Targeting Homer genes using adeno-associated viral vector: lessons learned from behavioural and neurochemical studies.

scientific article published on September 2008

Targeting Homer genes using adeno-associated viral vector: lessons learned from behavioural and neurochemical studies. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1097/FBP.0B013E32830C369F
P932PMC publication ID6415977
P698PubMed publication ID18690104

P2093author name stringMatthias Klugmann
Karen K Szumlinski
P2860cites workMouse brain and muscle tissues constitutively express high levels of Homer proteinsQ73395510
Taurine blocks the glutamate increase in the nucleus accumbens microdialysate of ethanol-dependent ratsQ73444520
Prenatal and postnatal exposure to ethanol induces changes in the shape of the dendritic spines from hippocampal CA1 pyramidal neurons of the ratQ73816066
Targeted retrograde gene delivery for neuronal protectionQ77474905
Differential control of postsynaptic density scaffolds via actin-dependent and -independent mechanismsQ79948920
Surface clustering of metabotropic glutamate receptor 1 induced by long Homer proteinsQ21262045
Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptorsQ22007971
Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteinsQ22008754
Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactinQ22010466
Homer Binds TRPC Family Channels and Is Required for Gating of TRPC1 by IP3 ReceptorsQ24295021
Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virionsQ24531466
Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognitionQ27622377
Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteinsQ28141190
Homer 1b regulates the trafficking of group I metabotropic glutamate receptorsQ28143150
Inhibition of dendritic spine morphogenesis and synaptic transmission by activity-inducible protein Homer1aQ28187839
Coincidence in dendritic clustering and synaptic targeting of homer proteins and NMDA receptor complex proteins NR2B and PSD95 during development of cultured hippocampal neuronsQ28188723
Rapid redistribution of the postsynaptic density protein PSD-Zip45 (Homer 1c) and its differential regulation by NMDA receptors and calcium channels.Q43819953
Development and optimization of adeno-associated virus vector transfer into the central nervous systemQ43943045
Distribution of cystine/glutamate exchange transporter, system x(c)-, in the mouse brain.Q44132586
Excitatory and inhibitory amino acid changes during repeated episodes of ethanol withdrawal: an in vivo microdialysis studyQ44275833
Synaptic targeting of PSD-Zip45 (Homer 1c) and its involvement in the synaptic accumulation of F-actin.Q44276056
Effects of acamprosate on excitatory amino acids during multiple ethanol withdrawal periods.Q44377070
Synaptic scaffolding protein Homer1a protects against chronic inflammatory painQ44385678
Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior.Q44419020
Vesl/Homer proteins regulate ryanodine receptor type 2 function and intracellular calcium signalingQ28190523
Homer regulates gain of ryanodine receptor type 1 channel complexQ28201200
Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein HomerQ28202988
PI3 kinase enhancer–Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosisQ28207557
Tetrameric hub structure of postsynaptic scaffolding protein homerQ28258271
Homer: a protein that selectively binds metabotropic glutamate receptorsQ28305877
Signaling complex formation of phospholipase Cbeta4 with metabotropic glutamate receptor type 1alpha and 1,4,5-trisphosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brainQ28511349
Novel members of the Vesl/Homer family of PDZ proteins that bind metabotropic glutamate receptorsQ28569381
The interaction of phospholipase C-beta3 with Shank2 regulates mGluR-mediated calcium signalQ28574773
An N-terminal sequence specific for a novel Homer1 isoform controls trafficking of group I metabotropic glutamate receptor in mammalian cellsQ28584758
Homer proteins regulate sensitivity to cocaineQ28587355
Cupidin, an isoform of Homer/Vesl, interacts with the actin cytoskeleton and activated rho family small GTPases and is expressed in developing mouse cerebellar granule cellsQ28590952
Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamicsQ28590972
Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCbeta GAP activitiesQ28592983
PDZ domain proteins of synapsesQ29616399
Pharmacology and functions of metabotropic glutamate receptorsQ29619150
Regulation of dendritic spine morphology and synaptic function by Shank and HomerQ30014842
Homers regulate drug-induced neuroplasticity: implications for addictionQ30491852
AAV vector-mediated RNAi of mutant huntingtin expression is neuroprotective in a novel genetic rat model of Huntington's diseaseQ30549911
Synaptic activity-induced conversion of intronic to exonic sequence in Homer 1 immediate early gene expression.Q30697805
Adeno-associated virus serotypes: vector toolkit for human gene therapyQ33249130
Characterization of adeno-associated virus genomes isolated from human tissuesQ34142848
Gene therapy: trials and tribulationsQ34186665
Ethanol and NMDA receptor signalingQ34186902
AAV8, 9, Rh10, Rh43 vector gene transfer in the rat brain: effects of serotype, promoter and purification methodQ34330377
Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmissionQ34400155
Viral-based gene transfer to the mammalian CNS for functional genomic studiesQ34446026
Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population.Q34471095
Human fibroblast growth factor receptor 1 is a co-receptor for infection by adeno-associated virus 2.Q34486856
AlphaVbeta5 integrin: a co-receptor for adeno-associated virus type 2 infectionQ34486863
Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: potential insight into their anti-addictive properties.Q34525273
Gene therapy for cystic fibrosis lung disease: current status and future perspectivesQ34578342
Aberrant synaptic activation of N-methyl-D-aspartate receptors underlies ethanol withdrawal hyperexcitability.Q34603130
Psychomotor stimulant addiction: a neural systems perspective.Q34616133
Neuroadaptations in cystine-glutamate exchange underlie cocaine relapseQ44460612
Homer1 proteins and AMPA receptors modulate cocaine‐induced behavioural plasticityQ44597465
Activity-inducible protein Homer1a/Vesl-1S promotes redistribution of postsynaptic protein Homer1c/Vesl-1L in cultured rat hippocampal neuronsQ44708409
Restoration of aspartoacylase activity in CNS neurons does not ameliorate motor deficits and demyelination in a model of Canavan disease.Q44719583
Anticonvulsant and antiepileptogenic effects mediated by adeno-associated virus vector neuropeptide Y expression in the rat hippocampus.Q44814719
Differential expression of Homer family proteins in the developing mouse brainQ44873450
Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous systemQ45007196
Cocaine increases medial prefrontal cortical glutamate overflow in cocaine-sensitized rats: a time course studyQ45049931
Chronic ethanol induces synaptic but not extrasynaptic targeting of NMDA receptors.Q45050785
Quantitative comparison of expression with adeno-associated virus (AAV-2) brain-specific gene cassettes.Q45735544
In vivo transduction of cerebellar Purkinje cells using adeno-associated virus vectorsQ45739687
Strain differences in alcohol-induced neurochemical plasticity: a role for accumbens glutamate in alcohol intakeQ45743679
Quantitative analysis of the packaging capacity of recombinant adeno-associated virusQ45766162
Recombinant AAV serotype 1 transduction efficiency and tropism in the murine brainQ45864411
Influence of promoter and WHV post-transcriptional regulatory element on AAV-mediated transgene expression in the rat brainQ45869654
Comparison of promoter strengths on gene delivery into mammalian brain cells using AAV vectorsQ45881872
Complex, multimodal behavioral profile of the Homer1 knockout mouse.Q45990816
Regional differences in the effects of withdrawal from repeated cocaine upon Homer and glutamate receptor expression: a two-species comparison.Q46010338
Accumbens neurochemical adaptations produced by binge-like alcohol consumption.Q46032431
Prenatal stress alters limbo-corticostriatal Homer protein expression.Q46036771
Ethanol exposure decreases glutamate uptake in the nucleus accumbensQ46381488
Homer expression in the Xenopus tadpole nervous systemQ46463678
