Gremlin-1 is an inhibitor of macrophage migration inhibitory factor and attenuates atherosclerotic plaque growth in ApoE-/- Mice

scientific article published on 03 September 2013

Gremlin-1 is an inhibitor of macrophage migration inhibitory factor and attenuates atherosclerotic plaque growth in ApoE-/- Mice is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M113.477745
P932PMC publication ID3814759
P698PubMed publication ID24003215
P5875ResearchGate publication ID256425703

P50authorOleg LunovQ57524185
Melanie ZieglerQ64515328
Madhumita ChatterjeeQ64858095
Jürgen BernhagenQ88059352
Peter SeizerQ88872106
Meinrad GawazQ89518767
Oliver BorstQ117266809
Tobias GeislerQ124254157
P2093author name stringMichael Lang
Karin Müller
Florian Lang
Tanja Schönberger
Uwe J F Tietge
Martina Schneider
Thomas Simmet
Jan Freark de Boer
Manuela Fahrleitner
Iris Müller
Christoph Leder
Berthold Büchele
Harald Langer
Marcus Olbrich
Florian Appenzeller
P2860cites workThe bone morphogenetic protein antagonist gremlin 1 is overexpressed in human cancers and interacts with YWHAH proteinQ21260414
I-TASSER server for protein 3D structure predictionQ21284202
Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2Q24293152
Skeletal overexpression of gremlin impairs bone formation and causes osteopeniaQ24314447
The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activitiesQ24314690
I-TASSER: a unified platform for automated protein structure and function predictionQ24605680
Crystal structure at 2.6-A resolution of human macrophage migration inhibitory factorQ24605965
AtherosclerosisQ24644573
Free-solution, label-free protein-protein interactions characterized by dynamic light scatteringQ24645138
LOMETS: a local meta-threading-server for protein structure predictionQ24682449
Atherosclerosis — An Inflammatory DiseaseQ26776972
MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitmentQ28298072
Cutting edge: bone morphogenetic protein antagonists Drm/Gremlin and Dan interact with Slits and act as negative regulators of monocyte chemotaxisQ28506053
Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterningQ28507504
Identification of drm, a novel gene whose expression is suppressed in transformed cells and which can inhibit growth of normal but not transformed cells in cultureQ28576024
Biosynthesis, post-translation modification, and functional characterization of Drm/GremlinQ28578839
Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesisQ28579502
Structure of the zebrafish snail1 gene and its expression in wild-type, spadetail and no tail mutant embryosQ29616784
Progress and challenges in translating the biology of atherosclerosisQ29619982
I-TASSER: fully automated protein structure prediction in CASP8Q30380936
Gremlin negatively modulates BMP-4 induction of embryonic mouse lung branching morphogenesisQ33941593
MolDock: a new technique for high-accuracy molecular dockingQ34530159
Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferationQ34569128
Chemokines in atherosclerosis: an updateQ34656531
From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I.Q35552554
Platelets in inflammation and atherogenesis.Q36328825
The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factorQ36363184
A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivoQ36370457
The immune response in atherosclerosis: a double-edged swordQ36508676
Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitmentQ36935739
The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse modelsQ37282249
Monocyte and macrophage dynamics during atherogenesisQ37890185
Atherosclerosis: current pathogenesis and therapeutic optionsQ37953777
Efficient docking of peptides to proteins without prior knowledge of the binding siteQ38270145
Heparan sulfate proteoglycans mediate the angiogenic activity of the vascular endothelial growth factor receptor-2 agonist gremlin.Q39473169
The Golgi-associated protein p115 mediates the secretion of macrophage migration inhibitory factor.Q39849398
Gremlin gene expression in bovine retinal pericytes exposed to elevated glucoseQ41812757
Accelerating and focusing protein-protein docking correlations using multi-dimensional rotational FFT generating functionsQ43063724
FGF2 signaling in mouse embryonic fibroblasts is crucial for self-renewal of embryonic stem cellsQ44091282
The immunoadhesin glycoprotein VI-Fc regulates arterial remodelling after mechanical injury in ApoE-/- miceQ46530171
Expression of gremlin, a bone morphogenetic protein antagonist, in human diabetic nephropathyQ46547780
Differential expression and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cellsQ47835116
Ultra-fast FFT protein docking on graphics processorsQ48191415
Effect of the oxLDL binding protein Fc-CD68 on plaque extension and vulnerability in atherosclerosis.Q50546627
Inhibition of foam cell formation using a soluble CD68-Fc fusion protein.Q51773709
Junctional adhesion molecule A expressed on human CD34+ cells promotes adhesion on vascular wall and differentiation into endothelial progenitor cells.Q51774114
Chemokine fractalkine mediates leukocyte recruitment to inflammatory endothelial cells in flowing whole blood: a critical role for P-selectin expressed on activated platelets.Q51795566
Extracellular matrix metalloproteinase inducer regulates matrix metalloproteinase activity in cardiovascular cells: implications in acute myocardial infarction.Q51810447
Soluble glycoprotein VI dimer inhibits platelet adhesion and aggregation to the injured vessel wall in vivo.Q51831538
Crystal structure of macrophage migration inhibitory factor from human lymphocyte at 2.1 A resolution.Q54586274
Bone Morphogenic Protein Antagonists Are Coexpressed With Bone Morphogenic Protein 4 in Endothelial Cells Exposed to Unstable Flow In Vitro in Mouse Aortas and in Human Coronary ArteriesQ64355517
Transcriptional profiling reveals novel markers of liver fibrogenesis: gremlin and insulin-like growth factor-binding proteins.Q64903798
ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial treeQ72689998
Platelets induce differentiation of human CD34+ progenitor cells into foam cells and endothelial cellsQ79319625
Gremlin promotes vascular smooth muscle cell proliferation and migrationQ80216002
Overexpression of apolipoprotein O does not impact on plasma HDL levels or functionality in human apolipoprotein A-I transgenic miceQ83376751
CD36 and macrophage scavenger receptor a modulate foam cell formation via inhibition of lipid-laden platelet phagocytosisQ84099965
P433issue44
P407language of work or nameEnglishQ1860
P921main subjectmacrophageQ184204
atherosclerosisQ12252367
P304page(s)31635-31645
P577publication date2013-09-03
P1433published inJournal of Biological ChemistryQ867727
P1476titleGremlin-1 is an inhibitor of macrophage migration inhibitory factor and attenuates atherosclerotic plaque growth in ApoE-/- Mice
P478volume288

