Phenotypic and functional immaturity of human umbilical cord blood T lymphocytes

scientific article published on November 1, 1992

Phenotypic and functional immaturity of human umbilical cord blood T lymphocytes is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode1992PNAS...8910006H
P356DOI10.1073/PNAS.89.21.10006
P953full work available at URLhttps://europepmc.org/articles/PMC50266
https://europepmc.org/articles/PMC50266?pdf=render
P932PMC publication ID50266
P698PubMed publication ID1438190
P5875ResearchGate publication ID21717908

P50authorEdward BoyseQ5341981
Judith BardQ111326139
P2093author name stringE. A. Boyse
G. B. Olson
M. J. Schumacher
D. DeLuca
D. T. Harris
F. J. Besencon
J. Locascio
L. Shenker
P2860cites workHuman umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cellsQ33858964
Spontaneous human lymphocyte-mediated cytotoxicity against tumor target cells. IX. The quantitation of natural killer cell activityQ34284797
Intrathymic maturation of murine T lymphocytes from CD8+ precursorsQ34308314
Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical siblingQ34668125
Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineageQ36360690
Human umbilical cord blood: a clinically useful source of transplantable hematopoietic stem/progenitor cellsQ37584173
Reconstruction of the haemopoietic and immune systems after marrow transplantationQ37922414
Late complications after allogeneic bone marrow transplantation for leukaemia.Q37954758
Lymphocyte subpopulations in the neonate: identification of an immature subset of OKT8-positive, OKT3-negative cells.Q41585232
The graft-versus-leukemia (GVL) phenomenon: is GVL separable from GVHD?Q41838168
The majority of CD4+8- thymocytes are functionally immatureQ45196734
Cell-mediated lympholysis by human neonatal lymphocytesQ67810398
Tolerance and MHC restriction in transgenic mice expressing a MHC class I gene in erythroid cellsQ68064183
Bone marrow transplantation for patients with chronic myeloid leukaemia: T-cell depletion with Campath-1 reduces the incidence of graft-versus-host disease but may increase the risk of leukaemic relapseQ68242090
Marrow transplantation. Can cord blood be used?Q69373411
Message amplification phenotyping (MAPPing): a technique to simultaneously measure multiple mRNAs from small numbers of cellsQ69572529
Suppressive characteristics of the cultured umbilical cord blood lymphocytes: enhanced suppression of non specific MLR by short term cultured peripheral blood and rosetted lymphocytesQ70049631
Immature T lymphocytes in human cord blood identified by monoclonal antibodies: a model for the study of the differentiation pathway of T cells in humansQ70387593
Cell-mediated lympholysis by fetal and neonatal lymphocytes in sheep and manQ70523821
Development of cell-mediated lympholysis in human foetal blood lymphocytesQ70543233
Recovery of antibody production in human allogeneic marrow graft recipients: influence of time posttransplantation, the presence or absence of chronic graft-versus-host disease, and antithymocyte globulin treatmentQ70549349
Characterization of immature T cell subpopulations in neonatal bloodQ72817349
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectlymphocyteQ715347
immunologic cytotoxicityQ60345185
P304page(s)10006-10010
P577publication date1992-11-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titlePhenotypic and functional immaturity of human umbilical cord blood T lymphocytes
P478volume89

Reverse relations

cites work (P2860)
Q73341608A gift of life: umbilical cord blood
Q34522072A single administration of human umbilical cord blood T cells produces long-lasting effects in the aging hippocampus
Q44406622Activated umbilical cord blood cells from pre-term and term neonates express CD69 and synthesize IL-2 but are unable to produce IFN-gamma.
Q35522878Activation of Wnt signaling arrests effector differentiation in human peripheral and cord blood-derived T lymphocytes
Q79769147Activation of peripheral blood monocytes results in more robust production of IL-10 in neonatal foals compared to adult horses
Q40578582Adjuvanting an inactivated influenza vaccine with flagellin improves the function and quantity of the long-term antibody response in a nonhuman primate neonate model
Q38734758Advances in umbilical cord blood cell therapy: the present and the future
Q43508307Age-related changes in the expression of CD95 (APO1/FAS) on blood lymphocytes.
