinase network topologies from phosphoproteomics data reveals cancer-associated rewiring
Q38789563Revisiting protein kinase-substrate interactions: Toward therapeutic development
Q26751042Targeting Syk in Autoimmune Rheumatic Diseases
Q57463001falciparum cGMP-dependent protein kinase interacts with a subunit of the parasite proteasome

Search more.