Intravitreal injection of ciliary neurotrophic factor (CNTF) causes peripheral remodeling and does not prevent photoreceptor loss in canine RPGR mutant retina

scientific article published on 09 January 2007

Intravitreal injection of ciliary neurotrophic factor (CNTF) causes peripheral remodeling and does not prevent photoreceptor loss in canine RPGR mutant retina is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.EXER.2006.12.019
P932PMC publication ID2709826
P698PubMed publication ID17320077
P5875ResearchGate publication ID6486374

P2093author name stringGregory M Acland
Gustavo D Aguirre
Rong Wen
William A Beltran
P2860cites workRPGR-ORF15, which is mutated in retinitis pigmentosa, associates with SMC1, SMC3, and microtubule transport proteinsQ24533513
Rod photoreceptor neurite sprouting in retinitis pigmentosaQ28116150
Absence of chx10 causes neural progenitors to persist in the adult retinaQ28586628
Müller cell and neuronal remodeling in retinal detachment and reattachment and their potential consequences for visual recovery: a review and reconsideration of recent dataQ30782341
CNTF induces dose-dependent alterations in retinal morphology in normal and rcd-1 canine retinaQ30862440
A combination of CNTF and BDNF rescues rd photoreceptors but changes rod differentiation in the presence of RPE in retinal explantsQ31776602
Dedifferentiation of adult human myoblasts induced by ciliary neurotrophic factor in vitroQ33877006
Ciliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implantsQ34410761
Neural remodeling in retinal degeneration.Q35189368
Population genetic studies of retinitis pigmentosa.Q35203707
Insights into X-linked retinitis pigmentosa type 3, allied diseases and underlying pathomechanismsQ36294702
Retinal remodellingQ36300057
Modifications of retinal neurons in a mouse model of retinitis pigmentosaQ37270730
Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant lightQ37315189
Sustained secretion of ciliary neurotrophic factor to the vitreous, using the encapsulated cell therapy-based NT-501 intraocular device.Q40463263
Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa.Q40700552
Glial cell line-derived neurotrophic factor induces histologic and functional protection of rod photoreceptors in the rd/rd mouse.Q40925242
Cloning, mapping, and retinal expression of the canine ciliary neurotrophic factor receptor alpha (CNTFRalpha).Q42604422
Different RPGR exon ORF15 mutations in Canids provide insights into photoreceptor cell degenerationQ42675161
Gene therapy restores vision in a canine model of childhood blindnessQ43590733
Long-term protection of retinal structure but not function using RAAV.CNTF in animal models of retinitis pigmentosaQ43715205
Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutationQ44070483
Ciliary neurotrophic factor as a transient negative regulator of rod development in rat retinaQ44119147
Intraocular gene delivery of ciliary neurotrophic factor results in significant loss of retinal function in normal mice and in the Prph2Rd2/Rd2 model of retinal degenerationQ44351246
Retinal remodeling triggered by photoreceptor degenerations.Q44515244
Basic fibroblast growth factor: a potential regulator of proliferation and intermediate filament expression in the retinaQ44688151
Persistent progenitors at the retinal margin of ptc+/- mice.Q44723208
Inner retinal abnormalities in a mouse model of Leber's congenital amaurosisQ44733603
Encapsulated cell-based intraocular delivery of ciliary neurotrophic factor in normal rabbit: dose-dependent effects on ERG and retinal histologyQ44956668
Nuclear receptor NR2E3 gene mutations distort human retinal laminar architecture and cause an unusual degenerationQ44960254
Effects of ciliary neurotrophic factor on differentiation of late retinal progenitor cellsQ45304955
Gene therapy restores vision-dependent behavior as well as retinal structure and function in a mouse model of RPE65 Leber congenital amaurosisQ45887612
Basic fibroblast growth factor and local injury protect photoreceptors from light damage in the ratQ45974666
Protection of mouse photoreceptors by survival factors in retinal degenerations.Q46022707
The beta subunit of cyclic GMP phosphodiesterase mRNA is deficient in canine rod-cone dysplasia 1Q46168845
Immunolocalization of ciliary neurotrophic factor receptor alpha (CNTFRalpha) in mammalian photoreceptor cellsQ46435422
STAT3 activation in response to growth factors or cytokines participates in retina precursor proliferationQ46566389
Leukemia inhibitory factor blocks expression of Crx and Nrl transcription factors to inhibit photoreceptor differentiationQ46568416
Leukemia inhibitory factor inhibits neuronal development and disrupts synaptic organization in the mouse retinaQ46737092
Repeated injections of a ciliary neurotrophic factor analogue leading to long-term photoreceptor survival in hereditary retinal degeneration.Q48217416
Ciliary neurotrophic factor activates astrocytes, redistributes their glutamate transporters GLAST and GLT-1 to raft microdomains, and improves glutamate handling in vivo.Q48515330
Postmitotic cells fated to become rod photoreceptors can be respecified by CNTF treatment of the retina.Q51105611
Ciliary neurotrophic factor blocks rod photoreceptor differentiation from postmitotic precursor cells in vitro.Q52189648
Onset of CNTFRalpha expression and signal transduction during neurogenesis in chick sensory dorsal root ganglia.Q52192201
Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factorQ59048466
Induction of motor neuron sprouting in vivo by ciliary neurotrophic factor and basic fibroblast growth factorQ68004823
[Epidemiology and prevalence of hereditary retinal dystrophies in the Northern France]Q68011734
Reductions in taurine secondary to photoreceptor loss in Irish setters with rod-cone dysplasiaQ70110890
The effects of bFGF on RCS rat eyesQ71810089
Cosegregation of codon 807 mutation of the canine rod cGMP phosphodiesterase beta gene and rcd1Q71991225
Ciliary neurotrophic factor is required for motoneuron sproutingQ73208908
Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerationsQ73277924
Müller-cell-derived leukaemia inhibitory factor arrests rod photoreceptor differentiation at a postmitotic pre-rod stage of developmentQ73450434
Abnormalities in rod photoreceptors, amacrine cells, and horizontal cells in human retinas with retinitis pigmentosaQ73465773
Identification of a proliferating marginal zone of retinal progenitors in postnatal chickensQ73642032
Distribution of intraocular pressure in dogsQ73988848
The effect of calcium channel blocker diltiazem on photoreceptor degeneration in the rhodopsin Pro213His ratQ74150940
A frameshift mutation in RPGR exon ORF15 causes photoreceptor degeneration and inner retina remodeling in a model of X-linked retinitis pigmentosaQ82973522
P433issue4
P921main subjectphotoreceptor proteinQ7187894
P304page(s)753-771
P577publication date2007-01-09
P1433published inExperimental Eye ResearchQ15754753
P1476titleIntravitreal injection of ciliary neurotrophic factor (CNTF) causes peripheral remodeling and does not prevent photoreceptor loss in canine RPGR mutant retina
P478volume84