Q53923738Age-related changes of immunophenotypically immature lymphocytes in normal human peripheral blood.
Q73822484Alloreactivity of umbilical cord blood mononuclear cells: specific hyporesponse to noninherited maternal antigens
Q73341627Alterations in cord blood leukocyte subsets of patients with severe hemolytic disease after intrauterine transfusion therapy
Q54778744Amplification of T cells from human cord blood in serum-deprived culture stimulated with stem cell factor, interleukin-7 and interleukin-2.
Q78059990An in vitro model of allogeneic stimulation of cord blood: induction of Fas independent apoptosis
Q74074329Analysis of neonatal T cell and antigen presenting cell functions
Q52035269Analysis of the cord blood T lymphocyte response to superantigen.
Q35630431Antigen-specific T-lymphocyte function after cord blood transplantation
Q44606441Association of CD26 with CD45RA outside lipid rafts attenuates cord blood T-cell activation
Q40744105B-cell precursors differentiated from cord blood CD34+ cells are more immature than those derived from granulocyte colony-stimulating factor-mobilized peripheral blood CD34+ cells
Q42045089Both CD4⁺ and CD8⁺ lymphocytes participate in the IFN-γ response to filamentous hemagglutinin from Bordetella pertussis in infants, children, and adults
Q72589420CD28 activation promotes Th2 subset differentiation by human CD4+ cells
Q33922377Can cord blood cells support the cytokine storm in GvHD?
Q33891053Cellular immune responses in neonates
Q74082601Characterization of the T cell receptor repertoire of neonatal T cells by RT-PCR and single strand conformation polymorphism analysis
Q36025790Clearance of CMV viremia and survival after double umbilical cord blood transplantation in adults depends on reconstitution of thymopoiesis
Q38690849Cord blood as a potential therapeutic for amyotrophic lateral sclerosis
Q71972998Cord blood grafts: perspectives and problems
Q52016467Cord blood memory responses: are we being naïve?
Q40639431Cord blood serum affects T cells ability to produce and respond to IL-2.
Q40893773Cord blood serum does not increase lymphocyte responses in comparison to adult serum
Q37096984Cord blood stem cell transplantation for haemoglobinopathies
Q34986499Cord blood-derived hematopoietic stem/progenitor cells: current challenges in engraftment, infection, and ex vivo expansion
Q40314920Cytokine signatures of innate and adaptive immunity in 17DD yellow fever vaccinated children and its association with the level of neutralizing antibody
Q47901481Cytokine-enhanced mixed lymphocyte reaction (MLR) in cord blood
Q35767479Cytomegalovirus infection according to cell source after hematopoietic cell transplantation in pediatric patients
Q35574412Defective antigen-presenting cell function in human neonates.
Q33962727Dendritic cells in uninfected infants born to hepatitis B virus-positive mothers
Q45737302Detection of EBV DNA in the cord blood donor for a patient developing Epstein-Barr virus-associated lymphoproliferative disorder following mismatched unrelated umbilical cord blood transplantation.
Q37792860Detection of β-herpesviruses in Polish adult cord blood stem cell recipients by real-time PCR: single centre study
Q34259946Development of interleukin-12-producing capacity throughout childhood
Q82815154Differential expression and interaction of host factors augment HIV-1 gene expression in neonatal mononuclear cells
Q30479628Differentiation of naive cord-blood T cells into CD19-specific cytolytic effectors for posttransplantation adoptive immunotherapy
Q37255692Direct TLR-2 Costimulation Unmasks the Proinflammatory Potential of Neonatal CD4+ T Cells.
Q53535911Early proliferation of umbilical cord blood cells from premature neonates.