Key role of the postsynaptic density scaffold proteins Shank and Homer in the functional architecture of Ca2+ homeostasis at dendritic spines in hippocampal neurons.Q46472740
Behavioral and neurochemical phenotyping of Homer1 mutant mice: possible relevance to schizophrenia.Q46596359
Homer2 is necessary for EtOH-induced neuroplasticity.Q46622590
Homer isoforms differentially regulate cocaine-induced neuroplasticity.Q46701582
A novel role of circadian transcription factor DBP in hippocampal plasticity.Q46780685
Homer interactions are necessary for metabotropic glutamate receptor-induced long-term depression and translational activationQ46815693
Distinct roles for different Homer1 isoforms in behaviors and associated prefrontal cortex function.Q46851475
A complex program of striatal gene expression induced by dopaminergic stimulation.Q47892574
Isolation of PSD-Zip45, a novel Homer/vesl family protein containing leucine zipper motifs, from rat brainQ48006881
Hippocampal gene expression profiling reveals the possible involvement of Homer1 and GABA(B) receptors in scopolamine-induced amnesia.Q48150837
On the regional distribution of heparan sulfate proteoglycan immunoreactivity in the rat brainQ48175852
Cocaine induces the expression of homer 1b/c, homer 3a/b, and hsp 27 proteins in rat cerebellumQ48190511
In vivo regulation of Homer1a expression in the striatum by cocaineQ48305377
Central effects of acamprosate: part 1. Acamprosate blocks the glutamate increase in the nucleus accumbens microdialysate in ethanol withdrawn ratsQ48386138
Conditional deletion of hypothalamic Y2 receptors reverts gonadectomy-induced bone loss in adult miceQ48492969
Ibotenic acid lesions of the dorsal prefrontal cortex disrupt the expression of behavioral sensitization to cocaineQ48534288
Homer-dependent cell surface expression of metabotropic glutamate receptor type 5 in neurons.Q48563098
Dose and promoter effects of adeno-associated viral vector for green fluorescent protein expression in the rat brainQ48563498
Interactions between ethanol and agents that act on the NMDA-type glutamate receptorQ48874007
Effects of ethanol and anesthetics on type 1 and 5 metabotropic glutamate receptors expressed in Xenopus laevis oocytesQ48947223
Repeated cocaine augments excitatory amino acid transmission in the nucleus accumbens only in rats having developed behavioral sensitization.Q49116012
Signaling proteins in raft-like microdomains are essential for Ca2+ wave propagation in glial cells.Q52572812
Acute ethanol increases taurine but neither glutamate nor GABA in the nucleus accumbens of male rats: a microdialysis studyQ72384610
Biphasic effect of ethanol on extracellular accumulation of glutamate in the hippocampus and the nucleus accumbensQ72396807
Homer proteins regulate coupling of group I metabotropic glutamate receptors to N-type calcium and M-type potassium channelsQ73011082
Functional genomics and rat modelsQ73198566
Dendritic and axonal targeting of type 5 metabotropic glutamate receptor is regulated by homer1 proteins and neuronal excitationQ73258556
Up-regulation of cortical AMPA receptor binding in the fawn-hooded rat following ethanol withdrawalQ73302793
Promoters and regulatory elements that improve adeno-associated virus transgene expression in the brainQ34987192
Elevated levels of GluR1 in the midbrain: a trigger for sensitization to drugs of abuse?Q35006478
Alcoholism: allostasis and beyondQ35073089
Viral vectors for gene delivery to the nervous systemQ35120134
The genetics of adult-onset neuropsychiatric disease: complexities and conundra?Q35573426
The Homer family and the signal transduction system at glutamatergic postsynaptic density: potential role in behavior and pharmacotherapyQ35580028
NMDA receptor antagonism and the ethanol intoxication signal: from alcoholism risk to pharmacotherapyQ35611019
Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectorsQ35749646
Chronic alcohol drinking alters neuronal dendritic spines in the brain reward center nucleus accumbensQ35762266
Cytogenetics and gene discovery in psychiatric disorders.Q36019357
Recombinant adeno-associated viral vectors in the nervous systemQ36184768
