Normalization of TAM post-receptor signaling reveals a cell invasive signature for Axl tyrosine kinase

scientific article published on 06 September 2016

Normalization of TAM post-receptor signaling reveals a cell invasive signature for Axl tyrosine kinase is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1003306433
P356DOI10.1186/S12964-016-0142-1
P932PMC publication ID5011882
P698PubMed publication ID27595981

P50authorSushil KumarQ57157332
P2093author name stringYun-Juan Chang
Sergei V Kotenko
Raymond B Birge
Wen-I Tsou
Mariana S De Lorenzo
Mainul Hoque
Anita Lewis-Antes
Andrej Boháč
Ke Geng
Viralkumar Davra
Stanley G Kimani
Canan Kasikara
Shenyan Wang
P2860cites workTransforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathwayQ22011040
The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entryQ24299966
rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brainQ24305209
Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-siteQ24309038
axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinaseQ24310364
Cloning and mRNA expression analysis of a novel human protooncogene, c-merQ24319969
IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complexQ24336912
Biological effects of c-Mer receptor tyrosine kinase in hematopoietic cells depend on the Grb2 binding site in the receptor and activation of NF-kappaB.Q24530573
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profilesQ24536351
The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entryQ24620686
Tyro3 family-mediated cell entry of Ebola and Marburg virusesQ24670567
Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancerQ26766332
Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamilyQ27654013
Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and AxlQ28277798
Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinasesQ28298018
Contribution of Defective PS Recognition and Efferocytosis to Chronic Inflammation and AutoimmunityQ28397407
Macrophages and dendritic cells use different Axl/Mertk/Tyro3 receptors in clearance of apoptotic cellsQ28505743
Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 familyQ28585446
TAM receptors are pleiotropic inhibitors of the innate immune responseQ28592484
Reciprocal regulation of Abl kinase by Crk Y251 and Abi1 controls invasive phenotypes in glioblastomaQ30009085
The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells.Q33357894
T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune responseQ33595572
Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survivalQ33667156
Overexpression of MERTK receptor tyrosine kinase in epithelial cancer cells drives efferocytosis in a gain-of-function capacityQ34170756
Receptor tyrosine kinases, TYRO3, AXL, and MER, demonstrate distinct patterns and complex regulation of ligand-induced activationQ34170762
Diversification of TAM receptor tyrosine kinase functionQ34214465
Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET.Q34217927
The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinasesQ34319294
Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivitiesQ34390266
Serum-derived protein S binds to phosphatidylserine and stimulates the phagocytosis of apoptotic cellsQ34529299
Optical imaging predicts tumor response to anti-EGFR therapyQ34581923
TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancerQ34794927
Akt phosphorylation on Thr308 but not on Ser473 correlates with Akt protein kinase activity in human non-small cell lung cancerQ35034550
TAM receptor signaling in immune homeostasisQ35819380
Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancerQ36128435
Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK inductionQ36301713
Differential activation of the Ras/extracellular-signal-regulated protein kinase pathway is responsible for the biological consequences induced by the Axl receptor tyrosine kinaseQ36556713
Analysis of alternative cleavage and polyadenylation by 3' region extraction and deep sequencing.Q36575994
The receptor tyrosine kinase MerTK activates phospholipase C gamma2 during recognition of apoptotic thymocytes by murine macrophagesQ36739689
MerTK inhibition in tumor leukocytes decreases tumor growth and metastasisQ37052927
Activation of protein kinase C beta II by the stereo-specific phosphatidylserine receptor is required for phagocytosis of apoptotic thymocytes by resident murine tissue macrophagesQ37093186
Enveloped viruses disable innate immune responses in dendritic cells by direct activation of TAM receptorsQ37188519
Biology of the TAM receptorsQ37258717
The receptor AXL diversifies EGFR signaling and limits the response to EGFR-targeted inhibitors in triple-negative breast cancer cellsQ37627397
Role of phosphatidylserine receptors in enveloped virus infectionQ37713918
Targeting Axl and Mer kinases in cancerQ37936028
TAM receptors in apoptotic cell clearance, autoimmunity, and cancerQ38105573
TAM receptors, Gas6, and protein S: roles in inflammation and hemostasisQ38193420
Axl mediates acquired resistance of head and neck cancer cells to the epidermal growth factor receptor inhibitor erlotinib.Q39097045
Mitogenic signals and transforming potential of Nyk, a newly identified neural cell adhesion molecule-related receptor tyrosine kinaseQ40017718
The mechanism of Axl-mediated Ebola virus infectionQ40042123
A NPxY-independent beta5 integrin activation signal regulates phagocytosis of apoptotic cells.Q40061608
A role for Mer tyrosine kinase in alphavbeta5 integrin-mediated phagocytosis of apoptotic cells.Q40464984
Mer receptor tyrosine kinase signaling: prevention of apoptosis and alteration of cytoskeletal architecture without stimulation or proliferationQ40740717
Stimulation of sky receptor tyrosine kinase by the product of growth arrest-specific gene 6.Q41293269
Activation of the Axl receptor tyrosine kinase induces mitogenesis and transformation in 32D cellsQ41439713
The Mer receptor tyrosine kinase is expressed on discrete macrophage subpopulations and mainly uses Gas6 as its ligand for uptake of apoptotic cellsQ41824557
ALK inhibitor resistance in ALK(F1174L)-driven neuroblastoma is associated with AXL activation and induction of EMT.Q42572358
R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancerQ43166849
Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6.Q43228829
Identification of Gas6 as a ligand for Mer, a neural cell adhesion molecule related receptor tyrosine kinase implicated in cellular transformation.Q46021434
Autophosphorylation docking site Tyr-867 in Mer receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic cells and down-modulation of lipopolysaccharide-inducible NF-kappaB transcriptional activatQ46881381
Structure, expression, and activity of Tyro 3, a neural adhesion-related receptor tyrosine kinase.Q46943661
The TAM family: phosphatidylserine sensing receptor tyrosine kinases gone awry in cancer.Q54298179
EfferocytosisQ87873982
P4510describes a project that useslimmaQ112236343
edgeRQ113334690
P433issue1
P304page(s)19
P577publication date2016-09-06
P1433published inCell Communication and SignalingQ1254390
P1476titleNormalization of TAM post-receptor signaling reveals a cell invasive signature for Axl tyrosine kinase
P478volume14