Q41893788Effect of dexamethasone on IL-2 and IL-3 production by mononuclear cells in neonates and adults
Q58605816Effects of HLA mismatch on cytomegalovirus reactivation in cord blood transplantation
Q45310597Effects of in utero JP-8 jet fuel exposure on the immune systems of pregnant and newborn mice
Q77921610Endogenous hematopoietic reconstitution induced by human umbilical cord blood cells in immunocompromised mice: implications for adoptive therapy
Q47672673Fetal natural killer cell function is suppressed
Q77462724Flow cytometric assessment of lymphocyte subsets, lymphoid progenitors, and hematopoietic stem cells in allogeneic stem cell grafts
Q34402073Functional analyses of cord blood natural killer cells and T cells: a distinctive interleukin-18 response
Q77891913Functional evaluation of ex vivo expanded cord blood lymphocytes: possible use for adoptive cellular immunotherapy
Q40855783Generation of HLA-A2 subtype specific cytotoxic T lymphocytes from cord blood used for cord blood stem cell transplantation
Q34177939Gimme shelter: the immune system during pregnancy
Q83480210HIV-1 replication and gene expression occur at higher levels in neonatal blood naive and memory T-lymphocytes compared with adult blood cells
Q45706991Herpes simplex virus infection in adult patients after unrelated cord blood transplantation: a single-institute experience in Japan
Q36672936Human bone marrow and umbilical cord blood cells generate CD4+ and CD8+ single-positive T cells in murine fetal thymus organ culture
Q40725991Human leucocyte antigen-Cw-specific cytotoxic T lymphocytes generated from naive cord blood used for cord blood stem cell transplantation
Q37517949Human umbilical cord blood cell grafts for brain ischemia
Q36388434Immune reconstitution after unrelated cord blood transplantation
Q73399817Immune reconstitution and outcome after unrelated cord blood transplantation: a single paediatric institution experience
Q37045929Immune reconstitution in children after unrelated cord blood transplantation
Q33643203Impact of cytomegalovirus (CMV) reactivation after umbilical cord blood transplantation
Q42289087In the presence of IL-21 human cord blood T cells differentiate to IL-10-producing Th1 but not Th17 or Th2 cells
Q43851518Incidence of, and risk factors for, nosocomial infections among hematopoietic stem cell transplantation recipients, with impact on procedure-related mortality
Q35758568Inclusion of Flagellin during Vaccination against Influenza Enhances Recall Responses in Nonhuman Primate Neonates.
Q34479089Induction of granulysin and perforin cytolytic mediator expression in 10-week-old infants vaccinated with BCG at birth
Q72687686Ineffective expression of CD40 ligand on cord blood T cells may contribute to poor immunoglobulin production in the newborn
Q38878646Infant birth outcomes are associated with DNA damage biomarkers as measured by the cytokinesis block micronucleus cytome assay: the DADHI study
Q40340770Interleukin 12 exerts a differential effect on the maturation of neonatal and adult human CD45R0- CD4 T cells.
Q30580565Intraarterial transplantation of human umbilical cord blood mononuclear cells is more efficacious and safer compared with umbilical cord mesenchymal stromal cells in a rodent stroke model
Q42170025JP-8 jet fuel exposure rapidly induces high levels of IL-10 and PGE2 secretion and is correlated with loss of immune function
Q47385161JP-8 jet fuel exposure results in immediate immunotoxicity, which is cumulative over time
Q84406525Lymphocyte phenotypic subsets in umbilical cord blood compared to peripheral blood from related mothers
Q40589105Lymphokine activated killer cells from umbilical cord blood show higher antitumor effect against anaplastic astrocytoma cell line (U87) and medulloblastoma cell line (TE671) than lymphokine activated killer cells from peripheral blood
Q37296284Mankind's first natural stem cell transplant.