Reverse relations

cites work (P2860)
Q35964344CNTF Gene Therapy Confers Lifelong Neuroprotection in a Mouse Model of Human Retinitis Pigmentosa
Q28731691CNTF and retina
Q33488875CREB1/ATF1 activation in photoreceptor degeneration and protection
Q47601916Ciliary neurotrophic factor (CNTF) delivery to retina: an overview of current research advancements
Q30498337Cone photoreceptors are the main targets for gene therapy of NPHP5 (IQCB1) or NPHP6 (CEP290) blindness: generation of an all-cone Nphp6 hypomorph mouse that mimics the human retinal ciliopathy
Q35809866Drusen and photoreceptor abnormalities in African-Americans with intermediate non-neovascular age-related macular degeneration
Q39727751Exogenous modulation of intrinsic optic nerve neuroprotective activity
Q35045072Gene augmentation for X-linked retinitis pigmentosa caused by mutations in RPGR
Q45941152Immunotoxin-induced ablation of melanopsin retinal ganglion cells in a non-murine mammalian model.
Q35228749Inner retinal abnormalities in X-linked retinitis pigmentosa with RPGR mutations
Q38915580Localizing the RPGR protein along the cilium: a new method to determine efficacies to treat RPGR mutations
Q93127430Molecular Strategies for RPGR Gene Therapy
Q34042789Photoreceptor cell death, proliferation and formation of hybrid rod/S-cone photoreceptors in the degenerating STK38L mutant retina
Q37822729RPGR: role in the photoreceptor cilium, human retinal disease, and gene therapy
Q26750520Retinal remodeling in human retinitis pigmentosa
Q37490759Retinal remodeling in the Tg P347L rabbit, a large-eye model of retinal degeneration.
Q27317308Successful subretinal delivery and monitoring of MicroBeads in mice
Q57933970The genetics of inherited retinal disorders in dogs: implications for diagnosis and management
Q37458980The use of canine models of inherited retinal degeneration to test novel therapeutic approaches
Q36915103Transient photoreceptor deconstruction by CNTF enhances rAAV-mediated cone functional rescue in late stage CNGB3-achromatopsia
Q38801986Variegated yet non-random rod and cone photoreceptor disease patterns in RPGR-ORF15-associated retinal degeneration

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