Binding of the sialic acid-binding lectin, Siglec-9, to the membrane mucin, MUC1, induces recruitment of β-catenin and subsequent cell growth

scientific article published on 17 September 2013

Binding of the sialic acid-binding lectin, Siglec-9, to the membrane mucin, MUC1, induces recruitment of β-catenin and subsequent cell growth is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M113.471318
P932PMC publication ID3814777
P698PubMed publication ID24045940
P5875ResearchGate publication ID256705343

P2093author name stringTetsuji Sawada
Kosei Hirakawa
Masakazu Yashiro
Hiroshi Nakada
Mariko Ohta
Kaoru Akita
Yugo Mori
Munetoyo Toda
Akiko Ishida
Mizue Inoue
Shuhei Tanida
P2860cites workCloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis pathwaysQ22254056
Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix componentsQ24312497
Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-cateninQ24522854
Siglecs in the immune systemQ24682458
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanismQ28114789
The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3 beta and beta-cateninQ28142359
DF3/MUC1 signaling in multiple myeloma cells is regulated by interleukin-7Q28204499
Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin signalingQ28205083
Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary glandQ28208406
The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-cateninQ28210439
MUC1, the renaissance moleculeQ28215731
Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta-catenin in cell adhesionQ28237260
Siglecs--the major subfamily of I-type lectinsQ28261393
MUC1 oncoprotein blocks glycogen synthase kinase 3beta-mediated phosphorylation and degradation of beta-cateninQ28281821
Cell-associated episialin is a complex containing two proteins derived from a common precursorQ28294785
The membrane mucin Muc4 inhibits apoptosis induced by multiple insults via ErbB2-dependent and ErbB2-independent mechanismsQ28566287
Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes.Q30868758
Isolation and sequencing of a cDNA coding for the human DF3 breast carcinoma-associated antigenQ33564580
Topology of cell adhesion moleculesQ33836280
MUC1 is a novel regulator of ErbB1 receptor traffickingQ34571022
MUC1 oncoprotein functions in activation of fibroblast growth factor receptor signalingQ34572658
Beta-catenin and the morphogenesis of colorectal cancerQ34732468
Cloning and sequencing of a human pancreatic tumor mucin cDNA.Q34942577
Cellular distribution of Lysyl-tRNA synthetase and its interaction with Gag during human immunodeficiency virus type 1 assemblyQ35123403
Two categories of mammalian galactose-binding receptors distinguished by glycan array profilingQ35545703
Galectin-3 interaction with Thomsen-Friedenreich disaccharide on cancer-associated MUC1 causes increased cancer cell endothelial adhesion.Q38307814
Immunomodulation of monocyte-derived dendritic cells through ligation of tumor-produced mucins to Siglec-9Q39640710
Interaction between circulating galectin-3 and cancer-associated MUC1 enhances tumour cell homotypic aggregation and prevents anoikis.Q39690197
Ligation of tumour-produced mucins to CD22 dramatically impairs splenic marginal zone B-cellsQ39928639
MUC1 initiates Src-CrkL-Rac1/Cdc42-mediated actin cytoskeletal protrusive motility after ligating intercellular adhesion molecule-1.Q39993144
MUC1 (CD227) interacts with lck tyrosine kinase in Jurkat lymphoma cells and normal T cellsQ40498647
MUC1 initiates a calcium signal after ligation by intercellular adhesion molecule-1.Q40550805
Tumour-associated leucocytes: friends or foes in breast carcinomaQ40758526
Identification of MUC1 proteolytic cleavage sites in vivoQ40807638
Purification and composition of a novel gastrointestinal tumor-associated glycoprotein expressing sialylated lacto-N-fucopentaose II (CA 19-9).Q44366720
Macrophage-tumour cell interactions: identification of MUC1 on breast cancer cells as a potential counter-receptor for the macrophage-restricted receptor, sialoadhesinQ73300727
Serine phosphorylation-regulated ubiquitination and degradation of beta-cateninQ73735409
Expression of CD33-related siglecs on human mononuclear phagocytes, monocyte-derived dendritic cells and plasmacytoid dendritic cellsQ80853556
Muc1 affects c-Src signaling in PyV MT-induced mammary tumorigenesisQ81753531
P4510describes a project that usesImageJQ1659584
P433issue44
P407language of work or nameEnglishQ1860
P921main subjectcell growthQ189159
P304page(s)31842-31852
P577publication date2013-09-17
P1433published inJournal of Biological ChemistryQ867727
P1476titleBinding of the sialic acid-binding lectin, Siglec-9, to the membrane mucin, MUC1, induces recruitment of β-catenin and subsequent cell growth
P478volume288

Reverse relations

cites work (P2860)
Q37581540Altered tumor-cell glycosylation promotes metastasis
Q36283550Binding of Galectin-3, a β-Galactoside-binding Lectin, to MUC1 Protein Enhances Phosphorylation of Extracellular Signal-regulated Kinase 1/2 (ERK1/2) and Akt, Promoting Tumor Cell Malignancy
Q38285397Cancer intelligence acquired (CIA): tumor glycosylation and sialylation codes dismantling antitumor defense
Q101226457Cancer-associated hypersialylated MUC1 drives the differentiation of human monocytes into macrophages with a pathogenic phenotype
Q51730575Cell-based glycan arrays for probing glycan-glycan binding protein interactions.
Q35612914Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis.
Q34314456Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer
Q36167300GABA selectively increases mucin-1 expression in isolated pig jejunum
Q47552397Implication of Soluble Forms of Cell Adhesion Molecules in Infectious Disease and Tumor: Insights from Transgenic Animal Models
Q34580364Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs.
Q58580439MUC1 Mucin: A Putative Regulatory (Checkpoint) Molecule of T Cells
Q34737810MUC1 protein induces urokinase-type plasminogen activator (uPA) by forming a complex with NF-κB p65 transcription factor and binding to the uPA promoter, leading to enhanced invasiveness of cancer cells
Q38177983MUC1: a novel metabolic master regulator
Q37578540Making Home Sweet and Sturdy: Toxoplasma gondii ppGalNAc-Ts Glycosylate in Hierarchical Order and Confer Cyst Wall Rigidity
Q57107715O-linked mucin-type glycosylation in breast cancer
Q36328299Pathobiological implications of mucin glycans in cancer: Sweet poison and novel targets
Q38676224Regulation of airway inflammation by Siglec-8 and Siglec-9 sialoglycan ligand expression
Q55318147Sialic Acid Metabolism: A Key Player in Breast Cancer Metastasis Revealed by Metabolomics.
Q48149385Siglec-9 is upregulated in rheumatoid arthritis and suppresses collagen-induced arthritis through reciprocal regulation of Th17-/Treg-cell differentiation.
Q92730933The Complex Interaction between the Tumor Micro-Environment and Immune Checkpoints in Breast Cancer
Q93167129The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour Progression
Q37600827The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9.
Q38598881Therapeutic Targeting of Siglecs using Antibody- and Glycan-Based Approaches.
Q38602821Transmembrane Mucin Expression and Function in Embryo Implantation and Placentation
Q55374172Triple-negative and HER2-overexpressing breast cancer cell sialylation impacts tumor microenvironment T-lymphocyte subset recruitment: a possible mechanism of tumor escape.
Q89736315Tumor Microenvironment-Associated Extracellular Matrix Components Regulate NK Cell Function
Q39160967Viewing Siglecs through the lens of tumor immunology

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