Conditional KIAA1549:BRAF mice reveal brain region- and cell type-specific effects.

scientific article published on 16 August 2013

Conditional KIAA1549:BRAF mice reveal brain region- and cell type-specific effects. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/DVG.22415
P932PMC publication ID3808469
P698PubMed publication ID23893969

P50authorDavid H. GutmannQ56670301
P2093author name stringScott M Gianino
Ryan J Emnett
Aparna Kaul
Yi-Hsien Chen
P2860cites workTandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomasQ28299301
Neurofibromin regulates neural stem cell proliferation, survival, and astroglial differentiation in vitro and in vivoQ28504560
CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2005-2009.Q30447832
BRAF activation induces transformation and then senescence in human neural stem cells: a pilocytic astrocytoma model.Q33862879
Activated BRAF induces gliomas in mice when combined with Ink4a/Arf loss or Akt activation.Q33945989
Neurofibromatosis-1 regulates neuroglial progenitor proliferation and glial differentiation in a brain region-specific manner.Q34206051
Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation.Q34441257
NG2 cells generate both oligodendrocytes and gray matter astrocytes.Q34719495
An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in miceQ34755317
Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformationQ34907204
Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner.Q35229380
BRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549:BRAF fusion variants.Q36239628
Pediatric glioma-associated KIAA1549:BRAF expression regulates neuroglial cell growth in a cell type-specific and mTOR-dependent manner.Q36464991
Dynamic contribution of nestin-expressing stem cells to adult neurogenesisQ37033019
Microarray analyses reveal regional astrocyte heterogeneity with implications for neurofibromatosis type 1 (NF1)-regulated glial proliferation.Q37253335
Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumoursQ37330655
NG2-cells are not the cell of origin for murine neurofibromatosis-1 (Nf1) optic glioma.Q37417578
Regulated expression of pdx-1 promotes in vitro differentiation of insulin-producing cells from embryonic stem cellsQ40521874
Innate neural stem cell heterogeneity determines the patterning of glioma formation in childrenQ42066665
Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytomaQ42636358
Epidemiology of central nervous system tumors in childhood and adolescence based on the new WHO classificationQ43569987
Frequent gains at chromosome 7q34 involving BRAF in pilocytic astrocytomaQ44739121
Proteomic analysis reveals hyperactivation of the mammalian target of rapamycin pathway in neurofibromatosis 1-associated human and mouse brain tumorsQ46417560
Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas.Q47992753
Prognostic factors of CNS tumours in Neurofibromatosis 1 (NF1): a retrospective study of 104 patientsQ48428414
Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris (HotSHOT).Q52166624
Loss of neurofibromatosis 1 (NF1) gene expression in NF1-associated pilocytic astrocytomas.Q55475325
The architecture of optic nerve gliomas with and without neurofibromatosis.Q55491018
Optic gliomas in children with neurofibromatosis type 1Q69195503
Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanismsQ80969366
P433issue10
P304page(s)708-716
P577publication date2013-08-16
P1433published inGenesisQ5532784
P1476titleConditional KIAA1549:BRAF mice reveal brain region- and cell type-specific effects
P478volume51

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cites work (P2860)
Q26864920Epigenetic dysregulation: a novel pathway of oncogenesis in pediatric brain tumors
Q59799266KIAA1549-BRAF Expression Establishes a Permissive Tumor Microenvironment Through NFκB-Mediated CCL2 Production
Q26748675Neurofibromatosis type 1 associated low grade gliomas: A comparison with sporadic low grade gliomas
Q36544705Non-random aneuploidy specifies subgroups of pilocytic astrocytoma and correlates with older age.
Q28552185P2A-Fluorophore Tagging of BRAF Tightly Links Expression to Fluorescence In Vivo
Q46667195Pediatric Low-Grade Gliomas: Next Biologically Driven Steps
Q36803476Pediatric gliomas as neurodevelopmental disorders
Q35184491The BRAF kinase domain promotes the development of gliomas in vivo
Q89587165The Sociobiology of Brain Tumors
Q35788566The impact of coexisting genetic mutations on murine optic glioma biology.

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