Targeting AKT with the allosteric AKT inhibitor MK-2206 in non-small cell lung cancer cells with acquired resistance to cetuximab

scientific article published on June 1, 2013

Targeting AKT with the allosteric AKT inhibitor MK-2206 in non-small cell lung cancer cells with acquired resistance to cetuximab is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4161/CBT.24342
P953full work available at URLhttp://www.tandfonline.com/doi/pdf/10.4161/cbt.24342
https://doi.org/10.4161/cbt.24342
https://europepmc.org/articles/PMC3813564
https://europepmc.org/articles/PMC3813564?pdf=render
https://www.tandfonline.com/doi/pdf/10.4161/cbt.24342?needAccess=true
P932PMC publication ID3813564
P698PubMed publication ID23760490

P2093author name stringMari Iida
Neha Luthar
David A. Campbell
Anne M. Traynor
Deric L. Wheeler
Toni M. Brand
Megan M. Starr
P2860cites workPhosphorylation and regulation of Akt/PKB by the rictor-mTOR complexQ24295120
Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphomaQ24561567
The PI3K pathway as drug target in human cancerQ24632283
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domainQ24794765
Cetuximab for the treatment of colorectal cancer.Q27851419
First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumorsQ27851678
The phosphoinositide 3-kinase pathwayQ27860738
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancerQ28240089
PI3K‐independent AKT activation in cancers: A treasure trove for novel therapeuticsQ28259003
Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancerQ28305293
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates AktQ29547767
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3KQ29614757
Targeting PI3K signalling in cancer: opportunities, challenges and limitationsQ29617685
EGF-ERBB signalling: towards the systems levelQ29619032
Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neckQ29619277
Platinum-based chemotherapy plus cetuximab in head and neck cancerQ33381094
Understanding resistance to EGFR inhibitors-impact on future treatment strategiesQ34088424
Combination of Farnesyltransferase and Akt Inhibitors Is Synergistic in Breast Cancer Cells and Causes Significant Breast Tumor Regression in ErbB2 Transgenic MiceQ34181861
Inhibition of AKT with the Orally Active Allosteric AKT Inhibitor, MK-2206, Sensitizes Endometrial Cancer Cells to ProgestinQ34388048
Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern Cooperative Oncology Group studyQ34471062
Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry.Q34554584
Molecular mechanisms of resistance to the EGFR monoclonal antibody cetuximabQ35001415
Akt inhibitors in clinical development for the treatment of cancerQ35628576
A portrait of AKT kinases: human cancer and animal models depict a family with strong individualitiesQ35701021
Adding cetuximab to capecitabine plus oxaliplatin (XELOX) in first-line treatment of metastatic colorectal cancer: a randomized phase II trial of the Swiss Group for Clinical Cancer Research SAKK.Q37113071
Biomarkers of Response to Akt Inhibitor MK-2206 in Breast CancerQ37168778
Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibitionQ37331610
Cetuximab: from bench to bedside.Q37678510
Protein kinase B (PKB/Akt), a key mediator of the PI3K signaling pathwayQ37762205
AKT signaling in physiology and diseaseQ37765214
MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivoQ38431323
Kinome siRNA-phosphoproteomic screen identifies networks regulating AKT signalingQ38500176
Combination of an allosteric Akt Inhibitor MK-2206 with etoposide or rapamycin enhances the antitumor growth effect in neuroblastoma.Q39355339
MK-2206, a Novel Allosteric Inhibitor of Akt, Synergizes with Gefitinib against Malignant Glioma via Modulating Both Autophagy and ApoptosisQ39447204
Activation of phosphatidylinositol 3-kinase/Akt signaling pathway mediates acquired resistance to sorafenib in hepatocellular carcinoma cellsQ39612275
Acquired resistance to cetuximab is mediated by increased PTEN instability and leads cross-resistance to gefitinib in HCC827 NSCLC cells.Q39707372
PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survivalQ39987929
Mechanisms of acquired resistance to cetuximab: role of HER (ErbB) family membersQ40009294
Basal and treatment-induced activation of AKT mediates resistance to cell death by AZD6244 (ARRY-142886) in Braf-mutant human cutaneous melanoma cellsQ42478581
Structural basis for inhibition of the epidermal growth factor receptor by cetuximabQ45345151
Phase II multicenter study of the epidermal growth factor receptor antibody cetuximab and cisplatin for recurrent and refractory squamous cell carcinoma of the head and neckQ46595210
EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancerQ46662707
Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors.Q46708758
Diversity of epidermal growth factor receptor-mediated activation of downstream molecules in human lung carcinomasQ51214174
Paradigm of kinase-driven pathway downstream of epidermal growth factor receptor/Akt in human lung carcinomas.Q54636490
Phase II Multicenter Study of the Antiepidermal Growth Factor Receptor Monoclonal Antibody Cetuximab in Combination With Platinum-Based Chemotherapy in Patients With Platinum-Refractory Metastatic and/or Recurrent Squamous Cell Carcinoma of the HeadQ56688854
Phospho-Akt overexpression in non-small cell lung cancer confers significant stage-independent survival disadvantageQ80901395
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectcetuximabQ420296
non-small-cell lung carcinomaQ3658562
MK-2206Q25100065
allosteric inhibitorQ70361704
P304page(s)481-491
P577publication date2013-06-01
P1433published inCancer Biology and TherapyQ2544651
P1476titleTargeting AKT with the allosteric AKT inhibitor MK-2206 in non-small cell lung cancer cells with acquired resistance to cetuximab
P478volume14

