Regulation of human CYP2C18 and CYP2C19 in transgenic mice: influence of castration, testosterone, and growth hormone

scientific article published on April 2009

Regulation of human CYP2C18 and CYP2C19 in transgenic mice: influence of castration, testosterone, and growth hormone is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1124/DMD.109.026963
P932PMC publication ID2698944
P698PubMed publication ID19339376
P5875ResearchGate publication ID24251064

P50authorMagnus Ingelman-SundbergQ5823202
David J. WaxmanQ30506493
Ronny Fransson-SteenQ47087834
Ylva TereliusQ47087838
Jessica MwinyiQ117257663
Susanne LöfgrenQ125292910
P2093author name stringR Michael Baldwin
Margareta Carlerös
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Cloning and characterization of a novel CYP3A1 allelic variant: analysis of CYP3A1 and CYP3A2 sex-hormone-dependent expression reveals that the CYP3A2 gene is regulated by testosterone.Q33275019
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Htra2-beta 1 stimulates an exonic splicing enhancer and can restore full-length SMN expression to survival motor neuron 2 (SMN2)Q35210565
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Interpulse interval in circulating growth hormone patterns regulates sexually dimorphic expression of hepatic cytochrome P450.Q37568745
Intermittent plasma growth hormone triggers tyrosine phosphorylation and nuclear translocation of a liver-expressed, Stat 5-related DNA binding protein. Proposed role as an intracellular regulator of male-specific liver gene transcriptionQ38294444
Sexual dimorphism in the control of growth hormone secretionQ39370450
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Hormonal regulation of rat renal cytochrome P450s by androgen and the pituitaryQ41905490
Sex-dependent expression and clofibrate inducibility of cytochrome P450 4A fatty acid omega-hydroxylases. Male specificity of liver and kidney CYP4A2 mRNA and tissue-specific regulation by growth hormone and testosteroneQ42468297
Effect of exogenous growth hormone on somatic growth, gonadal development, and hepatic CYP2C11 and CYP2C12 expression in prepubertal intact male ratsQ43594964
Effect of growth hormone on hepatic cytochrome P450 activity in healthy elderly men.Q43926467
4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and TanzaniansQ43944775
Bioequivalence revisited: influence of age and sex on CYP enzymesQ45183562
Generation of mice transgenic for human CYP2C18 and CYP2C19: characterization of the sexually dimorphic gene and enzyme expressionQ46752498
Modified expression of cytochrome P450 mRNAs by growth hormone in mouse liverQ46867572
Sexually dimorphic P450 gene expression in liver-specific hepatocyte nuclear factor 4alpha-deficient miceQ47447915
Effect of psychotropic medication on the in vitro metabolism of buprenorphine in human cDNA-expressed cytochrome P450 enzymes.Q48686176
Effects of gonadal steroid hormones on the hypothalamo-pituitary-liver axis in the control of sex differences in hepatic steroid metabolism in the rat.Q48878445
Evidence for the effect of gender on activity of (S)-mephenytoin 4'-hydroxylase (CYP2C19) in a Chinese population.Q50953435
An amplitude-specific divergence in the pulsatile mode of growth hormone (GH) secretion underlies the gender difference in mean GH concentrations in men and premenopausal women.Q51027368
Sex-dependent liver gene expression is extensive and largely dependent upon signal transducer and activator of transcription 5b (STAT5b): STAT5b-dependent activation of male genes and repression of female genes revealed by microarray analysis.Q51819758
Growth hormone determines sexual dimorphism of hepatic cytochrome P450 3A4 expression in transgenic mice.Q51832019
Codependence of growth hormone-responsive, sexually dimorphic hepatic gene expression on signal transducer and activator of transcription 5b and hepatic nuclear factor 4alpha.Q51835832
Adult male-specific and neonatally programmed rat hepatic P-450 forms RLM2 and 2a are not dependent on pulsatile plasma growth hormone for expression.Q52250583
Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes.Q52266254
Daily rhythmicity of serum testosterone concentration in the male laboratory ratQ52475544
Hormonal regulation of male-specific rat hepatic cytochrome P-450g (P-450IIC13) by androgens and the pituitary.Q53963847
Sex is a major determinant of CYP3A4 expression in human liverQ56453603
Hormonal regulation of rat liver microsomal enzymes. Role of gonadal steroids in programming, maintenance, and suppression of delta 4-steroid 5 alpha-reductase, flavin-containing monooxygenase, and sex-specific cytochromes P-450Q58483872
Hormonal and developmental regulation of expression of the hepatic microsomal steroid 16 alpha-hydroxylase cytochrome P-450 apoprotein in the ratQ69873409
Interindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to CYP2E1 genetic polymorphismsQ72313196
Imprinting of growth hormone secretion, body growth, and hepatic steroid metabolism by neonatal testosteroneQ93614295
P433issue7
P407language of work or nameEnglishQ1860
P921main subjecttestosteroneQ1318776
testosteroneQ27863114
P304page(s)1505-1512
P577publication date2009-04-01
P1433published inDrug Metabolism and DispositionQ1261140
P1476titleRegulation of human CYP2C18 and CYP2C19 in transgenic mice: influence of castration, testosterone, and growth hormone
P478volume37

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cites work (P2860)
Q51199766Absorption, distribution, metabolism and excretion of the novel SARM GTx-024 [(S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide] in rats.
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Q38120833Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications
Q37948908Humanized transgenic mouse models for drug metabolism and pharmacokinetic research
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Q57036560Tissue-specific gene regulation corresponds with seasonal plasticity in female testosterone

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