MTT assays cannot be utilized to study the effects of STI571/Gleevec on the viability of solid tumor cell lines

scientific article published on 26 April 2009

MTT assays cannot be utilized to study the effects of STI571/Gleevec on the viability of solid tumor cell lines is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00280-009-1004-Y
P932PMC publication ID2693457
P698PubMed publication ID19396599
P5875ResearchGate publication ID24362217

P2093author name stringRina Plattner
Jonathan T Sims
P2860cites workThe Abl family kinases: mechanisms of regulation and signalingQ28206550
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cellsQ28277030
A critical assessment of the use of microculture tetrazolium assays to measure cell growth and functionQ28294689
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemiaQ29547900
c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGFQ30448769
Appraisal of the MTT-based assay as a useful tool for predicting drug chemosensitivity in leukemiaQ35635570
Abl tyrosine kinases are required for infection by Shigella flexneriQ39962325
Aggressive breast cancer cells are dependent on activated Abl kinases for proliferation, anchorage-independent growth and survivalQ40093521
MDA-MB-435 cells are derived from M14 melanoma cells--a loss for breast cancer, but a boon for melanoma researchQ40227151
Activation of Abl tyrosine kinases promotes invasion of aggressive breast cancer cellsQ40272815
Antiproliferative effect of STI571 on cultured human cutaneous melanoma-derived cell linesQ40299260
Substrates and inhibitors of efflux proteins interfere with the MTT assay in cells and may lead to underestimation of drug toxicity.Q40510631
Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reductionQ41549753
c-KIT-expressing Ewing tumour cells are insensitive to imatinib mesylate (STI571).Q44098317
Enhanced MTT-reducing activity under growth inhibition by resveratrol in CEM-C7H2 lymphocytic leukemia cellsQ44454475
Mechanism of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction.Q46066087
MCF-7 cell cycle arrested at G1 through ursolic acid, and increased reduction of tetrazolium salts.Q50754986
Genistein inhibits tumour cell growth in vitro but enhances mitochondrial reduction of tetrazolium salts: a further pitfall in the use of the MTT assay for evaluating cell growth and survival.Q50787150
A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1Q73161644
P433issue3
P304page(s)629-633
P577publication date2009-04-26
P1433published inCancer Chemotherapy and PharmacologyQ326137
P1476titleMTT assays cannot be utilized to study the effects of STI571/Gleevec on the viability of solid tumor cell lines
P478volume64

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cites work (P2860)
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