Q45131421Maturation of CD4+ regulatory T lymphocytes and of cytokine secretions in infants born prematurely
Q78024334Neonatal dendritic cells are intrinsically biased against Th-1 immune responses
Q35170786Neonatal infection with species C adenoviruses confirmed in viable cord blood lymphocytes
Q41533871Neonatal umbilical cord blood transplantation halts skeletal disease progression in the murine model of MPS-I.
Q35070880Nonhuman primate infants have an impaired respiratory but not systemic IgG antibody response following influenza virus infection
Q44157136Ontogenic changes in CD95 expression on human leukocytes: prevalence of T-cells expressing activation markers and identification of CD95-CD45RO+ T-cells in the fetus
Q39631989PR1-specific cytotoxic T lymphocytes are relatively frequent in umbilical cord blood and can be effectively expanded to target myeloid leukemia.
Q39721212Performance analysis of a dual-buffer architecture for digital flow cytometry
Q41122141Personalizing Stem Cell Research and Therapy: The Arduous Road Ahead or Missed Opportunity?
Q74582418Phenotypic and functional analysis of human T lymphocytes in early second- and third-trimester fetuses
Q74813033Phenotypic characteristics of cord blood hemopoietic cells
Q33879367Pictorial review of mucopolysaccharidosis with emphasis on MRI features of brain and spine.
Q54409662Postnatal development of lipopolysaccharide-induced inflammatory response in the brain.
Q40435345Preemptive therapy with ganciclovir 5 mg/kg once daily for cytomegalovirus infection after unrelated cord blood transplantation
Q40432390Pulmonary Dendritic Cell Subsets Shape the Respiratory Syncytial Virus-Specific CD8+ T Cell Immunodominance Hierarchy in Neonates
Q48024843Reactive arthritis-associated bacteria can stimulate lymphocyte proliferation in non-exposed individuals and newborns
Q35072259Recommendations for immunizations in stem cell transplantation
Q34263277Status of umbilical cord blood transplantation in the year 2001.
Q35692623Stem cell transplantation in the fetus
Q35236878Successful hematopoietic reconstitution with transplantation of erythrocyte-depleted allogeneic human umbilical cord blood cells in a child with leukemia
Q79305225Successful reduced-intensity stem cell transplantation (RIST) with mismatched cord blood in a 70-year-old patient with severe aplastic anemia (SAA)
Q42683212Synthesis of a Functional Metal-Chelating Polymer and Steps toward Quantitative Mass Cytometry Bioassays
Q33667803T-cell function in newborn mice and humans
Q36933375T-lymphocyte recovery and function after cord blood transplantation
Q36142098The autoimmunity-associated BLK haplotype exhibits cis-regulatory effects on mRNA and protein expression that are prominently observed in B cells early in development.
Q73649345The cellular immune response of children is specifically decreased against their parents but not vice versa, independent of pregnancy, age, or HLA or HY antigens
Q34501067The immunobiology of cord blood transplantation
Q40517931The role of hematopoietic growth factors in transfusion medicine.
Q41231990Transforming growth factor beta is a major regulator of human neonatal immune responses following respiratory syncytial virus infection
Q37763613Transplantation of umbilical cord blood stem cells for treating spinal cord injury
Q73158574Umbilical cord blood dendritic cells are a rich source of soluble HLA-DR: synergistic effect of exosomes and dendritic cells on autologous or allogeneic T-Cell proliferation
Q37963798Umbilical cord blood immunology: relevance to stem cell transplantation
Q34202309Umbilical cord blood mononuclear cell transplantation for neonatal hypoxic-ischemic encephalopathy
Q36808858Umbilical cord blood research: current and future perspectives
Q74302237Umbilical cord blood transplantation for Maroteaux-Lamy syndrome (mucopolysaccharidosis type VI)
Q40968864Umbilical cord-blood transplantation: is there a future?
Q34242179Vaccination of neonates: problem and issues
Q38269845Vaccines against respiratory viral pathogens for use in neonates: opportunities and challenges
Q46808881Vdelta2 T-lymphocyte responses in cord blood samples from Italy and Côte d'Ivoire