Loss of glial glutamate and aspartate transporter (excitatory amino acid transporter 1) causes locomotor hyperactivity and exaggerated responses to psychotomimetics: rescue by haloperidol and metabotropic glutamate 2/3 agonist

scientific article published on 12 June 2008

Loss of glial glutamate and aspartate transporter (excitatory amino acid transporter 1) causes locomotor hyperactivity and exaggerated responses to psychotomimetics: rescue by haloperidol and metabotropic glutamate 2/3 agonist is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BIOPSYCH.2008.05.001
P932PMC publication ID2696047
P698PubMed publication ID18550032
P5875ResearchGate publication ID5307094

P50authorMarkus HeiligQ42632514
P2093author name stringRose-Marie Karlsson
Andrew Holmes
Kohichi Tanaka
P2860cites workActivation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trialQ28244389
Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophreniaQ28274064
Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in ratsQ28280906
Activation of metabotropic glutamate 2/3 receptors reverses the effects of NMDA receptor hypofunction on prefrontal cortex unit activity in awake ratsQ28297687
Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant miceQ28508015
Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergenceQ29618819
Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responsesQ29618915
Pharmacology and functions of metabotropic glutamate receptorsQ29619150
Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamateQ29620128
Effects of ketamine and N-methyl-D-aspartate on glutamate and dopamine release in the rat prefrontal cortex: modulation by a group II selective metabotropic glutamate receptor agonist LY379268.Q33186255
Glutamate and schizophrenia: beyond the dopamine hypothesisQ33996803
NMDA receptor hypofunction produces opposite effects on prefrontal cortex interneurons and pyramidal neuronsQ34197064
NMDA receptor hypofunction produces concomitant firing rate potentiation and burst activity reduction in the prefrontal cortexQ34376159
Antipsychotic drugs reverse the disruption in prefrontal cortex function produced by NMDA receptor blockade with phencyclidine.Q35990236
Schizophrenia-relevant behavioral testing in rodent models: a uniquely human disorder?Q36517227
Modeling madness in mice: one piece at a timeQ36610374
Glutamate and monoamine transporters: new visions of form and functionQ36825439
Glutamate transporters: confining runaway excitation by shaping synaptic transmissionQ36995107
Variations in promoter activity reveal a differential expression and physiology of glutamate transporters by glia in the developing and mature CNS.Q40117295
Clozapine and haloperidol differently suppress the MK-801-increased glutamatergic and serotonergic transmission in the medial prefrontal cortex of the rat.Q42171479
Mice lacking the AMPA GluR1 receptor exhibit striatal hyperdopaminergia and 'schizophrenia-related' behaviorsQ42628411
Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disorders.Q48273349
Ketamine-induced exacerbation of psychotic symptoms and cognitive impairment in neuroleptic-free schizophrenics.Q51536942
P433issue9
P407language of work or nameEnglishQ1860
P921main subjecthaloperidolQ251347
P304page(s)810-814
P577publication date2008-06-12
P1433published inBiological PsychiatryQ4914961
P1476titleLoss of glial glutamate and aspartate transporter (excitatory amino acid transporter 1) causes locomotor hyperactivity and exaggerated responses to psychotomimetics: rescue by haloperidol and metabotropic glutamate 2/3 agonist
P478volume64