Reverse relations

cites work (P2860)
Q360763645-lipoxygenase mediates docosahexaenoyl ethanolamide and N-arachidonoyl-L-alanine-induced reactive oxygen species production and inhibition of proliferation of head and neck squamous cell carcinoma cells
Q52731012A-674563, a putative AKT1 inhibitor that also suppresses CDK2 activity, inhibits human NSCLC cell growth more effectively than the pan-AKT inhibitor, MK-2206.
Q38465098Allosteric therapies for lung cancer
Q38868047Combining three antibodies nullifies feedback-mediated resistance to erlotinib in lung cancer
Q35754270Diverse involvement of isoforms and gene aberrations of Akt in human lung carcinomas
Q36036046Effects of AKT inhibition on HGF-mediated erlotinib resistance in non-small cell lung cancer cell lines
Q92538857FOXO3 Transcription Factor Regulates IL-10 Expression in Mycobacteria-Infected Macrophages, Tuning Their Polarization and the Subsequent Adaptive Immune Response
Q36241312Litchi seed extract inhibits epidermal growth factor receptor signaling and growth of Two Non-small cell lung carcinoma cells
Q33906921Non-Small Cell Lung Carcinoma Biomarker Testing: The Pathologist's Perspective
Q46278768Overcoming resistance to cetuximab with honokiol, a small-molecule polyphenol
Q40075067PPAR-γ and Akt regulate GLUT1 and GLUT3 surface localization during Mycobacterium tuberculosis infection
Q36117718Phase II Study of the AKT Inhibitor MK-2206 plus Erlotinib in Patients with Advanced Non-Small Cell Lung Cancer Who Previously Progressed on Erlotinib
Q34387657Proteogenomic analysis of human chromosome 9-encoded genes from human samples and lung cancer tissues
Q35144924RNA interference targeting enhancer of polycomb1 exerts anti-tumor effects in lung cancer
Q42381878Selective AKT Inhibition by MK-2206 Represses Colorectal Cancer-Initiating Stem Cells.
Q36909843Squamous Cell Cancers: A Unified Perspective on Biology and Genetics
Q35129076Synthetic lethal screening reveals FGFR as one of the combinatorial targets to overcome resistance to Met-targeted therapy
Q89973548Targeting AKT/PKB to improve treatment outcomes for solid tumors
Q48187016Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins
Q97074390The Relevance of Transcription Factors in Gastric and Colorectal Cancer Stem Cells Identification and Eradication
Q38199737Type III or allosteric kinase inhibitors for the treatment of non-small cell lung cancer

Search more.