Cloning of adeno-associated virus into pBR322: rescue of intact virus from the recombinant plasmid in human cellsQ36288360
Cortical mechanisms of cocaine sensitizationQ36523332
Dynamic regulation of ryanodine receptor type 1 (RyR1) channel activity by Homer 1Q36529038
NMDA receptors inhibit synapse unsilencing during brain developmentQ36535421
Phosphorylation of glutamate receptors: a potential mechanism for the regulation of receptor function and psychostimulant actionQ36597439
Airway epithelium directed gene therapy for cystic fibrosisQ36612211
Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an adeno-associated virus vectorQ36663364
Involvement of unique leucine-zipper motif of PSD-Zip45 (Homer 1c/vesl-1L) in group 1 metabotropic glutamate receptor clusteringQ36702025
Adaptive plasticity of NMDA receptors and dendritic spines: implications for enhanced vulnerability of the adolescent brain to alcohol addictionQ36732795
Molecular basis of genetic neuropsychiatric disordersQ36846974
A recombinant plasmid from which an infectious adeno-associated virus genome can be excised in vitro and its use to study viral replicationQ36919184
Accumbens Homer2 overexpression facilitates alcohol-induced neuroplasticity in C57BL/6J miceQ37398767
Woodchuck hepatitis virus contains a tripartite posttranscriptional regulatory element.Q39580820
A key role for diacylglycerol lipase-alpha in metabotropic glutamate receptor-dependent endocannabinoid mobilization.Q40116679
Homer 1 mediates store- and inositol 1,4,5-trisphosphate receptor-dependent translocation and retrieval of TRPC3 to the plasma membrane.Q40247997
Adeno-associated virus vectors serotyped with AAV8 capsid are more efficient than AAV-1 or -2 serotypes for widespread gene delivery to the neonatal mouse brainQ40329324
AAV-mediated hippocampal expression of short and long Homer 1 proteins differentially affect cognition and seizure activity in adult rats.Q40462041
Hepatocyte growth factor receptor is a coreceptor for adeno-associated virus type 2 infection.Q40726384
Homer-1c/Vesl-1L modulates the cell surface targeting of metabotropic glutamate receptor type 1alpha: evidence for an anchoring functionQ40901767
Enhanced expression of transgenes from adeno-associated virus vectors with the woodchuck hepatitis virus posttranscriptional regulatory element: implications for gene therapyQ40924169
Co-expression of metabotropic glutamate receptor type 1alpha with homer-1a/Vesl-1S increases the cell surface expression of the receptorQ40940136
The role of excitatory amino acids in behavioral sensitization to psychomotor stimulantsQ41749963
Generation and characterization of chimeric recombinant AAV vectorsQ41869331
The endocannabinoid system controls key epileptogenic circuits in the hippocampusQ42065383
Ca2+ signaling in microdomains: Homer1 mediates the interaction between RyR2 and Cav1.2 to regulate excitation-contraction couplingQ42170028
Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brainQ42280576
Select overexpression of homer1a in dorsal hippocampus impairs spatial working memoryQ42401422
Chronic ethanol exposure leads to a selective enhancement of N-methyl-D-aspartate receptor function in cultured hippocampal neurons.Q42448189
Homeostatic plasticity during alcohol exposure promotes enlargement of dendritic spinesQ42506908
HOMER2 binds MYO18B and enhances its activity to suppress anchorage independent growthQ42829829
Characterization of a metabotropic glutamate receptor type 5-green fluorescent protein chimera (mGluR5-GFP): pharmacology, surface expression, and differential effects of Homer-1a and Homer-1cQ43759581
Repeated cocaine administration attenuates group I metabotropic glutamate receptor-mediated glutamate release and behavioral activation: a potential role for Homer.Q43792467
P433issue5-6
P921main subjectlessons learnedQ1673259
P304page(s)485-500
P577publication date2008-09-01
P1433published inBehavioural PharmacologyQ15754239
P1476titleTargeting Homer genes using adeno-associated viral vector: lessons learned from behavioural and neurochemical studies
P478volume19

Reverse relations

cites work (P2860)
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