Reverse relations

cites work (P2860)
Q56355639A Glutamate Transporter EAAT1 Gene Variant Influences Amygdala Functional Connectivity in Bipolar Disorder
Q35749730Abnormal Astrocytosis in the Basal Ganglia Pathway of Git1(-/-) Mice
Q36609289Abnormal expression of glutamate transporters in temporal lobe areas in elderly patients with schizophrenia
Q35402761Ameliorating effect of Yokukansan on the development of atopic dermatitis-like lesions and scratching behavior in socially isolated NC/Nga mice
Q39250923Arundic acid attenuates retinal ganglion cell death by increasing glutamate/aspartate transporter expression in a model of normal tension glaucoma
Q30465586Assessment of glutamate transporter GLAST (EAAT1)-deficient mice for phenotypes relevant to the negative and executive/cognitive symptoms of schizophrenia
Q59128381Astrocytic Regulation of Glutamate Transmission in Schizophrenia
Q48027529Astroglia, Glutamatergic Transmission and Psychiatric Diseases
Q27310784Astroglial glutamate transporter deficiency increases synaptic excitability and leads to pathological repetitive behaviors in mice
Q39920030Behavioral and electrophysiological effects of endocannabinoid and dopaminergic systems on salient stimuli
Q30090165Caveolin-1 Sensitivity of Excitatory Amino Acid Transporters EAAT1, EAAT2, EAAT3, and EAAT4.
Q35791075Cell-specific abnormalities of glutamate transporters in schizophrenia: sick astrocytes and compensating relay neurons?
Q42154902Characterization of a Novel Mutation in SLC1A1 Associated with Schizophrenia
Q64063761Control of Long-Term Plasticity by Glutamate Transporters
Q38835953Disentangling the Role of Astrocytes in Alcohol Use Disorder
Q48572492Down-Regulation of Excitatory Amino Acid Transporters EAAT1 and EAAT2 by the Kinases SPAK and OSR1.
Q37112450Effects of Subchronic Phencyclidine (PCP) Treatment on Social Behaviors, and Operant Discrimination and Reversal Learning in C57BL/6J Mice
Q30466299Effects of genetic deletion of the Kv4.2 voltage-gated potassium channel on murine anxiety-, fear- and stress-related behaviors
Q37159920Effects of topiramate and other anti-glutamatergic drugs on the acute intoxicating actions of ethanol in mice: modulation by genetic strain and stress
Q90473578General Pathophysiology of Astroglia
Q30541844GluN2B in corticostriatal circuits governs choice learning and choice shifting.
Q51748790Glutamate Dehydrogenase-Deficient Mice Display Schizophrenia-Like Behavioral Abnormalities and CA1-Specific Hippocampal Dysfunction.
Q55505650Glutamate transporters, EAAT1 and EAAT2, are potentially important in the pathophysiology and treatment of schizophrenia and affective disorders.
Q34223138Glutamatergic mechanisms associated with stress-induced amygdala excitability and anxiety-related behavior
Q26824012Glutamatergic targets for new alcohol medications
Q30483032Glutaminase-deficient mice display hippocampal hypoactivity, insensitivity to pro-psychotic drugs and potentiated latent inhibition: relevance to schizophrenia.
Q48123221Hippocampal glutamate level and glutamate aspartate transporter (GLAST) are up-regulated in senior rat associated with isoflurane-induced spatial learning/memory impairment
Q34184026Localization of excitatory amino acid transporters EAAT1 and EAAT2 in human postmortem cortex: a light and electron microscopic study
Q64450655Loss of cerebellar glutamate transporters EAAT4 and GLAST differentially affects the spontaneous firing pattern and survival of Purkinje cells
Q64098548Mice lacking Casp1, Ifngr and Nos2 genes exhibit altered depressive- and anxiety-like behaviour, and gut microbiome composition
Q30454958Modeling resilience to schizophrenia in genetically modified mice: a novel approach to drug discovery
Q30476813Modeling the positive symptoms of schizophrenia in genetically modified mice: pharmacology and methodology aspects
Q38459199Molecular approaches for manipulating astrocytic signaling in vivo.
Q34181201New translational assays for preclinical modelling of cognition in schizophrenia: the touchscreen testing method for mice and rats
Q34273724Overstimulation of NMDA receptors impairs early brain development in vivo
Q35374971Pharmacological modulation of stress-induced behavioral changes in the light/dark exploration test in male C57BL/6J mice
Q34125605Predictably irrational: assaying cognitive inflexibility in mouse models of schizophrenia
Q30451627Reduced alcohol intake and reward associated with impaired endocannabinoid signaling in mice with a deletion of the glutamate transporter GLAST.
Q37495425SLC1 glutamate transporters
Q26825021Stress-induced deficits in cognition and emotionality: a role of glutamate
Q54323354Synergistic association of PI4KA and GRM3 genetic polymorphisms with poor antipsychotic response in south Indian schizophrenia patients with low severity of illness.
Q38069972Systems biology, bioinformatics, and biomarkers in neuropsychiatry
Q48709460Transcriptional regulation of the GLAST/EAAT-1 gene in rat and man.
Q38589482Translational potential of astrocytes in brain disorders
Q42968242Update on the neurobiology of schizophrenia: a role for extracellular microdomains.

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