Reverse relations

cites work (P2860)
Q38896053Agonists and Antagonists of TGF-β Family Ligands
Q64269818Comparison of adipose‑ and bone marrow‑derived stem cells in protecting against ox‑LDL‑induced inflammation in M1‑macrophage‑derived foam cells
Q57031658EXPRESS: Gremlin1 blocks vascular endothelial growth factor signalling in the pulmonary microvascular endothelium
Q47676484Gremlin and renal diseases: ready to jump the fence to clinical utility?
Q94596469Gremlin in the Vitreous of Patients with Proliferative Diabetic Retinopathy and the Downregulation of Gremlin in Retinal Pigment Epithelial Cells
Q37709009Gremlin inhibits UV-induced skin cell damages via activating VEGFR2-Nrf2 signaling
Q89909493Gremlin mediates the TGF-β-induced induction of profibrogenic genes in human retinal pigment epithelial cells
Q37702395Gremlin promotes retinal pigmentation epithelial (RPE) cell proliferation, migration and VEGF production via activating VEGFR2-Akt-mTORC2 signaling.
Q38895003Gremlin regulates renal inflammation via the vascular endothelial growth factor receptor 2 pathway.
Q27334805Gremlin-1 Overexpression in Mouse Lung Reduces Silica-Induced Lymphocyte Recruitment - A Link to Idiopathic Pulmonary Fibrosis through Negative Correlation with CXCL10 Chemokine
Q33867359Gremlin1 plays a key role in kidney development and renal fibrosis
Q46909789High Plasma Levels of Gremlin-1 and Macrophage Migration Inhibitory Factor, but Not Their Ratio, Indicate an Increased Risk for Acute Coronary Syndrome in Patients With Type 2 Diabetes Mellitus.
Q94547046Infection of Monocytes From Tuberculosis Patients With Two Virulent Clinical Isolates of Mycobacterium tuberculosis Induces Alterations in Myeloid Effector Functions
Q51178261Overexpression of Gremlin1 in Mesenchymal Stem Cells Improves Hindlimb Ischemia in Mice by Enhancing Cell Survival.
Q27329947Platelet-derived CXCL12 regulates monocyte function, survival, differentiation into macrophages and foam cells through differential involvement of CXCR4-CXCR7
Q64933431Porphyromonas gingivalis-Induced MIF Regulates Intercellular Adhesion Molecule-1 Expression in EA.hy926 Cells and Monocyte-Endothelial Cell Adhesion Through the Receptors CD74 and CXCR4.
Q91679381Screening and Risk Assessment of Coronary Artery Disease in Patients With Type 2 Diabetes: An Updated Review
Q30090218Structure of Gremlin-1 and analysis of its interaction with BMP-2
Q89723568Targeting the progression of chronic kidney disease
Q27025762The DAN family: modulators of TGF-β signaling and beyond

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